EA200870149A1 - Распадающиеся загружаемые таблетки - Google Patents

Распадающиеся загружаемые таблетки

Info

Publication number
EA200870149A1
EA200870149A1 EA200870149A EA200870149A EA200870149A1 EA 200870149 A1 EA200870149 A1 EA 200870149A1 EA 200870149 A EA200870149 A EA 200870149A EA 200870149 A EA200870149 A EA 200870149A EA 200870149 A1 EA200870149 A1 EA 200870149A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tablet
decomposed
surface area
active substance
compressed form
Prior art date
Application number
EA200870149A
Other languages
English (en)
Other versions
EA018606B1 (ru
Inventor
Пер Хольм
Лиллиан Слот
Original Assignee
Лайфсайкл Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лайфсайкл Фарма А/С filed Critical Лайфсайкл Фарма А/С
Publication of EA200870149A1 publication Critical patent/EA200870149A1/ru
Publication of EA018606B1 publication Critical patent/EA018606B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Распадающийся загружаемый таблетированный продукт в прессованой форме, включающий: i) по меньшей мере 60 мас./мас.% сорбирующего материала, имеющего удельную площадь поверхности (площадь поверхности по БЭТ) по меньшей мере 50 м/г при измерении газовой адсорбцией, или смеси указанных сорбирующих материалов, и ii) дезинтегрант или смесь дезинтегрантов, где таблетка в прессованой форме имеет: а) пористость 45 об./об.% или больше, b) твердость по меньшей мере 20 Н и с) емкость загрузки по меньшей мере 30% жидкости. Таблетка подходит для получения таблетки, содержащей активное вещество, например, посредством погружения таблетки в жидкость, содержащую активное вещество. Таким образом, изобретение предоставляет безопасный и воспроизводимый новый способ получения фармацевтических таблеток.
EA200870149A 2006-01-05 2007-01-05 Распадающиеся загружаемые таблетки EA018606B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200600028 2006-01-05
PCT/DK2007/000008 WO2007076874A1 (en) 2006-01-05 2007-01-05 Disintegrating loadable tablets

Publications (2)

Publication Number Publication Date
EA200870149A1 true EA200870149A1 (ru) 2009-04-28
EA018606B1 EA018606B1 (ru) 2013-09-30

Family

ID=36782289

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870149A EA018606B1 (ru) 2006-01-05 2007-01-05 Распадающиеся загружаемые таблетки

Country Status (13)

Country Link
US (1) US20090186081A1 (ru)
EP (1) EP1973529B1 (ru)
JP (1) JP5498020B2 (ru)
KR (1) KR101486590B1 (ru)
CN (1) CN101365428B (ru)
AT (1) ATE510535T1 (ru)
AU (1) AU2007203715B2 (ru)
BR (1) BRPI0706280A2 (ru)
CA (1) CA2634160C (ru)
DK (1) DK1973529T3 (ru)
EA (1) EA018606B1 (ru)
HK (1) HK1120402A1 (ru)
WO (1) WO2007076874A1 (ru)

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Also Published As

Publication number Publication date
WO2007076874A1 (en) 2007-07-12
JP5498020B2 (ja) 2014-05-21
JP2009522315A (ja) 2009-06-11
DK1973529T3 (da) 2011-09-12
EP1973529A1 (en) 2008-10-01
HK1120402A1 (en) 2009-04-03
US20090186081A1 (en) 2009-07-23
KR101486590B1 (ko) 2015-01-26
AU2007203715B2 (en) 2012-08-02
BRPI0706280A2 (pt) 2011-03-22
KR20080085903A (ko) 2008-09-24
EP1973529B1 (en) 2011-05-25
EA018606B1 (ru) 2013-09-30
AU2007203715A1 (en) 2007-07-12
CA2634160C (en) 2014-04-15
ATE510535T1 (de) 2011-06-15
CN101365428B (zh) 2012-08-29
CA2634160A1 (en) 2007-07-12
CN101365428A (zh) 2009-02-11

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