EA200802172A1 - Замещенные бифенилкарбоновые кислоты и их производные - Google Patents

Замещенные бифенилкарбоновые кислоты и их производные

Info

Publication number
EA200802172A1
EA200802172A1 EA200802172A EA200802172A EA200802172A1 EA 200802172 A1 EA200802172 A1 EA 200802172A1 EA 200802172 A EA200802172 A EA 200802172A EA 200802172 A EA200802172 A EA 200802172A EA 200802172 A1 EA200802172 A1 EA 200802172A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
substituted biphenyl
carbonic acids
group
compounds
Prior art date
Application number
EA200802172A
Other languages
English (en)
Other versions
EA016129B9 (ru
EA016129B1 (ru
Inventor
Фрэнцис Вилсн
Элисон Рид
Вэлери Ридер
Ричард Джон Хэррисон
Михиро Зунузэ
Рэмэдиос Хернадез-Перни
Джереми Мэйджер
Сирилль Буссар
Кэсрин Смэлт
Джесс Тэйлор
Эдэляйн Лёформаль
Эндру Кэнсфильд
Свенья Буркхардт
Чи Янг Хо
Ен Зэнг
Original Assignee
Орто-Макнил-Дженссен Фармасьютикэлз, Инк.
Целльзом Лимитид
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орто-Макнил-Дженссен Фармасьютикэлз, Инк., Целльзом Лимитид filed Critical Орто-Макнил-Дженссен Фармасьютикэлз, Инк.
Publication of EA200802172A1 publication Critical patent/EA200802172A1/ru
Publication of EA016129B1 publication Critical patent/EA016129B1/ru
Publication of EA016129B9 publication Critical patent/EA016129B9/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Настоящее изобретение касается соединений общей формулы (I) со значениями X, Y, R, R, R, R, Rи R, и/или к их солям или сложным эфирам. Кроме того, изобретение касается применения указанных соединений для лечения болезни Альцгеймера и их применения для модуляции активности γ-секретазы, где А представляет собой О, NH, S; Х представляет собой связь или группу -CRR; Н представляет собой карбоксильную группу или замещенную или незамещенную тетразольную группу.
EA200802172A 2006-04-21 2007-04-20 Замещенные бифенилкарбоновые кислоты и их производные EA016129B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112938A EP1849762B1 (en) 2006-04-21 2006-04-21 Substituted biphenyl carboxylic acids and derivatives thereof
PCT/US2007/067039 WO2007124394A1 (en) 2006-04-21 2007-04-20 Substituted biphenyl carboxylic acids and derivatives thereof

Publications (3)

Publication Number Publication Date
EA200802172A1 true EA200802172A1 (ru) 2009-06-30
EA016129B1 EA016129B1 (ru) 2012-02-28
EA016129B9 EA016129B9 (ru) 2012-06-29

Family

ID=36688012

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200802172A EA016129B9 (ru) 2006-04-21 2007-04-20 Замещенные бифенилкарбоновые кислоты и их производные

Country Status (35)

Country Link
US (1) US7557244B2 (ru)
EP (2) EP1849762B1 (ru)
JP (1) JP5479088B2 (ru)
KR (1) KR101542255B1 (ru)
CN (1) CN101687758B (ru)
AP (1) AP2008004656A0 (ru)
AR (1) AR060568A1 (ru)
AU (1) AU2007240335B2 (ru)
BR (1) BRPI0710656A2 (ru)
CA (1) CA2650006C (ru)
CR (2) CR10375A (ru)
CY (1) CY1109399T1 (ru)
DE (1) DE602006007810D1 (ru)
DK (1) DK1849762T3 (ru)
EA (1) EA016129B9 (ru)
ES (2) ES2328616T3 (ru)
GE (1) GEP20115269B (ru)
GT (1) GT200900120A (ru)
IL (2) IL194852A0 (ru)
MA (1) MA30475B1 (ru)
MX (1) MX2008013445A (ru)
MY (1) MY148953A (ru)
NO (1) NO20084517L (ru)
NZ (1) NZ573000A (ru)
PE (1) PE20080364A1 (ru)
PL (1) PL1849762T3 (ru)
PT (1) PT1849762E (ru)
SI (1) SI1849762T1 (ru)
SM (1) SMP200800061B (ru)
TN (1) TNSN08413A1 (ru)
TW (1) TWI399362B (ru)
UA (1) UA95952C2 (ru)
UY (1) UY30301A1 (ru)
WO (1) WO2007124394A1 (ru)
ZA (1) ZA200809856B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA019710B1 (ru) 2007-10-19 2014-05-30 Янссен Фармацевтика, Н.В. ПРОИЗВОДНЫЕ 2-АРИЛ-4-МЕТИЛПЕНТАНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ γ-СЕКРЕТАЗЫ
ES2378594T3 (es) 2007-10-19 2012-04-16 Janssen Pharmaceutica, N.V. Moduladores de piperidinilo y piperazinilo de la y-secretasa
WO2009052350A1 (en) * 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Amine linked modulators of y-secretase
JP2011500720A (ja) * 2007-10-19 2011-01-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｇｓｍ中間体
WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
US8217064B2 (en) 2007-12-20 2012-07-10 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
EP2488031A4 (en) * 2009-10-16 2014-07-23 Merck Sharp & Dohme DIARYL ETHER DERIVATIVES AS A NOTCH-PROOFING GAMMETRETASE INHIBITOR
US8785481B2 (en) 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
CA2828764A1 (en) * 2011-03-03 2012-09-07 Treventis Corporation Anti-amyloid compounds and methods
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
AU2001257022B2 (en) 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
NZ537206A (en) * 2002-06-27 2007-06-29 Astellas Pharma Inc Aminoalcohol derivatives
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
WO2006022237A1 (ja) * 2004-08-24 2006-03-02 Kissei Pharmaceutical Co., Ltd. 脂肪肝の予防または治療剤
US8148572B2 (en) * 2005-10-06 2012-04-03 Astrazeneca Ab Compounds

Also Published As

Publication number Publication date
PT1849762E (pt) 2009-09-16
IL194790A0 (en) 2009-08-03
PE20080364A1 (es) 2008-05-16
ES2400530T3 (es) 2013-04-10
ZA200809856B (en) 2009-06-24
AR060568A1 (es) 2008-06-25
TW200815320A (en) 2008-04-01
WO2007124394A1 (en) 2007-11-01
CR10451A (es) 2009-03-31
JP2009544573A (ja) 2009-12-17
NO20084517L (no) 2009-01-13
IL194790A (en) 2012-12-31
SI1849762T1 (sl) 2009-12-31
EA016129B9 (ru) 2012-06-29
MA30475B1 (fr) 2009-06-01
IL194852A0 (en) 2009-08-03
CN101687758A (zh) 2010-03-31
GT200900120A (es) 2009-11-16
AU2007240335A1 (en) 2007-11-01
CN101687758B (zh) 2014-05-14
PL1849762T3 (pl) 2009-12-31
GEP20115269B (en) 2011-08-25
DE602006007810D1 (de) 2009-08-27
NZ573000A (en) 2011-11-25
MY148953A (en) 2013-06-14
TWI399362B (zh) 2013-06-21
EP1849762A1 (en) 2007-10-31
ES2328616T3 (es) 2009-11-16
SMAP200800061A (it) 2008-11-19
AP2008004656A0 (en) 2008-10-31
EA016129B1 (ru) 2012-02-28
US7557244B2 (en) 2009-07-07
KR20090024679A (ko) 2009-03-09
EP1849762B1 (en) 2009-07-15
CA2650006A1 (en) 2007-11-01
US20070293567A1 (en) 2007-12-20
MX2008013445A (es) 2009-03-10
UY30301A1 (es) 2007-08-31
JP5479088B2 (ja) 2014-04-23
UA95952C2 (ru) 2011-09-26
CR10375A (es) 2009-02-26
SMP200800061B (it) 2009-07-14
CA2650006C (en) 2016-08-23
KR101542255B1 (ko) 2015-08-06
CY1109399T1 (el) 2014-07-02
EP2021314B1 (en) 2013-01-23
DK1849762T3 (da) 2009-10-12
BRPI0710656A2 (pt) 2011-08-16
AU2007240335B2 (en) 2013-05-02
TNSN08413A1 (en) 2010-04-14
EP2021314A1 (en) 2009-02-11

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU