EA200801420A1 - Фармацевтическое средство для лечения уретеролитиаза - Google Patents

Фармацевтическое средство для лечения уретеролитиаза

Info

Publication number
EA200801420A1
EA200801420A1 EA200801420A EA200801420A EA200801420A1 EA 200801420 A1 EA200801420 A1 EA 200801420A1 EA 200801420 A EA200801420 A EA 200801420A EA 200801420 A EA200801420 A EA 200801420A EA 200801420 A1 EA200801420 A1 EA 200801420A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
substituent
lower alkyl
carbamoyl
cyano
Prior art date
Application number
EA200801420A
Other languages
English (en)
Other versions
EA016008B1 (ru
Inventor
Мамору Кобаяси
Йоситака Томияма
Куми Кобаяси
Original Assignee
Киссеи Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Киссеи Фармасьютикал Ко., Лтд. filed Critical Киссеи Фармасьютикал Ко., Лтд.
Publication of EA200801420A1 publication Critical patent/EA200801420A1/ru
Publication of EA016008B1 publication Critical patent/EA016008B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Настоящее изобретение относится к фармацевтическим композициям, используемым для облегчения боли, вызываемой камнями в мочеточниках, как средство, способствующее выделению камней мочеточников или т.п. Иными словами, настоящее изобретение относится к фармацевтической композиции для лечения уретеролитиаза, которая включает в качестве активного ингредиента производное индолина, представленное общей формулой (I), или его соль. В указанной формуле R представляет собой насыщенную или ненасыщенную алифатическую ацильную группу, которая может иметь заместитель; гидроксиалгруппу; алифатическую ацилоксиалкилгруппу; низшую алкилгруппу, которая содержит в качестве заместителя низшую алкоксигруппу, карбоксигруппу, низшую алкоксикарбонилгруппу, арилзамещенную низшую алкоксикарбонилгруппу, карбамоилгруппу, моно- или ди(низший алкил)замещенную карбамоилгруппу или цианогруппу; необязательно замещенную ароматическую ацилгруппу; фуроилгруппу или пиридилкарбонилгруппу; R1 представляет собой цианогруппу или карбамоилгруппу; и R2 представляет собой низшую алкилгруппу, которая может иметь в качестве заместителя галоген, цианогруппу или арилгруппу.
EA200801420A 2005-11-24 2006-11-22 Применение силодозина для лечения уретеролитиаза EA016008B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005339188 2005-11-24
PCT/JP2006/323280 WO2007060974A1 (ja) 2005-11-24 2006-11-22 尿管結石症の治療用医薬

Publications (2)

Publication Number Publication Date
EA200801420A1 true EA200801420A1 (ru) 2009-02-27
EA016008B1 EA016008B1 (ru) 2012-01-30

Family

ID=38067199

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801420A EA016008B1 (ru) 2005-11-24 2006-11-22 Применение силодозина для лечения уретеролитиаза

Country Status (13)

Country Link
US (2) US20090163571A1 (ru)
EP (1) EP1956001A4 (ru)
JP (1) JP4865724B2 (ru)
KR (1) KR101232425B1 (ru)
CN (1) CN101336230B (ru)
BR (1) BRPI0618996A2 (ru)
CA (1) CA2628476C (ru)
EA (1) EA016008B1 (ru)
HK (1) HK1125634A1 (ru)
NO (1) NO20082816L (ru)
TW (1) TW200803843A (ru)
UA (1) UA92765C2 (ru)
WO (1) WO2007060974A1 (ru)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59309490D1 (de) * 1992-09-14 1999-05-06 Forssmann Wolf Georg Prof Dr Neue verwendung von inhibitoren der phosphodiesterase iv
EP0600675B1 (en) * 1992-12-02 1998-07-08 Kissei Pharmaceutical Co., Ltd. Indoline compounds for the treatment of dysuria
JP4324266B2 (ja) * 1999-02-26 2009-09-02 キッセイ薬品工業株式会社 α１Ａアドレナリン受容体の変異体、当該変異体を用いた測定方法及び前立腺肥大に伴う排尿困難症治療剤
CN1237060C (zh) * 2001-01-02 2006-01-18 弗·哈夫曼-拉罗切有限公司 用作α1A/B肾上腺素能受体拮抗剂的喹唑酮衍生物
JP2001288115A (ja) * 2001-02-07 2001-10-16 Yamanouchi Pharmaceut Co Ltd 下部尿路症治療剤
US20040072551A1 (en) * 2002-10-10 2004-04-15 Sanford John Richard Communication device with front-end integration

Also Published As

Publication number Publication date
CN101336230A (zh) 2008-12-31
JPWO2007060974A1 (ja) 2009-05-07
CN101336230B (zh) 2011-11-23
NO20082816L (no) 2008-08-13
WO2007060974A1 (ja) 2007-05-31
KR101232425B1 (ko) 2013-02-12
JP4865724B2 (ja) 2012-02-01
HK1125634A1 (en) 2009-08-14
US20090163571A1 (en) 2009-06-25
KR20080071603A (ko) 2008-08-04
TW200803843A (en) 2008-01-16
EA016008B1 (ru) 2012-01-30
BRPI0618996A2 (pt) 2011-09-20
UA92765C2 (ru) 2010-12-10
TWI379680B (ru) 2012-12-21
US20110230538A1 (en) 2011-09-22
EP1956001A4 (en) 2012-12-26
EP1956001A1 (en) 2008-08-13
CA2628476A1 (en) 2007-05-31
CA2628476C (en) 2013-10-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU