EA200800661A1 - Полимерные конъюгаты k-252а и его производных - Google Patents

Полимерные конъюгаты k-252а и его производных

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Publication number
EA200800661A1
EA200800661A1 EA200800661A EA200800661A EA200800661A1 EA 200800661 A1 EA200800661 A1 EA 200800661A1 EA 200800661 A EA200800661 A EA 200800661A EA 200800661 A EA200800661 A EA 200800661A EA 200800661 A1 EA200800661 A1 EA 200800661A1
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relates
alleviation
prevention
treatment
derivatives
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EA200800661A
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EA017318B1 (ru
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Сильвио Траверса
Раффаелла Баньод
Доменико Бароне
Луиза Бертирионе Рава Росса
Сильвано Фумеро
Валентина Майнеро
Алессандра МАРКОНИ
Сецилия Одерда
Карло ПИНЧЕЛЛИ
Кьяра Лоренцетто
Лука Беккария
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Креабилис Терапеутикс С.П.А.
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Application filed by Креабилис Терапеутикс С.П.А. filed Critical Креабилис Терапеутикс С.П.А.
Publication of EA200800661A1 publication Critical patent/EA200800661A1/ru
Publication of EA017318B1 publication Critical patent/EA017318B1/ru

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    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0666—Polycondensates containing five-membered rings, condensed with other rings, with nitrogen atoms as the only ring hetero atoms
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  • Health & Medical Sciences (AREA)
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Abstract

Настоящее изобретение относится к новым полимерным конъюгатам K-252а и его производных и их применению для получения фармацевтической композиции для предупреждения, облегчения и лечения киназассоциированных патологий. В частности, настоящее изобретение относится к предупреждению, облегчению и лечению HMGB1-ассоциированных патологий. В определенном аспекте изобретение относится к применению новых полимерных конъюгатов K-252а и его производных при получении фармацевтической композиции, применимой для предупреждения, облегчения и лечения неврологических расстройств, невропатий и нейродегенеративных расстройств центральной и периферической нервной системы. В другом предпочтительном аспекте изобретение относится к применению полимерных конъюгатов при получении фармацевтической композиции, применимой для предупреждения, облегчения и лечения кожных патологий, в частности кожных патологий, ассоциированных с избыточной пролиферацией кератиноцитов, в частности псориаза. В еще одном аспекте изобретение относится к применению полимерных конъюгатов для предупреждения, облегчения и лечения боли, связанной с NGF. Конкретнее, настоящее изобретение относится к полимерному конъюгату K-252а и его производным формулы (I), когда полимер представляет собой полиэтиленгликоль или метоксиполиэтиленгликоль.
EA200800661A 2005-08-25 2006-08-25 Полимерные конъюгаты индолокарбазола и его производных EA017318B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71089005P 2005-08-25 2005-08-25
US72045405P 2005-09-27 2005-09-27
US81146906P 2006-06-07 2006-06-07
PCT/EP2006/008374 WO2007022999A1 (en) 2005-08-25 2006-08-25 Polymer conjugates of k-252a and derivatives thereof

Publications (2)

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EA200800661A1 true EA200800661A1 (ru) 2008-06-30
EA017318B1 EA017318B1 (ru) 2012-11-30

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ID=37075187

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EA200800661A EA017318B1 (ru) 2005-08-25 2006-08-25 Полимерные конъюгаты индолокарбазола и его производных

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US (1) US8673347B2 (ru)
EP (1) EP1919979B2 (ru)
JP (1) JP5366548B2 (ru)
KR (1) KR101379693B1 (ru)
AU (1) AU2006284096B2 (ru)
BR (1) BRPI0615277A2 (ru)
CA (1) CA2620032C (ru)
CY (1) CY1114995T1 (ru)
DK (1) DK1919979T4 (ru)
EA (1) EA017318B1 (ru)
ES (1) ES2444003T5 (ru)
HK (1) HK1123563A1 (ru)
HR (1) HRP20140218T4 (ru)
IL (1) IL189187A (ru)
MX (1) MX2008002524A (ru)
NZ (1) NZ566160A (ru)
PL (1) PL1919979T5 (ru)
PT (1) PT1919979E (ru)
RS (1) RS53195B2 (ru)
SI (1) SI1919979T2 (ru)
WO (1) WO2007022999A1 (ru)

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