EA200800210A1 - Ингибиторы пролиферации раковых клеток, т-клеток и кератиноцитов - Google Patents

Ингибиторы пролиферации раковых клеток, т-клеток и кератиноцитов

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Publication number
EA200800210A1
EA200800210A1 EA200800210A EA200800210A EA200800210A1 EA 200800210 A1 EA200800210 A1 EA 200800210A1 EA 200800210 A EA200800210 A EA 200800210A EA 200800210 A EA200800210 A EA 200800210A EA 200800210 A1 EA200800210 A1 EA 200800210A1
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EA
Eurasian Patent Office
Prior art keywords
cells
amino acid
naturally occurring
side chain
occurring amino
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EA200800210A
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English (en)
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EA014688B1 (ru
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Йоханн Лебан
Мартин Кралик
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4ЭсЦэ АГ
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Application filed by 4ЭсЦэ АГ filed Critical 4ЭсЦэ АГ
Publication of EA200800210A1 publication Critical patent/EA200800210A1/ru
Publication of EA014688B1 publication Critical patent/EA014688B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/10—Anti-acne agents
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    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
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    • A61P19/00—Drugs for skeletal disorders
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/08—Tripeptides
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
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Abstract

Данное изобретение относится к соединениям общей формулы (I) и их солям и физиологически функциональным производным, где Y представляет собой -NRR, -RC=ONRR, -NRC=SNRR, -NRC=NRNR, гетероцикл, -C=ONRR, гетероцикл или арил; n равен числу от 0 до 8; m равен 0 или 1; r равен числу от 0 до 3; t равен числу от 0 до 3; Х представляет собой О или N; Z представляет собой СН, С=O, C=S или простую связь; Zпредставляет собой CO-R, CS-R, (CH)-Rили боковую цепь встречающейся в природе аминокислоты; Zпредставляет собой CO-R, CS-Rили (СН)-Rили боковую цепь встречающейся в природе аминокислоты; Zпредставляет собой CO-R, CS-Rили (CH)-Rили боковую цепь встречающейся в природе аминокислоты; Zпредставляет собой Н, алкил, алкокси или циклоалкил; R, R, Rи Rпредставляют собой независимо друг от друга Н, ОН, SH, NH, CN, NO, алкил, циклоалкил, гетероциклоалкил, галогеноалкил, алкилтио, галогеноалкилокси, гидроксиалкил, гидроксиалкиламино, алкиламино, алкиларил, алкилсульфинил, алкилсульфонил, алкилтиоалкил, алкилсульфинилалкил, алкилсульфонилалкил, алкоксиалкил, алкокси, арилокси, гетероарил, арил или галоген.
EA200800210A 2005-08-10 2006-08-10 Ингибиторы пролиферации раковых клеток, т-клеток и кератиноцитов EA014688B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05017391A EP1752467A1 (en) 2005-08-10 2005-08-10 Inhibitors of cancer cell, t-cell and keratinocyte proliferation
PCT/EP2006/007933 WO2007017284A2 (en) 2005-08-10 2006-08-10 Inhibitors of cancer cell, t-cell and keratinocyte proliferation

Publications (2)

Publication Number Publication Date
EA200800210A1 true EA200800210A1 (ru) 2008-08-29
EA014688B1 EA014688B1 (ru) 2010-12-30

Family

ID=34981872

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800210A EA014688B1 (ru) 2005-08-10 2006-08-10 Ингибиторы пролиферации раковых клеток, т-клеток и кератиноцитов

Country Status (14)

Country Link
EP (4) EP1752467A1 (ru)
JP (1) JP2009504596A (ru)
KR (1) KR20080039895A (ru)
CN (2) CN102174074A (ru)
AU (1) AU2006278150B2 (ru)
BR (1) BRPI0614902A2 (ru)
CA (1) CA2618750A1 (ru)
EA (1) EA014688B1 (ru)
IL (1) IL189413A0 (ru)
MX (1) MX2008001900A (ru)
NO (1) NO20080858L (ru)
NZ (1) NZ565793A (ru)
WO (1) WO2007017284A2 (ru)
ZA (1) ZA200801359B (ru)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
WO2007097720A2 (en) * 2006-02-21 2007-08-30 Agency For Science, Technology And Research Method and reagents for treating hepatic fibrosis and inflammation
US20090286968A1 (en) 2008-04-25 2009-11-19 Auburn University 2-Quinoxalinol Salen Compounds and Uses Thereof
WO2011089167A1 (en) 2010-01-19 2011-07-28 Virologik Gmbh Kombination of proteasome inhibitors and anti -hepatitis medication for treating retroviral diseases
CN103588761B (zh) * 2013-10-22 2015-05-27 湖南大学 N-[1-(苯并呋喃-5-基)-2-氧代乙基]苯并吡喃-4-酰胺的制备与应用
JP6768270B2 (ja) * 2015-08-03 2020-10-14 学校法人神戸学院 ビオチン直接結合型タンパク質活性調節物質
EP3512602B1 (en) 2016-09-16 2024-03-27 HSF Pharmaceuticals Inhibitors of heat shock factors (hsf) and uses thereof

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JPH05140063A (ja) * 1991-11-19 1993-06-08 Suntory Ltd ジペプチド誘導体及びそれを有効成分とする骨疾患の予防及び治療剤
GB9300048D0 (en) * 1993-01-04 1993-03-03 Wellcome Found Endothelin converting enzyme inhibitors
WO1994017817A1 (en) * 1993-02-12 1994-08-18 Corvas International, Inc. Inhibitors of thrombosis
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
CA2238175A1 (en) * 1995-11-28 1997-06-19 Cephalon, Inc. D-amino acid derived inhibitors of cysteine and serine proteases
AU2003255240A1 (en) 2002-08-09 2004-02-25 Axys Pharmaceuticals Proteasome inhibitors : peptide derivatives having c-terminal heteroaryl groups
US7223745B2 (en) * 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same

Also Published As

Publication number Publication date
AU2006278150A1 (en) 2007-02-15
IL189413A0 (en) 2008-06-05
AU2006278150B2 (en) 2012-03-08
EA014688B1 (ru) 2010-12-30
EP2284179A2 (en) 2011-02-16
NO20080858L (no) 2008-04-10
EP2284178A2 (en) 2011-02-16
EP1922327A2 (en) 2008-05-21
MX2008001900A (es) 2008-03-26
WO2007017284A3 (en) 2007-07-26
CA2618750A1 (en) 2007-02-15
JP2009504596A (ja) 2009-02-05
KR20080039895A (ko) 2008-05-07
NZ565793A (en) 2011-06-30
CN101233146A (zh) 2008-07-30
WO2007017284A2 (en) 2007-02-15
ZA200801359B (en) 2009-02-25
EP2284179A3 (en) 2011-08-31
BRPI0614902A2 (pt) 2011-04-19
CN102174074A (zh) 2011-09-07
EP1752467A1 (en) 2007-02-14
EP2284178A3 (en) 2011-09-14

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