EA200701645A1 - Инъекционные препараты диклофенака и его фармацевтически приемлемых солей - Google Patents

Инъекционные препараты диклофенака и его фармацевтически приемлемых солей

Info

Publication number
EA200701645A1
EA200701645A1 EA200701645A EA200701645A EA200701645A1 EA 200701645 A1 EA200701645 A1 EA 200701645A1 EA 200701645 A EA200701645 A EA 200701645A EA 200701645 A EA200701645 A EA 200701645A EA 200701645 A1 EA200701645 A1 EA 200701645A1
Authority
EA
Eurasian Patent Office
Prior art keywords
injection
salts
diclofenac
water
diclofenak
Prior art date
Application number
EA200701645A
Other languages
English (en)
Other versions
EA013616B1 (ru
Inventor
Кетан Раджнибхаи Пател
Милан Раджнибхаи Пател
Original Assignee
Троикаа Фармасьютикалз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36953757&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200701645(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Троикаа Фармасьютикалз Лтд. filed Critical Троикаа Фармасьютикалз Лтд.
Publication of EA200701645A1 publication Critical patent/EA200701645A1/ru
Publication of EA013616B1 publication Critical patent/EA013616B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Данное изобретение представляет инъекционные препараты водорастворимых солей диклофенака в однократных дозах в объеме менее 2 мл, который дает значительно меньшую боль в месте инъекции и который можно вводить путем инъекции в дельтовидную мышцу в дополнение к внутриягодичному введению и внутривенному пути введения. Более конкретно, данные инъекционные препараты содержат от 75 до 100 мг водорастворимых солей диклофенака в примерно 1 мл инъекционного раствора без значительного повышения вязкости инъекционного раствора, без использования поверхностно-активных веществ. Показатель рН препаратов доводят до рН 6-10 при содержании до 100 мг соли диклофенака в среде, состоящей из воды вместе с одним или более из сорастворителей/солюбилизаторов, антиоксидантов, консервантов, буферов, щелочей и стабилизаторов.
EA200701645A 2005-02-01 2006-01-30 Инъекционные препараты диклофенака и его фармацевтически приемлемых солей EA013616B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN96MU2005 2005-02-01
PCT/IN2006/000033 WO2006095363A2 (en) 2005-02-01 2006-01-30 Injectable preparations of diclofenic and its pharmaceutically acceptable salts

Publications (2)

Publication Number Publication Date
EA200701645A1 true EA200701645A1 (ru) 2008-02-28
EA013616B1 EA013616B1 (ru) 2010-06-30

Family

ID=36953757

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701645A EA013616B1 (ru) 2005-02-01 2006-01-30 Инъекционные препараты диклофенака и его фармацевтически приемлемых солей

Country Status (20)

Country Link
US (1) US8809393B2 (ru)
EP (1) EP1848419B1 (ru)
JP (1) JP2008528572A (ru)
KR (1) KR101226121B1 (ru)
CN (1) CN101123957B (ru)
AP (1) AP2888A (ru)
AU (2) AU2006221633B2 (ru)
BR (1) BRPI0606119B8 (ru)
CA (1) CA2596031C (ru)
DK (1) DK1848419T3 (ru)
EA (1) EA013616B1 (ru)
ES (1) ES2392097T3 (ru)
IL (1) IL184697A (ru)
MX (1) MX2007009312A (ru)
NZ (1) NZ554779A (ru)
PL (1) PL1848419T3 (ru)
PT (1) PT1848419E (ru)
UA (1) UA93365C2 (ru)
WO (1) WO2006095363A2 (ru)
ZA (1) ZA200705729B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009155315A (ja) * 2007-12-26 2009-07-16 Fujiyakuhin Co Ltd 注射剤
WO2013005226A1 (en) * 2011-07-04 2013-01-10 Zota Health Care Ltd A novel combined pharmaceutical composition containing diclofenac and methods of making and using the same
US20140187635A1 (en) 2012-12-28 2014-07-03 Themis Medicare Limited Diclofenac compositions
US20140275261A1 (en) * 2013-03-15 2014-09-18 Dr. Reddy's Laboratories, Inc. Diclofenac parenteral compositions
CN103432132B (zh) * 2013-08-31 2015-01-21 西南大学 甲磺酸普立地诺双氯芬酸钠注射液及其制备方法
WO2016170401A1 (en) * 2015-04-20 2016-10-27 Umedica Laboratories Pvt. Ltd Novel injectable composition of diclofenac sodium
WO2021048748A1 (en) 2019-09-09 2021-03-18 Ftf Pharma Private Limited Pharmaceutical formulations comprising diclofenac

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8200488L (sv) 1982-01-29 1983-07-30 Svenska Flaektfabriken Ab Arreteringsanordning, serskilt for forankring av till- och franluftventiler i ventilationskanaler
DE3328401A1 (de) 1983-08-05 1985-02-21 Merckle GmbH, 7902 Blaubeuren Injizierbare loesung zur behandlung von entzuendungen
DE3446873A1 (de) * 1984-12-21 1986-07-10 Merckle Gmbh Fluessige diclofenac-zubereitungen
DE3613799C1 (de) 1986-04-24 1987-09-03 Nattermann A & Cie Verwendung von Glycofurol zum Verfluessigen von Arzneimittelzubereitungen fuer das Abfuellen in Weichgelatinekapseln
EP0532546B1 (en) 1990-05-10 1998-03-18 Bechgaard International Research And Development A/S A pharmaceutical preparation containing n-glycofurols and n-ethylene glycols
US5389681A (en) 1992-10-22 1995-02-14 Ciba-Geigy Corporation Parenteral solutions for diclofenac salts
ZA949182B (en) 1993-12-02 1995-07-26 South African Druggists Ltd Pharmaceutical composition
US5554650A (en) 1994-07-28 1996-09-10 Southern Research Institute Antiphlogistic, analgesic, antipyretic injection preparation
GB9502695D0 (en) 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
HUP9903249A3 (en) 1996-06-25 2001-04-28 Glaxo Group Ltd Combinations comprising vx478, zidovudine, ftc and/or 3tc for use in the treatment of hiv
US5853263A (en) * 1996-08-15 1998-12-29 Accrued, Inc. System for installing raised road markers
US6846495B2 (en) 1999-01-11 2005-01-25 The Procter & Gamble Company Compositions having improved delivery of actives
DE10105576C1 (de) * 2001-02-07 2002-08-08 Underberg Kg Flasche mit im Boden ausgebildeten Griffmulden
IN192711B (ru) 2002-01-22 2004-05-15 Ketan Rajnibhai Patel
CH694034A8 (de) * 2002-12-12 2004-08-31 Mepha Ag Diclofenac-Kalium-Injektionsloesung.
JP2006514119A (ja) * 2003-02-12 2006-04-27 アール アンド ピー コリア カンパニー リミテッド 溶解率が向上した難溶性薬剤の溶媒系
KR100612070B1 (ko) * 2003-02-12 2006-08-11 알앤피코리아주식회사 용출률이 향상된 난용성 약제의 용매 시스템 및 이를 함유한 제약학적 제제
CN1557290A (zh) 2004-01-19 2004-12-29 江苏扬子江药业集团有限公司 复方双氯芬酸钾注射液制剂
DE602004025151D1 (de) 2004-03-10 2010-03-04 Shimoda Biotech Pty Ltd Stabile injizierbare Diclofenac- Zubereitungen
CN1279897C (zh) 2004-04-30 2006-10-18 济南百诺医药科技开发有限公司 含有双氯芬酸盐和利多卡因的冻干制剂及其制备方法
ITMI20041245A1 (it) 2004-06-22 2004-09-22 Ibsa Inst Biochimique Sa Composizioni farmaceutiche iniettabnili comprendenti diclofenac sodico e b-ciclodestrina

Also Published As

Publication number Publication date
AP2007004101A0 (en) 2007-08-31
EA013616B1 (ru) 2010-06-30
AU2006221633B2 (en) 2009-07-30
AU2009233594A1 (en) 2009-11-19
UA93365C2 (ru) 2011-02-10
CA2596031C (en) 2013-02-19
WO2006095363A2 (en) 2006-09-14
US20080153914A1 (en) 2008-06-26
KR20070107091A (ko) 2007-11-06
BRPI0606119B1 (pt) 2019-05-07
JP2008528572A (ja) 2008-07-31
PL1848419T3 (pl) 2012-12-31
WO2006095363A3 (en) 2006-12-14
PT1848419E (pt) 2012-10-31
WO2006095363B1 (en) 2007-02-01
BRPI0606119B8 (pt) 2021-05-25
AU2006221633A1 (en) 2006-09-14
ES2392097T3 (es) 2012-12-04
BRPI0606119A2 (pt) 2009-06-02
IL184697A (en) 2014-02-27
MX2007009312A (es) 2008-03-10
IL184697A0 (en) 2007-12-03
US8809393B2 (en) 2014-08-19
CN101123957A (zh) 2008-02-13
KR101226121B1 (ko) 2013-01-25
EP1848419A2 (en) 2007-10-31
NZ554779A (en) 2011-02-25
CN101123957B (zh) 2010-12-08
AP2888A (en) 2014-05-31
DK1848419T3 (da) 2012-11-05
CA2596031A1 (en) 2006-09-14
EP1848419B1 (en) 2012-07-25
ZA200705729B (en) 2008-08-27

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KG MD