EA200400968A1 - Агент для улучшения химиотерапии рака - Google Patents

Агент для улучшения химиотерапии рака

Info

Publication number
EA200400968A1
EA200400968A1 EA200400968A EA200400968A EA200400968A1 EA 200400968 A1 EA200400968 A1 EA 200400968A1 EA 200400968 A EA200400968 A EA 200400968A EA 200400968 A EA200400968 A EA 200400968A EA 200400968 A1 EA200400968 A1 EA 200400968A1
Authority
EA
Eurasian Patent Office
Prior art keywords
agent
cancer chemotherapy
hydrogen atom
alkyl group
lower alkyl
Prior art date
Application number
EA200400968A
Other languages
English (en)
Other versions
EA009082B1 (ru
Inventor
Цутому Каджийя
Хиронобу Мурасе
Нина Петровна Коновалова
Людмила Михайловна Волкова
Наталья Юрьевна Луговская
Любовь Сергеевна Васильева
Original Assignee
Си-Си-Ай Корпорейшн
Цутому Каджийя
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Си-Си-Ай Корпорейшн, Цутому Каджийя filed Critical Си-Си-Ай Корпорейшн
Publication of EA200400968A1 publication Critical patent/EA200400968A1/ru
Publication of EA009082B1 publication Critical patent/EA009082B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Агент для улучшения химиотерапии рака, который содержит хроманолглюкозид, представленный следующей общей формулой (1): (1), где R, R, Rи Rявляются одинаковыми или отличаются друг от друга и каждый из них представляет собой водород или низший алкил; Rпредставляет собой водород, низший алкил или низший ацил; X представляет собой моносахаридный или олигосахаридный остаток, в котором атом водорода гидроксильной группы может быть заменен низшим алкилом или низшим ацилом; n является целым числом в диапазоне от 0 до 6 и m является целым числом в диапазоне от 1 до 6. Этот агент для улучшения является новым и безопасным. Даже при использовании в малом количестве при химиотерапии рака он эффективно действует, увеличивая карциностатическую активность карциностатического вещества и подавляет побочные эффекты лечения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400968A 2002-03-26 2002-03-26 Агент для улучшения химиотерапии рака EA009082B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2002/002914 WO2003080075A1 (fr) 2002-03-26 2002-03-26 Ameliorant pour le traitement chimique du cancer

Publications (2)

Publication Number Publication Date
EA200400968A1 true EA200400968A1 (ru) 2005-04-28
EA009082B1 EA009082B1 (ru) 2007-10-26

Family

ID=28080696

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400968A EA009082B1 (ru) 2002-03-26 2002-03-26 Агент для улучшения химиотерапии рака

Country Status (7)

Country Link
US (1) US7462601B2 (ru)
EP (1) EP1488796B1 (ru)
JP (1) JP4509574B2 (ru)
AT (1) ATE493993T1 (ru)
DE (1) DE60238874D1 (ru)
EA (1) EA009082B1 (ru)
WO (1) WO2003080075A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070260550A1 (en) * 2006-04-20 2007-11-08 Tobid Pieper Digital goods export control
WO2017074211A1 (en) 2015-10-29 2017-05-04 Dmitry Dmitrievich Genkin Method to improve safety and efficacy of anti-cancer therapy

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0739000B2 (ja) * 1987-11-24 1995-05-01 株式会社明電舎 沈澱池の排泥制御装置
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JP3550412B2 (ja) * 1993-02-10 2004-08-04 シーシーアイ株式会社 新規なクロマノール配糖体およびその製造方法
FR2741534B1 (fr) 1995-11-23 1998-09-11 Mazal Pharma Composition pharmaceutique stable a base d'acide acetylsalicylique et de tocopherol
JP3809679B2 (ja) 1996-01-11 2006-08-16 シーシーアイ株式会社 クロマノール配糖体およびその製造方法、並びにそれを用いた抗酸化剤
JPH1036260A (ja) 1996-07-18 1998-02-10 Mitsui Norin Kk 抗ガン剤の効力増強方法
JP4027448B2 (ja) 1996-08-30 2007-12-26 シーシーアイ株式会社 放射線防護剤
JPH10168095A (ja) * 1996-12-10 1998-06-23 Cci Corp 炎症性腸疾患予防および治療剤
CN1261803A (zh) * 1997-07-01 2000-08-02 埃瑟若詹尼克斯公司 抗氧化剂增强对细胞过度增生性疾病的治疗
JP3861949B2 (ja) 1997-07-01 2006-12-27 シーシーアイ株式会社 クロマノール配糖体およびその製造方法
JP2903465B2 (ja) * 1997-07-16 1999-06-07 末綱 陽子 新規なペプチドおよび活性化酸素阻害剤
EP1174140B1 (en) * 1999-03-31 2009-11-11 Cci Corporation Chromanol glycosides for use in the treatment of dermopathy caused by ultraviolet light
JP2001261563A (ja) * 2000-03-16 2001-09-26 Cci Corp マトリックスメタロプロテアーゼ産生抑制剤

Also Published As

Publication number Publication date
WO2003080075A1 (fr) 2003-10-02
EA009082B1 (ru) 2007-10-26
EP1488796A1 (en) 2004-12-22
EP1488796A4 (en) 2008-02-13
EP1488796B1 (en) 2011-01-05
US7462601B2 (en) 2008-12-09
DE60238874D1 (de) 2011-02-17
US20050215492A1 (en) 2005-09-29
JP4509574B2 (ja) 2010-07-21
ATE493993T1 (de) 2011-01-15
JPWO2003080075A1 (ja) 2005-07-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU