TNSN05017A1 - Nouveaux composes gem difluores, leurs procedes de preparation et leurs applications - Google Patents
Nouveaux composes gem difluores, leurs procedes de preparation et leurs applicationsInfo
- Publication number
- TNSN05017A1 TNSN05017A1 TNP2005000017A TNSN05017A TNSN05017A1 TN SN05017 A1 TNSN05017 A1 TN SN05017A1 TN P2005000017 A TNP2005000017 A TN P2005000017A TN SN05017 A TNSN05017 A TN SN05017A TN SN05017 A1 TNSN05017 A1 TN SN05017A1
- Authority
- TN
- Tunisia
- Prior art keywords
- alkyl
- preparation
- compound
- group
- difluorated
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 3
- DCERHCFNWRGHLK-UHFFFAOYSA-N C[Si](C)C Chemical class C[Si](C)C DCERHCFNWRGHLK-UHFFFAOYSA-N 0.000 abstract 3
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical class C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 abstract 3
- -1 AMINO Chemical class 0.000 abstract 2
- 125000000037 tert-butyldiphenylsilyl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1[Si]([H])([*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical class NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 108010053481 Antifreeze Proteins Proteins 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical group [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000002528 anti-freeze Effects 0.000 abstract 1
- 229940124599 anti-inflammatory drug Drugs 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- DVFXLNFDWATPMW-IWOKLKJTSA-N tert-butyldiphenylsilyl Chemical class O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)C(C)(C)C)[C@@H](OP(O)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=O)OC[C@@H]2[C@H](CC(O2)N2C3=NC=NC(N)=C3N=C2)OP(O)(=O)OC[C@@H]2[C@H](C[C@@H](O2)N2C3=C(C(NC(N)=N3)=O)N=C2)O)C1 DVFXLNFDWATPMW-IWOKLKJTSA-N 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LE PRODUIT SELON L'INVENTION CONCERNE UN COMPOSE GEM DIFLUORE DE FORMULE (I) OU R1 EST UN GROUPEMENT COMPORTANT UNE CHAINE ALKYLE SUBSTITUEE PAR AU MOINS UNE FONCTION AMINE, AMIDE OU ACIDE, R2 EST UN ATOME D'HYDROGENE H OU UNE FONCTION ALCOOL LIBRE OU PROTEGEE, R3 EST UN GROUPEMENT H, CH3, CH2OH, CH2-OGP OU GP EST UN GROUPE PROTECTEUR TEL QU'UN GROUPE ALKYLE, BENZYLE (Bn), TRIMETHYLSILYLE (TMS), TERT-BUTYLDIMETHYLSILYLE (TBDMS), TERT-BUTYLDIPHENYLSILYLE (TBDPS), ACETATE (AC)..., Y, Y', Y" SONT DES GROUPES INDEPENDANTS OU Y, Y', Y" = H, OR, N3, NR'R", SR`... AVEC R = H, Bn, AC, TMS, TBDMS, TBDPS,..., R', R" = H, ALKYL, ALLYL, Bn, TOSYLATE (Ts), C(=O)-ALKYL, C(=O)-Bn,..., R"' = H, ALKYL, AC. ELLE S'APPLIQUE NOTAMMENT A L'UTILISATION DUDIT COMPOSE POUR LA PREPARATION DE MEDICAMENTS ANTITUMORAUX, ANTIVIRAUX, HYPOGLYCEMIANTS, ANTI-INFLAMMATOIRES ET DE COMPOSES POUR L'IMMUNOLOGIE, POUR LA COSMETOLOGIE, OU ENCORE D'ANALOGUES GLYCOPEPTIDIQUES DE MOLECULES ANTIGEL.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0209627A FR2842810B1 (fr) | 2002-07-25 | 2002-07-25 | Nouveaux composes gem difluores, leur procedes de preparation et leurs applications. |
| PCT/FR2003/002330 WO2004014928A2 (fr) | 2002-07-25 | 2003-07-23 | Nouveaux composes gem difluores, leurs procedes de preparation et leurs applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN05017A1 true TNSN05017A1 (fr) | 2007-05-14 |
Family
ID=30011584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNP2005000017A TNSN05017A1 (fr) | 2002-07-25 | 2005-01-24 | Nouveaux composes gem difluores, leurs procedes de preparation et leurs applications |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060142206A1 (fr) |
| EP (1) | EP1525208A2 (fr) |
| JP (1) | JP2006508048A (fr) |
| CN (1) | CN1671723A (fr) |
| AU (1) | AU2003274202A1 (fr) |
| BR (1) | BR0312917A (fr) |
| CA (1) | CA2492940A1 (fr) |
| FR (1) | FR2842810B1 (fr) |
| RU (1) | RU2369612C2 (fr) |
| TN (1) | TNSN05017A1 (fr) |
| WO (1) | WO2004014928A2 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2878851B1 (fr) * | 2004-12-02 | 2007-02-09 | Inst Nat Sciences Appliq | Composes c-glycopeptides gem-difluores, leur preparation et leur utilisation en cryochirurgie et/ou cryopreservation |
| FR2900405B1 (fr) * | 2006-04-27 | 2013-11-29 | Inst Nat Sciences Appliq | Nouveaux composes c-glycosides monofluores, leurs procedes de preparation et leurs applications |
| FR2900406B1 (fr) * | 2006-04-27 | 2013-09-06 | Inst Nat Sciences Appliq | Mimes stables de sucres de type c-glycosides et c-glycoconjugues,leur procede de preparation et leurs applications notamment dans le domaine de la cosmetique et du medicament. |
| FR2900656A1 (fr) * | 2006-05-03 | 2007-11-09 | Inst Nat Sciences Appliq | Composes c-glycopeptides gem-difluores, leur preparation et leur utilisation notamment pour la preservation de materiaux biologiques |
| CA2653153A1 (fr) * | 2008-02-07 | 2009-08-07 | University Of Ottawa | Analogues de glycoproteine antigel et utilisations connexes |
| FR2929615B1 (fr) * | 2008-04-02 | 2010-12-17 | Tfchem | Composes c-aryl glycosides pour le traitement du diabete et de l'obesite. |
| KR100931249B1 (ko) * | 2008-06-05 | 2009-12-11 | 주식회사 알앤엘바이오 | 신규 디아릴 헵타노이드계 화합물 및 그 용도 |
| WO2012016935A1 (fr) | 2010-08-02 | 2012-02-09 | Centrum Für Angewandte Nanotechnologie (Can) Gmbh | Dérivés de sucres à sept atomes de carbone (c-7) et leur utilisation |
| CA2822097C (fr) | 2010-12-22 | 2020-06-09 | Tfchem | Derives de glyco-cf2-serine et de glyco-cf2-threonine |
| EP2742032B1 (fr) | 2011-08-08 | 2015-05-06 | Tfchem | Dérivés de c-isopropylgalactoside gem-difluorés |
| CN103497223B (zh) * | 2013-09-13 | 2015-08-05 | 中国人民解放军第二军医大学 | 一种北沙参中所含的糖苷类化合物及其制备方法和应用 |
| CN106459122B (zh) | 2014-03-17 | 2019-12-03 | Tf化学公司 | 用于生物材料和微生物的保存和保护的糖肽衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0354323A3 (fr) * | 1988-08-12 | 1990-06-13 | American Cyanamid Company | Phosphates antidiabétiques |
| US5739279A (en) * | 1992-07-31 | 1998-04-14 | Pfizer Inc. | Peptidyl 4-amino-2,2-difluoro-3-oxo-1,6-hexanedioic acid derivatives as antiinflammatory agents |
| GB9723589D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
| PT1220849E (pt) * | 1999-10-15 | 2004-10-29 | Sucampo Ag | Composicao de compostos biciclicos e metodo para a sua estabilizacao |
-
2002
- 2002-07-25 FR FR0209627A patent/FR2842810B1/fr not_active Expired - Fee Related
-
2003
- 2003-07-23 US US10/522,365 patent/US20060142206A1/en not_active Abandoned
- 2003-07-23 JP JP2004526949A patent/JP2006508048A/ja active Pending
- 2003-07-23 EP EP03758183A patent/EP1525208A2/fr not_active Withdrawn
- 2003-07-23 CN CNA038177706A patent/CN1671723A/zh active Pending
- 2003-07-23 RU RU2005105066/04A patent/RU2369612C2/ru not_active IP Right Cessation
- 2003-07-23 CA CA002492940A patent/CA2492940A1/fr not_active Abandoned
- 2003-07-23 WO PCT/FR2003/002330 patent/WO2004014928A2/fr active Application Filing
- 2003-07-23 AU AU2003274202A patent/AU2003274202A1/en not_active Abandoned
- 2003-07-23 BR BR0312917-9A patent/BR0312917A/pt not_active IP Right Cessation
-
2005
- 2005-01-24 TN TNP2005000017A patent/TNSN05017A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060142206A1 (en) | 2006-06-29 |
| FR2842810A1 (fr) | 2004-01-30 |
| RU2005105066A (ru) | 2005-08-27 |
| FR2842810B1 (fr) | 2006-01-27 |
| BR0312917A (pt) | 2005-07-05 |
| AU2003274202A1 (en) | 2004-02-25 |
| JP2006508048A (ja) | 2006-03-09 |
| WO2004014928A2 (fr) | 2004-02-19 |
| RU2369612C2 (ru) | 2009-10-10 |
| WO2004014928A3 (fr) | 2004-04-01 |
| EP1525208A2 (fr) | 2005-04-27 |
| CA2492940A1 (fr) | 2004-02-19 |
| CN1671723A (zh) | 2005-09-21 |
| AU2003274202A8 (en) | 2004-02-25 |
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