EA200300914A1 - Сочетание ингибиторов белка, переносящего эфир холестерила, и производных фибриновой кислоты для сердечно-сосудистых показаний - Google Patents
Сочетание ингибиторов белка, переносящего эфир холестерила, и производных фибриновой кислоты для сердечно-сосудистых показанийInfo
- Publication number
- EA200300914A1 EA200300914A1 EA200300914A EA200300914A EA200300914A1 EA 200300914 A1 EA200300914 A1 EA 200300914A1 EA 200300914 A EA200300914 A EA 200300914A EA 200300914 A EA200300914 A EA 200300914A EA 200300914 A1 EA200300914 A1 EA 200300914A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cholesteril
- derivatives
- combination
- protein inhibitors
- fibric acid
- Prior art date
Links
- 230000002526 effect on cardiovascular system Effects 0.000 title abstract 2
- ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical class OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 title 1
- 229940121649 protein inhibitor Drugs 0.000 title 1
- 239000012268 protein inhibitor Substances 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical class CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 abstract 1
- 229940125881 cholesteryl ester transfer protein inhibitor Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Настоящее изобретение раскрывает применение сочетаний сердечно-сосудистых терапевтических соединений для профилактики или лечения сердечно-сосудистого заболевания, включая гиперхолестеринемию, атеросклероз или гиперлипидемию. Раскрытые сочетания включают производное фибриновой кислоты вместе с ингибитором белка, переносящего эфир холестерила.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11395598P | 1998-12-23 | 1998-12-23 | |
US14261699P | 1999-07-07 | 1999-07-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200300914A1 true EA200300914A1 (ru) | 2003-12-25 |
EA009466B1 EA009466B1 (ru) | 2007-12-28 |
Family
ID=26811677
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200300914A EA009466B1 (ru) | 1998-12-23 | 1999-12-17 | Ингибитор белка, переносящего эфир холестерила |
EA200100706A EA004231B1 (ru) | 1998-12-23 | 1999-12-17 | Сочетание ингибиторов белка, переносящего эфир холестерила, и производных фибриновой кислоты для сердечно-сосудистых показаний |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100706A EA004231B1 (ru) | 1998-12-23 | 1999-12-17 | Сочетание ингибиторов белка, переносящего эфир холестерила, и производных фибриновой кислоты для сердечно-сосудистых показаний |
Country Status (23)
Country | Link |
---|---|
US (2) | US6458850B1 (ru) |
EP (2) | EP1140186B1 (ru) |
JP (1) | JP2002533410A (ru) |
KR (1) | KR20010099937A (ru) |
CN (1) | CN1338944A (ru) |
AT (1) | ATE242009T1 (ru) |
AU (1) | AU776664B2 (ru) |
BR (1) | BR9916485A (ru) |
CA (1) | CA2356157C (ru) |
CZ (1) | CZ20012341A3 (ru) |
DE (1) | DE69908645T2 (ru) |
DK (1) | DK1140186T3 (ru) |
EA (2) | EA009466B1 (ru) |
ES (1) | ES2201827T3 (ru) |
HK (2) | HK1040925B (ru) |
HU (1) | HUP0400886A2 (ru) |
IL (1) | IL143949A0 (ru) |
MX (1) | MXPA01006469A (ru) |
NO (1) | NO20013158L (ru) |
NZ (1) | NZ512534A (ru) |
PL (1) | PL348503A1 (ru) |
PT (1) | PT1140186E (ru) |
WO (1) | WO2000038724A1 (ru) |
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1999
- 1999-12-17 NZ NZ512534A patent/NZ512534A/en unknown
- 1999-12-17 WO PCT/US1999/027945 patent/WO2000038724A1/en active IP Right Grant
- 1999-12-17 EA EA200300914A patent/EA009466B1/ru not_active Application Discontinuation
- 1999-12-17 HU HU0400886A patent/HUP0400886A2/hu unknown
- 1999-12-17 IL IL14394999A patent/IL143949A0/xx unknown
- 1999-12-17 ES ES99965900T patent/ES2201827T3/es not_active Expired - Lifetime
- 1999-12-17 EA EA200100706A patent/EA004231B1/ru not_active IP Right Cessation
- 1999-12-17 DK DK99965900T patent/DK1140186T3/da active
- 1999-12-17 DE DE69908645T patent/DE69908645T2/de not_active Expired - Fee Related
- 1999-12-17 AT AT99965900T patent/ATE242009T1/de not_active IP Right Cessation
- 1999-12-17 CN CN99816149A patent/CN1338944A/zh active Pending
- 1999-12-17 KR KR1020017008091A patent/KR20010099937A/ko not_active Application Discontinuation
- 1999-12-17 US US09/466,413 patent/US6458850B1/en not_active Expired - Fee Related
- 1999-12-17 PT PT99965900T patent/PT1140186E/pt unknown
- 1999-12-17 PL PL99348503A patent/PL348503A1/xx not_active Application Discontinuation
- 1999-12-17 EP EP19990965900 patent/EP1140186B1/en not_active Expired - Lifetime
- 1999-12-17 JP JP2000590675A patent/JP2002533410A/ja active Pending
- 1999-12-17 CA CA002356157A patent/CA2356157C/en not_active Expired - Fee Related
- 1999-12-17 BR BR9916485-0A patent/BR9916485A/pt not_active Application Discontinuation
- 1999-12-17 CZ CZ20012341A patent/CZ20012341A3/cs unknown
- 1999-12-17 EP EP03012144A patent/EP1340509A1/en not_active Withdrawn
- 1999-12-17 MX MXPA01006469A patent/MXPA01006469A/es unknown
- 1999-12-17 AU AU21576/00A patent/AU776664B2/en not_active Expired - Fee Related
-
2001
- 2001-06-22 NO NO20013158A patent/NO20013158L/no not_active Application Discontinuation
-
2002
- 2002-04-10 HK HK02102720.1A patent/HK1040925B/zh not_active IP Right Cessation
- 2002-07-23 US US10/200,600 patent/US20030166720A1/en not_active Abandoned
- 2002-09-02 HK HK02106472.2A patent/HK1045108A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA01006469A (es) | 2004-03-10 |
DE69908645D1 (de) | 2003-07-10 |
KR20010099937A (ko) | 2001-11-09 |
PL348503A1 (en) | 2002-05-20 |
EP1140186B1 (en) | 2003-06-04 |
BR9916485A (pt) | 2002-01-15 |
DK1140186T3 (da) | 2003-09-29 |
HK1040925B (zh) | 2003-09-11 |
PT1140186E (pt) | 2003-10-31 |
AU776664B2 (en) | 2004-09-16 |
HUP0400886A2 (hu) | 2004-07-28 |
HK1040925A1 (en) | 2002-06-28 |
ATE242009T1 (de) | 2003-06-15 |
EA200100706A1 (ru) | 2001-12-24 |
US20030166720A1 (en) | 2003-09-04 |
NO20013158D0 (no) | 2001-06-22 |
ES2201827T3 (es) | 2004-03-16 |
WO2000038724A1 (en) | 2000-07-06 |
CA2356157C (en) | 2008-04-01 |
NO20013158L (no) | 2001-08-22 |
EA009466B1 (ru) | 2007-12-28 |
DE69908645T2 (de) | 2004-05-13 |
AU2157600A (en) | 2000-07-31 |
US6458850B1 (en) | 2002-10-01 |
NZ512534A (en) | 2003-11-28 |
EA004231B1 (ru) | 2004-02-26 |
CA2356157A1 (en) | 2000-07-06 |
CN1338944A (zh) | 2002-03-06 |
CZ20012341A3 (cs) | 2001-12-12 |
EP1340509A1 (en) | 2003-09-03 |
EP1140186A1 (en) | 2001-10-10 |
HK1045108A1 (zh) | 2002-11-15 |
JP2002533410A (ja) | 2002-10-08 |
IL143949A0 (en) | 2002-04-21 |
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