EA200300023A1 - 3'-ПРОЛЕКАРСТВА 2'-ДЕЗОКСИ-β-L-НУКЛЕОЗИДОВ - Google Patents

3'-ПРОЛЕКАРСТВА 2'-ДЕЗОКСИ-β-L-НУКЛЕОЗИДОВ

Info

Publication number
EA200300023A1
EA200300023A1 EA200300023A EA200300023A EA200300023A1 EA 200300023 A1 EA200300023 A1 EA 200300023A1 EA 200300023 A EA200300023 A EA 200300023A EA 200300023 A EA200300023 A EA 200300023A EA 200300023 A1 EA200300023 A1 EA 200300023A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nucleosides
deoxy
compositions
compounds
hepatitis
Prior art date
Application number
EA200300023A
Other languages
English (en)
Other versions
EA005774B1 (ru
Inventor
Мартин Л. Брайант
Жилль Госселэн
Жан-Луи Эмбаш
Original Assignee
Айденикс (Кайман) Лимитед
Л'Юниверсите Монпелье Ii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Айденикс (Кайман) Лимитед, Л'Юниверсите Монпелье Ii filed Critical Айденикс (Кайман) Лимитед
Publication of EA200300023A1 publication Critical patent/EA200300023A1/ru
Publication of EA005774B1 publication Critical patent/EA005774B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к соединениям, композициям и способам лечения хозяина, зараженного вирусом гепатита B. В частности, раскрываются соединения и композиции 3'-сложных эфиров 2'-дезокси-β-L-нуклеозидов, которые можно вводить одни или в комбинации с другими агентами против вируса гепатита B. Также раскрываются соединения и композиции 3',5'-сложных эфиров 2'-дезокси-β-L-нуклеозидов, которые можно вводить одни или в комбинации с другими агентами против вирусного гепатита B.Отчет о международном поиске был опубликован 2002.04.18.
EA200300023A 2000-06-15 2001-06-15 3'-ПРОЛЕКАРСТВА 2'-ДЕЗОКСИ-β-L-НУКЛЕОЗИДОВ EA005774B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21210000P 2000-06-15 2000-06-15
PCT/US2001/019147 WO2001096353A2 (en) 2000-06-15 2001-06-15 3'-PRODRUGS OF 2'-DEOXY-β-L-NUCLEOSIDES

Publications (2)

Publication Number Publication Date
EA200300023A1 true EA200300023A1 (ru) 2003-08-28
EA005774B1 EA005774B1 (ru) 2005-06-30

Family

ID=22789563

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300023A EA005774B1 (ru) 2000-06-15 2001-06-15 3'-ПРОЛЕКАРСТВА 2'-ДЕЗОКСИ-β-L-НУКЛЕОЗИДОВ

Country Status (27)

Country Link
EP (1) EP1296995B1 (ru)
JP (1) JP4639032B2 (ru)
KR (2) KR20030032967A (ru)
CN (3) CN1295242C (ru)
AP (1) AP1771A (ru)
AR (1) AR035711A1 (ru)
AT (1) ATE411332T1 (ru)
AU (2) AU6692701A (ru)
BR (1) BR0111732A (ru)
CA (1) CA2413163C (ru)
CZ (1) CZ2003122A3 (ru)
DE (1) DE60136181D1 (ru)
EA (1) EA005774B1 (ru)
ES (1) ES2317912T3 (ru)
IL (3) IL153379A0 (ru)
MA (1) MA27126A1 (ru)
MX (1) MXPA02012443A (ru)
MY (1) MY141594A (ru)
NO (1) NO20026001L (ru)
NZ (2) NZ523632A (ru)
OA (1) OA12384A (ru)
PE (1) PE20020216A1 (ru)
PL (1) PL360404A1 (ru)
UY (1) UY26779A1 (ru)
WO (1) WO2001096353A2 (ru)
YU (1) YU94802A (ru)
ZA (2) ZA200300168B (ru)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100457118C (zh) 2000-04-13 2009-02-04 法玛塞特有限公司 用于治疗肝炎病毒感染的3′-或2′-羟甲基取代的核苷衍生物
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
NZ547204A (en) 2000-05-26 2008-01-31 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
KR20050055630A (ko) 2002-06-28 2005-06-13 이데닉스 (케이만) 리미티드 플라비비리다에 감염 치료를 위한 1'-, 2'- 및 3'-변형된뉴클레오시드 유도체
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
MXPA04012709A (es) * 2002-06-28 2005-09-30 Idenix Cayman Ltd Profarmacos modificados de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae.
JP2005533824A (ja) 2002-06-28 2005-11-10 イデニクス（ケイマン）リミテツド フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン
SI1572095T1 (sl) 2002-09-13 2015-12-31 Novartis Ag Beta-l-2'-deoksinukleozidi za uporabo pri zdravljenju odpornih sevov hbv
WO2004046331A2 (en) 2002-11-15 2004-06-03 Idenix (Cayman) Limited 2’-branched nucleosides and flaviviridae mutation
WO2004084453A2 (en) 2003-03-20 2004-09-30 Microbiologica Quimica E Farmaceutica Ltd. METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES
KR20060015542A (ko) * 2003-04-28 2006-02-17 이데닉스 (케이만) 리미티드 산업 규모의 뉴클레오시드 합성
WO2005003147A2 (en) 2003-05-30 2005-01-13 Pharmasset, Inc. Modified fluorinated nucleoside analogues
MXPA06000162A (es) 2003-06-30 2006-03-21 Idenix Cayman Ltd Sintesis de ?-l-2-desoxinucleosidos.
US7754718B2 (en) 2004-05-05 2010-07-13 Yale University Antiviral helioxanthin analogs
EP1809301B1 (en) 2004-09-14 2019-11-06 Gilead Pharmasset LLC 2-fluoro-2-alkyl-substituted d-ribonolactone intermediates
US7524831B2 (en) 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
CN101242842A (zh) 2005-06-17 2008-08-13 诺瓦提斯公司 Sanglifehrin在hcv中的用途
GB0609178D0 (en) * 2006-05-09 2006-06-21 Univ Cardiff Novel compounds
US7897737B2 (en) 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
TW200946541A (en) 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
KR101677772B1 (ko) 2008-06-11 2016-11-18 레이저젠, 인코퍼레이티드 뉴클레오타이드 및 뉴클레오사이드 그리고 시퀀싱에서의 이들의 이용 방법
EP3222628A1 (en) 2008-12-23 2017-09-27 Gilead Pharmasset LLC Nucleoside phosphoramidates
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
PT3290428T (pt) 2010-03-31 2021-12-27 Gilead Pharmasset Llc Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
WO2011123586A1 (en) 2010-04-01 2011-10-06 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
AU2011336632B2 (en) 2010-11-30 2015-09-03 Gilead Pharmasset Llc Compounds
EP2691409B1 (en) 2011-03-31 2018-02-21 Idenix Pharmaceuticals LLC. Compounds and pharmaceutical compositions for the treatment of viral infections
AU2012308900A1 (en) 2011-09-12 2013-05-09 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
CA2848049C (en) 2011-09-13 2021-01-26 Lasergen, Inc. 5-methoxy, 3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
ME03009B (me) 2011-09-16 2018-10-20 Gilead Pharmasset Llc Metode za lecenje hcv-a
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
JP2015508418A (ja) 2013-01-31 2015-03-19 ギリアド ファーマセット エルエルシー ２種の抗ウイルス化合物のコンビナトリアル製剤
EP4005560A1 (en) 2013-08-27 2022-06-01 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
BR112020020804A2 (pt) 2018-04-12 2021-01-12 Modis Therapeutics Inc. Pró-fármacos de desoxinucleosídeos para tratamento de doenças causadas por agrupamentos de nucleotídeos não balanceados

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958013A (en) * 1989-06-06 1990-09-18 Northwestern University Cholesteryl modified oligonucleotides
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
SE505648C2 (sv) * 1996-08-30 1997-09-22 Scania Cv Ab Anordning vid ett fordon för monterbar anfästning av en förarplatsmodul
CA2340156C (en) * 1998-08-10 2007-10-23 Novirio Pharmaceuticals Limited .beta.-l-2'-deoxy-nucleosides for the treatment of hepatitis b

Also Published As

Publication number Publication date
CA2413163C (en) 2008-11-18
AU2001266927B2 (en) 2006-12-14
CZ2003122A3 (cs) 2003-06-18
NO20026001L (no) 2003-02-12
AP2003002713A0 (en) 2003-03-31
ZA200404306B (en) 2005-06-15
CN1452627A (zh) 2003-10-29
NZ523632A (en) 2005-03-24
ATE411332T1 (de) 2008-10-15
KR20070048277A (ko) 2007-05-08
IL153379A0 (en) 2003-07-06
UY26779A1 (es) 2001-12-28
MXPA02012443A (es) 2004-09-10
BR0111732A (pt) 2003-06-24
EA005774B1 (ru) 2005-06-30
EP1296995B1 (en) 2008-10-15
NO20026001D0 (no) 2002-12-13
AR035711A1 (es) 2004-07-07
AP1771A (en) 2007-08-23
MA27126A1 (fr) 2005-01-03
AU6692701A (en) 2001-12-24
JP4639032B2 (ja) 2011-02-23
ES2317912T3 (es) 2009-05-01
IL153379A (en) 2007-02-11
WO2001096353A3 (en) 2002-04-18
ZA200300168B (en) 2004-07-07
YU94802A (sh) 2006-03-03
EP1296995A2 (en) 2003-04-02
JP2004533403A (ja) 2004-11-04
OA12384A (en) 2006-04-17
NZ535246A (en) 2006-06-30
CN1900104A (zh) 2007-01-24
KR20030032967A (ko) 2003-04-26
PL360404A1 (en) 2004-09-06
PE20020216A1 (es) 2002-04-16
CA2413163A1 (en) 2001-12-20
CN1295242C (zh) 2007-01-17
DE60136181D1 (de) 2008-11-27
IL178864A0 (en) 2007-03-08
WO2001096353A2 (en) 2001-12-20
CN101012259A (zh) 2007-08-08
MY141594A (en) 2010-05-14

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU