EA200300023A1 - 3'-ПРОЛЕКАРСТВА 2'-ДЕЗОКСИ-β-L-НУКЛЕОЗИДОВ - Google Patents
3'-ПРОЛЕКАРСТВА 2'-ДЕЗОКСИ-β-L-НУКЛЕОЗИДОВInfo
- Publication number
- EA200300023A1 EA200300023A1 EA200300023A EA200300023A EA200300023A1 EA 200300023 A1 EA200300023 A1 EA 200300023A1 EA 200300023 A EA200300023 A EA 200300023A EA 200300023 A EA200300023 A EA 200300023A EA 200300023 A1 EA200300023 A1 EA 200300023A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- nucleosides
- deoxy
- compositions
- compounds
- hepatitis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к соединениям, композициям и способам лечения хозяина, зараженного вирусом гепатита B. В частности, раскрываются соединения и композиции 3'-сложных эфиров 2'-дезокси-β-L-нуклеозидов, которые можно вводить одни или в комбинации с другими агентами против вируса гепатита B. Также раскрываются соединения и композиции 3',5'-сложных эфиров 2'-дезокси-β-L-нуклеозидов, которые можно вводить одни или в комбинации с другими агентами против вирусного гепатита B.Отчет о международном поиске был опубликован 2002.04.18.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21210000P | 2000-06-15 | 2000-06-15 | |
PCT/US2001/019147 WO2001096353A2 (en) | 2000-06-15 | 2001-06-15 | 3'-PRODRUGS OF 2'-DEOXY-β-L-NUCLEOSIDES |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200300023A1 true EA200300023A1 (ru) | 2003-08-28 |
EA005774B1 EA005774B1 (ru) | 2005-06-30 |
Family
ID=22789563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200300023A EA005774B1 (ru) | 2000-06-15 | 2001-06-15 | 3'-ПРОЛЕКАРСТВА 2'-ДЕЗОКСИ-β-L-НУКЛЕОЗИДОВ |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP1296995B1 (ru) |
JP (1) | JP4639032B2 (ru) |
KR (2) | KR20030032967A (ru) |
CN (3) | CN1295242C (ru) |
AP (1) | AP1771A (ru) |
AR (1) | AR035711A1 (ru) |
AT (1) | ATE411332T1 (ru) |
AU (2) | AU6692701A (ru) |
BR (1) | BR0111732A (ru) |
CA (1) | CA2413163C (ru) |
CZ (1) | CZ2003122A3 (ru) |
DE (1) | DE60136181D1 (ru) |
EA (1) | EA005774B1 (ru) |
ES (1) | ES2317912T3 (ru) |
IL (3) | IL153379A0 (ru) |
MA (1) | MA27126A1 (ru) |
MX (1) | MXPA02012443A (ru) |
MY (1) | MY141594A (ru) |
NO (1) | NO20026001L (ru) |
NZ (2) | NZ523632A (ru) |
OA (1) | OA12384A (ru) |
PE (1) | PE20020216A1 (ru) |
PL (1) | PL360404A1 (ru) |
UY (1) | UY26779A1 (ru) |
WO (1) | WO2001096353A2 (ru) |
YU (1) | YU94802A (ru) |
ZA (2) | ZA200300168B (ru) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100457118C (zh) | 2000-04-13 | 2009-02-04 | 法玛塞特有限公司 | 用于治疗肝炎病毒感染的3′-或2′-羟甲基取代的核苷衍生物 |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
US6787526B1 (en) | 2000-05-26 | 2004-09-07 | Idenix Pharmaceuticals, Inc. | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides |
KR20050055630A (ko) | 2002-06-28 | 2005-06-13 | 이데닉스 (케이만) 리미티드 | 플라비비리다에 감염 치료를 위한 1'-, 2'- 및 3'-변형된뉴클레오시드 유도체 |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
MXPA04012709A (es) * | 2002-06-28 | 2005-09-30 | Idenix Cayman Ltd | Profarmacos modificados de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae. |
JP2005533824A (ja) | 2002-06-28 | 2005-11-10 | イデニクス(ケイマン)リミテツド | フラビウイルス科感染の治療のための2’−c−メチル−3’−o−l−バリンエステルリボフラノシルシチジン |
SI1572095T1 (sl) | 2002-09-13 | 2015-12-31 | Novartis Ag | Beta-l-2'-deoksinukleozidi za uporabo pri zdravljenju odpornih sevov hbv |
WO2004046331A2 (en) | 2002-11-15 | 2004-06-03 | Idenix (Cayman) Limited | 2’-branched nucleosides and flaviviridae mutation |
WO2004084453A2 (en) | 2003-03-20 | 2004-09-30 | Microbiologica Quimica E Farmaceutica Ltd. | METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES |
KR20060015542A (ko) * | 2003-04-28 | 2006-02-17 | 이데닉스 (케이만) 리미티드 | 산업 규모의 뉴클레오시드 합성 |
WO2005003147A2 (en) | 2003-05-30 | 2005-01-13 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
MXPA06000162A (es) | 2003-06-30 | 2006-03-21 | Idenix Cayman Ltd | Sintesis de ?-l-2-desoxinucleosidos. |
US7754718B2 (en) | 2004-05-05 | 2010-07-13 | Yale University | Antiviral helioxanthin analogs |
EP1809301B1 (en) | 2004-09-14 | 2019-11-06 | Gilead Pharmasset LLC | 2-fluoro-2-alkyl-substituted d-ribonolactone intermediates |
US7524831B2 (en) | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
CN101242842A (zh) | 2005-06-17 | 2008-08-13 | 诺瓦提斯公司 | Sanglifehrin在hcv中的用途 |
GB0609178D0 (en) * | 2006-05-09 | 2006-06-21 | Univ Cardiff | Novel compounds |
US7897737B2 (en) | 2006-12-05 | 2011-03-01 | Lasergen, Inc. | 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
TW200946541A (en) | 2008-03-27 | 2009-11-16 | Idenix Pharmaceuticals Inc | Solid forms of an anti-HIV phosphoindole compound |
KR101677772B1 (ko) | 2008-06-11 | 2016-11-18 | 레이저젠, 인코퍼레이티드 | 뉴클레오타이드 및 뉴클레오사이드 그리고 시퀀싱에서의 이들의 이용 방법 |
EP3222628A1 (en) | 2008-12-23 | 2017-09-27 | Gilead Pharmasset LLC | Nucleoside phosphoramidates |
US8551973B2 (en) | 2008-12-23 | 2013-10-08 | Gilead Pharmasset Llc | Nucleoside analogs |
US8716263B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
PT3290428T (pt) | 2010-03-31 | 2021-12-27 | Gilead Pharmasset Llc | Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino |
WO2011123586A1 (en) | 2010-04-01 | 2011-10-06 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
AU2011336632B2 (en) | 2010-11-30 | 2015-09-03 | Gilead Pharmasset Llc | Compounds |
EP2691409B1 (en) | 2011-03-31 | 2018-02-21 | Idenix Pharmaceuticals LLC. | Compounds and pharmaceutical compositions for the treatment of viral infections |
AU2012308900A1 (en) | 2011-09-12 | 2013-05-09 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
CA2848049C (en) | 2011-09-13 | 2021-01-26 | Lasergen, Inc. | 5-methoxy, 3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing |
ME03009B (me) | 2011-09-16 | 2018-10-20 | Gilead Pharmasset Llc | Metode za lecenje hcv-a |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
AR090699A1 (es) * | 2012-04-18 | 2014-12-03 | Biocryst Pharm Inc | Compuestos inhibidores de la actividad de la arn polimerasa viral |
JP2015508418A (ja) | 2013-01-31 | 2015-03-19 | ギリアド ファーマセット エルエルシー | 2種の抗ウイルス化合物のコンビナトリアル製剤 |
EP4005560A1 (en) | 2013-08-27 | 2022-06-01 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
BR112020020804A2 (pt) | 2018-04-12 | 2021-01-12 | Modis Therapeutics Inc. | Pró-fármacos de desoxinucleosídeos para tratamento de doenças causadas por agrupamentos de nucleotídeos não balanceados |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4958013A (en) * | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
IT1246983B (it) * | 1990-11-13 | 1994-12-12 | Consiglio Nazionale Ricerche | L-2'-desossiuridine e composizioni farmaceutiche che le contengono. |
US5559101A (en) * | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
SE505648C2 (sv) * | 1996-08-30 | 1997-09-22 | Scania Cv Ab | Anordning vid ett fordon för monterbar anfästning av en förarplatsmodul |
CA2340156C (en) * | 1998-08-10 | 2007-10-23 | Novirio Pharmaceuticals Limited | .beta.-l-2'-deoxy-nucleosides for the treatment of hepatitis b |
-
2001
- 2001-06-14 MY MYPI20012807A patent/MY141594A/en unknown
- 2001-06-15 AU AU6692701A patent/AU6692701A/xx active Pending
- 2001-06-15 ES ES01944522T patent/ES2317912T3/es not_active Expired - Lifetime
- 2001-06-15 AR ARP010102881A patent/AR035711A1/es not_active Application Discontinuation
- 2001-06-15 EP EP01944522A patent/EP1296995B1/en not_active Expired - Lifetime
- 2001-06-15 BR BR0111732-7A patent/BR0111732A/pt not_active IP Right Cessation
- 2001-06-15 NZ NZ523632A patent/NZ523632A/en unknown
- 2001-06-15 KR KR1020027017018A patent/KR20030032967A/ko active IP Right Grant
- 2001-06-15 CA CA002413163A patent/CA2413163C/en not_active Expired - Lifetime
- 2001-06-15 KR KR1020077009124A patent/KR20070048277A/ko not_active Application Discontinuation
- 2001-06-15 UY UY26779A patent/UY26779A1/es not_active Application Discontinuation
- 2001-06-15 DE DE60136181T patent/DE60136181D1/de not_active Expired - Lifetime
- 2001-06-15 IL IL15337901A patent/IL153379A0/xx active IP Right Grant
- 2001-06-15 EA EA200300023A patent/EA005774B1/ru not_active IP Right Cessation
- 2001-06-15 CN CNB018138020A patent/CN1295242C/zh not_active Expired - Fee Related
- 2001-06-15 OA OA1200200374A patent/OA12384A/en unknown
- 2001-06-15 AT AT01944522T patent/ATE411332T1/de not_active IP Right Cessation
- 2001-06-15 CZ CZ2003122A patent/CZ2003122A3/cs unknown
- 2001-06-15 WO PCT/US2001/019147 patent/WO2001096353A2/en active Application Filing
- 2001-06-15 CN CNA2006101495863A patent/CN101012259A/zh active Pending
- 2001-06-15 MX MXPA02012443A patent/MXPA02012443A/es active IP Right Grant
- 2001-06-15 AU AU2001266927A patent/AU2001266927B2/en not_active Ceased
- 2001-06-15 PE PE2001000584A patent/PE20020216A1/es not_active Application Discontinuation
- 2001-06-15 PL PL36040401A patent/PL360404A1/xx not_active Application Discontinuation
- 2001-06-15 NZ NZ535246A patent/NZ535246A/en unknown
- 2001-06-15 CN CNA2006100741038A patent/CN1900104A/zh active Pending
- 2001-06-15 YU YU94802A patent/YU94802A/sh unknown
- 2001-06-15 JP JP2002510494A patent/JP4639032B2/ja not_active Expired - Lifetime
- 2001-06-15 AP APAP/P/2003/002713A patent/AP1771A/en active
-
2002
- 2002-12-11 IL IL153379A patent/IL153379A/en not_active IP Right Cessation
- 2002-12-13 NO NO20026001A patent/NO20026001L/no unknown
-
2003
- 2003-01-02 MA MA26989A patent/MA27126A1/fr unknown
- 2003-01-07 ZA ZA200300168A patent/ZA200300168B/en unknown
-
2004
- 2004-06-01 ZA ZA200404306A patent/ZA200404306B/xx unknown
-
2006
- 2006-10-25 IL IL178864A patent/IL178864A0/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |