ATE199538T1 - Antivirusverbindungen - Google Patents

Antivirusverbindungen

Info

Publication number
ATE199538T1
ATE199538T1 AT97303023T AT97303023T ATE199538T1 AT E199538 T1 ATE199538 T1 AT E199538T1 AT 97303023 T AT97303023 T AT 97303023T AT 97303023 T AT97303023 T AT 97303023T AT E199538 T1 ATE199538 T1 AT E199538T1
Authority
AT
Austria
Prior art keywords
compounds
antivirus
virus
cell
mammal
Prior art date
Application number
AT97303023T
Other languages
English (en)
Inventor
Scott Carl Mauldin
John Edwin Munroe
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE199538T1 publication Critical patent/ATE199538T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/42—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97303023T 1996-05-06 1997-05-02 Antivirusverbindungen ATE199538T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1692696P 1996-05-06 1996-05-06

Publications (1)

Publication Number Publication Date
ATE199538T1 true ATE199538T1 (de) 2001-03-15

Family

ID=21779768

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97303023T ATE199538T1 (de) 1996-05-06 1997-05-02 Antivirusverbindungen

Country Status (13)

Country Link
US (2) US6124494A (de)
EP (1) EP0811599B1 (de)
JP (1) JP2000510834A (de)
AT (1) ATE199538T1 (de)
AU (1) AU2826597A (de)
CA (1) CA2253398A1 (de)
DE (1) DE69704180T2 (de)
DK (1) DK0811599T3 (de)
ES (1) ES2154879T3 (de)
GR (1) GR3035870T3 (de)
PT (1) PT811599E (de)
SI (1) SI0811599T1 (de)
WO (1) WO1997041860A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103923A (en) * 1996-05-06 2000-08-15 Eli Lilly And Company Anti-viral compounds
US6124494A (en) * 1996-05-06 2000-09-26 Eli Lilly And Company Anti-viral compounds
US6156924A (en) * 1996-05-06 2000-12-05 Eli Lilly And Company Anti-viral compounds
US6127422A (en) * 1996-05-06 2000-10-03 Eli Lilly And Company Anti-viral method
EP0806205A3 (de) * 1996-05-06 1997-11-19 Eli Lilly And Company Harnstoff-, Thioharnstoff- und Guanidinverbindungen und deren Verwendung als antivirale Mittel
DE69703672T2 (de) * 1996-05-06 2001-05-17 Eli Lilly And Co., Indianapolis Antivirusverbindungen
JP2000511886A (ja) * 1996-05-06 2000-09-12 イーライ・リリー・アンド・カンパニー 抗ウイルス方法
CA2253857A1 (en) * 1996-05-06 1997-11-13 Scott Carl Mauldin Anti-viral compounds
US6096917A (en) * 1997-05-02 2000-08-01 Eli Lilly And Company Anti-viral compounds
US6175034B1 (en) 2000-04-10 2001-01-16 Eli Lilly And Company Anti-viral compounds
US6908934B2 (en) * 2001-06-11 2005-06-21 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
US7312031B1 (en) 2002-12-06 2007-12-25 The Salk Institute For Biological Studies Alpha-complementation viral fusion assay
CN108299330B (zh) * 2018-02-06 2021-02-12 桂林医学院 去氢枞酸噁唑烷酮衍生物及其制备方法和应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2750405A (en) * 1952-06-18 1956-06-12 Hercules Powder Co Ltd Hydroxydehydroabietic acid and esters thereof
US2744102A (en) * 1952-12-13 1956-05-01 Hercules Powder Co Ltd Acetoxydehydroabietic acid derivatives
US2744100A (en) * 1952-12-13 1956-05-01 Hercules Powder Co Ltd Bromodehydroabietic acid derivatives
US2759014A (en) * 1953-04-06 1956-08-14 Searle & Co Derivatives of 9-oxo-octahydrophenan-threne-1-carboxylic acid
US2750407A (en) * 1953-07-31 1956-06-12 Hercules Powder Co Ltd Substituted phenanthrenecarboxylic acid and esters thereof
US2703809A (en) * 1953-07-31 1955-03-08 Hercules Powder Co Ltd 7-acetyl-1, 2, 3, 4, 4alpha, 9, 10, 10alpha-octahydro-1, 4alpha-dimethyl-9-oxo-1-phenhrenecarboxylic acid and esters thereof
US2767162A (en) * 1953-11-23 1956-10-16 Searle & Co Glycolyl derivatives of 1, 12-dimethylpolyhydrophenanthrene-1-carboxylic acid esters
US2750382A (en) * 1953-12-03 1956-06-12 Searle & Co Basic esters of 1, 12-dimethyl-6-alkoxy-1, 2, 3, 4, 9, 10, 11, 12-octahydrophenanthrene-1-carboxylic acids
US2753357A (en) * 1954-11-26 1956-07-03 Searle & Co Lactones of 1, 12-dimethyl-6, 10-dihydroxy-9-oxo-1, 2, 3, 4, 9, 10, 11, 12-octahydrophenanthrene-1-carboxylic acid
US2862955A (en) * 1955-08-17 1958-12-02 Searle & Co Esters of hydroxyacyl-9-oxodehydroabietic acid
US2854474A (en) * 1956-07-19 1958-09-30 Searle & Co 1,12-dimethyl-6-hydroxy-7-acyl-9-oxo-1,2,3,4,9,10,11,12-cotahydrophenan-threne-1-carboxylic acids and derivatives thereof
US2947778A (en) * 1958-09-23 1960-08-02 Searle & Co 1, 12-dimethyl-6-hydroxy-7-aroyl-1, 2, 3, 4, 9, 10, 11, 12-octahydrophenanthrene-1-car-boxylic acids, ethers and esters thereof
US3014957A (en) * 1959-01-23 1961-12-26 G D Searle & Co Inc 6-(substituted benzoyl) dehydroabietonitriles and derivatives
US3038930A (en) * 1960-08-12 1962-06-12 Searle & Co 1, 2, 3, 4, 4a, 9, 10, 10a-octahydro-7-hydroxy-6-methoxy-1, 4a-dimethyl-phenanthrene-1-(carboxylic acid/methanol)and corresponding esters
US3668223A (en) * 1970-08-19 1972-06-06 Merck & Co Inc 2-oxo-3-benzoxepins
US4333941A (en) * 1975-12-22 1982-06-08 The Dow Chemical Company Inhibition of enveloped viruses with phenyl ketones
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
US5015644A (en) * 1987-06-02 1991-05-14 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
US5180736A (en) * 1989-03-23 1993-01-19 Warner-Lambert Company Polycyclic amines useful as cerebrovascular agents
US5116865A (en) * 1990-09-05 1992-05-26 Peters Richard H 15,16-seco-19-nor progestins
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds
NL1003010C2 (nl) * 1996-05-03 1997-11-06 Dsm Nv Werkwijze voor het omzetten van een geminaal gesubstitueerd cyclopentadieen.
JP2000510464A (ja) 1996-05-06 2000-08-15 イーライ・リリー・アンド・カンパニー 抗―ウイルス性化合物群
DE69705582T2 (de) 1996-05-06 2002-06-06 Eli Lilly And Co., Indianapolis Antivirusverbindungen
JP2000511886A (ja) * 1996-05-06 2000-09-12 イーライ・リリー・アンド・カンパニー 抗ウイルス方法
DE69703672T2 (de) * 1996-05-06 2001-05-17 Eli Lilly And Co., Indianapolis Antivirusverbindungen
CA2253857A1 (en) 1996-05-06 1997-11-13 Scott Carl Mauldin Anti-viral compounds
AU2826697A (en) 1996-05-06 1997-11-26 Eli Lilly And Company Anti-viral compounds
US6124494A (en) * 1996-05-06 2000-09-26 Eli Lilly And Company Anti-viral compounds

Also Published As

Publication number Publication date
US6180816B1 (en) 2001-01-30
JP2000510834A (ja) 2000-08-22
DK0811599T3 (da) 2001-04-17
HK1006087A1 (en) 1999-02-12
EP0811599A3 (de) 1998-07-01
DE69704180D1 (de) 2001-04-12
US6124494A (en) 2000-09-26
EP0811599B1 (de) 2001-03-07
CA2253398A1 (en) 1997-11-13
EP0811599A2 (de) 1997-12-10
PT811599E (pt) 2001-06-29
AU2826597A (en) 1997-11-26
WO1997041860A1 (en) 1997-11-13
ES2154879T3 (es) 2001-04-16
SI0811599T1 (en) 2001-08-31
GR3035870T3 (en) 2001-08-31
DE69704180T2 (de) 2001-08-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee