ES2154879T3 - Compuestos antiviricos. - Google Patents

Compuestos antiviricos.

Info

Publication number
ES2154879T3
ES2154879T3 ES97303023T ES97303023T ES2154879T3 ES 2154879 T3 ES2154879 T3 ES 2154879T3 ES 97303023 T ES97303023 T ES 97303023T ES 97303023 T ES97303023 T ES 97303023T ES 2154879 T3 ES2154879 T3 ES 2154879T3
Authority
ES
Spain
Prior art keywords
compounds
antivirical
virus
cell
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97303023T
Other languages
English (en)
Inventor
Scott Carl Mauldin
John Edwin Munroe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2154879T3 publication Critical patent/ES2154879T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/42—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA COMPUESTOS QUE INHIBEN UN VIRUS CON ENVUELTA INHIBIENDO LA FUSION DEL VIRUS CON LA CELULA HOSPEDANTE. EL VIRUS PUEDE ESTAR INHIBIDO EN UNA CELULA INFECTADA, EN UNA CELULA SUSCEPTIBLE DE SER INFECTADA O EN UN MAMIFERO QUE LO NECESITE.
ES97303023T 1996-05-06 1997-05-02 Compuestos antiviricos. Expired - Lifetime ES2154879T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1692696P 1996-05-06 1996-05-06

Publications (1)

Publication Number Publication Date
ES2154879T3 true ES2154879T3 (es) 2001-04-16

Family

ID=21779768

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97303023T Expired - Lifetime ES2154879T3 (es) 1996-05-06 1997-05-02 Compuestos antiviricos.

Country Status (14)

Country Link
US (2) US6124494A (es)
EP (1) EP0811599B1 (es)
JP (1) JP2000510834A (es)
AT (1) ATE199538T1 (es)
AU (1) AU2826597A (es)
CA (1) CA2253398A1 (es)
DE (1) DE69704180T2 (es)
DK (1) DK0811599T3 (es)
ES (1) ES2154879T3 (es)
GR (1) GR3035870T3 (es)
HK (1) HK1006087A1 (es)
PT (1) PT811599E (es)
SI (1) SI0811599T1 (es)
WO (1) WO1997041860A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE198070T1 (de) * 1996-05-06 2000-12-15 Lilly Co Eli Antivirusverbindungen
WO1997041849A1 (en) * 1996-05-06 1997-11-13 Eli Lilly And Company Anti-viral method
JP2000511514A (ja) 1996-05-06 2000-09-05 イーライ・リリー・アンド・カンパニー 抗ウイルス化合物
EP0806205A3 (en) * 1996-05-06 1997-11-19 Eli Lilly And Company Urea, thiourea and guanidine compounds and their use as anti-viral agents
US6127422A (en) * 1996-05-06 2000-10-03 Eli Lilly And Company Anti-viral method
US6103923A (en) * 1996-05-06 2000-08-15 Eli Lilly And Company Anti-viral compounds
ES2154879T3 (es) * 1996-05-06 2001-04-16 Lilly Co Eli Compuestos antiviricos.
US6156924A (en) * 1996-05-06 2000-12-05 Eli Lilly And Company Anti-viral compounds
US6096917A (en) * 1997-05-02 2000-08-01 Eli Lilly And Company Anti-viral compounds
US6175034B1 (en) 2000-04-10 2001-01-16 Eli Lilly And Company Anti-viral compounds
US6908934B2 (en) * 2001-06-11 2005-06-21 Merck & Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
US7312031B1 (en) 2002-12-06 2007-12-25 The Salk Institute For Biological Studies Alpha-complementation viral fusion assay
CN108299330B (zh) * 2018-02-06 2021-02-12 桂林医学院 去氢枞酸噁唑烷酮衍生物及其制备方法和应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2750405A (en) * 1952-06-18 1956-06-12 Hercules Powder Co Ltd Hydroxydehydroabietic acid and esters thereof
US2744102A (en) * 1952-12-13 1956-05-01 Hercules Powder Co Ltd Acetoxydehydroabietic acid derivatives
US2744100A (en) * 1952-12-13 1956-05-01 Hercules Powder Co Ltd Bromodehydroabietic acid derivatives
US2759014A (en) * 1953-04-06 1956-08-14 Searle & Co Derivatives of 9-oxo-octahydrophenan-threne-1-carboxylic acid
US2703809A (en) * 1953-07-31 1955-03-08 Hercules Powder Co Ltd 7-acetyl-1, 2, 3, 4, 4alpha, 9, 10, 10alpha-octahydro-1, 4alpha-dimethyl-9-oxo-1-phenhrenecarboxylic acid and esters thereof
US2750407A (en) * 1953-07-31 1956-06-12 Hercules Powder Co Ltd Substituted phenanthrenecarboxylic acid and esters thereof
US2767162A (en) * 1953-11-23 1956-10-16 Searle & Co Glycolyl derivatives of 1, 12-dimethylpolyhydrophenanthrene-1-carboxylic acid esters
US2750382A (en) * 1953-12-03 1956-06-12 Searle & Co Basic esters of 1, 12-dimethyl-6-alkoxy-1, 2, 3, 4, 9, 10, 11, 12-octahydrophenanthrene-1-carboxylic acids
US2753357A (en) * 1954-11-26 1956-07-03 Searle & Co Lactones of 1, 12-dimethyl-6, 10-dihydroxy-9-oxo-1, 2, 3, 4, 9, 10, 11, 12-octahydrophenanthrene-1-carboxylic acid
US2862955A (en) * 1955-08-17 1958-12-02 Searle & Co Esters of hydroxyacyl-9-oxodehydroabietic acid
US2854474A (en) * 1956-07-19 1958-09-30 Searle & Co 1,12-dimethyl-6-hydroxy-7-acyl-9-oxo-1,2,3,4,9,10,11,12-cotahydrophenan-threne-1-carboxylic acids and derivatives thereof
US2947778A (en) * 1958-09-23 1960-08-02 Searle & Co 1, 12-dimethyl-6-hydroxy-7-aroyl-1, 2, 3, 4, 9, 10, 11, 12-octahydrophenanthrene-1-car-boxylic acids, ethers and esters thereof
US3014957A (en) * 1959-01-23 1961-12-26 G D Searle & Co Inc 6-(substituted benzoyl) dehydroabietonitriles and derivatives
US3038930A (en) * 1960-08-12 1962-06-12 Searle & Co 1, 2, 3, 4, 4a, 9, 10, 10a-octahydro-7-hydroxy-6-methoxy-1, 4a-dimethyl-phenanthrene-1-(carboxylic acid/methanol)and corresponding esters
US3668223A (en) * 1970-08-19 1972-06-06 Merck & Co Inc 2-oxo-3-benzoxepins
US4333941A (en) * 1975-12-22 1982-06-08 The Dow Chemical Company Inhibition of enveloped viruses with phenyl ketones
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
US5015644A (en) * 1987-06-02 1991-05-14 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
US5180736A (en) * 1989-03-23 1993-01-19 Warner-Lambert Company Polycyclic amines useful as cerebrovascular agents
US5116865A (en) * 1990-09-05 1992-05-26 Peters Richard H 15,16-seco-19-nor progestins
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds
NL1003010C2 (nl) * 1996-05-03 1997-11-06 Dsm Nv Werkwijze voor het omzetten van een geminaal gesubstitueerd cyclopentadieen.
ES2154879T3 (es) * 1996-05-06 2001-04-16 Lilly Co Eli Compuestos antiviricos.
JP2000511514A (ja) 1996-05-06 2000-09-05 イーライ・リリー・アンド・カンパニー 抗ウイルス化合物
AU2750597A (en) 1996-05-06 1997-11-26 Eli Lilly And Company Anti-viral compounds
WO1997041849A1 (en) * 1996-05-06 1997-11-13 Eli Lilly And Company Anti-viral method
ATE198070T1 (de) 1996-05-06 2000-12-15 Lilly Co Eli Antivirusverbindungen
PT806410E (pt) 1996-05-06 2001-10-31 Lilly Co Eli Compostos anti-virais
DK0806409T3 (da) * 1996-05-06 2001-04-17 Lilly Co Eli Antivirale forbindelser

Also Published As

Publication number Publication date
US6180816B1 (en) 2001-01-30
DE69704180D1 (de) 2001-04-12
EP0811599A3 (en) 1998-07-01
EP0811599A2 (en) 1997-12-10
WO1997041860A1 (en) 1997-11-13
US6124494A (en) 2000-09-26
EP0811599B1 (en) 2001-03-07
DE69704180T2 (de) 2001-08-30
PT811599E (pt) 2001-06-29
DK0811599T3 (da) 2001-04-17
SI0811599T1 (en) 2001-08-31
GR3035870T3 (en) 2001-08-31
HK1006087A1 (en) 1999-02-12
ATE199538T1 (de) 2001-03-15
JP2000510834A (ja) 2000-08-22
CA2253398A1 (en) 1997-11-13
AU2826597A (en) 1997-11-26

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