EA200201239A1 - Замещенные имидазолы в качестве ингибиторов активированной формы активируемого тромбином ингибитора фибринолиза (tafia) - Google Patents

Замещенные имидазолы в качестве ингибиторов активированной формы активируемого тромбином ингибитора фибринолиза (tafia)

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Publication number
EA200201239A1
EA200201239A1 EA200201239A EA200201239A EA200201239A1 EA 200201239 A1 EA200201239 A1 EA 200201239A1 EA 200201239 A EA200201239 A EA 200201239A EA 200201239 A EA200201239 A EA 200201239A EA 200201239 A1 EA200201239 A1 EA 200201239A1
Authority
EA
Eurasian Patent Office
Prior art keywords
activated
fibrinolysis
tafia
inhibitors
thrombin inhibitor
Prior art date
Application number
EA200201239A
Other languages
English (en)
Other versions
EA005532B1 (ru
Inventor
Шарлотт Мойра Норфор Аллертон
Джулиан Блэгг
Марк Эдвард Баннейдж
Джон Стил
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0020346A external-priority patent/GB0020346D0/en
Priority claimed from GB0027409A external-priority patent/GB0027409D0/en
Priority claimed from GB0029556A external-priority patent/GB0029556D0/en
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200201239A1 publication Critical patent/EA200201239A1/ru
Publication of EA005532B1 publication Critical patent/EA005532B1/ru

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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
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  • Reproductive Health (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

В настоящем изобретении предложены соединения формулы (I). Эти соединения представляют собой класс ингибиторов TAFIa (active Thrombin Activatable Fibrinolysis Inhibitor, активированная форма активируемого тромбином ингибитора фибринолиза), атеросклероза, спаек, кожного рубцевания, рака, фиброзных состояний, воспалительных заболеваний и таких состояний, при которых полезно поддержание или повышение уровней брадикинина в организме.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200201239A 2000-08-17 2001-08-08 Замещенные имидазолы в качестве ингибиторов активированной формы активируемого тромбином ингибитора фибринолиза (tafia) EA005532B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0020346A GB0020346D0 (en) 2000-08-17 2000-08-17 Pharmaceuticals
GB0027409A GB0027409D0 (en) 2000-11-09 2000-11-09 Pharmaceuticals
GB0029556A GB0029556D0 (en) 2000-12-04 2000-12-04 Pharmaceuticals
PCT/IB2001/001425 WO2002014285A1 (en) 2000-08-17 2001-08-08 Substituted imidazoles as tafia inhibitors

Publications (2)

Publication Number Publication Date
EA200201239A1 true EA200201239A1 (ru) 2003-08-28
EA005532B1 EA005532B1 (ru) 2005-04-28

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EA200201239A EA005532B1 (ru) 2000-08-17 2001-08-08 Замещенные имидазолы в качестве ингибиторов активированной формы активируемого тромбином ингибитора фибринолиза (tafia)

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EP (1) EP1311488B1 (ru)
JP (2) JP4119746B2 (ru)
KR (1) KR20030022412A (ru)
CN (1) CN1443173A (ru)
AP (1) AP1375A (ru)
AR (1) AR035580A1 (ru)
AT (1) ATE447557T1 (ru)
AU (1) AU2001276605A1 (ru)
BG (1) BG107330A (ru)
BR (1) BR0113289A (ru)
CA (1) CA2419633C (ru)
CY (1) CY1109693T1 (ru)
CZ (1) CZ2003388A3 (ru)
DE (1) DE60140368D1 (ru)
DK (1) DK1311488T3 (ru)
DO (1) DOP2001000233A (ru)
EA (1) EA005532B1 (ru)
EE (1) EE200300070A (ru)
ES (1) ES2334101T3 (ru)
HR (1) HRP20030103A2 (ru)
HU (1) HUP0303763A3 (ru)
IL (1) IL153225A0 (ru)
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MA (1) MA26940A1 (ru)
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TN (1) TNSN01126A1 (ru)
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WO (1) WO2002014285A1 (ru)

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SE0103272D0 (sv) 2001-09-28 2001-09-28 Astrazeneca Ab Chemical compounds
US6713496B2 (en) 2002-01-22 2004-03-30 Pfizer Inc 3-(imidazolyl)-2-alkoxypropanoic acids
EP1467731A1 (en) * 2002-01-22 2004-10-20 Pfizer Limited 3-(imidazolyl)-2-alkoxypropanoic acids as tafia inhibitors
JP2005516972A (ja) * 2002-01-22 2005-06-09 ファイザー・インク 血栓疾患の治療のためのｔａｆｉ−ａ阻害剤として使用される３−（イミダゾリル）−２−アミノプロピオン酸
US8512675B2 (en) 2003-04-29 2013-08-20 Mallinckrodt Llc N and/or Nα derivatized, metal and organic protected L-histidine for coupling to biomolecules for highly efficient labeling with [M(OH2)3 (CO)3]+ by fac coordination
SE0302853D0 (sv) * 2003-10-29 2003-10-29 Astrazeneca Ab Chemical compounds
ZA200603165B (en) * 2003-11-03 2007-07-25 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
WO2005051384A1 (en) * 2003-11-25 2005-06-09 Pfizer Limited Stabilised pharmaceutical compositions
JP2008536923A (ja) * 2005-04-18 2008-09-11 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト 心筋の再灌流の増強およびｐｃｉの容易化のためのｔａｆｉ阻害剤の使用
DE102005049385A1 (de) * 2005-10-15 2007-04-19 Sanofi-Aventis Deutschland Gmbh Imidazolderivate als Inhibitoren von TAFIa
NZ577312A (en) * 2006-12-06 2012-02-24 Sanofi Aventis Urea and sulfamide derivatives as tafia inhibitors
WO2009103432A2 (en) * 2008-02-21 2009-08-27 Sanofi-Aventis Covalently binding imaging probes
EP2361910A4 (en) * 2008-10-29 2012-08-01 Taisho Pharmaceutical Co Ltd CONNECTION WITH TAFIA-INHIBITOR EFFECT
FR2947266B1 (fr) * 2009-06-26 2011-06-17 Servier Lab Nouveaux derives d'acide 2-mercaptocyclopentanecarboxylique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
LT2548871T (lt) * 2010-03-18 2017-09-25 Daiichi Sankyo Company, Limited Cikloalkilpakeistieji imidazolo dariniai
CN102884053B (zh) 2010-03-18 2016-03-02 第一三共株式会社 环丙烷甲酸衍生物
PE20141161A1 (es) * 2011-05-17 2014-10-01 Pharmasyntez Los compuestos para el tratamiento y la prevencion de la adhesion, las composiciones farmaceuticas relacionados con el compuesto y los metodos para la prevencion y el tratamiento de adherencias
DK2734508T3 (en) * 2011-07-22 2018-05-22 Cambrex Karlskoga Ab NEW PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED IMIDAZOLS
WO2013039202A1 (ja) * 2011-09-15 2013-03-21 第一三共株式会社 新規アクリル酸誘導体
CA2914533A1 (en) 2013-06-10 2014-12-18 Sanofi Macrocyclic urea derivatives as inhibitors of tafia, their preparation and their use as pharmaceuticals
DK3359528T3 (en) 2015-10-07 2022-03-07 Mitobridge Inc Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
FR3046793B1 (fr) * 2016-01-14 2018-01-05 Les Laboratoires Servier Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP3437641A4 (en) * 2016-03-29 2019-11-20 Daiichi Sankyo Company, Limited THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASES
KR102430906B1 (ko) * 2016-04-13 2022-08-10 미토브리지, 인크. Ppar 효능제, 화합물, 제약 조성물, 및 그의 사용 방법

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US5993815A (en) * 1996-11-08 1999-11-30 University Of Vermont Methods and compositions for inhibiting the activation of thrombin-activatable fibrinolysis inhibitor (TAFI)
SE9901572D0 (sv) * 1999-05-03 1999-05-03 Astra Ab New compounds

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CA2419633C (en) 2011-05-10
ES2334101T3 (es) 2010-03-05
TNSN01126A1 (fr) 2005-11-10
AU2001276605A1 (en) 2002-02-25
HRP20030103A2 (en) 2003-04-30
DOP2001000233A (es) 2002-05-15
JP4119746B2 (ja) 2008-07-16
NO20030706L (no) 2003-04-15
PA8525401A1 (es) 2002-04-25
SV2002000602A (es) 2002-10-24
DK1311488T3 (da) 2010-01-04
PE20020352A1 (es) 2002-05-11
JP2004506044A (ja) 2004-02-26
CZ2003388A3 (cs) 2004-03-17
EA005532B1 (ru) 2005-04-28
IS6638A (is) 2002-11-28
WO2002014285A1 (en) 2002-02-21
IL153225A0 (en) 2003-07-06
KR20030022412A (ko) 2003-03-15
ATE447557T1 (de) 2009-11-15
OA12362A (en) 2004-04-07
HUP0303763A2 (hu) 2004-04-28
DE60140368D1 (de) 2009-12-17
EP1311488B1 (en) 2009-11-04
AP1375A (en) 2005-03-03
AR035580A1 (es) 2004-06-16
SK1732003A3 (en) 2004-08-03
JP4778531B2 (ja) 2011-09-21
NZ522823A (en) 2004-11-26
UY26889A1 (es) 2002-03-22
PT1311488E (pt) 2009-12-30
NO20030706D0 (no) 2003-02-14
EP1311488A1 (en) 2003-05-21
MA26940A1 (fr) 2004-12-20
SI1311488T1 (sl) 2010-01-29
AP2001002250A0 (en) 2001-09-30
PL361054A1 (en) 2004-09-20
CN1443173A (zh) 2003-09-17
EE200300070A (et) 2005-02-15
HUP0303763A3 (en) 2004-06-28
CY1109693T1 (el) 2014-08-13
CA2419633A1 (en) 2002-02-21
BR0113289A (pt) 2003-06-17
BG107330A (en) 2003-06-30
MXPA03001425A (es) 2003-06-06
JP2008169224A (ja) 2008-07-24

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