EA200200358A1 - Глюкопиранозидные конъюгаты 2-(4-гидроксифенил)-1-[4-(2-амин-1-илэтокси)бензил]-1h-индол-5-олов - Google Patents
Глюкопиранозидные конъюгаты 2-(4-гидроксифенил)-1-[4-(2-амин-1-илэтокси)бензил]-1h-индол-5-оловInfo
- Publication number
- EA200200358A1 EA200200358A1 EA200200358A EA200200358A EA200200358A1 EA 200200358 A1 EA200200358 A1 EA 200200358A1 EA 200200358 A EA200200358 A EA 200200358A EA 200200358 A EA200200358 A EA 200200358A EA 200200358 A1 EA200200358 A1 EA 200200358A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbon atoms
- iletoxi
- hydroxifenil
- glucopiranoside
- benzil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Abstract
Данное изобретение относится к гистоселективным эстрогенам формулы (I), имеющим структуру (I), в которой Rи Rнезависимо представляют собой водород, алкильную цепь из 1-6 атомов углерода, бензил, ацил из 2-7 атомов углерода, бензоил, (1) или (2); Х представляет собой водород, алкил из 1-6 атомов углерода, CN, галоген, трифторметил или тиоалкил из 1-6 атомов углерода; n=1-3; при условии, что, по меньшей мере, один из Rи Rпредставляет собой (1) или (2); или к их фармацевтически приемлемым солям.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39424099A | 1999-09-13 | 1999-09-13 | |
PCT/US2000/024738 WO2001019839A1 (en) | 1999-09-13 | 2000-09-11 | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-ols |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200200358A1 true EA200200358A1 (ru) | 2002-08-29 |
EA005371B1 EA005371B1 (ru) | 2005-02-24 |
Family
ID=23558135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200200358A EA005371B1 (ru) | 1999-09-13 | 2000-09-11 | Глюкопиранозидные конъюгаты 2-(4-гидроксифенил)-1-[4-(2-амин-1-илэтокси)бензил]-1h-индол-5-олов |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1212335B1 (ru) |
JP (1) | JP2003509435A (ru) |
KR (1) | KR100653570B1 (ru) |
CN (1) | CN1196708C (ru) |
AR (1) | AR025638A1 (ru) |
AT (1) | ATE316093T1 (ru) |
AU (1) | AU764436B2 (ru) |
BR (1) | BR0013943A (ru) |
CA (1) | CA2382683A1 (ru) |
CY (1) | CY1104970T1 (ru) |
CZ (1) | CZ298862B6 (ru) |
DE (1) | DE60025630T2 (ru) |
DK (1) | DK1212335T3 (ru) |
EA (1) | EA005371B1 (ru) |
ES (1) | ES2254215T3 (ru) |
HK (1) | HK1044777B (ru) |
HU (1) | HUP0202679A3 (ru) |
IL (2) | IL148273A0 (ru) |
MX (1) | MXPA02002654A (ru) |
NO (1) | NO322250B1 (ru) |
NZ (1) | NZ517645A (ru) |
PL (1) | PL354179A1 (ru) |
TW (1) | TWI287018B (ru) |
WO (1) | WO2001019839A1 (ru) |
ZA (1) | ZA200201876B (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL159897A0 (en) * | 2001-07-19 | 2004-06-20 | Cv Therapeutics Inc | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
WO2006027987A1 (ja) * | 2004-09-06 | 2006-03-16 | Kissei Pharmaceutical Co., Ltd. | 排尿障害の予防又は治療薬 |
RU2011145811A (ru) * | 2009-04-13 | 2013-05-20 | Сандоз Аг | Способы синтеза базедоксифенацетата и его промежуточных продуктов |
CN101857617A (zh) * | 2010-04-28 | 2010-10-13 | 中国海洋大学 | 喹唑啉类糖衍生物及其制备方法和应用 |
CN102690225B (zh) * | 2012-04-11 | 2014-12-24 | 南京友杰医药科技有限公司 | 巴多昔芬的合成方法 |
CN104798294B (zh) * | 2012-11-22 | 2018-09-25 | 艾默生电气公司 | 电机、定子和压缩机,以及制造它们的方法 |
CN104151265B (zh) * | 2013-05-13 | 2016-10-05 | 上海医药工业研究院 | 醋酸巴多昔芬中间体的制备方法 |
CN104725334A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | (4-(2-(氮杂环庚烷-1-基)乙氧基)苯基)甲醇的制备方法 |
CN105085365B (zh) * | 2014-05-12 | 2018-06-19 | 四川科伦药业股份有限公司 | 醋酸巴多昔芬及其中间体的制备方法 |
CN107033062B (zh) * | 2017-03-24 | 2019-10-29 | 梯尔希(南京)药物研发有限公司 | 一种巴多昔芬衍生物的制备方法 |
CN107400087B (zh) * | 2017-09-15 | 2019-12-13 | 济南美高生物医药科技有限公司 | 一种1-(2-(4-(氯甲基)苯氧基)乙基)氮杂环庚烷盐酸盐的制备方法 |
CN111196831B (zh) * | 2020-01-20 | 2023-05-09 | 山西医科大学 | 一种呋喃酚葡萄糖醛酸结合物的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3821148A1 (de) * | 1988-06-23 | 1989-12-28 | Erwin Von Dr Angerer | Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
EP0639567A1 (en) * | 1992-05-08 | 1995-02-22 | Otsuka Pharmaceutical Factory, Inc. | Indole derivative |
GB9326332D0 (en) * | 1993-12-23 | 1994-02-23 | Karo Bio | Indole derivatives |
EP0746544B1 (en) * | 1994-02-22 | 1998-09-09 | Merrell Pharmaceuticals Inc. | Novel indole derivatives useful to treat estrogen-related neoplasms and disorders |
US6723739B1 (en) * | 1994-05-20 | 2004-04-20 | Eli Lilly And Company | Glucopyranoside benzothiophenes |
DE4426625A1 (de) * | 1994-07-27 | 1996-03-14 | Schering Ag | 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
SK281737B6 (sk) * | 1996-04-19 | 2001-07-10 | American Home Products Corporation | 2-fenylindolové zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie |
CA2306343C (en) * | 1997-10-15 | 2010-08-03 | American Home Products Corporation | Novel aryloxy-alkyl-dialkylamines |
ID24568A (id) * | 1997-11-06 | 2000-07-27 | American Home Prod | Kontrasepsi oral yang mengandung anti-estrogen plus progestin |
-
2000
- 2000-09-11 EA EA200200358A patent/EA005371B1/ru not_active IP Right Cessation
- 2000-09-11 DE DE60025630T patent/DE60025630T2/de not_active Expired - Lifetime
- 2000-09-11 ES ES00960064T patent/ES2254215T3/es not_active Expired - Lifetime
- 2000-09-11 PL PL00354179A patent/PL354179A1/xx unknown
- 2000-09-11 MX MXPA02002654A patent/MXPA02002654A/es active IP Right Grant
- 2000-09-11 CA CA002382683A patent/CA2382683A1/en not_active Abandoned
- 2000-09-11 WO PCT/US2000/024738 patent/WO2001019839A1/en active IP Right Grant
- 2000-09-11 CN CNB00814754XA patent/CN1196708C/zh not_active Expired - Fee Related
- 2000-09-11 DK DK00960064T patent/DK1212335T3/da active
- 2000-09-11 AT AT00960064T patent/ATE316093T1/de not_active IP Right Cessation
- 2000-09-11 AU AU71284/00A patent/AU764436B2/en not_active Ceased
- 2000-09-11 CZ CZ20020881A patent/CZ298862B6/cs not_active IP Right Cessation
- 2000-09-11 HU HU0202679A patent/HUP0202679A3/hu unknown
- 2000-09-11 JP JP2001523616A patent/JP2003509435A/ja active Pending
- 2000-09-11 EP EP00960064A patent/EP1212335B1/en not_active Expired - Lifetime
- 2000-09-11 BR BR0013943-2A patent/BR0013943A/pt not_active IP Right Cessation
- 2000-09-11 NZ NZ517645A patent/NZ517645A/en unknown
- 2000-09-11 TW TW089118581A patent/TWI287018B/zh active
- 2000-09-11 KR KR1020027003352A patent/KR100653570B1/ko not_active IP Right Cessation
- 2000-09-11 IL IL14827300A patent/IL148273A0/xx active IP Right Grant
- 2000-09-12 AR ARP000104778A patent/AR025638A1/es unknown
-
2002
- 2002-02-20 IL IL148273A patent/IL148273A/en not_active IP Right Cessation
- 2002-03-06 ZA ZA200201876A patent/ZA200201876B/xx unknown
- 2002-03-12 NO NO20021203A patent/NO322250B1/no not_active IP Right Cessation
- 2002-09-02 HK HK02106468.8A patent/HK1044777B/zh not_active IP Right Cessation
-
2006
- 2006-02-08 CY CY20061100176T patent/CY1104970T1/el unknown
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Legal Events
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FA9A | Withdrawal of a eurasian application | ||
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |