DK1212335T3 - Glucopyranosid-konjugater af 2-(4-hydroxyphenyl)-1-[4-(2-amin-1-ylethoxy)-benzyl]-1H-indol-5-oler - Google Patents

Glucopyranosid-konjugater af 2-(4-hydroxyphenyl)-1-[4-(2-amin-1-ylethoxy)-benzyl]-1H-indol-5-oler

Info

Publication number
DK1212335T3
DK1212335T3 DK00960064T DK00960064T DK1212335T3 DK 1212335 T3 DK1212335 T3 DK 1212335T3 DK 00960064 T DK00960064 T DK 00960064T DK 00960064 T DK00960064 T DK 00960064T DK 1212335 T3 DK1212335 T3 DK 1212335T3
Authority
DK
Denmark
Prior art keywords
ylethoxy
amin
glucopyranoside
indol
conjugates
Prior art date
Application number
DK00960064T
Other languages
English (en)
Inventor
Christopher Paul Miller
Michael David Collini
Bach Dinh Tran
Anita Wai-Yin Chan
Arkadiy Zinoviy Rubezhov
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1212335T3 publication Critical patent/DK1212335T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
DK00960064T 1999-09-13 2000-09-11 Glucopyranosid-konjugater af 2-(4-hydroxyphenyl)-1-[4-(2-amin-1-ylethoxy)-benzyl]-1H-indol-5-oler DK1212335T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39424099A 1999-09-13 1999-09-13

Publications (1)

Publication Number Publication Date
DK1212335T3 true DK1212335T3 (da) 2006-03-20

Family

ID=23558135

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00960064T DK1212335T3 (da) 1999-09-13 2000-09-11 Glucopyranosid-konjugater af 2-(4-hydroxyphenyl)-1-[4-(2-amin-1-ylethoxy)-benzyl]-1H-indol-5-oler

Country Status (25)

Country Link
EP (1) EP1212335B1 (da)
JP (1) JP2003509435A (da)
KR (1) KR100653570B1 (da)
CN (1) CN1196708C (da)
AR (1) AR025638A1 (da)
AT (1) ATE316093T1 (da)
AU (1) AU764436B2 (da)
BR (1) BR0013943A (da)
CA (1) CA2382683A1 (da)
CY (1) CY1104970T1 (da)
CZ (1) CZ298862B6 (da)
DE (1) DE60025630T2 (da)
DK (1) DK1212335T3 (da)
EA (1) EA005371B1 (da)
ES (1) ES2254215T3 (da)
HK (1) HK1044777B (da)
HU (1) HUP0202679A3 (da)
IL (2) IL148273A0 (da)
MX (1) MXPA02002654A (da)
NO (1) NO322250B1 (da)
NZ (1) NZ517645A (da)
PL (1) PL354179A1 (da)
TW (1) TWI287018B (da)
WO (1) WO2001019839A1 (da)
ZA (1) ZA200201876B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6930111B2 (en) * 2001-07-19 2005-08-16 Cv Therapeutics, Inc. Substituted heterocyclic compounds
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP4847333B2 (ja) * 2004-09-06 2011-12-28 キッセイ薬品工業株式会社 排尿障害の予防又は治療薬
WO2010118997A1 (en) * 2009-04-13 2010-10-21 Sandoz Ag Processes for the synthesis of bazedoxifene acetate and intermediates thereof
CN101857617A (zh) * 2010-04-28 2010-10-13 中国海洋大学 喹唑啉类糖衍生物及其制备方法和应用
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
KR102066767B1 (ko) * 2012-11-22 2020-01-15 에머슨 일렉트릭 컴파니 전기기계, 스테이터 및 압축기와 그 제조 방법
CN104151265B (zh) * 2013-05-13 2016-10-05 上海医药工业研究院 醋酸巴多昔芬中间体的制备方法
CN104725334A (zh) * 2013-12-20 2015-06-24 北京蓝贝望生物医药科技股份有限公司 (4-(2-(氮杂环庚烷-1-基)乙氧基)苯基)甲醇的制备方法
CN105085365B (zh) * 2014-05-12 2018-06-19 四川科伦药业股份有限公司 醋酸巴多昔芬及其中间体的制备方法
CN107033062B (zh) * 2017-03-24 2019-10-29 梯尔希（南京）药物研发有限公司 一种巴多昔芬衍生物的制备方法
CN107400087B (zh) * 2017-09-15 2019-12-13 济南美高生物医药科技有限公司 一种1-(2-(4-(氯甲基)苯氧基)乙基)氮杂环庚烷盐酸盐的制备方法
CN111196831B (zh) * 2020-01-20 2023-05-09 山西医科大学 一种呋喃酚葡萄糖醛酸结合物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3821148A1 (de) * 1988-06-23 1989-12-28 Erwin Von Dr Angerer Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US5496844A (en) * 1992-05-08 1996-03-05 Otsuka Pharmaceutical Factory, Inc. Indole derivatives
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
ES2122555T3 (es) * 1994-02-22 1998-12-16 Merrell Pharma Inc Nuevos derivados indolicos utiles para tratar neoplasmas y trastornos relacionados con estrogenos.
US5567820A (en) * 1994-05-20 1996-10-22 Eli Lilly And Company Glucopyranoside benzothiophenes
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
ATE206701T1 (de) * 1996-04-19 2001-10-15 American Home Prod Östrogene verbindungen
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
EP1777214A3 (en) * 1997-10-15 2007-05-09 Wyeth Novel aryloxy-alkyl-dialkylamines
UA68365C2 (en) * 1997-11-06 2004-08-16 Wyeth Corp Peroral contraception by combination of anti-estrogen and progestin

Also Published As

Publication number Publication date
AU7128400A (en) 2001-04-17
DE60025630T2 (de) 2006-08-10
IL148273A0 (en) 2002-09-12
NO322250B1 (no) 2006-09-04
DE60025630D1 (de) 2006-04-06
PL354179A1 (en) 2003-12-29
CA2382683A1 (en) 2001-03-22
ES2254215T3 (es) 2006-06-16
HK1044777B (zh) 2006-04-13
WO2001019839A1 (en) 2001-03-22
BR0013943A (pt) 2002-05-14
CZ298862B6 (cs) 2008-02-27
HUP0202679A2 (hu) 2003-01-28
IL148273A (en) 2007-03-08
JP2003509435A (ja) 2003-03-11
KR20020027643A (ko) 2002-04-13
MXPA02002654A (es) 2002-07-30
CN1382151A (zh) 2002-11-27
CY1104970T1 (el) 2010-03-03
EA200200358A1 (ru) 2002-08-29
HK1044777A1 (en) 2002-11-01
EA005371B1 (ru) 2005-02-24
HUP0202679A3 (en) 2003-04-28
AU764436B2 (en) 2003-08-21
ATE316093T1 (de) 2006-02-15
ZA200201876B (en) 2003-08-27
NO20021203D0 (no) 2002-03-12
CZ2002881A3 (cs) 2003-01-15
EP1212335A1 (en) 2002-06-12
AR025638A1 (es) 2002-12-04
NO20021203L (no) 2002-03-12
NZ517645A (en) 2003-09-26
TWI287018B (en) 2007-09-21
KR100653570B1 (ko) 2006-12-05
CN1196708C (zh) 2005-04-13
EP1212335B1 (en) 2006-01-18

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