IL148273A0 - Glucopyranoside conijugates of 2-(4-hydroxy-phenyl)-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-ols - Google Patents
Glucopyranoside conijugates of 2-(4-hydroxy-phenyl)-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-olsInfo
- Publication number
- IL148273A0 IL148273A0 IL14827300A IL14827300A IL148273A0 IL 148273 A0 IL148273 A0 IL 148273A0 IL 14827300 A IL14827300 A IL 14827300A IL 14827300 A IL14827300 A IL 14827300A IL 148273 A0 IL148273 A0 IL 148273A0
- Authority
- IL
- Israel
- Prior art keywords
- conijugates
- ols
- amin
- glucopyranoside
- indol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39424099A | 1999-09-13 | 1999-09-13 | |
PCT/US2000/024738 WO2001019839A1 (en) | 1999-09-13 | 2000-09-11 | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-ols |
Publications (1)
Publication Number | Publication Date |
---|---|
IL148273A0 true IL148273A0 (en) | 2002-09-12 |
Family
ID=23558135
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14827300A IL148273A0 (en) | 1999-09-13 | 2000-09-11 | Glucopyranoside conijugates of 2-(4-hydroxy-phenyl)-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-ols |
IL148273A IL148273A (en) | 1999-09-13 | 2002-02-20 | Glucopyranoside Couplings of 2 - (4-Hydroxy-Phenyl) -1 - [4- (2-Amin - 1-Il-Ethoxy) -Benzyl] - H 1 - Indole-5 - Oils, their preparation and pharmaceutical preparations containing them |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL148273A IL148273A (en) | 1999-09-13 | 2002-02-20 | Glucopyranoside Couplings of 2 - (4-Hydroxy-Phenyl) -1 - [4- (2-Amin - 1-Il-Ethoxy) -Benzyl] - H 1 - Indole-5 - Oils, their preparation and pharmaceutical preparations containing them |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1212335B1 (xx) |
JP (1) | JP2003509435A (xx) |
KR (1) | KR100653570B1 (xx) |
CN (1) | CN1196708C (xx) |
AR (1) | AR025638A1 (xx) |
AT (1) | ATE316093T1 (xx) |
AU (1) | AU764436B2 (xx) |
BR (1) | BR0013943A (xx) |
CA (1) | CA2382683A1 (xx) |
CY (1) | CY1104970T1 (xx) |
CZ (1) | CZ298862B6 (xx) |
DE (1) | DE60025630T2 (xx) |
DK (1) | DK1212335T3 (xx) |
EA (1) | EA005371B1 (xx) |
ES (1) | ES2254215T3 (xx) |
HK (1) | HK1044777B (xx) |
HU (1) | HUP0202679A3 (xx) |
IL (2) | IL148273A0 (xx) |
MX (1) | MXPA02002654A (xx) |
NO (1) | NO322250B1 (xx) |
NZ (1) | NZ517645A (xx) |
PL (1) | PL354179A1 (xx) |
TW (1) | TWI287018B (xx) |
WO (1) | WO2001019839A1 (xx) |
ZA (1) | ZA200201876B (xx) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6930111B2 (en) * | 2001-07-19 | 2005-08-16 | Cv Therapeutics, Inc. | Substituted heterocyclic compounds |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
JP4847333B2 (ja) * | 2004-09-06 | 2011-12-28 | キッセイ薬品工業株式会社 | 排尿障害の予防又は治療薬 |
WO2010118997A1 (en) * | 2009-04-13 | 2010-10-21 | Sandoz Ag | Processes for the synthesis of bazedoxifene acetate and intermediates thereof |
CN101857617A (zh) * | 2010-04-28 | 2010-10-13 | 中国海洋大学 | 喹唑啉类糖衍生物及其制备方法和应用 |
CN102690225B (zh) * | 2012-04-11 | 2014-12-24 | 南京友杰医药科技有限公司 | 巴多昔芬的合成方法 |
KR102066767B1 (ko) * | 2012-11-22 | 2020-01-15 | 에머슨 일렉트릭 컴파니 | 전기기계, 스테이터 및 압축기와 그 제조 방법 |
CN104151265B (zh) * | 2013-05-13 | 2016-10-05 | 上海医药工业研究院 | 醋酸巴多昔芬中间体的制备方法 |
CN104725334A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | (4-(2-(氮杂环庚烷-1-基)乙氧基)苯基)甲醇的制备方法 |
CN105085365B (zh) * | 2014-05-12 | 2018-06-19 | 四川科伦药业股份有限公司 | 醋酸巴多昔芬及其中间体的制备方法 |
CN107033062B (zh) * | 2017-03-24 | 2019-10-29 | 梯尔希(南京)药物研发有限公司 | 一种巴多昔芬衍生物的制备方法 |
CN107400087B (zh) * | 2017-09-15 | 2019-12-13 | 济南美高生物医药科技有限公司 | 一种1-(2-(4-(氯甲基)苯氧基)乙基)氮杂环庚烷盐酸盐的制备方法 |
CN111196831B (zh) * | 2020-01-20 | 2023-05-09 | 山西医科大学 | 一种呋喃酚葡萄糖醛酸结合物的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3821148A1 (de) * | 1988-06-23 | 1989-12-28 | Erwin Von Dr Angerer | Aminoalkylindole, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
US5496844A (en) * | 1992-05-08 | 1996-03-05 | Otsuka Pharmaceutical Factory, Inc. | Indole derivatives |
GB9326332D0 (en) * | 1993-12-23 | 1994-02-23 | Karo Bio | Indole derivatives |
ES2122555T3 (es) * | 1994-02-22 | 1998-12-16 | Merrell Pharma Inc | Nuevos derivados indolicos utiles para tratar neoplasmas y trastornos relacionados con estrogenos. |
US5567820A (en) * | 1994-05-20 | 1996-10-22 | Eli Lilly And Company | Glucopyranoside benzothiophenes |
DE4426625A1 (de) * | 1994-07-27 | 1996-03-14 | Schering Ag | 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
ATE206701T1 (de) * | 1996-04-19 | 2001-10-15 | American Home Prod | Östrogene verbindungen |
TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
EP1777214A3 (en) * | 1997-10-15 | 2007-05-09 | Wyeth | Novel aryloxy-alkyl-dialkylamines |
UA68365C2 (en) * | 1997-11-06 | 2004-08-16 | Wyeth Corp | Peroral contraception by combination of anti-estrogen and progestin |
-
2000
- 2000-09-11 JP JP2001523616A patent/JP2003509435A/ja active Pending
- 2000-09-11 AT AT00960064T patent/ATE316093T1/de not_active IP Right Cessation
- 2000-09-11 CN CNB00814754XA patent/CN1196708C/zh not_active Expired - Fee Related
- 2000-09-11 IL IL14827300A patent/IL148273A0/xx active IP Right Grant
- 2000-09-11 WO PCT/US2000/024738 patent/WO2001019839A1/en active IP Right Grant
- 2000-09-11 HU HU0202679A patent/HUP0202679A3/hu unknown
- 2000-09-11 EA EA200200358A patent/EA005371B1/ru not_active IP Right Cessation
- 2000-09-11 CA CA002382683A patent/CA2382683A1/en not_active Abandoned
- 2000-09-11 AU AU71284/00A patent/AU764436B2/en not_active Ceased
- 2000-09-11 PL PL00354179A patent/PL354179A1/xx unknown
- 2000-09-11 BR BR0013943-2A patent/BR0013943A/pt not_active IP Right Cessation
- 2000-09-11 NZ NZ517645A patent/NZ517645A/en unknown
- 2000-09-11 EP EP00960064A patent/EP1212335B1/en not_active Expired - Lifetime
- 2000-09-11 DK DK00960064T patent/DK1212335T3/da active
- 2000-09-11 DE DE60025630T patent/DE60025630T2/de not_active Expired - Lifetime
- 2000-09-11 TW TW089118581A patent/TWI287018B/zh active
- 2000-09-11 ES ES00960064T patent/ES2254215T3/es not_active Expired - Lifetime
- 2000-09-11 CZ CZ20020881A patent/CZ298862B6/cs not_active IP Right Cessation
- 2000-09-11 KR KR1020027003352A patent/KR100653570B1/ko not_active IP Right Cessation
- 2000-09-11 MX MXPA02002654A patent/MXPA02002654A/es active IP Right Grant
- 2000-09-12 AR ARP000104778A patent/AR025638A1/es unknown
-
2002
- 2002-02-20 IL IL148273A patent/IL148273A/en not_active IP Right Cessation
- 2002-03-06 ZA ZA200201876A patent/ZA200201876B/xx unknown
- 2002-03-12 NO NO20021203A patent/NO322250B1/no not_active IP Right Cessation
- 2002-09-02 HK HK02106468.8A patent/HK1044777B/zh not_active IP Right Cessation
-
2006
- 2006-02-08 CY CY20061100176T patent/CY1104970T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |