EA200200147A1 - Фармацевтическая композиция, содержащая фенофибрат, и способ ее получения - Google Patents

Фармацевтическая композиция, содержащая фенофибрат, и способ ее получения

Info

Publication number
EA200200147A1
EA200200147A1 EA200200147A EA200200147A EA200200147A1 EA 200200147 A1 EA200200147 A1 EA 200200147A1 EA 200200147 A EA200200147 A EA 200200147A EA 200200147 A EA200200147 A EA 200200147A EA 200200147 A1 EA200200147 A1 EA 200200147A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical composition
phenophydrate
preparation
composition containing
composition
Prior art date
Application number
EA200200147A
Other languages
English (en)
Other versions
EA004294B1 (ru
Inventor
Брюно Криер
Паскаль Сюпли
Филипп Шеневьер
Original Assignee
Лаборатуар Де Продюи Этик Этифарм
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9547923&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200200147(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Лаборатуар Де Продюи Этик Этифарм filed Critical Лаборатуар Де Продюи Этик Этифарм
Publication of EA200200147A1 publication Critical patent/EA200200147A1/ru
Publication of EA004294B1 publication Critical patent/EA004294B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Настоящее изобретение относится к фармацевтической композиции, содержащей микронизированный фенофибрат, поверхностно-активное вещество и связующее производное целлюлозы, являющееся адъювант солюбилизации, предпочтительно гидроксипропилметилцеллюлозу. Производное целлюлозы составляет менее 20 мас.% по отношению к массе композиции. Ассоциация микронизированного фенофибрата со связующим производным целлюлозы, являющимся адъювантом солюбилизации, и поверхностно-активного вещества позволяет улучшать биодоступность действующего начала. Изобретение относится также к способу получения этой композиции, согласно которому не используют никакого органического растворителя.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200147A 1999-07-09 2000-07-07 Фармацевтическая композиция, содержащая фенофибрат, и способ ее получения EA004294B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9908923A FR2795961B1 (fr) 1999-07-09 1999-07-09 Composition pharmaceutique contenant du fenofibrate micronise, un tensioactif et un derive cellulosique liant et procede de preparation
PCT/FR2000/001971 WO2001003693A1 (fr) 1999-07-09 2000-07-07 Composition pharmaceutique contenant du fenofibrate et procede de preparation

Publications (2)

Publication Number Publication Date
EA200200147A1 true EA200200147A1 (ru) 2002-06-27
EA004294B1 EA004294B1 (ru) 2004-02-26

Family

ID=9547923

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200147A EA004294B1 (ru) 1999-07-09 2000-07-07 Фармацевтическая композиция, содержащая фенофибрат, и способ ее получения

Country Status (37)

Country Link
US (4) US7101574B1 (ru)
EP (3) EP1523983B1 (ru)
JP (2) JP4841092B2 (ru)
KR (3) KR20020025188A (ru)
CN (2) CN1204885C (ru)
AT (3) ATE399006T1 (ru)
AU (1) AU782282B2 (ru)
BG (1) BG65504B1 (ru)
BR (1) BR0012335A (ru)
CA (1) CA2377909C (ru)
CY (1) CY1106206T1 (ru)
CZ (1) CZ300094B6 (ru)
DE (3) DE60039313D1 (ru)
DK (3) DK1194140T3 (ru)
EA (1) EA004294B1 (ru)
EE (1) EE04995B1 (ru)
ES (3) ES2271924T3 (ru)
FR (1) FR2795961B1 (ru)
GE (1) GEP20043287B (ru)
HK (3) HK1044894B (ru)
HR (1) HRP20020111B1 (ru)
HU (1) HU229044B1 (ru)
IL (2) IL147499A0 (ru)
IS (1) IS2157B (ru)
ME (1) ME01361B (ru)
MX (1) MXPA02000324A (ru)
NO (1) NO333301B1 (ru)
NZ (1) NZ516416A (ru)
PL (1) PL212082B1 (ru)
PT (3) PT1194140E (ru)
RS (1) RS50035B (ru)
SI (2) SI1194140T1 (ru)
SK (1) SK287484B6 (ru)
TR (1) TR200200008T2 (ru)
UA (1) UA72925C2 (ru)
WO (1) WO2001003693A1 (ru)
ZA (1) ZA200200169B (ru)

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RU2500398C2 (ru) * 2002-12-17 2013-12-10 Эббетт ГмбХ унд Ко. КГ Композиция, включающая фенофибриновую кислоту или ее физиологически приемлемую соль, и капсула, включающая композицию

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Publication number Priority date Publication date Assignee Title
RU2500398C2 (ru) * 2002-12-17 2013-12-10 Эббетт ГмбХ унд Ко. КГ Композиция, включающая фенофибриновую кислоту или ее физиологически приемлемую соль, и капсула, включающая композицию

Also Published As

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ATE399006T1 (de) 2008-07-15
ES2271924T3 (es) 2007-04-16
BG65504B1 (bg) 2008-10-31
NO333301B1 (no) 2013-04-29
BG106280A (en) 2002-08-30
DE60039313D1 (de) 2008-08-07
EE04995B1 (et) 2008-04-15
IS6218A (is) 2002-01-03
AU782282B2 (en) 2005-07-14
UA72925C2 (ru) 2005-05-16
DK1523983T3 (da) 2008-10-13
US20070071812A1 (en) 2007-03-29
TR200200008T2 (tr) 2002-06-21
IS2157B (is) 2006-11-15
CN1682707B (zh) 2010-05-05
DE60019120T2 (de) 2006-02-09
ATE291912T1 (de) 2005-04-15
KR20020025188A (ko) 2002-04-03
EP1523983B1 (fr) 2008-06-25
FR2795961A1 (fr) 2001-01-12
HUP0202338A2 (en) 2002-10-28
WO2001003693A1 (fr) 2001-01-18
CZ20022A3 (cs) 2002-05-15
FR2795961B1 (fr) 2004-05-28
MXPA02000324A (es) 2002-06-21
IL147499A0 (en) 2002-08-14
DE60031184D1 (de) 2006-11-16
HK1044894B (zh) 2005-06-24
NO20020014L (no) 2002-03-04
SI1194140T1 (en) 2005-06-30
ES2309438T3 (es) 2008-12-16
EP1574214A1 (fr) 2005-09-14
NO20020014D0 (no) 2002-01-02
PT1523983E (pt) 2008-09-19
DE60019120D1 (de) 2005-05-04
YU93201A (sh) 2004-09-03
ME01361B (me) 2008-11-28
ATE341320T1 (de) 2006-10-15
HK1074588A1 (en) 2005-11-18
US20110159082A1 (en) 2011-06-30
EP1194140A1 (fr) 2002-04-10
US8563042B2 (en) 2013-10-22
EE200200011A (et) 2003-02-17
PL212082B1 (pl) 2012-08-31
DE60031184T2 (de) 2007-08-23
JP2011148813A (ja) 2011-08-04
CA2377909A1 (fr) 2001-01-18
HRP20020111A2 (en) 2003-04-30
ES2235919T3 (es) 2005-07-16
KR20070026716A (ko) 2007-03-08
HK1080391A1 (en) 2006-04-28
CN1204885C (zh) 2005-06-08
EP1574214B1 (fr) 2006-10-04
NZ516416A (en) 2003-10-31
PT1194140E (pt) 2005-07-29
CZ300094B6 (cs) 2009-01-28
KR20060073549A (ko) 2006-06-28
KR100766644B1 (ko) 2007-10-15
EP1523983A1 (fr) 2005-04-20
GEP20043287B (en) 2004-07-26
US20080248101A1 (en) 2008-10-09
CA2377909C (fr) 2011-06-28
HRP20020111B1 (en) 2005-12-31
PL352307A1 (en) 2003-08-11
DK1574214T3 (da) 2007-01-22
US7101574B1 (en) 2006-09-05
RS50035B (sr) 2008-11-28
SK152002A3 (en) 2002-07-02
DK1194140T3 (da) 2005-07-04
CY1106206T1 (el) 2011-06-08
CN1360499A (zh) 2002-07-24
SI1574214T1 (sl) 2006-12-31
HUP0202338A3 (en) 2003-03-28
EA004294B1 (ru) 2004-02-26
JP2003504331A (ja) 2003-02-04
US8658212B2 (en) 2014-02-25
ZA200200169B (en) 2002-07-31
HU229044B1 (hu) 2013-07-29
BR0012335A (pt) 2002-03-19
IL147499A (en) 2007-03-08
HK1044894A1 (en) 2002-11-08
SK287484B6 (sk) 2010-11-08
AU6296000A (en) 2001-01-30
PT1574214E (pt) 2007-01-31
CN1682707A (zh) 2005-10-19
JP4841092B2 (ja) 2011-12-21
EP1194140B1 (fr) 2005-03-30

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