EA200100637A1 - Ингибиторы вирусов герпеса на основе тиомочевины - Google Patents
Ингибиторы вирусов герпеса на основе тиомочевиныInfo
- Publication number
- EA200100637A1 EA200100637A1 EA200100637A EA200100637A EA200100637A1 EA 200100637 A1 EA200100637 A1 EA 200100637A1 EA 200100637 A EA200100637 A EA 200100637A EA 200100637 A EA200100637 A EA 200100637A EA 200100637 A1 EA200100637 A1 EA 200100637A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbon atoms
- alkyl
- heteroaryl
- sor
- cor
- Prior art date
Links
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 241001529453 unidentified herpesvirus Species 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 abstract 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 abstract 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 abstract 1
- 241000700584 Simplexvirus Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20854098A | 1998-12-09 | 1998-12-09 | |
| PCT/US1999/028892 WO2000034269A1 (en) | 1998-12-09 | 1999-12-06 | Thiourea inhibitors of herpes viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200100637A1 true EA200100637A1 (ru) | 2001-12-24 |
Family
ID=22774965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100637A EA200100637A1 (ru) | 1998-12-09 | 1999-12-06 | Ингибиторы вирусов герпеса на основе тиомочевины |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1140913A1 (cs) |
| JP (1) | JP2002531558A (cs) |
| KR (1) | KR20010086082A (cs) |
| CN (1) | CN1335843A (cs) |
| AU (1) | AU756043B2 (cs) |
| BG (1) | BG105580A (cs) |
| BR (1) | BR9916042A (cs) |
| CA (1) | CA2351390A1 (cs) |
| CZ (1) | CZ20011958A3 (cs) |
| EA (1) | EA200100637A1 (cs) |
| HU (1) | HUP0104758A3 (cs) |
| ID (1) | ID29064A (cs) |
| IL (1) | IL143203A0 (cs) |
| NO (1) | NO20012836L (cs) |
| PL (1) | PL348177A1 (cs) |
| SK (1) | SK7692001A3 (cs) |
| TR (1) | TR200101598T2 (cs) |
| ZA (1) | ZA200104373B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2251360T3 (es) * | 1999-03-12 | 2006-05-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Compuestos heterociclicos aromaticos en calidad de agentes antiinflamatorios. |
| JP3938651B2 (ja) * | 2000-04-13 | 2007-06-27 | セントラル硝子株式会社 | 光学活性α−メチル−ビス−３、５−（トリフルオロメチル）ベンジルアミンの製造方法 |
| US20060148893A1 (en) * | 2003-06-10 | 2006-07-06 | Blanc Jean-Baptiste E | Chemical compounds |
| EP1928847A4 (en) * | 2005-08-29 | 2011-08-10 | Gerard M Housey | THERAMUTEINE MODULATORS |
| CN108642926B (zh) * | 2018-04-26 | 2023-11-14 | 浙江汉邦新材料股份有限公司 | 一种涤纶染色清洗用的硫脲衍生物及其制备方法 |
| US20220411369A1 (en) * | 2019-11-19 | 2022-12-29 | Takeda Pharmaceutical Company Limited | Method for producing pyrrolidine compound |
-
1999
- 1999-12-06 IL IL14320399A patent/IL143203A0/xx unknown
- 1999-12-06 JP JP2000586716A patent/JP2002531558A/ja active Pending
- 1999-12-06 EA EA200100637A patent/EA200100637A1/ru unknown
- 1999-12-06 BR BR9916042-0A patent/BR9916042A/pt not_active Application Discontinuation
- 1999-12-06 EP EP99965143A patent/EP1140913A1/en not_active Withdrawn
- 1999-12-06 AU AU31122/00A patent/AU756043B2/en not_active Ceased
- 1999-12-06 PL PL99348177A patent/PL348177A1/xx not_active Application Discontinuation
- 1999-12-06 SK SK769-2001A patent/SK7692001A3/sk unknown
- 1999-12-06 KR KR1020017007051A patent/KR20010086082A/ko not_active Withdrawn
- 1999-12-06 ID IDW00200101230A patent/ID29064A/id unknown
- 1999-12-06 TR TR2001/01598T patent/TR200101598T2/xx unknown
- 1999-12-06 CN CN99815807A patent/CN1335843A/zh active Pending
- 1999-12-06 CZ CZ20011958A patent/CZ20011958A3/cs unknown
- 1999-12-06 CA CA002351390A patent/CA2351390A1/en not_active Abandoned
- 1999-12-06 HU HU0104758A patent/HUP0104758A3/hu unknown
-
2001
- 2001-05-28 ZA ZA200104373A patent/ZA200104373B/en unknown
- 2001-06-08 BG BG105580A patent/BG105580A/bg unknown
- 2001-06-08 NO NO20012836A patent/NO20012836L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1335843A (zh) | 2002-02-13 |
| AU3112200A (en) | 2000-06-26 |
| JP2002531558A (ja) | 2002-09-24 |
| SK7692001A3 (en) | 2002-09-10 |
| AU756043B2 (en) | 2003-01-02 |
| HUP0104758A3 (en) | 2002-05-28 |
| BR9916042A (pt) | 2001-12-04 |
| NO20012836L (no) | 2001-08-08 |
| CZ20011958A3 (cs) | 2001-10-17 |
| IL143203A0 (en) | 2002-04-21 |
| ID29064A (id) | 2001-07-26 |
| EP1140913A1 (en) | 2001-10-10 |
| KR20010086082A (ko) | 2001-09-07 |
| BG105580A (bg) | 2002-01-31 |
| NO20012836D0 (no) | 2001-06-08 |
| HUP0104758A2 (hu) | 2002-04-29 |
| ZA200104373B (en) | 2002-09-18 |
| CA2351390A1 (en) | 2000-06-15 |
| PL348177A1 (en) | 2002-05-06 |
| TR200101598T2 (tr) | 2001-10-22 |
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