HUP0104758A2 - Herpeszvírus inhibitor hatású tiokarbamidszármazékok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Herpeszvírus inhibitor hatású tiokarbamidszármazékok és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0104758A2 HUP0104758A2 HU0104758A HUP0104758A HUP0104758A2 HU P0104758 A2 HUP0104758 A2 HU P0104758A2 HU 0104758 A HU0104758 A HU 0104758A HU P0104758 A HUP0104758 A HU P0104758A HU P0104758 A2 HUP0104758 A2 HU P0104758A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- formula
- heteroaryl
- aryl
- Prior art date
Links
- 241001529453 unidentified herpesvirus Species 0.000 title abstract 3
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 title 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyano- Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 abstract 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 abstract 1
- 241000701041 Human betaherpesvirus 7 Species 0.000 abstract 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 abstract 1
- 241000701027 Human herpesvirus 6 Species 0.000 abstract 1
- 241000700584 Simplexvirus Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A tal lm ny (I) ltal nos képletű vegyületekre és gyógy szatilagelfogadható sóikra vonatkozik, ahol R1-R5 jelentése egym stólfüggetlenül hidrogénatom, alkil-, alkenil-, alkinil-,perhalogénalkil-, cikloalkil-, heterocikloalkil-, aril-,heteroarilcsoport, halogénatom, ciano-, nitrocsoport, -CO2R6, -COR6, -OR6, -SR6, -SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7 R8) vagy W-Y-(CH2)n-Z ltal nos képletű csoport, vagy R2 és R3 vagy R3 és R4 együtt3-7 tagú heterocikloalkilcsoportot vagy 3-7 tagú heteroarilcsoportotalkot; R6 és R7 jelentése egym stól függetlenül hidrogénatom, alkil-,perhalogénalkil-, vagy arilcsoport; R8 jelentése hidrogénatom, alkil-,perhalogénalkil-, cikloalkil-, heterocikloalkil-, aril-,heteroarilcsoport, vagy R7 és R8 együtt 3-7 tagúheterocikloalkilcsoportot alkothat; A jelentése heteroarilcsoport; Wjelentése oxigénatom, -NR6 ltal nos képletű csoport, vagy hi nyzik; Yjelentése -(CO)- vagy -(CO2)-, vagy hi nyzik; Z jelentése 1-4szénatomos alkil-, cianocsoport, -CO2R6, -COR6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N(R7R8), -N(R7R8) ltalnos képletű csoport vagy fenilcsoport; G jelentése aril- vagyheteroarilcsoport; X jelentése vegyértékk"tés, -NH-, alkil-, alkenil-,alkoxi-, alkil-tio-, 1-6 szénatomos alkil-amino-csoport vagy (CH)Jltal nos képletű csoport; J jelentése alkil-, cikloalkil-, fenil- vagybenzilcsoport; és n értéke 1-6. A vegyületek g tolj k és/vagy gyógyítjk a herpeszvírusok, péld ul a hum n citomegalovírusok, herpeszszimplex vírusok, Epstein-Barr vírus, varicella-zoster vírus, hum nherpeszvírus-6 és -7 és a Kaposi herpeszvírus ltal okozottbetegségeket. A tal lm ny a vegyületeket tartalmazógyógyszerkészítményekre és a vegyületek alkalmaz s ra is vonatkozik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20854098A | 1998-12-09 | 1998-12-09 | |
PCT/US1999/028892 WO2000034269A1 (en) | 1998-12-09 | 1999-12-06 | Thiourea inhibitors of herpes viruses |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0104758A2 true HUP0104758A2 (hu) | 2002-04-29 |
HUP0104758A3 HUP0104758A3 (en) | 2002-05-28 |
Family
ID=22774965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0104758A HUP0104758A3 (en) | 1998-12-09 | 1999-12-06 | Thiourea inhibitors of herpes viruses and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1140913A1 (hu) |
JP (1) | JP2002531558A (hu) |
KR (1) | KR20010086082A (hu) |
CN (1) | CN1335843A (hu) |
AU (1) | AU756043B2 (hu) |
BG (1) | BG105580A (hu) |
BR (1) | BR9916042A (hu) |
CA (1) | CA2351390A1 (hu) |
CZ (1) | CZ20011958A3 (hu) |
EA (1) | EA200100637A1 (hu) |
HU (1) | HUP0104758A3 (hu) |
ID (1) | ID29064A (hu) |
IL (1) | IL143203A0 (hu) |
NO (1) | NO20012836L (hu) |
PL (1) | PL348177A1 (hu) |
SK (1) | SK7692001A3 (hu) |
TR (1) | TR200101598T2 (hu) |
ZA (1) | ZA200104373B (hu) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60023853T2 (de) * | 1999-03-12 | 2006-05-24 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Aromatische heterozyklische verbindungen als antientzündungwirkstoffe |
JP3938651B2 (ja) * | 2000-04-13 | 2007-06-27 | セントラル硝子株式会社 | 光学活性α−メチル−ビス−3、5−(トリフルオロメチル)ベンジルアミンの製造方法 |
EP1654221A2 (en) * | 2003-06-10 | 2006-05-10 | Smithkline Beecham Corporation | Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators |
KR20080090381A (ko) * | 2005-08-29 | 2008-10-08 | 제라드 엠. 하우지 | 테라뮤틴 조절물질 |
CN108642926B (zh) * | 2018-04-26 | 2023-11-14 | 浙江汉邦新材料股份有限公司 | 一种涤纶染色清洗用的硫脲衍生物及其制备方法 |
JPWO2021100730A1 (hu) * | 2019-11-19 | 2021-05-27 |
-
1999
- 1999-12-06 CZ CZ20011958A patent/CZ20011958A3/cs unknown
- 1999-12-06 PL PL99348177A patent/PL348177A1/xx not_active Application Discontinuation
- 1999-12-06 EA EA200100637A patent/EA200100637A1/ru unknown
- 1999-12-06 HU HU0104758A patent/HUP0104758A3/hu unknown
- 1999-12-06 SK SK769-2001A patent/SK7692001A3/sk unknown
- 1999-12-06 EP EP99965143A patent/EP1140913A1/en not_active Withdrawn
- 1999-12-06 CN CN99815807A patent/CN1335843A/zh active Pending
- 1999-12-06 ID IDW00200101230A patent/ID29064A/id unknown
- 1999-12-06 TR TR2001/01598T patent/TR200101598T2/xx unknown
- 1999-12-06 KR KR1020017007051A patent/KR20010086082A/ko not_active Application Discontinuation
- 1999-12-06 AU AU31122/00A patent/AU756043B2/en not_active Ceased
- 1999-12-06 BR BR9916042-0A patent/BR9916042A/pt not_active Application Discontinuation
- 1999-12-06 IL IL14320399A patent/IL143203A0/xx unknown
- 1999-12-06 JP JP2000586716A patent/JP2002531558A/ja active Pending
- 1999-12-06 CA CA002351390A patent/CA2351390A1/en not_active Abandoned
-
2001
- 2001-05-28 ZA ZA200104373A patent/ZA200104373B/en unknown
- 2001-06-08 NO NO20012836A patent/NO20012836L/no not_active Application Discontinuation
- 2001-06-08 BG BG105580A patent/BG105580A/bg unknown
Also Published As
Publication number | Publication date |
---|---|
NO20012836L (no) | 2001-08-08 |
CZ20011958A3 (cs) | 2001-10-17 |
AU3112200A (en) | 2000-06-26 |
EP1140913A1 (en) | 2001-10-10 |
BR9916042A (pt) | 2001-12-04 |
KR20010086082A (ko) | 2001-09-07 |
AU756043B2 (en) | 2003-01-02 |
ZA200104373B (en) | 2002-09-18 |
TR200101598T2 (tr) | 2001-10-22 |
CN1335843A (zh) | 2002-02-13 |
EA200100637A1 (ru) | 2001-12-24 |
NO20012836D0 (no) | 2001-06-08 |
HUP0104758A3 (en) | 2002-05-28 |
JP2002531558A (ja) | 2002-09-24 |
ID29064A (id) | 2001-07-26 |
SK7692001A3 (en) | 2002-09-10 |
BG105580A (bg) | 2002-01-31 |
PL348177A1 (en) | 2002-05-06 |
CA2351390A1 (en) | 2000-06-15 |
IL143203A0 (en) | 2002-04-21 |
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