HUP0104758A2 - Herpeszvírus inhibitor hatású tiokarbamidszármazékok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Herpeszvírus inhibitor hatású tiokarbamidszármazékok és az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0104758A2
HUP0104758A2 HU0104758A HUP0104758A HUP0104758A2 HU P0104758 A2 HUP0104758 A2 HU P0104758A2 HU 0104758 A HU0104758 A HU 0104758A HU P0104758 A HUP0104758 A HU P0104758A HU P0104758 A2 HUP0104758 A2 HU P0104758A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
formula
heteroaryl
aryl
Prior art date
Application number
HU0104758A
Other languages
English (en)
Inventor
Jonathan David Bloom
Martin Joseph Digrandi
Russell George Dushin
Stanley Albert Lang
Bryan Mark O'hara
Original Assignee
American Home Products Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp. filed Critical American Home Products Corp.
Priority claimed from PCT/US1999/028892 external-priority patent/WO2000034269A1/en
Publication of HUP0104758A2 publication Critical patent/HUP0104758A2/hu
Publication of HUP0104758A3 publication Critical patent/HUP0104758A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A tal lm ny (I) ltal nos képletű vegyületekre és gyógy szatilagelfogadható sóikra vonatkozik, ahol R1-R5 jelentése egym stólfüggetlenül hidrogénatom, alkil-, alkenil-, alkinil-,perhalogénalkil-, cikloalkil-, heterocikloalkil-, aril-,heteroarilcsoport, halogénatom, ciano-, nitrocsoport, -CO2R6, -COR6, -OR6, -SR6, -SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7 R8) vagy W-Y-(CH2)n-Z ltal nos képletű csoport, vagy R2 és R3 vagy R3 és R4 együtt3-7 tagú heterocikloalkilcsoportot vagy 3-7 tagú heteroarilcsoportotalkot; R6 és R7 jelentése egym stól függetlenül hidrogénatom, alkil-,perhalogénalkil-, vagy arilcsoport; R8 jelentése hidrogénatom, alkil-,perhalogénalkil-, cikloalkil-, heterocikloalkil-, aril-,heteroarilcsoport, vagy R7 és R8 együtt 3-7 tagúheterocikloalkilcsoportot alkothat; A jelentése heteroarilcsoport; Wjelentése oxigénatom, -NR6 ltal nos képletű csoport, vagy hi nyzik; Yjelentése -(CO)- vagy -(CO2)-, vagy hi nyzik; Z jelentése 1-4szénatomos alkil-, cianocsoport, -CO2R6, -COR6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N(R7R8), -N(R7R8) ltalnos képletű csoport vagy fenilcsoport; G jelentése aril- vagyheteroarilcsoport; X jelentése vegyértékk"tés, -NH-, alkil-, alkenil-,alkoxi-, alkil-tio-, 1-6 szénatomos alkil-amino-csoport vagy (CH)Jltal nos képletű csoport; J jelentése alkil-, cikloalkil-, fenil- vagybenzilcsoport; és n értéke 1-6. A vegyületek g tolj k és/vagy gyógyítjk a herpeszvírusok, péld ul a hum n citomegalovírusok, herpeszszimplex vírusok, Epstein-Barr vírus, varicella-zoster vírus, hum nherpeszvírus-6 és -7 és a Kaposi herpeszvírus ltal okozottbetegségeket. A tal lm ny a vegyületeket tartalmazógyógyszerkészítményekre és a vegyületek alkalmaz s ra is vonatkozik. Ó
HU0104758A 1998-12-09 1999-12-06 Thiourea inhibitors of herpes viruses and pharmaceutical compositions containing them HUP0104758A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20854098A 1998-12-09 1998-12-09
PCT/US1999/028892 WO2000034269A1 (en) 1998-12-09 1999-12-06 Thiourea inhibitors of herpes viruses

Publications (2)

Publication Number Publication Date
HUP0104758A2 true HUP0104758A2 (hu) 2002-04-29
HUP0104758A3 HUP0104758A3 (en) 2002-05-28

Family

ID=22774965

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104758A HUP0104758A3 (en) 1998-12-09 1999-12-06 Thiourea inhibitors of herpes viruses and pharmaceutical compositions containing them

Country Status (18)

Country Link
EP (1) EP1140913A1 (hu)
JP (1) JP2002531558A (hu)
KR (1) KR20010086082A (hu)
CN (1) CN1335843A (hu)
AU (1) AU756043B2 (hu)
BG (1) BG105580A (hu)
BR (1) BR9916042A (hu)
CA (1) CA2351390A1 (hu)
CZ (1) CZ20011958A3 (hu)
EA (1) EA200100637A1 (hu)
HU (1) HUP0104758A3 (hu)
ID (1) ID29064A (hu)
IL (1) IL143203A0 (hu)
NO (1) NO20012836L (hu)
PL (1) PL348177A1 (hu)
SK (1) SK7692001A3 (hu)
TR (1) TR200101598T2 (hu)
ZA (1) ZA200104373B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60023853T2 (de) * 1999-03-12 2006-05-24 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Aromatische heterozyklische verbindungen als antientzündungwirkstoffe
JP3938651B2 (ja) * 2000-04-13 2007-06-27 セントラル硝子株式会社 光学活性α−メチル−ビス−3、5−(トリフルオロメチル)ベンジルアミンの製造方法
EP1654221A2 (en) * 2003-06-10 2006-05-10 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
KR20080090381A (ko) * 2005-08-29 2008-10-08 제라드 엠. 하우지 테라뮤틴 조절물질
CN108642926B (zh) * 2018-04-26 2023-11-14 浙江汉邦新材料股份有限公司 一种涤纶染色清洗用的硫脲衍生物及其制备方法
JPWO2021100730A1 (hu) * 2019-11-19 2021-05-27

Also Published As

Publication number Publication date
NO20012836L (no) 2001-08-08
CZ20011958A3 (cs) 2001-10-17
AU3112200A (en) 2000-06-26
EP1140913A1 (en) 2001-10-10
BR9916042A (pt) 2001-12-04
KR20010086082A (ko) 2001-09-07
AU756043B2 (en) 2003-01-02
ZA200104373B (en) 2002-09-18
TR200101598T2 (tr) 2001-10-22
CN1335843A (zh) 2002-02-13
EA200100637A1 (ru) 2001-12-24
NO20012836D0 (no) 2001-06-08
HUP0104758A3 (en) 2002-05-28
JP2002531558A (ja) 2002-09-24
ID29064A (id) 2001-07-26
SK7692001A3 (en) 2002-09-10
BG105580A (bg) 2002-01-31
PL348177A1 (en) 2002-05-06
CA2351390A1 (en) 2000-06-15
IL143203A0 (en) 2002-04-21

Similar Documents

Publication Publication Date Title
NO983711L (no) Azabicykliske estere av karbaminsyrer som er nyttige i terapi
HUT72653A (en) N-acyl-sulfamic acid esters (or thioesters), n-acyl-sulfonamides and n-sulfonyl-carbamic-acid-esters (or thioesters) and pharmaceutical compositions of hypercholesterolemic activity containing them
HUP0200804A2 (hu) 4-H-1-benzopirán-4-on-származékokat tartalmazó gyógyászati készítmények alkalmazása simaizomsejt proliferáció gátlására
HUP0001760A2 (hu) Aril-acil-piridazin-származékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és a vegyületek alkalmazása gyógyszerkészítmények előállítására
NO942316L (no) Isatinderivater, fremgangsmåter for deres fremstilling og farmasöytisk preparat omfattende slike derivater
ATE108791T1 (de) Neue 4-oxobenzotriazine und 4-oxochinazoline.
HUP0000426A2 (hu) Új benzonaftiridinek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
ATE25682T1 (de) Indol-3-carboxamid-derivate.
ES8606341A1 (es) Un procedimiento para la preparacion de pirazolo piridinas.
HUP0200232A2 (hu) Fenilén-diamin-csoportot és heterociklikus karboxamid-csoportot hordozó herpeszvírus inhibitor hatású tiokarbamid-származékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
HUP0104763A2 (hu) Herpeszvírus inhibítor hatású tiokarbamidszármazékok
ES2123652T3 (es) 7-(2-aminoetil)-benzotiazolonas.
AU2866297A (en) Neuraminic acid derivatives, their preparation and their medical use
HUP0104758A2 (hu) Herpeszvírus inhibitor hatású tiokarbamidszármazékok és az ezeket tartalmazó gyógyszerkészítmények
HUP0104492A2 (hu) Fenilén-diamin-csoportot és alfa-metil-benzil-csoportot hordozó herpeszvírus inhibítor hatású tiokarbamid származékok
NO905172D0 (no) Aminokarbonylkarbamater beslektet med fysostigmin og fremgangsmaate for fremstilling derav.
HUP0203405A2 (hu) Szubsztituált fenilén-diamin-csoportot és heterociklikus karboxamidcsoportot hordozó herpeszvírus inhibitor hatású tiokarbamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
FI844333L (fi) 11-substituerade 5h,11h-pyrrolo/2,1-c/ /1,4/benzoxazepiner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
HUP0104944A2 (hu) Acetamidot és szubsztituált acetamidot tartalmazó tiokarbamidok, mint herpeszvírus inhibitorok és ezeket tartalmazó gyógyszerkészítmények
ES8706144A1 (es) Un procedimiento para preparar derivados de 1,8-naftiridina
HUP0203478A2 (hu) Új tiazolidin-dion-származékok, mint antidiabéteszes szerek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0104611A2 (hu) Herpeszvírus inhibitor hatású tiokarbamid származékok és ezeket tartalmazó gyógyszerkészítmények
NO941150L (no) Tiadiazinoner
IE812913L (en) Sulphonyl azabicyclo benzamides
KR970009570B1 (en) Intermediates of aminobenzoic acid