ES8606341A1 - Un procedimiento para la preparacion de pirazolo piridinas. - Google Patents

Un procedimiento para la preparacion de pirazolo piridinas.

Info

Publication number
ES8606341A1
ES8606341A1 ES540609A ES540609A ES8606341A1 ES 8606341 A1 ES8606341 A1 ES 8606341A1 ES 540609 A ES540609 A ES 540609A ES 540609 A ES540609 A ES 540609A ES 8606341 A1 ES8606341 A1 ES 8606341A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
alkoxy
pyrazolopyridine derivatives
independently hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540609A
Other languages
English (en)
Other versions
ES540609A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES540609A0 publication Critical patent/ES540609A0/es
Publication of ES8606341A1 publication Critical patent/ES8606341A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PIRAZOLOPIRIDINAS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R2 REPRESENTA HIDROGENO O ALQUILO C1-6; R4 Y R5 REPRESENTAN HIDROGENO O ALQUILO C1-4; Y R1, R3 Y R6 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA R9HNRK2, EN LAS QUE Q ES UN GRUPO SALIENTE, R10 ES HIDROGENO, CARBOXI O CARBOXI PROTEGIDO, RK2 ES R2 O UN GRUPO CONVERTIBLE EN R2, R9 ES CR3R4R5 O UN GRUPO CONVERTIBLE EN ESTE Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); SEGUIDA DE LA TRANSFORMACION DEL GRUPO R10 EN HIDROGENO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A TEMPERATURA ELEVADA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIINFLAMATORIA Y ANTIALERGICA.
ES540609A 1984-02-22 1985-02-21 Un procedimiento para la preparacion de pirazolo piridinas. Expired ES8606341A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848404584A GB8404584D0 (en) 1984-02-22 1984-02-22 Compounds

Publications (2)

Publication Number Publication Date
ES540609A0 ES540609A0 (es) 1986-04-16
ES8606341A1 true ES8606341A1 (es) 1986-04-16

Family

ID=10556988

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540609A Expired ES8606341A1 (es) 1984-02-22 1985-02-21 Un procedimiento para la preparacion de pirazolo piridinas.

Country Status (11)

Country Link
US (1) US4670432A (es)
EP (1) EP0152910B1 (es)
JP (1) JPS60193987A (es)
AU (1) AU581207B2 (es)
CA (1) CA1242714A (es)
DE (1) DE3571437D1 (es)
ES (1) ES8606341A1 (es)
GB (1) GB8404584D0 (es)
GR (1) GR850441B (es)
NZ (1) NZ211166A (es)
ZA (1) ZA851281B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT382377B (de) * 1985-04-27 1987-02-25 Beecham Group Plc Verfahren zur herstellung von neuen 7-substituierten aminopyrazolo(4,3-b)pyridinen
EP0239191A3 (en) * 1986-01-30 1988-07-20 Beecham Group Plc Pyrazolo[4,3-b]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them
GB8609421D0 (en) * 1986-04-17 1986-05-21 Beecham Group Plc Compounds
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
ES2243579T3 (es) * 2000-12-15 2005-12-01 Glaxo Group Ltd Derivados de pirazolopirideno.
DE60112609T2 (de) * 2000-12-15 2006-01-19 Glaxo Group Ltd., Greenford Pyrazolopyridine
ATE274515T1 (de) * 2001-03-08 2004-09-15 Smithkline Beecham Corp Pyrazolopyridinderivate
US20050107400A1 (en) * 2001-03-30 2005-05-19 Boyd Leslie F. Use of pyrazolopyridines as therapeutic compounds
US7034030B2 (en) * 2001-03-30 2006-04-25 Smithkline Beecham Corporation Pyralopyridines, process for their preparation and use as therapeutic compounds
WO2002083672A1 (en) * 2001-04-10 2002-10-24 Smithkline Beecham Corporation Antiviral pyrazolopyridine compounds
DE60204452T2 (de) * 2001-04-27 2005-12-15 Smithkline Beecham Corp. Pyrazolo[1,5a]Pyridinderivate
EP1401836B1 (en) * 2001-06-21 2006-08-23 SmithKline Beecham Corporation Imidazo¬1,2-a|pyridine derivatives for the prophylaxis and treatment of herpes viral infections
JP2005507878A (ja) * 2001-09-07 2005-03-24 スミスクライン ビーチャム コーポレーション ヘルペス感染症を治療するためのピラゾロ−ピリジン類
DE60211539T2 (de) * 2001-10-05 2006-09-21 Smithkline Beecham Corp. Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion
DE60222465T2 (de) * 2001-12-11 2008-06-05 Smithkline Beecham Corp. Pyrazolopyridin-derivate als antiherpesmittel
WO2004033454A1 (en) * 2002-10-03 2004-04-22 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridine derivatives
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7880004B2 (en) 2005-09-15 2011-02-01 Bristol-Myers Squibb Company Met kinase inhibitors
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4048184A (en) * 1976-11-15 1977-09-13 E. R. Squibb & Sons, Inc. 6-Phenyl-2H-pyrazolo[3,4-b]pyridines
DE3464368D1 (de) * 1983-03-09 1987-07-30 Beecham Group Plc Anti-inflammatory pyrazolo pyridines
EP0151962A3 (en) * 1984-01-25 1985-10-02 Beecham Group Plc Pyrazolopyridine derivatives
EP0193329A3 (en) * 1985-02-22 1987-08-19 Beecham Group Plc Pyrazolopyridines, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NZ211166A (en) 1988-01-08
ES540609A0 (es) 1986-04-16
EP0152910B1 (en) 1989-07-12
EP0152910A2 (en) 1985-08-28
EP0152910A3 (en) 1986-07-16
DE3571437D1 (de) 1989-08-17
US4670432A (en) 1987-06-02
CA1242714A (en) 1988-10-04
AU581207B2 (en) 1989-02-16
ZA851281B (en) 1985-11-27
GB8404584D0 (en) 1984-03-28
AU3897285A (en) 1985-08-29
JPS60193987A (ja) 1985-10-02
GR850441B (es) 1985-06-19

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