ES8605517A1 - Un procedimiento para la preparacion de pirazolopiridinas. - Google Patents
Un procedimiento para la preparacion de pirazolopiridinas.Info
- Publication number
- ES8605517A1 ES8605517A1 ES540610A ES540610A ES8605517A1 ES 8605517 A1 ES8605517 A1 ES 8605517A1 ES 540610 A ES540610 A ES 540610A ES 540610 A ES540610 A ES 540610A ES 8605517 A1 ES8605517 A1 ES 8605517A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- hydroxy
- cor5
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE PIRAZOLOPIRIDINAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (IX) CON UN COMPUESTO DE FORMULA (X), EN DISOLVENTE INERTE, COMO TOLUENO, ETANOL, DIOXANO O AGUA, A TEMPERATURAS ELEVADAS, PARA OBTENER UN COMPUESTO DE FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE, POR ADICION DEL ACIDO CORRESPONDIENTE. SIENDO: Q, GRUPO SALIENTE; R1, COR5, O GRUPO ESTER O AMIDO FARMACEUTICAMENTE ACEPTABLE; R2, H, ALQUILO DE C 1 A 6 Y OTROS; R3, ALQUILO DE C 1 A 10, ALCOXI DE C 1 A 4 Y OTROS; R4, H, ALQUILO DE C 1 A 4; R5, HIDROXI; R1, R1 O GRUPO CONVERTIBLE EN R1; R2, R2 O GRUPO CONVERTIBLE EN R2; R3, R3 O GRUPO O ATOMO CONVERTIBLE EN R3; X, NR; R, H, OXIGENO Y OTROS; Y X2, NR, OXIGENO O AZUFRE. SE UTILIZAN COMO ANTIINFLAMATORIOS DE USO TOPICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848404586A GB8404586D0 (en) | 1984-02-22 | 1984-02-22 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES540610A0 ES540610A0 (es) | 1986-03-16 |
ES8605517A1 true ES8605517A1 (es) | 1986-03-16 |
Family
ID=10556990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES540610A Expired ES8605517A1 (es) | 1984-02-22 | 1985-02-21 | Un procedimiento para la preparacion de pirazolopiridinas. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4621089A (es) |
EP (1) | EP0154220A3 (es) |
JP (1) | JPS60214787A (es) |
AU (1) | AU3897385A (es) |
ES (1) | ES8605517A1 (es) |
GB (1) | GB8404586D0 (es) |
GR (1) | GR850440B (es) |
ZA (1) | ZA851279B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0193329A3 (en) * | 1985-02-22 | 1987-08-19 | Beecham Group Plc | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them |
AT382377B (de) * | 1985-04-27 | 1987-02-25 | Beecham Group Plc | Verfahren zur herstellung von neuen 7-substituierten aminopyrazolo(4,3-b)pyridinen |
EP0239191A3 (en) * | 1986-01-30 | 1988-07-20 | Beecham Group Plc | Pyrazolo[4,3-b]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them |
GB8609421D0 (en) * | 1986-04-17 | 1986-05-21 | Beecham Group Plc | Compounds |
PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
ES2243579T3 (es) * | 2000-12-15 | 2005-12-01 | Glaxo Group Ltd | Derivados de pirazolopirideno. |
DE60112609T2 (de) * | 2000-12-15 | 2006-01-19 | Glaxo Group Ltd., Greenford | Pyrazolopyridine |
ATE274515T1 (de) * | 2001-03-08 | 2004-09-15 | Smithkline Beecham Corp | Pyrazolopyridinderivate |
US20050107400A1 (en) * | 2001-03-30 | 2005-05-19 | Boyd Leslie F. | Use of pyrazolopyridines as therapeutic compounds |
US7034030B2 (en) * | 2001-03-30 | 2006-04-25 | Smithkline Beecham Corporation | Pyralopyridines, process for their preparation and use as therapeutic compounds |
WO2002083672A1 (en) * | 2001-04-10 | 2002-10-24 | Smithkline Beecham Corporation | Antiviral pyrazolopyridine compounds |
DE60204452T2 (de) * | 2001-04-27 | 2005-12-15 | Smithkline Beecham Corp. | Pyrazolo[1,5a]Pyridinderivate |
EP1401836B1 (en) * | 2001-06-21 | 2006-08-23 | SmithKline Beecham Corporation | Imidazo¬1,2-a|pyridine derivatives for the prophylaxis and treatment of herpes viral infections |
JP2005507878A (ja) * | 2001-09-07 | 2005-03-24 | スミスクライン ビーチャム コーポレーション | ヘルペス感染症を治療するためのピラゾロ−ピリジン類 |
DE60211539T2 (de) * | 2001-10-05 | 2006-09-21 | Smithkline Beecham Corp. | Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion |
DE60222465T2 (de) * | 2001-12-11 | 2008-06-05 | Smithkline Beecham Corp. | Pyrazolopyridin-derivate als antiherpesmittel |
WO2004033454A1 (en) * | 2002-10-03 | 2004-04-22 | Smithkline Beecham Corporation | Therapeutic compounds based on pyrazolopyridine derivatives |
BRPI0910175A2 (pt) * | 2008-07-01 | 2017-03-21 | Genentech Inc | composto de fórmula i e ii, composição farmacêutica, método de inibição do crescimento de células anormais ou de tratamento de um distúrbio hiperproliferativo em um mamífero e método de tratamento de uma doença inflamatória em um mamífero |
MX2010014565A (es) * | 2008-07-01 | 2011-03-04 | Genentech Inc | Isoindolona y metodos de uso. |
WO2011056895A1 (en) * | 2009-11-03 | 2011-05-12 | University Of Notre Dame Du Lac | Ionic liquids comprising heteraromatic anions |
WO2015048765A1 (en) | 2013-09-30 | 2015-04-02 | University Of Notre Dame Du Lac | Compounds, complexes, compositions, methods and systems for heating and cooling |
US10086331B2 (en) | 2013-11-05 | 2018-10-02 | University Of Notre Dame Du Lac | Carbon dioxide capture using phase change ionic liquids |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5814436B2 (ja) * | 1975-12-22 | 1983-03-18 | タイホウヤクヒンコウギヨウ カブシキガイシヤ | ピラゾロピリジンユウドウタイノセイゾウホウ |
-
1984
- 1984-02-22 GB GB848404586A patent/GB8404586D0/en active Pending
-
1985
- 1985-02-13 EP EP85101565A patent/EP0154220A3/en not_active Ceased
- 1985-02-20 ZA ZA851279A patent/ZA851279B/xx unknown
- 1985-02-20 AU AU38973/85A patent/AU3897385A/en not_active Abandoned
- 1985-02-20 GR GR850440A patent/GR850440B/el unknown
- 1985-02-21 ES ES540610A patent/ES8605517A1/es not_active Expired
- 1985-02-21 JP JP60031700A patent/JPS60214787A/ja active Pending
- 1985-02-22 US US06/704,621 patent/US4621089A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB8404586D0 (en) | 1984-03-28 |
JPS60214787A (ja) | 1985-10-28 |
ZA851279B (en) | 1986-05-28 |
EP0154220A3 (en) | 1986-07-16 |
EP0154220A2 (en) | 1985-09-11 |
AU3897385A (en) | 1985-08-29 |
US4621089A (en) | 1986-11-04 |
ES540610A0 (es) | 1986-03-16 |
GR850440B (es) | 1985-06-19 |
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