ES8605517A1 - Un procedimiento para la preparacion de pirazolopiridinas. - Google Patents

Un procedimiento para la preparacion de pirazolopiridinas.

Info

Publication number
ES8605517A1
ES8605517A1 ES540610A ES540610A ES8605517A1 ES 8605517 A1 ES8605517 A1 ES 8605517A1 ES 540610 A ES540610 A ES 540610A ES 540610 A ES540610 A ES 540610A ES 8605517 A1 ES8605517 A1 ES 8605517A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
alkoxy
hydroxy
cor5
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540610A
Other languages
English (en)
Other versions
ES540610A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8605517A1 publication Critical patent/ES8605517A1/es
Publication of ES540610A0 publication Critical patent/ES540610A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PIRAZOLOPIRIDINAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (IX) CON UN COMPUESTO DE FORMULA (X), EN DISOLVENTE INERTE, COMO TOLUENO, ETANOL, DIOXANO O AGUA, A TEMPERATURAS ELEVADAS, PARA OBTENER UN COMPUESTO DE FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE, POR ADICION DEL ACIDO CORRESPONDIENTE. SIENDO: Q, GRUPO SALIENTE; R1, COR5, O GRUPO ESTER O AMIDO FARMACEUTICAMENTE ACEPTABLE; R2, H, ALQUILO DE C 1 A 6 Y OTROS; R3, ALQUILO DE C 1 A 10, ALCOXI DE C 1 A 4 Y OTROS; R4, H, ALQUILO DE C 1 A 4; R5, HIDROXI; R1, R1 O GRUPO CONVERTIBLE EN R1; R2, R2 O GRUPO CONVERTIBLE EN R2; R3, R3 O GRUPO O ATOMO CONVERTIBLE EN R3; X, NR; R, H, OXIGENO Y OTROS; Y X2, NR, OXIGENO O AZUFRE. SE UTILIZAN COMO ANTIINFLAMATORIOS DE USO TOPICO.
ES540610A 1984-02-22 1985-02-21 Un procedimiento para la preparacion de pirazolopiridinas. Expired ES8605517A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848404586A GB8404586D0 (en) 1984-02-22 1984-02-22 Compounds

Publications (2)

Publication Number Publication Date
ES8605517A1 true ES8605517A1 (es) 1986-03-16
ES540610A0 ES540610A0 (es) 1986-03-16

Family

ID=10556990

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540610A Expired ES8605517A1 (es) 1984-02-22 1985-02-21 Un procedimiento para la preparacion de pirazolopiridinas.

Country Status (8)

Country Link
US (1) US4621089A (es)
EP (1) EP0154220A3 (es)
JP (1) JPS60214787A (es)
AU (1) AU3897385A (es)
ES (1) ES8605517A1 (es)
GB (1) GB8404586D0 (es)
GR (1) GR850440B (es)
ZA (1) ZA851279B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0193329A3 (en) * 1985-02-22 1987-08-19 Beecham Group Plc Pyrazolopyridines, their preparation and pharmaceutical compositions containing them
AT382377B (de) * 1985-04-27 1987-02-25 Beecham Group Plc Verfahren zur herstellung von neuen 7-substituierten aminopyrazolo(4,3-b)pyridinen
EP0239191A3 (en) * 1986-01-30 1988-07-20 Beecham Group Plc Pyrazolo[4,3-b]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them
GB8609421D0 (en) * 1986-04-17 1986-05-21 Beecham Group Plc Compounds
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
ATE301653T1 (de) 2000-12-15 2005-08-15 Glaxo Group Ltd Pyrazolopyridine
ES2243579T3 (es) * 2000-12-15 2005-12-01 Glaxo Group Ltd Derivados de pirazolopirideno.
WO2002072581A2 (en) * 2001-03-08 2002-09-19 Smithkline Beecham Corporation Pyrazolopyriadine derivatives
US20050107400A1 (en) * 2001-03-30 2005-05-19 Boyd Leslie F. Use of pyrazolopyridines as therapeutic compounds
JP4237497B2 (ja) 2001-03-30 2009-03-11 スミスクライン ビーチャム コーポレーション ピラゾロピリジン類、その調製方法及びその治療用化合物としての使用
US7141569B2 (en) * 2001-04-10 2006-11-28 Smithkline Beecham Corporation Antiviral pyrazolopyridine compounds
JP2004527560A (ja) * 2001-04-27 2004-09-09 スミスクライン ビーチャム コーポレーション ピラゾロ［１，５−α］ピリジン誘導体
BR0210464A (pt) * 2001-06-21 2004-07-20 Smithkline Beecham Corp Composto, composição farmacêutica, processo para preparar um composto, e, uso de um composto
JP2005507878A (ja) * 2001-09-07 2005-03-24 スミスクライン ビーチャム コーポレーション ヘルペス感染症を治療するためのピラゾロ−ピリジン類
EP1432712B1 (en) * 2001-10-05 2006-05-17 SmithKline Beecham Corporation Imidazo-pyridine derivatives for use in the treatment of herpes viral infection
ES2292839T3 (es) * 2001-12-11 2008-03-16 Smithkline Beecham Corporation Derivados de pirazolo-piridina como agentes contra el herpes.
AU2003275266A1 (en) * 2002-10-03 2004-05-04 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridine derivatives
US8492427B2 (en) * 2008-07-01 2013-07-23 Genentech, Inc. Isoindolones derivatives as MEK kinase inhibitors and methods of use
RU2509078C2 (ru) * 2008-07-01 2014-03-10 Дженентек, Инк. Бициклические гетероциклы в качестве ингибиторов киназы мек
WO2011056895A1 (en) * 2009-11-03 2011-05-12 University Of Notre Dame Du Lac Ionic liquids comprising heteraromatic anions
US10385251B2 (en) 2013-09-30 2019-08-20 University Of Notre Dame Du Lac Compounds, complexes, compositions, methods and systems for heating and cooling
US10086331B2 (en) 2013-11-05 2018-10-02 University Of Notre Dame Du Lac Carbon dioxide capture using phase change ionic liquids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5814436B2 (ja) * 1975-12-22 1983-03-18 タイホウヤクヒンコウギヨウ カブシキガイシヤ ピラゾロピリジンユウドウタイノセイゾウホウ

Also Published As

Publication number Publication date
ES540610A0 (es) 1986-03-16
GB8404586D0 (en) 1984-03-28
ZA851279B (en) 1986-05-28
JPS60214787A (ja) 1985-10-28
US4621089A (en) 1986-11-04
EP0154220A3 (en) 1986-07-16
GR850440B (es) 1985-06-19
EP0154220A2 (en) 1985-09-11
AU3897385A (en) 1985-08-29

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