EA200000249A1 - ПИРАЗОЛО[3,4-d]ПИРИМИДИНЫ С ПРОТИВОКОНВУЛЬСИВНЫМ, ПРОТИВОАЛЛЕРГИЧЕСКИМ/ПРОТИВОАСТМАТИЧЕСКИМ ДЕЙСТВИЕМ - Google Patents

ПИРАЗОЛО[3,4-d]ПИРИМИДИНЫ С ПРОТИВОКОНВУЛЬСИВНЫМ, ПРОТИВОАЛЛЕРГИЧЕСКИМ/ПРОТИВОАСТМАТИЧЕСКИМ ДЕЙСТВИЕМ

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Publication number
EA200000249A1
EA200000249A1 EA200000249A EA200000249A EA200000249A1 EA 200000249 A1 EA200000249 A1 EA 200000249A1 EA 200000249 A EA200000249 A EA 200000249A EA 200000249 A EA200000249 A EA 200000249A EA 200000249 A1 EA200000249 A1 EA 200000249A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazolo
pyrimidine
allergic
convulsant
asthma action
Prior art date
Application number
EA200000249A
Other languages
English (en)
Other versions
EA002768B1 (ru
Inventor
Томас Арнольд
Ханс-Йоахим Ланкау
Манфред Менцер
Ангелика Росток
Кристине Тобер
Клаус Унферферт
Original Assignee
Арцнаймиттельверк Дрезден Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Арцнаймиттельверк Дрезден Гмбх filed Critical Арцнаймиттельверк Дрезден Гмбх
Publication of EA200000249A1 publication Critical patent/EA200000249A1/ru
Publication of EA002768B1 publication Critical patent/EA002768B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к пиразоло[3,4-d]пиримидин-4(5H)-онам и пиразоло[3,4-d]пиримидин-4(5H)-тионам и их таутомерам, которые в положении 2 имеют бензильный остаток, способу их получения и их применению в качестве лекарственных средств, в частности, для лечения различных форм эпилепсии, а также аллергических/астматических заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000249A 1998-06-22 1999-06-04 ПИРАЗОЛО [3,4-d] ПИРИМИДИНЫ С ПРОТИВОКОНВУЛЬСИВНЫМ, ПРОТИВОАЛЛЕРГИЧЕСКИМ/ПРОТИВОАСТМАТИЧЕСКИМ ДЕЙСТВИЕМ EA002768B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19827679A DE19827679A1 (de) 1998-06-22 1998-06-22 Adenosinrezeptoraffine, antikonvulsiv und antiallergisch/antiasthmatisch wirkende Pyrazolo[3,4-d]pyrimidine und Verfahren zu deren Herstellung
CZ2000594A CZ288195B6 (en) 1998-06-22 1999-06-04 Derivative of pyrazolo[3,4-d]pyrimidines exhibiting anticonvulsive a antiallergic/anti-asthmatic activity, process of its preparation and use
PCT/EP1999/003863 WO1999067243A1 (de) 1998-06-22 1999-06-04 Antikonvulsiv und antiallergisch/antiasthmatisch wirkende pyrazolo(3,4-d)pyrimidine
CA002297706A CA2297706A1 (en) 1998-06-22 2000-02-02 Anticonvulsive and antiallergic/anti-asthmatic pyrazolo-(3,4-d)pyrimidines having affinity for the adenosine receptor, and process for their preparation

Publications (2)

Publication Number Publication Date
EA200000249A1 true EA200000249A1 (ru) 2000-08-28
EA002768B1 EA002768B1 (ru) 2002-08-29

Family

ID=27171156

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000249A EA002768B1 (ru) 1998-06-22 1999-06-04 ПИРАЗОЛО [3,4-d] ПИРИМИДИНЫ С ПРОТИВОКОНВУЛЬСИВНЫМ, ПРОТИВОАЛЛЕРГИЧЕСКИМ/ПРОТИВОАСТМАТИЧЕСКИМ ДЕЙСТВИЕМ

Country Status (26)

Country Link
US (1) US6054460A (ru)
EP (1) EP1005471B1 (ru)
JP (1) JP2002518499A (ru)
CN (1) CN1126753C (ru)
AT (1) ATE223412T1 (ru)
AU (1) AU748090B2 (ru)
BG (1) BG104150A (ru)
BR (1) BR9906552A (ru)
CA (2) CA2301107A1 (ru)
CZ (1) CZ288195B6 (ru)
DE (2) DE19827679A1 (ru)
DK (1) DK1005471T3 (ru)
EA (1) EA002768B1 (ru)
ES (1) ES2182541T3 (ru)
HU (1) HUP0003783A3 (ru)
IL (1) IL134439A0 (ru)
NO (1) NO314760B1 (ru)
NZ (1) NZ502880A (ru)
PL (1) PL338897A1 (ru)
PT (1) PT1005471E (ru)
RU (1) RU2194050C2 (ru)
SK (1) SK283506B6 (ru)
TR (1) TR200000473T1 (ru)
TW (1) TW449476B (ru)
WO (1) WO1999067243A1 (ru)
ZA (1) ZA200000742B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10042092A1 (de) * 2000-08-26 2002-03-07 Dresden Arzneimittel Antikonvulsiv wirkende 2,5-Dihydro-pyrazolo(3,4-d)pyrimidin-4-one und Verfahren zu deren Darstellung
WO2012125400A1 (en) * 2011-03-14 2012-09-20 Acorn Biomedical, Inc. Compositions and methods using adenosine a3 receptor antagonists for the treatment of inflammatory eye diseases
CN106749271B (zh) * 2016-12-07 2019-04-05 青岛科技大学 一类[1,2,4]-三氮唑并[1,5-a]嘧啶酮类杂环化合物、其制备方法及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000192A1 (en) * 1986-06-26 1988-01-14 Warner-Lambert Company 5-SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDIN-7-ONES
DE19649460A1 (de) * 1996-11-26 1998-05-28 Bayer Ag Neue substituierte Pyrazolderivate

Also Published As

Publication number Publication date
BR9906552A (pt) 2000-08-15
TR200000473T1 (tr) 2000-09-21
EP1005471B1 (de) 2002-09-04
DE19827679A1 (de) 1999-12-23
RU2194050C2 (ru) 2002-12-10
JP2002518499A (ja) 2002-06-25
ZA200000742B (en) 2000-10-27
IL134439A0 (en) 2001-04-30
AU4605499A (en) 2000-01-10
CN1126753C (zh) 2003-11-05
SK283506B6 (sk) 2003-08-05
DK1005471T3 (da) 2002-10-14
EA002768B1 (ru) 2002-08-29
AU748090B2 (en) 2002-05-30
NO20000748L (no) 2000-04-07
WO1999067243A1 (de) 1999-12-29
CN1275128A (zh) 2000-11-29
NO314760B1 (no) 2003-05-19
CA2301107A1 (en) 1999-12-29
TW449476B (en) 2001-08-11
US6054460A (en) 2000-04-25
ATE223412T1 (de) 2002-09-15
PT1005471E (pt) 2003-01-31
DE59902538D1 (de) 2002-10-10
NO20000748D0 (no) 2000-02-15
EP1005471A1 (de) 2000-06-07
BG104150A (en) 2000-12-29
CA2297706A1 (en) 2001-08-02
CZ288195B6 (en) 2001-05-16
CZ2000594A3 (cs) 2000-10-11
SK2252000A3 (en) 2000-08-14
ES2182541T3 (es) 2003-03-01
NZ502880A (en) 2001-12-21
HUP0003783A2 (hu) 2001-04-28
PL338897A1 (en) 2000-11-20
HUP0003783A3 (en) 2001-08-28

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU