EA199900835A1 - Стабильная частица в жидких композициях - Google Patents

Стабильная частица в жидких композициях

Info

Publication number
EA199900835A1
EA199900835A1 EA199900835A EA199900835A EA199900835A1 EA 199900835 A1 EA199900835 A1 EA 199900835A1 EA 199900835 A EA199900835 A EA 199900835A EA 199900835 A EA199900835 A EA 199900835A EA 199900835 A1 EA199900835 A1 EA 199900835A1
Authority
EA
Eurasian Patent Office
Prior art keywords
microparticles
sugar glass
stable particle
liquid compositions
mannitol
Prior art date
Application number
EA199900835A
Other languages
English (en)
Other versions
EA001873B1 (ru
Inventor
Джаап Кампинга
Original Assignee
Квадрант Холдингс Кембридж Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10809442&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199900835(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Квадрант Холдингс Кембридж Лимитед filed Critical Квадрант Холдингс Кембридж Лимитед
Publication of EA199900835A1 publication Critical patent/EA199900835A1/ru
Publication of EA001873B1 publication Critical patent/EA001873B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Стабильная частица в жидкой композиции, включающей дисперсные фазы микрочастиц, суспендируется в однородной фазе, которая представляет собой неводную жидкость, предпочтительно биосовместимую, в которой микрочастицы не растворяются. Микрочастицы содержат тонкоизмельченное сахарное "стекло" <1>, удерживающее, по крайней мере, один биомолекулярный продукт, биомолекулярный продукт в сахарном "стекле" либо находится в стабильном твердом растворе, либо сам по себе в суспензии в сахарном "стекле". Монодисперсная, состоящая из одного типа частиц суспензия микрочастиц может быть получена в неводной однородной жидкой фазе посредством включения в однородную фазу, по крайней мере, одного поверхностно-активного вещества, имеющего низкий или очень низкий гидрофильный липофильный баланс.Отчет о международном поиске был опубликован 1998.12.10.
EA199900835A 1997-03-18 1998-03-18 Стабильная частица в жидких композициях EA001873B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9705588.3A GB9705588D0 (en) 1997-03-18 1997-03-18 Stable particle in liquid formulations
PCT/GB1998/000817 WO1998041188A2 (en) 1997-03-18 1998-03-18 Stable particle in liquid formulations

Publications (2)

Publication Number Publication Date
EA199900835A1 true EA199900835A1 (ru) 2000-04-24
EA001873B1 EA001873B1 (ru) 2001-10-22

Family

ID=10809442

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900835A EA001873B1 (ru) 1997-03-18 1998-03-18 Стабильная частица в жидких композициях

Country Status (14)

Country Link
US (1) US6669963B1 (ru)
EP (1) EP1007000B1 (ru)
JP (1) JP2002504090A (ru)
CN (1) CN1256626A (ru)
AT (1) ATE325605T1 (ru)
AU (1) AU722627B2 (ru)
BR (1) BR9808920A (ru)
CA (1) CA2293682C (ru)
DE (1) DE69834495T2 (ru)
EA (1) EA001873B1 (ru)
GB (1) GB9705588D0 (ru)
NO (1) NO994508L (ru)
NZ (1) NZ337666A (ru)
WO (1) WO1998041188A2 (ru)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10508744A (ja) 1994-09-22 1998-09-02 クオドラント ホールディングス ケンブリッジ リミテッド 運動競技の間の水分補給および栄養摂取の用途のための組成物ならびにその製造法
US6946117B1 (en) * 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
EP1071465A1 (en) * 1998-03-18 2001-01-31 Ronai, Peter Amorphous glasses for stabilising sensitive products
US6190701B1 (en) 1999-03-17 2001-02-20 Peter M. Ronai Composition and method for stable injectable liquids
US6102896A (en) * 1999-09-08 2000-08-15 Cambridge Biostability Limited Disposable injector device
DE19943491B4 (de) * 1999-09-10 2010-04-01 Südzucker AG Mannheim/Ochsenfurt Verbesserte Komprimate
WO2001037804A2 (en) * 1999-11-22 2001-05-31 Universal Preservation Technologies, Inc. Preservation and formulation of bioactive materials
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US6653062B1 (en) 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
GB0024271D0 (en) * 2000-09-25 2000-11-15 Colaco Camilo Improved methods and compositions for pulmonary delivery of actives
DE60043459D1 (de) * 2000-10-13 2010-01-14 Cambridge Biostability Ltd Pharmazeutische flüssige Suspensionen
JP2004513093A (ja) * 2000-10-13 2004-04-30 ケンブリッジ、バイオスタビリティー、リミテッド 安定注射液用の組成物および方法
WO2002032398A2 (en) * 2000-10-16 2002-04-25 Massachusetts Institute Of Technology Lipid-protein-sugar particles for drug delivery
US7153472B1 (en) 2000-11-22 2006-12-26 Quadrant Drug Delivery Limited Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers
US6623762B2 (en) 2001-02-16 2003-09-23 Cambridge Biostability Ltd. Composition and method for controlled release injections
FR2825276B1 (fr) * 2001-05-31 2004-11-26 Seppic Sa Adujvant d'immunite sous forme solide et vaccin le contenant
WO2003004633A1 (fr) * 2001-07-02 2003-01-16 Asahi Kasei Kabushiki Kaisha Procede de stabilisation de la phosphatase alcaline
BRPI0211842B1 (pt) * 2001-08-10 2018-04-03 Hayashibara Co., Ltd. Associado cristalino compreendendo trealose e cloreto de cálcio e composição que o compreende
GB2379390B (en) 2001-09-11 2005-01-26 Caretek Medical Ltd A novel drug delivery technology
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US7943179B2 (en) 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
MXPA06004489A (es) * 2003-10-23 2006-06-20 Otsuka Pharma Co Ltd Formulacion y metodo de aripiprazol inyectable esteril de liberacion controlada.
FR2873386B1 (fr) 2004-07-22 2011-01-14 Agence Francaise De Securite Sanitaire Des Aliments Afssa Composition vaccinale contre le rhodococcus equi
US20060045891A1 (en) * 2004-08-24 2006-03-02 Lovalenti Phillip M Density-matched suspension vehicles and pharmaceutical suspensions
US20060142630A1 (en) * 2004-12-29 2006-06-29 Attila Meretei Systems and methods for treating a thrombus in a blood vessel
US7515971B1 (en) * 2005-09-09 2009-04-07 Pacesetter, Inc. Left atrial pressure sensor lead
GB2430880A (en) * 2005-10-04 2007-04-11 Cambridge Biostability Ltd Pharmaceutical compositions stabilized in glassy particles
GB0523638D0 (en) * 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
US8946200B2 (en) 2006-11-02 2015-02-03 Southwest Research Institute Pharmaceutically active nanosuspensions
DE102006056790B3 (de) * 2006-12-01 2008-01-17 IfP Privates Institut für Produktqualität GmbH Laboreinmalartikel für Analyse und Diagnosik
EP1930396B1 (de) * 2006-12-04 2011-07-06 Merck Patent GmbH Furochromanderivate
WO2008092084A2 (en) 2007-01-26 2008-07-31 Centocor, Inc. Injectable non-aqueous suspension with high concentration of therapeutic agent
TWI410255B (zh) * 2007-07-31 2013-10-01 Otsuka Pharma Co Ltd 阿立哌唑（Ａｒｉｐｉｐｒａｚｏｌｅ）懸浮液及冷凍乾燥調配物之製法
RU2010139478A (ru) * 2008-02-25 2012-05-20 Новавакс, Инк. (Us) Соединенные с сахарным стеклом вирусоподобные частицы (vlp)
US8404850B2 (en) 2008-03-13 2013-03-26 Southwest Research Institute Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors
US8722706B2 (en) 2008-08-15 2014-05-13 Southwest Research Institute Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts
US8309134B2 (en) 2008-10-03 2012-11-13 Southwest Research Institute Modified calcium phosphate nanoparticle formation
WO2011007327A2 (en) * 2009-07-16 2011-01-20 Koninklijke Philips Electronics N.V. Suspension for therapeutic use and device for delivering said suspension
US8293299B2 (en) 2009-09-11 2012-10-23 Kraft Foods Global Brands Llc Containers and methods for dispensing multiple doses of a concentrated liquid, and shelf stable Concentrated liquids
CN102115737B (zh) * 2009-12-31 2015-06-03 深圳迈瑞生物医疗电子股份有限公司 稳定碱性磷酸酶或其标记物的试剂和方法
US9028873B2 (en) 2010-02-08 2015-05-12 Southwest Research Institute Nanoparticles for drug delivery to the central nervous system
CN102269762B (zh) 2010-06-04 2014-12-10 深圳迈瑞生物医疗电子股份有限公司 结合物的制备方法及相关试剂盒
CN102269761A (zh) 2010-06-04 2011-12-07 深圳迈瑞生物医疗电子股份有限公司 一种碱性磷酸酶结合物的合成工艺
US8512679B2 (en) 2011-03-04 2013-08-20 Elwha Llc Glassy compositions
EP2753185B1 (en) 2011-09-09 2018-08-01 Kraft Foods Group Brands LLC Shelf stable, brewed beverage concentrates and methods of making the same
WO2013063284A1 (en) 2011-10-25 2013-05-02 Onclave Therapeutics Antibody formulations and methods
US11013248B2 (en) 2012-05-25 2021-05-25 Kraft Foods Group Brands Llc Shelf stable, concentrated, liquid flavorings and methods of preparing beverages with the concentrated liquid flavorings
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
NZ728172A (en) 2014-07-03 2023-06-30 Kraft Foods Group Brands Llc Low water coffee and tea beverage concentrates and methods for making the same
CN111558046A (zh) * 2020-05-27 2020-08-21 华润昂德生物药业有限公司 海藻糖在制备重组人促红素液体制剂中的应用及重组人促红素液体制剂、制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031255A (en) * 1975-07-03 1977-06-21 General Foods Corporation Fixing acetaldehyde in sucrose
US3970765A (en) * 1975-07-03 1976-07-20 General Foods Corporation Method for producing sucrose fixed volatile flavors
GB1490814A (en) * 1975-07-22 1977-11-02 Cadbury Ltd Heat-resistant chocolate product and method of manufacturing same
JPS562908A (en) * 1979-06-20 1981-01-13 Nikken Kagaku Kk Preparation of stable live bacterial pharmaceutical remedy
EP0140255B1 (en) * 1983-10-14 1991-05-15 Sumitomo Pharmaceuticals Company, Limited Sustained-release injections
WO1989003671A1 (en) * 1987-10-29 1989-05-05 Dainippon Pharmaceutical Co., Ltd. Sustained-release preparation
US5250429A (en) * 1991-09-20 1993-10-05 Pharmacia P-L Biochemicals Inc. Glassified restriction enzymes
US5424289A (en) * 1993-07-30 1995-06-13 Alza Corporation Solid formulations of therapeutic proteins for gastrointestinal delivery
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
EP1138319A3 (en) * 1994-08-04 2003-03-19 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US5593824A (en) * 1994-09-02 1997-01-14 Pharmacia Biotech, Inc. Biological reagent spheres
GB9508691D0 (en) * 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
EP0831790B1 (en) 1995-06-07 2003-05-07 Elan Drug Delivery Limited Methods for stably incorporating substances within dry, foamed glass matrices and compositions obtained thereby
US5958455A (en) 1996-02-09 1999-09-28 Quadrant Holdings Cambridge Ltd Oral solid dosage forms, methods of making same and compositions thereof
US5762961A (en) 1996-02-09 1998-06-09 Quadrant Holdings Cambridge Ltd. Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
US5766520A (en) 1996-07-15 1998-06-16 Universal Preservation Technologies, Inc. Preservation by foam formation

Also Published As

Publication number Publication date
NZ337666A (en) 2001-04-27
CN1256626A (zh) 2000-06-14
WO1998041188A2 (en) 1998-09-24
ATE325605T1 (de) 2006-06-15
CA2293682C (en) 2007-01-16
WO1998041188A3 (en) 1998-12-10
DE69834495D1 (de) 2006-06-14
GB9705588D0 (en) 1997-05-07
BR9808920A (pt) 2000-08-01
JP2002504090A (ja) 2002-02-05
EP1007000B1 (en) 2006-05-10
NO994508L (no) 1999-11-17
EP1007000A2 (en) 2000-06-14
CA2293682A1 (en) 1998-09-24
DE69834495T2 (de) 2006-09-07
US6669963B1 (en) 2003-12-30
EA001873B1 (ru) 2001-10-22
AU6510198A (en) 1998-10-12
NO994508D0 (no) 1999-09-17
AU722627B2 (en) 2000-08-10

Similar Documents

Publication Publication Date Title
EA199900835A1 (ru) Стабильная частица в жидких композициях
IL96276A0 (en) Transdermal delivery system of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole
NZ336594A (en) Formulation for inhalation which includes a carrier (lactose, glucose, raffinose, melezitose, lactitol, trehalose, sucrose, mannitol or starch
TW224428B (ru)
ZA9811799B (en) Solid galenic form of the controlled release tablet type for the instant and then prolonged release of one or more active substances
HK1007108A1 (en) Compositions and methods for the controlled release of soluble active substances
IL84855A (en) Hydrosols of pharmacologically active agents,their preparation and pharmaceutical compositions containing them
CA2024291A1 (en) Dosage device and preparation and use thereof
PT1137400E (pt) Composicoes contendo um peptideo e um acido polilactico-glicolico apropriado para preparar implantes subscutaneos com um periodo de libertacao prolongado
FI953442A (fi) Gonadotropiinia sisältäviä pakastekuivattuja pallosia
HUP0203935A3 (en) Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their use
GB2246514B (en) Sustained release pharmaceutical compositions and the preparation of particles for use therein
NZ336593A (en) Formulation comprising finely divided formoterol and a carrier (lactose, glucose, raffinose, melezitose, lactitol, maltitol, trehalose, sucrose, mannitol or starch
IT8720129A0 (it) Composizioni farmaceutiche sottoforma di sospensioni stabili di sucralfato esenti da agenti sospendenti.
HUP0500127A3 (en) Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
AU2002327097A1 (en) Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
BR0008713A (pt) Processos para preparar formulações ecomposições farmacêuticas orais com ecb
MX9606391A (es) Preparacion farmaceutica con una sustancia activa hidrofobica y un sistema efervecente, y proceso para preparar la misma.
AU8229998A (en) Modified glycosides, compositions comprised thereof and methods of use thereof
NZ336595A (en) Formulation for inhalation comprising finely divided terbutaline sulphate and a carrier (lactose, glucose, raffinose, melezitose, lactitol, maltitol, trehalose, sucrose, mannitol or starch)
NO307466B1 (no) Blanding av sulfaterte polysakkarider, deres fremstilling, farmasøytiske preparater inneholdende sakkaridene samt deres anvendelse
MXPA03008061A (es) Composiciones desodorantes y antitranspirantes anhidras que contienen un agente dermoactivo solido soluble en agua y glicerina.
EP1086933A3 (en) Cement composition
CA2314112A1 (en) A method for making a pharmaceutical formulation
AU6787687A (en) Symmetrical O-substituted dioximes of benzo-fused beta- diketocycloalkylenes, the processes for their preparation and their application as drugs

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU