EA199900091A1 - Терапевтическое применение t-bam(cd40l)-технологии для лечения заболеваний с участием клеток гладкой мускулатуры - Google Patents

Терапевтическое применение t-bam(cd40l)-технологии для лечения заболеваний с участием клеток гладкой мускулатуры

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Publication number
EA199900091A1
EA199900091A1 EA199900091A EA199900091A EA199900091A1 EA 199900091 A1 EA199900091 A1 EA 199900091A1 EA 199900091 A EA199900091 A EA 199900091A EA 199900091 A EA199900091 A EA 199900091A EA 199900091 A1 EA199900091 A1 EA 199900091A1
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EA
Eurasian Patent Office
Prior art keywords
smooth muscle
muscle cells
cd40l
bam
participation
Prior art date
Application number
EA199900091A
Other languages
English (en)
Other versions
EA004401B1 (ru
Inventor
Майкл Дж. Йеллин
Сет Ледерман
Леонард Чесс
Михаил Н. Карпусас
Дэвид В. Томас
Original Assignee
Дзе, Трастиз Оф Колумбия Юниверсити Ин Дзе Сити Оф Нью Йорк
Байоджен,, Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Дзе, Трастиз Оф Колумбия Юниверсити Ин Дзе Сити Оф Нью Йорк, Байоджен,, Инкорпорейтед filed Critical Дзе, Трастиз Оф Колумбия Юниверсити Ин Дзе Сити Оф Нью Йорк
Publication of EA199900091A1 publication Critical patent/EA199900091A1/ru
Publication of EA004401B1 publication Critical patent/EA004401B1/ru

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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061Muscle cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G01MEASURING; TESTING
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    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
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Abstract

Активацию CD4C-лигандом (CD40L) клеток гладкой мускулатуры, несущих CD40 на поверхности клеток, ингибируют in vivo и ex vivo посредством приведения в контакт этих клеток с агентом, способным к ингибированию взаимодействия между CD40L и CD40 на клетках. Ингибирование in vivo несущих CD40 клеток гладкой мускулатуры используют для лечения заболеваний, зависимых от клеток гладких мышц.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900091A 1996-07-08 1997-07-03 Терапевтическое применение т-вам(cd40l)-технологии для лечения заболеваний с участием клеток гладкой мускулатуры EA004401B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67773096A 1996-07-08 1996-07-08
PCT/US1997/012925 WO1998001145A1 (en) 1996-07-08 1997-07-03 Therapeutic applications of t-bam (cd40l) technology to treat diseases involving smooth muscle cells

Publications (2)

Publication Number Publication Date
EA199900091A1 true EA199900091A1 (ru) 1999-08-26
EA004401B1 EA004401B1 (ru) 2004-04-29

Family

ID=24719894

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900091A EA004401B1 (ru) 1996-07-08 1997-07-03 Терапевтическое применение т-вам(cd40l)-технологии для лечения заболеваний с участием клеток гладкой мускулатуры

Country Status (20)

Country Link
US (2) US20030219437A1 (ru)
EP (1) EP0956030A4 (ru)
JP (1) JP2000515507A (ru)
CN (1) CN1242809C (ru)
AU (1) AU731299B2 (ru)
BG (1) BG63489B1 (ru)
BR (1) BR9710264A (ru)
CA (1) CA2259962C (ru)
CZ (1) CZ297300B6 (ru)
EA (1) EA004401B1 (ru)
EE (1) EE9900010A (ru)
HU (1) HUP9904669A3 (ru)
IL (1) IL127884A0 (ru)
IS (1) IS4935A (ru)
NO (1) NO990019L (ru)
NZ (1) NZ333602A (ru)
PL (1) PL188408B1 (ru)
SK (1) SK499A3 (ru)
TR (1) TR199900029T2 (ru)
WO (1) WO1998001145A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0110779A (pt) 2000-05-12 2005-01-11 Beth Israel Hospital Composições e métodos para adquirir supressão imunológica
US20020173053A1 (en) * 2001-04-27 2002-11-21 Bassam Damaj Multiple simultaneous antigen detection by immunohistochemistry
ES2263984T3 (es) * 2002-06-28 2006-12-16 Domantis Limited Ligandos doble-especificos con una vida media serica aumentada.
US7563443B2 (en) * 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
UY32802A (es) * 2009-07-23 2011-01-31 Provimi Holding B V Composiciones para reducir la metanogénesis gastrointestinal en rumiantes
TW201741337A (zh) * 2016-05-13 2017-12-01 麥迪紐有限責任公司 CD40L-Fc融合多肽及其使用方法
KR102019033B1 (ko) * 2016-11-11 2019-09-06 다이노나(주) Cd40에 특이적으로 결합하는 항체 및 그의 용도
US11793854B2 (en) 2019-03-21 2023-10-24 Op-T Llc Methods for reducing symptoms of multiple sclerosis using a six-amino acid long peptide that inhibits CD40-CD150 interaction

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474771A (en) * 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
CA2089229C (en) * 1992-02-14 2010-04-13 Alejandro A. Aruffo Cd40cr receptor and ligands therefor
US6001358A (en) * 1995-11-07 1999-12-14 Idec Pharmaceuticals Corporation Humanized antibodies to human gp39, compositions containing thereof
US6340459B1 (en) * 1995-12-01 2002-01-22 The Trustees Of Columbia University In The City Of New York Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients
US6822070B2 (en) * 1996-03-11 2004-11-23 David Baltimore Truncated CRAF1 inhibits CD40 signaling

Also Published As

Publication number Publication date
TR199900029T2 (xx) 1999-04-21
NO990019L (no) 1999-03-08
CA2259962A1 (en) 1998-01-15
AU4229297A (en) 1998-02-02
AU731299B2 (en) 2001-03-29
BR9710264A (pt) 1999-08-10
BG103148A (en) 1999-10-29
NZ333602A (en) 2000-06-23
PL188408B1 (pl) 2005-01-31
CN1227494A (zh) 1999-09-01
EP0956030A4 (en) 2001-11-28
CZ2699A3 (cs) 1999-05-12
IL127884A0 (en) 1999-10-28
EA004401B1 (ru) 2004-04-29
NO990019D0 (no) 1999-01-04
US20030219437A1 (en) 2003-11-27
WO1998001145A1 (en) 1998-01-15
BG63489B1 (bg) 2002-03-29
CN1242809C (zh) 2006-02-22
CA2259962C (en) 2002-01-22
EP0956030A1 (en) 1999-11-17
HUP9904669A2 (hu) 2000-05-28
CZ297300B6 (cs) 2006-11-15
US20080050369A1 (en) 2008-02-28
IS4935A (is) 1998-12-23
SK499A3 (en) 1999-08-06
EE9900010A (et) 1999-06-15
HUP9904669A3 (en) 2001-06-28
JP2000515507A (ja) 2000-11-21
PL331104A1 (en) 1999-06-21

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