EA199800141A1 - Гетероциклические соединения - Google Patents

Гетероциклические соединения

Info

Publication number
EA199800141A1
EA199800141A1 EA199800141A EA199800141A EA199800141A1 EA 199800141 A1 EA199800141 A1 EA 199800141A1 EA 199800141 A EA199800141 A EA 199800141A EA 199800141 A EA199800141 A EA 199800141A EA 199800141 A1 EA199800141 A1 EA 199800141A1
Authority
EA
Eurasian Patent Office
Prior art keywords
denotes
aryl
heterocyclic compounds
carboxy
acceptable substituents
Prior art date
Application number
EA199800141A
Other languages
English (en)
Other versions
EA002156B1 (ru
Inventor
Киеси Танигути
Коудзи Хаттори
Казунори Цубаки
Осаму Окицу
Сейитиро Табути
Original Assignee
Фудзисава Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515085.0A external-priority patent/GB9515085D0/en
Priority claimed from AUPN9002A external-priority patent/AUPN900296A0/en
Application filed by Фудзисава Фармасьютикал Ко., Лтд. filed Critical Фудзисава Фармасьютикал Ко., Лтд.
Publication of EA199800141A1 publication Critical patent/EA199800141A1/ru
Publication of EA002156B1 publication Critical patent/EA002156B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Гетероциклические соединения формулыгде Rобозначает карбокси или защищенный карбокси, Rобозначает арил, который может иметь один или несколько приемлемых заместителей, Rобозначает арил, который может иметь один или несколько приемлемых заместителей, Rобозначает водород, низший алкил, гидрокси или арил, Aобозначает низший алкилен,обозначаети другие, Аобозначаети другие, n равен 0 или 1, и их фармацевтически приемлемые соли, которые являются полезными лекарственными средствами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800141A 1995-07-21 1996-07-18 Производные 4,5-диарилоксазолов, способ их получения и применение в качестве лекарственных средств EA002156B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9515085.0A GB9515085D0 (en) 1995-07-21 1995-07-21 Heterocyclic compounds
AUPN9002A AUPN900296A0 (en) 1996-03-29 1996-03-29 Heterocyclic compounds
PCT/JP1996/001996 WO1997003973A1 (en) 1995-07-21 1996-07-18 4,5-diaryl oxazole derivatives

Publications (2)

Publication Number Publication Date
EA199800141A1 true EA199800141A1 (ru) 1998-08-27
EA002156B1 EA002156B1 (ru) 2001-12-24

Family

ID=25645150

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800141A EA002156B1 (ru) 1995-07-21 1996-07-18 Производные 4,5-диарилоксазолов, способ их получения и применение в качестве лекарственных средств

Country Status (17)

Country Link
US (2) US5972965A (ru)
EP (2) EP0842161B1 (ru)
JP (1) JPH11509191A (ru)
KR (1) KR19990063582A (ru)
CN (1) CN1095839C (ru)
AT (1) ATE224380T1 (ru)
AU (1) AU716304B2 (ru)
CA (1) CA2227442A1 (ru)
DE (1) DE69623785T2 (ru)
DK (1) DK0842161T3 (ru)
EA (1) EA002156B1 (ru)
ES (1) ES2181902T3 (ru)
HU (1) HUP9900881A3 (ru)
MX (1) MX9800577A (ru)
PT (1) PT842161E (ru)
TW (1) TW401408B (ru)
WO (1) WO1997003973A1 (ru)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO713297A0 (en) * 1997-06-02 1997-06-26 Fujisawa Pharmaceutical Co., Ltd. Oxazole compound
GB9720270D0 (en) 1997-09-25 1997-11-26 Pharmagene Lab Limited Medicaments for the treatment of migraine
AUPP003297A0 (en) 1997-10-27 1997-11-20 Fujisawa Pharmaceutical Co., Ltd. 4,5-diaryloxazole compounds
AUPP029197A0 (en) 1997-11-10 1997-12-04 Fujisawa Pharmaceutical Co., Ltd. Benzocycloheptene derivatives
AUPP109097A0 (en) 1997-12-22 1998-01-22 Fujisawa Pharmaceutical Co., Ltd. Napthalene derivatives
DE19801648A1 (de) * 1998-01-17 1999-07-22 Bayer Ag alpha-Substituierte Lactone
GB9804426D0 (en) 1998-03-02 1998-04-29 Pfizer Ltd Heterocycles
AUPP608898A0 (en) * 1998-09-23 1998-10-15 Fujisawa Pharmaceutical Co., Ltd. New use of prostaglandin E2 antagonists
US6437146B1 (en) 1998-09-25 2002-08-20 Fujisawa Pharmaceutical Co., Ltd. Oxazole compounds as prostaglandin e2 agonists or antagonists
US6335459B1 (en) 1998-12-23 2002-01-01 Syntex (U.S.A.) Llc Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators
PL350917A1 (en) 1999-03-05 2003-02-10 Procter & Gamble C16 unsaturated fp-selective prostaglandins analogs
AU5249200A (en) * 1999-06-21 2001-01-09 Fujisawa Pharmaceutical Co., Ltd. Remedies for skin ulcer
US6894175B1 (en) * 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
AUPQ253199A0 (en) * 1999-08-30 1999-09-23 Fujisawa Pharmaceutical Co., Ltd. Non-prostanoid prostaglandin I2-agonist
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
WO2002085412A1 (fr) * 2001-04-18 2002-10-31 Fujisawa Pharmaceutical Co., Ltd. Inhibiteurs de la fibrose des tissus
BR0208985A (pt) * 2001-04-19 2004-03-09 Eisai Co Ltd Derivados de 2-iminopirrolidina
MXPA04008596A (es) * 2002-03-05 2004-12-06 Ono Pharmaceutical Co Compuestos derivados de 8-azaprostaglandina y farmacos que contienen los compuestos como ingrediente activo.
NZ535748A (en) 2002-04-12 2007-06-29 Pfizer Use of EP4 receptor ligands in the treatment of IL-6 involved diseases
KR100468352B1 (ko) * 2002-09-24 2005-01-27 한국과학기술연구원 신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물
ATE478859T1 (de) 2003-02-07 2010-09-15 Daiichi Sankyo Co Ltd Pyrazolderivat
AU2004218187C1 (en) 2003-02-19 2011-04-07 Eisai R&D Management Co., Ltd. Methods for producing cyclic benzamidine derivatives
US7557095B2 (en) * 2006-05-12 2009-07-07 Allergan, Inc. Therapeutic compounds
JP5609643B2 (ja) 2008-07-23 2014-10-22 東レ株式会社 慢性腎不全処置剤
JP5468007B2 (ja) 2008-09-10 2014-04-09 旭硝子株式会社 新規なプロスタグランジンｉ２誘導体
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
CN102917703B (zh) * 2010-03-08 2015-08-19 科研制药株式会社 新型ep4激动剂
SG188245A1 (en) * 2010-08-20 2013-04-30 Allergan Inc Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response
NZ704799A (en) 2012-08-24 2018-06-29 Univ Texas Heterocyclic modulators of hif activity for treatment of disease
WO2014031933A2 (en) * 2012-08-24 2014-02-27 Philip Jones Heterocyclic modulators of hif activity for treatment of disease
WO2014031928A2 (en) * 2012-08-24 2014-02-27 Philip Jones Heterocyclic modulators of hif activity for treatment of disease
WO2015130790A2 (en) * 2014-02-25 2015-09-03 Board Of Regents, University Of Texas System Salts of heterocyclic modulators of hif activity for treatment of disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ236474A (en) * 1989-12-20 1993-07-27 Bristol Myers Squibb Co 4,5-diphenyl-2-oxazole octanoic, nonanoic and decanoic acid and ester derivatives, preparation and pharmaceutical compositions thereof
US5187188A (en) * 1992-04-03 1993-02-16 Bristol-Myers Squibb Company Oxazole carboxylic acid derivatives
US5348969A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Diphenyloxazolyl-oxazoles as platelet aggregation inhibitors
US5362879A (en) * 1993-04-15 1994-11-08 Bristol-Myers Squibb Company 4-5-diphenyloxazole derivatives as inhibitors of blood platelet aggregation
CN1046714C (zh) * 1993-12-20 1999-11-24 藤泽药品工业株式会社 二芳基噁唑衍生物及其制法、应用和药物组合物
KR100383305B1 (ko) 1994-03-10 2003-11-01 후지사와 야꾸힝 고교 가부시키가이샤 프로스타글란딘i₂작용물질로서의나프탈렌유도체

Also Published As

Publication number Publication date
MX9800577A (es) 1998-04-30
DE69623785T2 (de) 2003-08-07
US6300344B1 (en) 2001-10-09
EP1213285A3 (en) 2002-07-03
DK0842161T3 (da) 2003-01-27
AU6469796A (en) 1997-02-18
EP0842161B1 (en) 2002-09-18
HUP9900881A3 (en) 2000-09-28
PT842161E (pt) 2003-02-28
CN1095839C (zh) 2002-12-11
AU716304B2 (en) 2000-02-24
KR19990063582A (ko) 1999-07-26
DE69623785D1 (de) 2002-10-24
ES2181902T3 (es) 2003-03-01
EA002156B1 (ru) 2001-12-24
EP1213285A2 (en) 2002-06-12
US5972965A (en) 1999-10-26
ATE224380T1 (de) 2002-10-15
CA2227442A1 (en) 1997-02-06
WO1997003973A1 (en) 1997-02-06
CN1196726A (zh) 1998-10-21
EP0842161A1 (en) 1998-05-20
HUP9900881A2 (hu) 1999-08-30
JPH11509191A (ja) 1999-08-17
TW401408B (en) 2000-08-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU