EA199700251A1 - 5-замещенные-3-(1,2,3,6-тетрагидропиридин-4-ил)- и 3-(пиперидин-4-ил)-1н-индолы и их фармацевтически приемлемые соли и сольваты, фармацевтическая композиция на их основе, способ активации рецепторов 5-нти способ ингибирования нейронной белковой транссудации - Google Patents

5-замещенные-3-(1,2,3,6-тетрагидропиридин-4-ил)- и 3-(пиперидин-4-ил)-1н-индолы и их фармацевтически приемлемые соли и сольваты, фармацевтическая композиция на их основе, способ активации рецепторов 5-нти способ ингибирования нейронной белковой транссудации

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Publication number
EA199700251A1
EA199700251A1 EA199700251A EA199700251A EA199700251A1 EA 199700251 A1 EA199700251 A1 EA 199700251A1 EA 199700251 A EA199700251 A EA 199700251A EA 199700251 A EA199700251 A EA 199700251A EA 199700251 A1 EA199700251 A1 EA 199700251A1
Authority
EA
Eurasian Patent Office
Prior art keywords
transsudation
solvat
indols
tetrahydropyridin
nti
Prior art date
Application number
EA199700251A
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English (en)
Other versions
EA001113B1 (ru
Inventor
Джеймс Эдмунд Одиа
Брюс Энтони Дрессман
Джеймс Джозеф Дрост
Джеймс Эрвин Фриц
Стефен Уоррен Кэлдор
Дэниел Джеймс Кох
Джозеф Герман мл. Крушинский
Деннис Чарльз Томпсон
Джеффри Скотт Ниссен
Винсент Патрик Рокко
Джон Мехнет Шос
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199700251A1 publication Critical patent/EA199700251A1/ru
Publication of EA001113B1 publication Critical patent/EA001113B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В соответствии с настоящим изобретением предлагаются новые агонисты 5-HT, которые полезны для лечения мигрени и связанных с ней расстройств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700251A 1995-03-20 1996-03-15 5-замещенные-3-(1,2,3,6-тетрагидропиридин-4-ил)- и 3-(пиперидин-4-ил)-1н-индолы и их фармацевтически приемлемые соли и сольваты, фармацевтическая композиция на их основе, способ активации рецепторов 5-нт1 и способ ингибирования нейронной белковой транссудации EA001113B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40755395A 1995-03-20 1995-03-20
PCT/US1996/003500 WO1996029075A1 (en) 1995-03-20 1996-03-15 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists

Publications (2)

Publication Number Publication Date
EA199700251A1 true EA199700251A1 (ru) 1998-04-30
EA001113B1 EA001113B1 (ru) 2000-10-30

Family

ID=23612560

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700251A EA001113B1 (ru) 1995-03-20 1996-03-15 5-замещенные-3-(1,2,3,6-тетрагидропиридин-4-ил)- и 3-(пиперидин-4-ил)-1н-индолы и их фармацевтически приемлемые соли и сольваты, фармацевтическая композиция на их основе, способ активации рецепторов 5-нт1 и способ ингибирования нейронной белковой транссудации

Country Status (25)

Country Link
US (2) US5708008A (ru)
EP (1) EP0733628B9 (ru)
JP (1) JPH11502816A (ru)
KR (1) KR19980703048A (ru)
CN (1) CN1184425A (ru)
AR (1) AR002971A1 (ru)
AT (1) ATE198332T1 (ru)
AU (1) AU702322B2 (ru)
BR (1) BR9601061A (ru)
CA (1) CA2215322A1 (ru)
CZ (1) CZ288897A3 (ru)
DE (1) DE69611315T2 (ru)
DK (1) DK0733628T3 (ru)
EA (1) EA001113B1 (ru)
ES (1) ES2153078T3 (ru)
GR (1) GR3035487T3 (ru)
HU (1) HUP9800417A3 (ru)
MX (1) MX9706969A (ru)
NO (1) NO974220L (ru)
NZ (1) NZ305166A (ru)
PL (1) PL322843A1 (ru)
PT (1) PT733628E (ru)
SI (1) SI0733628T1 (ru)
TR (1) TR199700993T1 (ru)
WO (1) WO1996029075A1 (ru)

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HUP9800417A2 (hu) 1999-06-28
WO1996029075A1 (en) 1996-09-26
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CZ288897A3 (cs) 1998-02-18
US5962474A (en) 1999-10-05
JPH11502816A (ja) 1999-03-09
SI0733628T1 (en) 2001-06-30
GR3035487T3 (en) 2001-05-31
DE69611315T2 (de) 2001-05-31
EP0733628B1 (en) 2000-12-27
ATE198332T1 (de) 2001-01-15
TR199700993T1 (xx) 1998-03-21
CN1184425A (zh) 1998-06-10
AR002971A1 (es) 1998-05-27
DE69611315D1 (de) 2001-02-01
CA2215322A1 (en) 1996-09-26
AU5311296A (en) 1996-10-08
EP0733628A1 (en) 1996-09-25
US5708008A (en) 1998-01-13
EP0733628B9 (en) 2002-06-12
KR19980703048A (ko) 1998-09-05
EA001113B1 (ru) 2000-10-30
BR9601061A (pt) 1998-01-06
ES2153078T3 (es) 2001-02-16
AU702322B2 (en) 1999-02-18
MX9706969A (es) 1997-11-29
PL322843A1 (en) 1998-02-16
NZ305166A (en) 1998-12-23
PT733628E (pt) 2001-06-29
NO974220L (no) 1997-11-04
NO974220D0 (no) 1997-09-12

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