EA199900429A1 - Синтез бензо[f]хинолинонов - Google Patents

Синтез бензо[f]хинолинонов

Info

Publication number
EA199900429A1
EA199900429A1 EA199900429A EA199900429A EA199900429A1 EA 199900429 A1 EA199900429 A1 EA 199900429A1 EA 199900429 A EA199900429 A EA 199900429A EA 199900429 A EA199900429 A EA 199900429A EA 199900429 A1 EA199900429 A1 EA 199900429A1
Authority
EA
Eurasian Patent Office
Prior art keywords
quinolinons
benzo
synthesis
pharmaceutical agents
benzoquinone
Prior art date
Application number
EA199900429A
Other languages
English (en)
Inventor
Джон Бреннан
Кристофер В. Доэк
Перри К. Хет
Лоренс Э. Паттерсон
Уко Э. Удодонг
Лилэнд О. Вейджел
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199900429A1 publication Critical patent/EA199900429A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)

Abstract

В настоящем изобретении описан способ получения промежуточных соединений и бензохинон-3-оновых фармацевтических агентов, причем такие фармацевтические агенты эффективны при лечении состояний, связанных 5 α-редуктазой.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900429A 1996-10-30 1997-10-27 Синтез бензо[f]хинолинонов EA199900429A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2786896P 1996-10-30 1996-10-30
PCT/US1997/019229 WO1998018757A1 (en) 1996-10-30 1997-10-27 Synthesis of benzo[f]quinolinones

Publications (1)

Publication Number Publication Date
EA199900429A1 true EA199900429A1 (ru) 1999-10-28

Family

ID=21840234

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900429A EA199900429A1 (ru) 1996-10-30 1997-10-27 Синтез бензо[f]хинолинонов

Country Status (20)

Country Link
EP (1) EP0839807A1 (ru)
JP (1) JP2001504816A (ru)
KR (1) KR20000052952A (ru)
AR (1) AR011268A1 (ru)
AU (1) AU735651B2 (ru)
BR (1) BR9712711A (ru)
CA (1) CA2270433A1 (ru)
CO (1) CO4930266A1 (ru)
EA (1) EA199900429A1 (ru)
HU (1) HUP9904069A2 (ru)
ID (1) ID21978A (ru)
IL (1) IL129689A0 (ru)
NO (1) NO992110L (ru)
NZ (1) NZ335512A (ru)
PE (1) PE13899A1 (ru)
PL (1) PL333303A1 (ru)
TR (1) TR199901543T2 (ru)
TW (1) TW438752B (ru)
WO (1) WO1998018757A1 (ru)
ZA (1) ZA979612B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL140321A0 (en) * 1998-06-18 2002-02-10 Lilly Co Eli Synthesis of benzo [f] quinolinones
CA2338298A1 (en) * 1998-07-29 2000-02-10 Merck & Co., Inc. Tricyclic compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5239075A (en) * 1991-08-21 1993-08-24 Eli Lilly And Company Process for the preparation of benzo (f) quinolinones
US5574160A (en) * 1994-05-26 1996-11-12 Eli Lilly And Company Syntheis of benzoquinolinones
US5578724A (en) * 1994-09-20 1996-11-26 Eli Lilly And Company Process for preparation of benzo[f]quinolinones
US5629007A (en) * 1995-03-21 1997-05-13 Eli Lilly And Company Method of preventing prostatic cancer development
US5635197A (en) * 1995-03-21 1997-06-03 Eli Lilly And Company Treatment and prevention of prostatic cancer metastasis
TW450809B (en) * 1995-03-21 2001-08-21 Lilly Co Eli Pharmaceutical compositions for preventing or treating prostatic cancer comprising benzoquinolin-3-one derivatives
US5550134A (en) * 1995-05-10 1996-08-27 Eli Lilly And Company Methods for inhibiting bone loss

Also Published As

Publication number Publication date
NO992110D0 (no) 1999-04-30
TR199901543T2 (xx) 1999-09-21
TW438752B (en) 2001-06-07
AU735651B2 (en) 2001-07-12
JP2001504816A (ja) 2001-04-10
AU4917297A (en) 1998-05-22
AR011268A1 (es) 2000-08-16
KR20000052952A (ko) 2000-08-25
IL129689A0 (en) 2000-02-29
BR9712711A (pt) 1999-10-26
ID21978A (id) 1999-08-19
ZA979612B (en) 1999-04-28
EP0839807A1 (en) 1998-05-06
CO4930266A1 (es) 2000-06-27
NZ335512A (en) 2001-08-31
NO992110L (no) 1999-04-30
CA2270433A1 (en) 1998-05-07
PL333303A1 (en) 1999-11-22
WO1998018757A1 (en) 1998-05-07
HUP9904069A2 (hu) 2000-04-28
PE13899A1 (es) 1999-02-25

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