SI0733628T1 - 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists - Google Patents

5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists

Info

Publication number
SI0733628T1
SI0733628T1 SI9630288T SI9630288T SI0733628T1 SI 0733628 T1 SI0733628 T1 SI 0733628T1 SI 9630288 T SI9630288 T SI 9630288T SI 9630288 T SI9630288 T SI 9630288T SI 0733628 T1 SI0733628 T1 SI 0733628T1
Authority
SI
Slovenia
Prior art keywords
tetrahydropyridin
indoles
piperidin
substituted
ht1f agonists
Prior art date
Application number
SI9630288T
Other languages
English (en)
Inventor
James Edmund Audia
Bruce Anthony Dressmann
James Joseph Droste
James Erwin Fritz
Stephen Warren Kaldor
Daniel James Koch
Joseph Herman Krushinski Jr
Dennis Charles Thompson
Jeffrey Scott Nissen
Vincent Patrick Rocco
John Mehnert Schaus
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SI0733628T1 publication Critical patent/SI0733628T1/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI9630288T 1995-03-20 1996-03-19 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists SI0733628T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40755395A 1995-03-20 1995-03-20
EP96301845A EP0733628B9 (en) 1995-03-20 1996-03-19 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists

Publications (1)

Publication Number Publication Date
SI0733628T1 true SI0733628T1 (en) 2001-06-30

Family

ID=23612560

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630288T SI0733628T1 (en) 1995-03-20 1996-03-19 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists

Country Status (25)

Country Link
US (2) US5708008A (xx)
EP (1) EP0733628B9 (xx)
JP (1) JPH11502816A (xx)
KR (1) KR19980703048A (xx)
CN (1) CN1184425A (xx)
AR (1) AR002971A1 (xx)
AT (1) ATE198332T1 (xx)
AU (1) AU702322B2 (xx)
BR (1) BR9601061A (xx)
CA (1) CA2215322A1 (xx)
CZ (1) CZ288897A3 (xx)
DE (1) DE69611315T2 (xx)
DK (1) DK0733628T3 (xx)
EA (1) EA001113B1 (xx)
ES (1) ES2153078T3 (xx)
GR (1) GR3035487T3 (xx)
HU (1) HUP9800417A3 (xx)
MX (1) MX9706969A (xx)
NO (1) NO974220L (xx)
NZ (1) NZ305166A (xx)
PL (1) PL322843A1 (xx)
PT (1) PT733628E (xx)
SI (1) SI0733628T1 (xx)
TR (1) TR199700993T1 (xx)
WO (1) WO1996029075A1 (xx)

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TWI776175B (zh) 2019-07-09 2022-09-01 美商美國禮來大藥廠 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備
CN113233964A (zh) * 2021-05-14 2021-08-10 武汉工程大学 一种5-甲氧基-2-萘满酮的合成方法
CN113336633B (zh) * 2021-05-14 2022-12-06 武汉工程大学 一种5-羟基-2-萘满酮的合成方法
CN114539120A (zh) * 2022-03-09 2022-05-27 台州学院 一种吲哚类钾离子通道激动剂的制备方法

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Also Published As

Publication number Publication date
MX9706969A (es) 1997-11-29
CZ288897A3 (cs) 1998-02-18
DK0733628T3 (da) 2001-02-05
CA2215322A1 (en) 1996-09-26
PT733628E (pt) 2001-06-29
US5708008A (en) 1998-01-13
WO1996029075A1 (en) 1996-09-26
GR3035487T3 (en) 2001-05-31
HUP9800417A2 (hu) 1999-06-28
NZ305166A (en) 1998-12-23
PL322843A1 (en) 1998-02-16
DE69611315D1 (de) 2001-02-01
KR19980703048A (ko) 1998-09-05
ATE198332T1 (de) 2001-01-15
DE69611315T2 (de) 2001-05-31
ES2153078T3 (es) 2001-02-16
AR002971A1 (es) 1998-05-27
EP0733628B1 (en) 2000-12-27
BR9601061A (pt) 1998-01-06
AU702322B2 (en) 1999-02-18
NO974220D0 (no) 1997-09-12
HUP9800417A3 (en) 2001-04-28
JPH11502816A (ja) 1999-03-09
US5962474A (en) 1999-10-05
EA199700251A1 (ru) 1998-04-30
TR199700993T1 (xx) 1998-03-21
EP0733628B9 (en) 2002-06-12
NO974220L (no) 1997-11-04
AU5311296A (en) 1996-10-08
EA001113B1 (ru) 2000-10-30
EP0733628A1 (en) 1996-09-25
CN1184425A (zh) 1998-06-10

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