ATE198332T1 - 5-substituierte-3-(1,2,3,6-tetrahydropyridin-4- yl) und 3-(piperidin-4-yl)-1h-indole: 5-ht1f agonisten - Google Patents

5-substituierte-3-(1,2,3,6-tetrahydropyridin-4- yl) und 3-(piperidin-4-yl)-1h-indole: 5-ht1f agonisten

Info

Publication number
ATE198332T1
ATE198332T1 AT96301845T AT96301845T ATE198332T1 AT E198332 T1 ATE198332 T1 AT E198332T1 AT 96301845 T AT96301845 T AT 96301845T AT 96301845 T AT96301845 T AT 96301845T AT E198332 T1 ATE198332 T1 AT E198332T1
Authority
AT
Austria
Prior art keywords
tetrahydropyridine
indoles
piperidine
substituted
ht1f agonists
Prior art date
Application number
AT96301845T
Other languages
English (en)
Inventor
James Edmund Audia
Bruce Anthony Dressmann
James Joseph Droste
James Erwin Fritz
Stephen Warren Kaldor
Daniel James Koch
Joseph Herman Krushinski Jr
Dennis Charles Thompson
Jeffrey Scott Nissen
Vincent Patrick Rocco
John Mehnert Schaus
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE198332T1 publication Critical patent/ATE198332T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96301845T 1995-03-20 1996-03-19 5-substituierte-3-(1,2,3,6-tetrahydropyridin-4- yl) und 3-(piperidin-4-yl)-1h-indole: 5-ht1f agonisten ATE198332T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40755395A 1995-03-20 1995-03-20

Publications (1)

Publication Number Publication Date
ATE198332T1 true ATE198332T1 (de) 2001-01-15

Family

ID=23612560

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96301845T ATE198332T1 (de) 1995-03-20 1996-03-19 5-substituierte-3-(1,2,3,6-tetrahydropyridin-4- yl) und 3-(piperidin-4-yl)-1h-indole: 5-ht1f agonisten

Country Status (25)

Country Link
US (2) US5708008A (de)
EP (1) EP0733628B9 (de)
JP (1) JPH11502816A (de)
KR (1) KR19980703048A (de)
CN (1) CN1184425A (de)
AR (1) AR002971A1 (de)
AT (1) ATE198332T1 (de)
AU (1) AU702322B2 (de)
BR (1) BR9601061A (de)
CA (1) CA2215322A1 (de)
CZ (1) CZ288897A3 (de)
DE (1) DE69611315T2 (de)
DK (1) DK0733628T3 (de)
EA (1) EA001113B1 (de)
ES (1) ES2153078T3 (de)
GR (1) GR3035487T3 (de)
HU (1) HUP9800417A3 (de)
MX (1) MX9706969A (de)
NO (1) NO974220L (de)
NZ (1) NZ305166A (de)
PL (1) PL322843A1 (de)
PT (1) PT733628E (de)
SI (1) SI0733628T1 (de)
TR (1) TR199700993T1 (de)
WO (1) WO1996029075A1 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9615658D0 (en) * 1996-07-25 1996-09-04 Merck Sharp & Dohme Therapeutic agents
US5962473A (en) * 1996-08-16 1999-10-05 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F
WO1998011895A1 (en) * 1996-09-18 1998-03-26 Eli Lilly And Company A method for the prevention of migraine
US5792763A (en) * 1996-10-08 1998-08-11 Eli Lilly And Company Serotonin 5-HT1F agonists
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
EP1082958A3 (de) * 1996-11-15 2002-12-11 Eli Lilly And Company 5-HT1F Agonisten in chronischem Schmerz
EP0875513A1 (de) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituierte heteroaromatische 5-HT1F Agoniste
US6221884B1 (en) 1997-06-04 2001-04-24 Eli Lilly And Company Carboxamides useful as 5-HT1F agonists
ID23053A (id) * 1997-06-04 2000-01-20 Lilly Co Eli Karboksamida yang digunakan sebagai agonis 5-ht <if>
US6380201B1 (en) 1997-08-05 2002-04-30 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists
EP1003738B1 (de) * 1997-08-09 2003-11-19 SmithKline Beecham plc Bizyklische verbindungen als liganden der 5-ht1 rezeptoren
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
ZA989389B (en) * 1997-11-14 2000-04-14 Lilly Co Eli Pyrrolo [3,2-b] pyridine processes and intermediates.
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
US6673827B1 (en) 1999-06-29 2004-01-06 The Uab Research Foundation Methods of treating fungal infections with inhibitors of NAD synthetase enzyme
CA2317439A1 (en) 1998-01-14 1999-07-22 Wayne J. Brouillette Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial nad synthetase enzyme
US6861448B2 (en) * 1998-01-14 2005-03-01 Virtual Drug Development, Inc. NAD synthetase inhibitors and uses thereof
WO1999050268A2 (en) * 1998-03-31 1999-10-07 The Institutes For Pharmaceutical Discovery, Inc. Substituted indolealkanoic acids
JP2002510682A (ja) * 1998-04-08 2002-04-09 アメリカン・ホーム・プロダクツ・コーポレイション うつ病治療用のインドール−３−イル−シクロヘキシルアミン誘導体（５−ｈｔ１受容体拮抗薬）
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
US6066637A (en) * 1998-06-19 2000-05-23 American Home Products Corporation Indolyl derivatives as serotonergic agents
WO2000000490A2 (en) * 1998-06-26 2000-01-06 Eli Lilly And Company 5-ht1f agonists
US6133290A (en) * 1998-07-31 2000-10-17 Eli Lilly And Company 5-HT1F agonists
US6608079B1 (en) 1998-12-11 2003-08-19 Eli Lilly And Company Indole derivatives and their use as 5-HT1F agonists
US6200994B1 (en) 1999-01-07 2001-03-13 American Home Products Corp 1,4-Disubstituted cyclohexane derivatives for the treatment of depression
ES2182775T3 (es) * 1999-01-07 2003-03-16 Wyeth Corp Derivados de ciclohexano 1,4-disustituidos para el tratamiento de la depresion.
US6777428B1 (en) 1999-02-10 2004-08-17 Eli Lilly And Company 5-HT1f agonist
KR20010102003A (ko) * 1999-02-10 2001-11-15 피터 지. 스트링거 5-ｈｔ1ｆ 효능제
US6696439B1 (en) 1999-02-26 2004-02-24 Eli Lilly And Company 5-HT1F agonists
CA2371784A1 (en) * 1999-02-26 2000-08-31 Eli Lilly And Company 5-ht1f agonists
JP2003509509A (ja) * 1999-09-09 2003-03-11 ハー・ルンドベック・アクチエゼルスカベット ５−アミノアルキル及び５−アミノカルボニル置換されたインドール類
BR0206595A (pt) * 2001-01-30 2004-07-13 Lilly Co Eli Composto, composição farmacêutica, e uso de um composto
ES2187300B1 (es) * 2001-11-14 2004-06-16 Laboratorios Del Dr. Esteve, S.A. Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
TWI263497B (en) 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
AU2003224257A1 (en) * 2002-04-09 2003-10-27 Astex Technology Limited Heterocyclic compounds and their use as modulators of p38 map kinase
JP2006505571A (ja) * 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びｈｃｖ阻害剤としてのその使用
BRPI0409211A (pt) 2003-04-18 2006-03-28 Lilly Co Eli composto, composição farmacêutica, métodos para ativar receptores 5-ht1f, para inibir extravasão de proteìna neuronial, e para o tratamento ou prevenção de enxaqueca em um mamìfero, e, uso de um composto
US20050065202A1 (en) * 2003-05-09 2005-03-24 Vidal Ramon Merce Use of sulphonamide derivatives for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
ES2219181B1 (es) * 2003-05-09 2005-12-16 Laboratorios Del Dr. Esteve, S.A. Uso de derivados de sulfonamidas para la fabricacion de un medicamento para la profilaxis y/o tratamiento de las disfunciones alimentarias.
ES2222829B1 (es) 2003-07-30 2006-03-01 Laboratorios Del Dr. Esteve, S.A. Derivados de 4-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
ES2222832B1 (es) 2003-07-30 2006-02-16 Laboratorios Del Dr. Esteve, S.A. Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
UA82711C2 (en) 2003-09-12 2008-05-12 Эли Лилли Энд Компани Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists
WO2005061439A1 (en) 2003-12-17 2005-07-07 Eli Lilly And Company Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-ht1f agonists
US7550499B2 (en) * 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7645778B2 (en) * 2005-01-19 2010-01-12 Bristol-Myers Squibb Company Heteroaryl compounds as P2Y1 receptor inhibitors
JP5833804B2 (ja) * 2005-04-13 2015-12-16 ニューラクソン，インコーポレーテッド Ｎｏｓ阻害活性を有する置換インドール化合物
US7816382B2 (en) 2005-06-27 2010-10-19 Bristol-Myers Squibb Company Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition
WO2007002634A1 (en) * 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
ATE485269T1 (de) * 2005-06-27 2010-11-15 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden
AR056867A1 (es) * 2005-06-27 2007-10-31 Bristol Myers Squibb Co Antagonistas heterociclicos n- enlazados del receptor de p2y1 utiles en el tratamiento de condiciones tromboticas. composiciones farmaceuticas.
TW200808780A (en) * 2006-04-13 2008-02-16 Neuraxon Inc 1,5 and 3,6- substituted indole compounds having NOS inhibitory activity
US7960569B2 (en) * 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
CA2705422A1 (en) * 2007-11-16 2009-05-22 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating visceral pain
MX356032B (es) * 2007-11-16 2018-04-11 Neuraxon Inc Compuestos indola y métodos para tratar el dolor visceral.
MX2010005343A (es) * 2007-11-16 2010-08-09 Neuraxon Inc Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina.
MX2011010359A (es) * 2009-04-02 2012-02-23 Colucid Pharmaceuticals Inc Composición de 2,4,6-trifluoro-n-[6-(1-metilo-piperidina-4-carboni lo)-piridina-2-ilo]-benzamida.
US8697876B2 (en) 2010-04-02 2014-04-15 Colucid Pharmaceuticals, Inc. Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists
WO2014055142A1 (en) * 2012-06-20 2014-04-10 Cocrystal Discovery, Inc. Inhibitors of hepatitis c virus polymerase
LT3027603T (lt) * 2013-08-02 2018-08-10 Pfizer Inc. Heterobicikloarilo rorc2 inhibitoriai ir jų panaudojimo būdai
MA40759A (fr) 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
TWI731854B (zh) 2015-03-23 2021-07-01 美商共結晶製藥公司 Ｃ型肝炎病毒聚合酶之抑制劑
WO2018085491A1 (en) * 2016-11-02 2018-05-11 Musc Foundation For Research Development 5ht1f receptor agonists and mitochondrial biogenesis
TWI826514B (zh) 2018-09-04 2023-12-21 美商美國禮來大藥廠 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥
TWI829107B (zh) 2019-07-09 2024-01-11 美商美國禮來大藥廠 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備
CN113233964A (zh) * 2021-05-14 2021-08-10 武汉工程大学 一种5-甲氧基-2-萘满酮的合成方法
CN113336633B (zh) * 2021-05-14 2022-12-06 武汉工程大学 一种5-羟基-2-萘满酮的合成方法
CN114539120A (zh) * 2022-03-09 2022-05-27 台州学院 一种吲哚类钾离子通道激动剂的制备方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2193584B1 (de) * 1972-07-28 1975-08-08 Roussel Uclaf
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
US4359468A (en) * 1981-02-25 1982-11-16 Boehringer Ingelheim Ltd. Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones
FR2533924A1 (fr) * 1982-10-05 1984-04-06 Roussel Uclaf Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
IL87437A0 (en) * 1987-08-13 1989-01-31 Glaxo Group Ltd Indole derivatives,their preparation and pharmaceutical compositions containing them
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
DK733788A (da) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
SI9111010B (sl) * 1990-06-07 2005-02-28 Astrazeneca Ab 3,5-disubstituirani indolni derivati kot "5-HT1-podobni" receptorski agonisti
US5322851A (en) * 1990-07-02 1994-06-21 H. Lundbeck A/S Indole derivatives
DK158590D0 (da) * 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
US5187280A (en) * 1990-09-20 1993-02-16 Warner-Lambert Company Substituted tetrahydropyridines and their use as central nervous system agents
US5118691A (en) * 1990-09-20 1992-06-02 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents
PL168919B1 (pl) * 1990-10-15 1996-05-31 Pfizer Sposób wytwarzania nowych pochodnych indolu PL PL PL PL
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW263508B (de) * 1991-02-12 1995-11-21 Pfizer
CA2124206C (en) * 1991-11-25 2001-02-27 John Eugene Macor Indole derivatives
GB9201089D0 (en) * 1992-01-18 1992-03-11 Scient Generics Ltd A diagnostic article
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
TW251284B (de) * 1992-11-02 1995-07-11 Pfizer
GB9226532D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
HUT73807A (en) * 1993-04-22 1996-09-30 Pfizer Res & Dev 5-ht1-like indole derivatives and pharmaceutical compositions containing them
FR2705346B1 (fr) * 1993-05-18 1995-08-11 Union Pharma Scient Appl Nouveaux dérivés de pipéridinyl thio indole, leurs procédés de préparation, compositions pharmaceutiques les contenant, utiles notamment comme antalgiques .
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists

Also Published As

Publication number Publication date
EP0733628A1 (de) 1996-09-25
AR002971A1 (es) 1998-05-27
KR19980703048A (ko) 1998-09-05
NO974220L (no) 1997-11-04
TR199700993T1 (xx) 1998-03-21
PT733628E (pt) 2001-06-29
ES2153078T3 (es) 2001-02-16
CZ288897A3 (cs) 1998-02-18
GR3035487T3 (en) 2001-05-31
AU702322B2 (en) 1999-02-18
DE69611315T2 (de) 2001-05-31
HUP9800417A2 (hu) 1999-06-28
CA2215322A1 (en) 1996-09-26
MX9706969A (es) 1997-11-29
US5708008A (en) 1998-01-13
SI0733628T1 (en) 2001-06-30
PL322843A1 (en) 1998-02-16
WO1996029075A1 (en) 1996-09-26
EP0733628B9 (de) 2002-06-12
EA001113B1 (ru) 2000-10-30
NZ305166A (en) 1998-12-23
CN1184425A (zh) 1998-06-10
AU5311296A (en) 1996-10-08
EP0733628B1 (de) 2000-12-27
DE69611315D1 (de) 2001-02-01
JPH11502816A (ja) 1999-03-09
HUP9800417A3 (en) 2001-04-28
US5962474A (en) 1999-10-05
DK0733628T3 (da) 2001-02-05
NO974220D0 (no) 1997-09-12
BR9601061A (pt) 1998-01-06
EA199700251A1 (ru) 1998-04-30

Similar Documents

Publication Publication Date Title
ATE198332T1 (de) 5-substituierte-3-(1,2,3,6-tetrahydropyridin-4- yl) und 3-(piperidin-4-yl)-1h-indole: 5-ht1f agonisten
HUP0003217A3 (en) Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines and pharmaceutical compositions containing them
NO2008012I1 (no) Dabigatran-etexilate og salter derav-spesielt dabigatran-etexilate-mesylate
NO961156D0 (no) 3-(5-tetrazolyl-benzyl) amino-piperidin-derivater og antagonister for tachykiner
NO20004095D0 (no) Blandinger og fremgangsmÕter for regulering av lymfocyttaktivering
HRP20120132A8 (hr) Azabicikloalkani u svojstvu modulatora ccr5
IS5941A (is) Píperidín sem CCR5 stillar
BR9713237B1 (pt) comprimido de liberaÇço controlada de cloridrato de alfuzosina e composiÇço farmacÊutica compreendendo o mesmo.
EE9600186A (et) Neurokiniini (tahhüülkiniini) antagonistid
ID17259A (id) Fluorina mengandung turunan piperidina 1,4-disubtitusikan
CY2408B1 (en) Paroxetine controlled release compositions.
DK1077941T3 (da) Forbindelser med væksthormonfrigörende egenskaber
IT1312329B1 (it) Dispositivo per l&#39;alimentazione selettiva dei fili in macchine permaglieria o simili.
FI962185A7 (fi) Suulaitteisto leuan asennon säätämiseksi
IT1284346B1 (it) Cerniera per mobili
GB2356213B (en) Glass-breaking device (2)
IT1311758B1 (it) Dispositivo di supporto e comando per l&#39;apertura o la chiusura di unelemento di afferraggio in due parti
DE69940932D1 (de) Orale Zusammensetzungen mit 8-chloro-6,11-dihydro-11-(4-piperidylene)-5H-benzoÄ5,6Ü-cyclo-heptaÄ1,2-bÜpyridin
IT236507Y1 (it) Dispositivo frenante per mobili con chiusura e apertura asaracinesca
DE69826736D1 (de) Speichervorrichtung, Speicher-/Wiedergabevorrichtung und Wiedergabevorrichtung
EP1276353A4 (de) Lampenzustandsdetektor und lampenzustandsüberwachungseinrichtung mit einem solchen detektor
KR970014708U (ko) 노내 산소 침투방지 장치
KR950024113U (ko) 오픈탑형 큐에프피 핸들러용 소켓
DE69627543D1 (de) Kleiderbügel und lagerungsvorrichtung dafür
DK0627885T3 (da) Voksfrit tyggegummi med forbedrede forarbejdningsegenskaber

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee