EA038994B1 - Способы лечения таупатии - Google Patents

Способы лечения таупатии Download PDF

Info

Publication number
EA038994B1
EA038994B1 EA201690898A EA201690898A EA038994B1 EA 038994 B1 EA038994 B1 EA 038994B1 EA 201690898 A EA201690898 A EA 201690898A EA 201690898 A EA201690898 A EA 201690898A EA 038994 B1 EA038994 B1 EA 038994B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
tau protein
amino acid
tau
seq
Prior art date
Application number
EA201690898A
Other languages
English (en)
Russian (ru)
Other versions
EA201690898A1 (ru
Inventor
Ирэн Грисволд-Преннер
Грэм Пэрри
Original Assignee
Айпириэн, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Айпириэн, Инк. filed Critical Айпириэн, Инк.
Publication of EA201690898A1 publication Critical patent/EA201690898A1/ru
Publication of EA038994B1 publication Critical patent/EA038994B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
EA201690898A 2013-11-27 2014-11-25 Способы лечения таупатии EA038994B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361909965P 2013-11-27 2013-11-27
PCT/US2014/067360 WO2015081085A2 (en) 2013-11-27 2014-11-25 Methods of treating a tauopathy

Publications (2)

Publication Number Publication Date
EA201690898A1 EA201690898A1 (ru) 2016-09-30
EA038994B1 true EA038994B1 (ru) 2021-11-18

Family

ID=52232410

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690898A EA038994B1 (ru) 2013-11-27 2014-11-25 Способы лечения таупатии

Country Status (9)

Country Link
US (2) US20160289309A1 (cg-RX-API-DMAC7.html)
EP (1) EP3074420A2 (cg-RX-API-DMAC7.html)
JP (1) JP6629201B2 (cg-RX-API-DMAC7.html)
CN (2) CN105899230B (cg-RX-API-DMAC7.html)
BR (1) BR112016010454A2 (cg-RX-API-DMAC7.html)
CA (1) CA2931396C (cg-RX-API-DMAC7.html)
EA (1) EA038994B1 (cg-RX-API-DMAC7.html)
MX (2) MX384909B (cg-RX-API-DMAC7.html)
WO (1) WO2015081085A2 (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013302540B2 (en) * 2012-08-16 2018-02-15 Ipierian, Inc. Methods of treating a tauopathy
US12024568B2 (en) 2012-09-13 2024-07-02 Cornell University Treatment of brain cancers using central nervous system mediated gene transfer of monoclonal antibodies
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
CN105121465B (zh) 2013-03-13 2020-09-08 普罗塞纳生物科技公司 Tau免疫疗法
JP2017512751A (ja) 2014-02-14 2017-05-25 アイピエリアン，インコーポレイティド タウペプチド、抗タウ抗体、およびそれらの使用方法
CA3258972A1 (en) 2015-06-05 2025-04-17 Ac Immune Sa TAU ANTIBODIES AND METHODS OF USING THEM
WO2017100632A1 (en) * 2015-12-11 2017-06-15 Arizona Board Of Regents On Behalf Of Arizona State University Human alzheimer's disease and traumatic brain injury associated tau variants as biomarkers and methods of use thereof
FI3452507T3 (fi) 2016-05-02 2022-12-15 Tau-immuunihoito
IL262726B2 (en) 2016-05-02 2024-07-01 Prothena Biosciences Ltd Antibodies recognizing tau
WO2018106781A1 (en) 2016-12-07 2018-06-14 Genentech, Inc Anti-tau antibodies and methods of use
JP2020511937A (ja) 2016-12-07 2020-04-23 ジェネンテック， インコーポレイテッド 抗ｔａｕ抗体及び使用方法
CN110520440A (zh) 2017-02-17 2019-11-29 戴纳立制药公司 抗τ抗体及其使用方法
IL270375B2 (en) 2017-05-02 2024-12-01 Prothena Biosciences Ltd Antibodies recognizing tau
KR20200018502A (ko) * 2017-06-16 2020-02-19 브리스톨-마이어스 스큅 컴퍼니 타우병증 치료를 위한 조성물 및 방법
US20190135905A1 (en) * 2017-06-16 2019-05-09 Bristol-Myers Squibb Company Compositions and methods for treating tauopathies
KR20210134943A (ko) 2019-03-03 2021-11-11 프로테나 바이오사이언시즈 리미티드 타우 인식 항체
GB202010652D0 (en) * 2020-07-10 2020-08-26 Wista Lab Ltd Anti-tau antibodies
CN115607684A (zh) * 2021-07-15 2023-01-17 华中科技大学 一种内耳药物纳米载体及其应用
TW202334201A (zh) * 2021-11-03 2023-09-01 日商衛材R&D企管股份有限公司 抗Ｔａｕ抗體之組成物、劑型及方法
WO2025196217A1 (en) * 2024-03-21 2025-09-25 UCB Biopharma SRL Treatment of tauopathies with tau-binding antibodies

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050383A1 (en) * 2006-03-29 2008-02-28 New York University Immunotherapy for clearing pathological tau conformers
WO2010144711A2 (en) * 2009-06-10 2010-12-16 New York University Immunological targeting of pathological tau proteins
WO2012045882A2 (en) * 2010-10-07 2012-04-12 Ac Immune S.A. Pharmaceutical composition
WO2012049570A1 (en) * 2010-10-11 2012-04-19 Panima Pharmaceuticals Ag Human anti-tau antibodies
WO2014028777A2 (en) * 2012-08-16 2014-02-20 Ipierian, Inc. Methods of treating a tauopathy

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4866132A (en) 1986-04-17 1989-09-12 The Research Foundation Of State University Of New York Novel radiopaque barium polymer complexes, compositions of matter and articles prepared therefrom
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
EP0318554B2 (en) 1987-05-21 2005-01-12 Micromet AG Targeted multifunctional proteins
US5256334A (en) 1988-09-08 1993-10-26 The Research Foundation Of The State University Of New York Homogeneous radiopaque polymer-organobismuth composites
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
ATE181571T1 (de) 1991-09-23 1999-07-15 Medical Res Council Methoden zur herstellung humanisierter antikörper
DK1136556T3 (da) 1991-11-25 2005-10-03 Enzon Inc Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner
US5346981A (en) 1993-01-13 1994-09-13 Miles Inc. Radiopaque polyurethanes
CA2115811A1 (en) 1993-02-17 1994-08-18 Claus Krebber A method for in vivo selection of ligand-binding proteins
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
WO1996019487A1 (en) 1994-12-22 1996-06-27 Nissan Chemical Industries, Ltd. Organobismuth derivatives and process for producing the same
US5958713A (en) 1995-01-31 1999-09-28 Novo Nordisk A/S Method of detecting biologically active substances by using green fluorescent protein
US5670477A (en) 1995-04-20 1997-09-23 Joseph F. Poduslo Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents
US5968738A (en) 1995-12-06 1999-10-19 The Board Of Trustees Of The Leland Stanford Junior University Two-reporter FACS analysis of mammalian cells using green fluorescent proteins
US6020192A (en) 1996-01-18 2000-02-01 University Of Florida Humanized green fluorescent protein genes and methods
US5874304A (en) 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
DE69708318T3 (de) 1996-08-27 2006-11-16 Novartis Vaccines and Diagnostics, Inc., Emeryville Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung
US5976796A (en) 1996-10-04 1999-11-02 Loma Linda University Construction and expression of renilla luciferase and green fluorescent protein fusion genes
TW371617B (en) 1996-10-09 1999-10-11 Of Animal And Plant Health Inspection And Quarantine Council Of Agriculture Executive Yuan Bureau Method to transplant GFP into autographa californica multiple nuclear polyhedrosis virus for inflicting pest in an attempt to detect and flow up it existence and to improve life span against UV
CA2313225A1 (en) 1997-12-12 1999-06-17 Macromed, Inc. Heterofunctionalized star-shaped poly(ethylene glycols) for protein modification
US5985577A (en) 1998-10-14 1999-11-16 The Trustees Of Columbia University In The City Of New York Protein conjugates containing multimers of green fluorescent protein
CA2568952C (en) 2004-06-18 2019-05-21 Ambrx, Inc. Novel antigen-binding polypeptides and their uses
US20090016959A1 (en) 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
US8741260B2 (en) 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
BRPI0923283A2 (pt) 2008-12-05 2017-06-06 Angiochem Inc conjugados terapêuticos de peptídeo e usos dos mesmos
EP2470211B1 (en) * 2009-08-28 2016-01-27 The Board of Regents of The University of Texas System Antibodies that bind tau oligomers
AU2010315780A1 (en) * 2009-11-06 2012-05-17 The J. David Gladstone Institutes Methods and compositions for modulating Tau levels
GB201112056D0 (en) * 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
KR20210099167A (ko) * 2011-09-19 2021-08-11 악손 뉴로사이언스 에스이 알쯔하이머병의 타우 매개된 병리학의 단백질 기재 요법 및 진단

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050383A1 (en) * 2006-03-29 2008-02-28 New York University Immunotherapy for clearing pathological tau conformers
WO2010144711A2 (en) * 2009-06-10 2010-12-16 New York University Immunological targeting of pathological tau proteins
WO2012045882A2 (en) * 2010-10-07 2012-04-12 Ac Immune S.A. Pharmaceutical composition
WO2012049570A1 (en) * 2010-10-11 2012-04-19 Panima Pharmaceuticals Ag Human anti-tau antibodies
WO2014028777A2 (en) * 2012-08-16 2014-02-20 Ipierian, Inc. Methods of treating a tauopathy

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
D. R. WILLIAMS: "Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau", INTERNAL MEDICINE JOURNAL, BLACKWELL SCIENCE ASIA, vol. 36, no. 10, 1 October 2006 (2006-10-01), pages 652 - 660, XP055174109, ISSN: 14440903, DOI: 10.1111/j.1445-5994.2006.01153.x *
DIANA L. CASTILLO-CARRANZA, CRISTIAN A. LASAGNA-REEVES, RAKEZ KAYED: "Tau aggregates as immunotherapeutic targets ", FRONTIERS IN BIOSCIENCE, vol. 5, 1 January 2013 (2013-01-01), pages 426 - 438, XP055053507, ISSN: 19450516, DOI: 10.2741/S381 *
Einar M. Sigurdsson: "Tau-Focused Immunotherapy for Alzheimer's Disease and Related Tauopathies", Curr Alzheimer Res., 1 October 2009 (2009-10-01), pages 446-450, XP055081685, Retrieved from the Internet: URL:http://europepmc.org/articles/PMC2891148?pdf=render [retrieved on 2013-09-30] the whole document in particular, pages 3-4 *
N GHOSHAL: "Tau Conformational Changes Correspond to Impairments of Episodic Memory in Mild Cognitive Impairment and Alzheimer's Disease", EXPERIMENTAL NEUROLOGY, ACADEMIC PRESS, vol. 177, no. 2, 1 October 2002 (2002-10-01), pages 475 - 493, XP055089574, ISSN: 00144886, DOI: 10.1006/exnr.2002.8014 *
N. KFOURY, B. B. HOLMES, H. JIANG, D. M. HOLTZMAN, M. I. DIAMOND: "Trans-cellular Propagation of Tau Aggregation by Fibrillar Species", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 287, no. 23, 1 June 2012 (2012-06-01), pages 19440 - 19451, XP055087124, ISSN: 00219258, DOI: 10.1074/jbc.M112.346072 *
X. CHAI, S. WU, T. K. MURRAY, R. KINLEY, C. V. CELLA, H. SIMS, N. BUCKNER, J. HANMER, P. DAVIES, M. J. O'NEILL, M. L. HUTTON, M. C: "Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models: REDUCTION OF TAU PATHOLOGY AND DELAY OF DISEASE PROGRESSION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 286, no. 39, 30 September 2011 (2011-09-30), pages 34457 - 34467, XP055087176, ISSN: 00219258, DOI: 10.1074/jbc.M111.229633 *
YANAMANDRA KIRAN; KFOURY NAJLA; JIANG HONG; MAHAN THOMAS E.; MA SHENGMEI; MALONEY SUSAN E.; WOZNIAK DAVID F.; DIAMOND MARC I.; HOL: "Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo ", NEURON, ELSEVIER, AMSTERDAM, NL, vol. 80, no. 2, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 402 - 414, XP028757368, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2013.07.046 *

Also Published As

Publication number Publication date
MX2016006356A (es) 2016-10-28
CA2931396C (en) 2022-09-06
US20160289309A1 (en) 2016-10-06
EA201690898A1 (ru) 2016-09-30
MX2021008755A (es) 2021-08-24
EP3074420A2 (en) 2016-10-05
CN111569063A (zh) 2020-08-25
JP6629201B2 (ja) 2020-01-15
JP2017504570A (ja) 2017-02-09
MX384909B (es) 2025-03-14
CN105899230B (zh) 2020-06-09
BR112016010454A2 (pt) 2017-12-05
CN105899230A (zh) 2016-08-24
WO2015081085A3 (en) 2015-08-06
US20200102375A1 (en) 2020-04-02
WO2015081085A2 (en) 2015-06-04
CA2931396A1 (en) 2015-06-04

Similar Documents

Publication Publication Date Title
EA038994B1 (ru) Способы лечения таупатии
US12215169B2 (en) Anti-complement C1s antibodies and uses thereof
AU2019200448B2 (en) Anti-complement C1s antibodies and uses thereof
US9447180B2 (en) Methods of treating a tauopathy
JP4738696B2 (ja) Ａβペプチドを隔離するヒト化抗体
CN105339002B (zh) 治疗tau病变的方法
RS60080B1 (sr) Metodi lečenja tauopatije
HK40035696A (en) Methods of treating a tauopathy