CA2931396C - An anti-tau antibody for treating tauopothy - Google Patents

An anti-tau antibody for treating tauopothy Download PDF

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Publication number
CA2931396C
CA2931396C CA2931396A CA2931396A CA2931396C CA 2931396 C CA2931396 C CA 2931396C CA 2931396 A CA2931396 A CA 2931396A CA 2931396 A CA2931396 A CA 2931396A CA 2931396 C CA2931396 C CA 2931396C
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Canada
Prior art keywords
tau
antibody
amino acid
seq
ipn002
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Active
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CA2931396A
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English (en)
French (fr)
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CA2931396A1 (en
Inventor
Irene Griswold-Prenner
Graham Parry
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iPierian Inc
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iPierian Inc
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Publication of CA2931396A1 publication Critical patent/CA2931396A1/en
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Publication of CA2931396C publication Critical patent/CA2931396C/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CA2931396A 2013-11-27 2014-11-25 An anti-tau antibody for treating tauopothy Active CA2931396C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361909965P 2013-11-27 2013-11-27
US61/909,965 2013-11-27
PCT/US2014/067360 WO2015081085A2 (en) 2013-11-27 2014-11-25 Methods of treating a tauopathy

Publications (2)

Publication Number Publication Date
CA2931396A1 CA2931396A1 (en) 2015-06-04
CA2931396C true CA2931396C (en) 2022-09-06

Family

ID=52232410

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2931396A Active CA2931396C (en) 2013-11-27 2014-11-25 An anti-tau antibody for treating tauopothy

Country Status (9)

Country Link
US (2) US20160289309A1 (cg-RX-API-DMAC7.html)
EP (1) EP3074420A2 (cg-RX-API-DMAC7.html)
JP (1) JP6629201B2 (cg-RX-API-DMAC7.html)
CN (2) CN105899230B (cg-RX-API-DMAC7.html)
BR (1) BR112016010454A2 (cg-RX-API-DMAC7.html)
CA (1) CA2931396C (cg-RX-API-DMAC7.html)
EA (1) EA038994B1 (cg-RX-API-DMAC7.html)
MX (2) MX384909B (cg-RX-API-DMAC7.html)
WO (1) WO2015081085A2 (cg-RX-API-DMAC7.html)

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CN105121465B (zh) 2013-03-13 2020-09-08 普罗塞纳生物科技公司 Tau免疫疗法
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KR20200018502A (ko) * 2017-06-16 2020-02-19 브리스톨-마이어스 스큅 컴퍼니 타우병증 치료를 위한 조성물 및 방법
US20190135905A1 (en) * 2017-06-16 2019-05-09 Bristol-Myers Squibb Company Compositions and methods for treating tauopathies
KR20210134943A (ko) 2019-03-03 2021-11-11 프로테나 바이오사이언시즈 리미티드 타우 인식 항체
GB202010652D0 (en) * 2020-07-10 2020-08-26 Wista Lab Ltd Anti-tau antibodies
CN115607684A (zh) * 2021-07-15 2023-01-17 华中科技大学 一种内耳药物纳米载体及其应用
TW202334201A (zh) * 2021-11-03 2023-09-01 日商衛材R&D企管股份有限公司 抗Tau抗體之組成物、劑型及方法
WO2025196217A1 (en) * 2024-03-21 2025-09-25 UCB Biopharma SRL Treatment of tauopathies with tau-binding antibodies

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Also Published As

Publication number Publication date
MX2016006356A (es) 2016-10-28
US20160289309A1 (en) 2016-10-06
EA201690898A1 (ru) 2016-09-30
MX2021008755A (es) 2021-08-24
EP3074420A2 (en) 2016-10-05
CN111569063A (zh) 2020-08-25
EA038994B1 (ru) 2021-11-18
JP6629201B2 (ja) 2020-01-15
JP2017504570A (ja) 2017-02-09
MX384909B (es) 2025-03-14
CN105899230B (zh) 2020-06-09
BR112016010454A2 (pt) 2017-12-05
CN105899230A (zh) 2016-08-24
WO2015081085A3 (en) 2015-08-06
US20200102375A1 (en) 2020-04-02
WO2015081085A2 (en) 2015-06-04
CA2931396A1 (en) 2015-06-04

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