EA038531B1 - Способ лечения амиотрофного латерального склероза, применение фармацевтической композиции, содержащей мазитиниб - Google Patents
Способ лечения амиотрофного латерального склероза, применение фармацевтической композиции, содержащей мазитиниб Download PDFInfo
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- EA038531B1 EA038531B1 EA201800499A EA201800499A EA038531B1 EA 038531 B1 EA038531 B1 EA 038531B1 EA 201800499 A EA201800499 A EA 201800499A EA 201800499 A EA201800499 A EA 201800499A EA 038531 B1 EA038531 B1 EA 038531B1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16162490 | 2016-03-25 | ||
| PCT/EP2017/057134 WO2017162884A1 (en) | 2016-03-25 | 2017-03-24 | Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201800499A1 EA201800499A1 (ru) | 2019-03-29 |
| EA038531B1 true EA038531B1 (ru) | 2021-09-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201800499A EA038531B1 (ru) | 2016-03-25 | 2017-03-24 | Способ лечения амиотрофного латерального склероза, применение фармацевтической композиции, содержащей мазитиниб |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10092564B2 (OSRAM) |
| EP (1) | EP3240538B1 (OSRAM) |
| JP (2) | JP7250312B2 (OSRAM) |
| KR (1) | KR102293847B1 (OSRAM) |
| CN (1) | CN108883108B (OSRAM) |
| AU (1) | AU2017236177B2 (OSRAM) |
| BR (1) | BR112018069515A2 (OSRAM) |
| CA (1) | CA3018635C (OSRAM) |
| DK (1) | DK3240538T3 (OSRAM) |
| EA (1) | EA038531B1 (OSRAM) |
| ES (1) | ES2899929T3 (OSRAM) |
| HU (1) | HUE057398T2 (OSRAM) |
| IL (1) | IL261856B (OSRAM) |
| MX (1) | MX390495B (OSRAM) |
| NZ (1) | NZ745778A (OSRAM) |
| PL (1) | PL3240538T3 (OSRAM) |
| PT (1) | PT3240538T (OSRAM) |
| SG (1) | SG11201808106YA (OSRAM) |
| SI (1) | SI3240538T1 (OSRAM) |
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| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| CN109846862A (zh) | 2012-10-25 | 2019-06-07 | 通用医疗公司 | 治疗阿尔茨海默病及相关疾病的组合疗法 |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| EP3060205A4 (en) | 2013-10-22 | 2017-06-28 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| WO2018045217A1 (en) | 2016-08-31 | 2018-03-08 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| EP3425390B1 (en) | 2016-11-25 | 2020-12-23 | Genuv Inc. | Composition for promoting differentiation of and protecting neural stem cells and method for inducing neural regeneration using same |
| CN116139135A (zh) * | 2017-03-28 | 2023-05-23 | 诺华股份有限公司 | 治疗多发性硬化的方法 |
| JP6957650B2 (ja) * | 2017-05-30 | 2021-11-02 | デシフェラ・ファーマシューティカルズ，エルエルシー | 血小板由来成長因子受容体アルファの遺伝的異常に関連する癌の治療のための、１−［４−ブロモ−５−［１−エチル−７−（メチルアミノ）−２−オキソ−１，２−ジヒドロ−１，６−ナフチリジン−３−イル］−２−フルオロフェニル］−３−フェニルウレアおよびアナログの使用 |
| JP7463281B2 (ja) * | 2018-03-05 | 2024-04-08 | ザ スキーペンズ アイ リサーチ インスティチュート インコーポレイテッド | コロニー刺激因子を標的とすることによる、緑内障および視神経症のための療法 |
| CN113038944A (zh) | 2018-07-02 | 2021-06-25 | 通用医疗公司 | 色甘酸钠和α-乳糖的粉末化制剂 |
| MX2021006869A (es) | 2018-12-10 | 2021-07-02 | Massachusetts Gen Hospital | Esteres de cromolin y usos de los mismos. |
| CN112618717A (zh) * | 2019-09-24 | 2021-04-09 | 北京大学深圳研究生院 | Btk抑制剂用于治疗肌萎缩侧索硬化症的用途 |
| KR20250057151A (ko) * | 2019-12-30 | 2025-04-28 | 데시페라 파마슈티칼스, 엘엘씨 | 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의조성물 |
| WO2021207060A1 (en) | 2020-04-06 | 2021-10-14 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
| WO2025113494A1 (zh) * | 2023-11-27 | 2025-06-05 | 浙江径科医药有限公司 | 多环类化合物及其应用 |
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| WO2015063318A1 (en) * | 2013-11-04 | 2015-05-07 | Ab Science | Use of masitinib for treatment of amyotrophic lateral sclerosis |
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| TW225528B (OSRAM) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| ATE375342T1 (de) | 2002-08-02 | 2007-10-15 | Ab Science | 2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren |
| US8153792B2 (en) | 2007-02-13 | 2012-04-10 | Ab Science | Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors |
| US8906357B2 (en) | 2010-04-20 | 2014-12-09 | Ab Science | Treatment of multiple sclerosis with masitinib |
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Also Published As
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| SI3240538T1 (sl) | 2022-02-28 |
| EP3240538A1 (en) | 2017-11-08 |
| PL3240538T3 (pl) | 2022-01-31 |
| KR20180125966A (ko) | 2018-11-26 |
| JP2019515884A (ja) | 2019-06-13 |
| EP3240538B1 (en) | 2021-09-29 |
| MX2018011349A (es) | 2019-02-07 |
| WO2017162884A1 (en) | 2017-09-28 |
| PT3240538T (pt) | 2021-12-07 |
| BR112018069515A2 (pt) | 2019-04-16 |
| JP7250312B2 (ja) | 2023-04-03 |
| AU2017236177A1 (en) | 2018-09-20 |
| US10092564B2 (en) | 2018-10-09 |
| NZ745778A (en) | 2022-07-01 |
| US20180117037A1 (en) | 2018-05-03 |
| IL261856A (en) | 2018-10-31 |
| CN108883108A (zh) | 2018-11-23 |
| KR102293847B1 (ko) | 2021-08-26 |
| DK3240538T3 (da) | 2021-12-06 |
| AU2017236177B2 (en) | 2022-03-31 |
| CA3018635A1 (en) | 2017-09-28 |
| CN108883108B (zh) | 2021-08-06 |
| CA3018635C (en) | 2023-09-26 |
| SG11201808106YA (en) | 2018-10-30 |
| ES2899929T3 (es) | 2022-03-15 |
| JP2022037132A (ja) | 2022-03-08 |
| IL261856B (en) | 2022-04-01 |
| HUE057398T2 (hu) | 2022-05-28 |
| MX390495B (es) | 2025-03-20 |
| EA201800499A1 (ru) | 2019-03-29 |
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