EA037654B1 - Анти-cd47-антитела и их применения - Google Patents
Анти-cd47-антитела и их применения Download PDFInfo
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- EA037654B1 EA037654B1 EA201791485A EA201791485A EA037654B1 EA 037654 B1 EA037654 B1 EA 037654B1 EA 201791485 A EA201791485 A EA 201791485A EA 201791485 A EA201791485 A EA 201791485A EA 037654 B1 EA037654 B1 EA 037654B1
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- antibody
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
- Health & Medical Sciences (AREA)
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462098291P | 2014-12-30 | 2014-12-30 | |
| PCT/US2015/067642 WO2016109415A1 (en) | 2014-12-30 | 2015-12-28 | Anti-cd47 antibodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
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| EA201791485A1 EA201791485A1 (ru) | 2018-02-28 |
| EA037654B1 true EA037654B1 (ru) | 2021-04-27 |
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| EA201791485A EA037654B1 (ru) | 2014-12-30 | 2015-12-28 | Анти-cd47-антитела и их применения |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EA037654B1 (ru) | 2014-12-30 | 2021-04-27 | Селджин Корпорейшн | Анти-cd47-антитела и их применения |
| BR112017020434A2 (pt) * | 2015-05-04 | 2018-06-26 | Pieris Pharmaceuticals Gmbh | polipeptídeos de fusão, molécula de ácido nucleico, célula hospedeira, método para produzir um polipeptídeo de fusão, usos do polipeptídeo de fusão, métodos para ativar as vias de sinalização, para coestimular células, para induzir a proliferação de linfócitos t, para direcionar o agrupamento de cd137, para induzir uma resposta local de células t, para induzir uma resposta local de células nk e para induzir a produção de il-2 |
| BR112019000166A2 (pt) * | 2016-07-06 | 2019-10-01 | Celgene Corp | anticorpos com baixa imunogenicidade e usos dos mesmos |
| EP3504234A4 (en) | 2016-09-29 | 2020-12-02 | Beijing Hanmi Pharmaceutical Co., Ltd. | CONSTRUCTIONS OF HETERODIMERIC IMMUNOGLOBULINS AND THEIR PREPARATION PROCESSES |
| BR112019008010A2 (pt) | 2016-10-20 | 2019-07-09 | I Mab | anticorpo monoclonal isolado ou fragmento imunologicamente ativo do mesmo, anticorpo monoclonal biespecífico isolado, composição farmacêutica, método para tratamento de uma doença em um sujeito humano em necessidade do mesmo, proteína de fusão, epítopo imunodominante codificado pelo gene cd47, e, molécula biológica |
| CA3042583A1 (en) | 2016-11-03 | 2018-05-11 | Trillium Therapeutics Inc. | Improvements in cd47 blockade therapy by hdac inhibitors |
| US11352425B2 (en) * | 2016-11-08 | 2022-06-07 | Absos, Llc | Anti-CD47 antibodies |
| SG10201913260VA (en) | 2016-11-18 | 2020-03-30 | Beijing Hanmi Pharmaceutical Co Ltd | Anti-pd-1/anti-her2 natural antibody structural heterodimeric bispecific antibody and method of preparing the same |
| US11267885B2 (en) * | 2017-01-26 | 2022-03-08 | Zlip Holding Limited | CD47 antigen binding unit and uses thereof |
| WO2018152033A1 (en) * | 2017-02-14 | 2018-08-23 | Promab Biotechnologies, Inc. | Cd47-car-t cells |
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| KR20220028157A (ko) * | 2017-11-10 | 2022-03-08 | 아이-맵 바이오파마 유에스 리미티드 | Cd47 항체 및 사이토카인을 포함하는 융합 단백질 |
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| HK1245154A1 (zh) | 2018-08-24 |
| AU2015374301A1 (en) | 2017-07-20 |
| JP2018506964A (ja) | 2018-03-15 |
| CA2972604A1 (en) | 2016-07-07 |
| CN107530421B (zh) | 2021-07-20 |
| US20210054070A1 (en) | 2021-02-25 |
| ECSP17041865A (es) | 2017-08-31 |
| US11787860B2 (en) | 2023-10-17 |
| CL2017001736A1 (es) | 2018-03-16 |
| ZA201704467B (en) | 2019-09-25 |
| EP3240569A1 (en) | 2017-11-08 |
| MX2017008819A (es) | 2018-03-14 |
| US10870699B2 (en) | 2020-12-22 |
| KR20170100652A (ko) | 2017-09-04 |
| CA2972604C (en) | 2023-07-04 |
| JP2021048858A (ja) | 2021-04-01 |
| WO2016109415A1 (en) | 2016-07-07 |
| SG11201705310TA (en) | 2017-07-28 |
| CN107530421A (zh) | 2018-01-02 |
| BR112017014258A2 (pt) | 2018-03-06 |
| EA201791485A1 (ru) | 2018-02-28 |
| MX391051B (es) | 2025-03-21 |
| JP6850255B2 (ja) | 2021-03-31 |
| CO2017007673A2 (es) | 2018-01-05 |
| US20170369572A1 (en) | 2017-12-28 |
| SG10202007176TA (en) | 2020-08-28 |
| AU2015374301B2 (en) | 2021-02-11 |
| KR102489471B1 (ko) | 2023-01-18 |
| EP3240569A4 (en) | 2018-05-30 |
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