EA037611B1 - Онколитический аденовирус, кодирующий белок b7 - Google Patents

Онколитический аденовирус, кодирующий белок b7 Download PDF

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Publication number
EA037611B1
EA037611B1 EA201791971A EA201791971A EA037611B1 EA 037611 B1 EA037611 B1 EA 037611B1 EA 201791971 A EA201791971 A EA 201791971A EA 201791971 A EA201791971 A EA 201791971A EA 037611 B1 EA037611 B1 EA 037611B1
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Eurasian Patent Office
Prior art keywords
cells
protein
virus
sequence
cell
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EA201791971A
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English (en)
Russian (ru)
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EA201791971A1 (ru
Inventor
Брайан Роберт Чемпион
Брайан Роберт ЧЕМПИОН
Элис Клэр Ноэль Бромли
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Псайоксус Терапьютикс Лимитед
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Priority claimed from GBGB1507419.8A external-priority patent/GB201507419D0/en
Priority claimed from GBGB1516936.0A external-priority patent/GB201516936D0/en
Priority claimed from GBGB1522013.0A external-priority patent/GB201522013D0/en
Application filed by Псайоксус Терапьютикс Лимитед filed Critical Псайоксус Терапьютикс Лимитед
Publication of EA201791971A1 publication Critical patent/EA201791971A1/ru
Publication of EA037611B1 publication Critical patent/EA037611B1/ru

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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K35/761—Adenovirus
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    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10371—Demonstrated in vivo effect

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EA201791971A 2015-04-30 2016-04-29 Онколитический аденовирус, кодирующий белок b7 EA037611B1 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1507419.8A GB201507419D0 (en) 2015-04-30 2015-04-30 Virus
GB1507419.8 2015-04-30
GB1516936.0 2015-09-24
GBGB1516936.0A GB201516936D0 (en) 2015-09-24 2015-09-24 Virus
GB1522013.0 2015-12-14
GBGB1522013.0A GB201522013D0 (en) 2015-12-14 2015-12-14 Virus
PCT/EP2016/059609 WO2016174200A1 (en) 2015-04-30 2016-04-29 Oncolytic adenovirus encoding a b7 protein

Publications (2)

Publication Number Publication Date
EA201791971A1 EA201791971A1 (ru) 2018-04-30
EA037611B1 true EA037611B1 (ru) 2021-04-21

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EA201791971A EA037611B1 (ru) 2015-04-30 2016-04-29 Онколитический аденовирус, кодирующий белок b7

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US (6) US11000559B2 (cg-RX-API-DMAC7.html)
EP (2) EP3391892A1 (cg-RX-API-DMAC7.html)
JP (3) JP6931229B2 (cg-RX-API-DMAC7.html)
KR (4) KR102854512B1 (cg-RX-API-DMAC7.html)
CN (2) CN108396015B (cg-RX-API-DMAC7.html)
AU (3) AU2016256582B2 (cg-RX-API-DMAC7.html)
BR (2) BR112017023171A2 (cg-RX-API-DMAC7.html)
CA (1) CA2984038C (cg-RX-API-DMAC7.html)
CL (2) CL2017002731A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017010831A2 (cg-RX-API-DMAC7.html)
CY (1) CY1122833T1 (cg-RX-API-DMAC7.html)
DK (1) DK3288573T3 (cg-RX-API-DMAC7.html)
EA (1) EA037611B1 (cg-RX-API-DMAC7.html)
ES (1) ES2780366T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20200439T1 (cg-RX-API-DMAC7.html)
HU (1) HUE048320T2 (cg-RX-API-DMAC7.html)
IL (3) IL284375B (cg-RX-API-DMAC7.html)
LT (1) LT3288573T (cg-RX-API-DMAC7.html)
MX (1) MX2017013684A (cg-RX-API-DMAC7.html)
MY (1) MY183703A (cg-RX-API-DMAC7.html)
PE (2) PE20181140A1 (cg-RX-API-DMAC7.html)
PH (1) PH12017501942A1 (cg-RX-API-DMAC7.html)
PL (1) PL3288573T3 (cg-RX-API-DMAC7.html)
PT (1) PT3288573T (cg-RX-API-DMAC7.html)
RS (1) RS60105B1 (cg-RX-API-DMAC7.html)
SA (2) SA517390260B1 (cg-RX-API-DMAC7.html)
SG (3) SG10201901482XA (cg-RX-API-DMAC7.html)
SI (1) SI3288573T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202000222T1 (cg-RX-API-DMAC7.html)
WO (1) WO2016174200A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201801589B (cg-RX-API-DMAC7.html)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3777870A1 (en) 2013-06-14 2021-02-17 Psioxus Therapeutics Limited A dosing regime and formulations for type b adenoviruses
GB201322851D0 (en) 2013-12-23 2014-02-12 Psioxus Therapeutics Ltd Method
SI3021859T1 (en) 2013-10-25 2018-04-30 Psioxus Therapeutics Limited Oncolytic adenoviruses equipped with heterologous genes
GB201406608D0 (en) 2014-04-12 2014-05-28 Psioxus Therapeutics Ltd Virus
KR102854512B1 (ko) 2015-04-30 2025-09-04 아카미스 바이오 리미티드 B7 단백질을 암호화하는 종양세포붕괴 아데노바이러스
PE20181300A1 (es) 2015-11-02 2018-08-09 Five Prime Therapeutics Inc Polipeptidos del dominio extracelular de cd80 y su uso en el tratamiento del cancer
KR20180108590A (ko) * 2015-12-17 2018-10-04 싸이오서스 테라퓨틱스 엘티디. 항-tcr-복합체 항체 또는 단편을 암호화하는 바이러스
DK3436591T5 (da) * 2016-03-31 2024-09-16 The European Molecular Biology Laboratory Adenovirale coat-protein-afledte transportvehikler
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
CN110214025B (zh) 2016-08-29 2024-08-02 阿卡米斯生物公司 携带双特异性t细胞衔接器的腺病毒
ES2981703T3 (es) * 2016-09-02 2024-10-10 Lentigen Tech Inc Composiciones y métodos para tratar cáncer con DuoCars
AU2017335673B2 (en) * 2016-09-27 2024-11-14 Sator Therapeutics LLC Optimized oncolytic viruses and uses thereof
WO2018083259A1 (en) * 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018083258A1 (en) * 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding at least three transgenes
WO2018083257A1 (en) * 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
CA3052463A1 (en) * 2017-02-03 2018-08-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Oncolytic virus therapy
EA201992586A1 (ru) 2017-04-28 2020-03-03 Файв Прайм Терапьютикс, Инк. Способы лечения с помощью полипептидов внеклеточного домена cd80
AU2018273963B2 (en) * 2017-05-25 2023-07-20 University Of Central Florida Research Foundation, Inc. Novel oncolytic viruses for sensitizing tumor cells to killing by natural killer cells
JP7216668B2 (ja) 2017-05-26 2023-02-01 エピセントアールエックス，インコーポレイテッド 導入遺伝子を保持する組換えアデノウイルス
JP7394628B2 (ja) 2017-06-01 2023-12-08 アカミス バイオ リミテッド 腫瘍溶解性ウイルスおよび方法
WO2019147921A1 (en) 2018-01-26 2019-08-01 Nantcell, Inc. Rapid verification of virus particle production for a personalized vaccine
GB201801614D0 (en) * 2018-01-31 2018-03-14 Psioxus Therapeutics Ltd Formulation
WO2019173334A1 (en) * 2018-03-05 2019-09-12 The Schepens Eye Research Institute, Inc. Engineered vegf variants for retinal neuroprotection, promotion of axon growth and axon regeneration
EP3789489A4 (en) * 2018-03-30 2022-01-05 Tomoki Todo ANTI-SWEEPER TYPE ONCOLYTIC VIRUS
CN113164538B (zh) * 2018-09-10 2025-03-04 上海锦斯生物技术有限公司 修饰的溶瘤病毒、其组合物和用途
CA3131529A1 (en) * 2019-03-05 2020-09-10 Amgen Inc. Use of oncolytic viruses for the treatment of cancer
EP3725323A1 (en) * 2019-04-17 2020-10-21 Targovax Asa Oncolytic adenoviral vector expressing a member of the b7 family of costimulatory ligands and ada
JP7674738B2 (ja) * 2019-05-14 2025-05-12 オンコリスバイオファーマ株式会社 腫瘍組織に腫瘍溶解ウイルスを投与する方法、及び投与用デバイス
KR102503349B1 (ko) 2019-05-14 2023-02-23 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
GB201909081D0 (en) 2019-06-25 2019-08-07 Psioxus Therapeutics Ltd Method
WO2021252917A2 (en) 2020-06-11 2021-12-16 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
GB202102049D0 (en) 2021-02-13 2021-03-31 Psioxus Therapeutics Ltd Viruses
CN113544263B (zh) * 2021-06-03 2022-12-06 上海允英生物医药科技有限公司 溶瘤病毒载体及其应用
CA3233100A1 (en) 2021-09-23 2023-03-30 Sagittarius Bio, Inc. Adenoviruses and methods for using adenoviruses
WO2023180527A1 (en) * 2022-03-25 2023-09-28 Universität Zürich Adenoviral mediated targeting of activated immune cells
AU2024277678A1 (en) 2023-05-25 2025-11-27 Dispatch Biotherapeutics, Inc. Synthetic cancer antigens as targets for treating cancers
WO2025171388A1 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens with modified domains and related methods and uses
WO2025171383A2 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens and related methods and uses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000015823A1 (en) * 1998-09-11 2000-03-23 Genvec, Inc. Alternatively targeted adenovirus
WO2001053506A2 (en) * 2000-01-21 2001-07-26 Biovex Limited Virus strains for the oncolytic treatment of cancer
WO2005118825A2 (en) * 2004-05-26 2005-12-15 Schering Aktiengesellschaft Chimeric adenoviruses for use in cancer treatment
WO2015059303A1 (en) * 2013-10-25 2015-04-30 Psioxus Therapeutics Limited Oncolytic adenoviruses armed with heterologous genes

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358866A (en) 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
US5846945A (en) 1993-02-16 1998-12-08 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
FR2705361B1 (fr) 1993-05-18 1995-08-04 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
PT667912E (pt) 1993-07-13 2008-10-15 Centelion Vectores adenovirais deficientes e utilização em terapia génica
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5830686A (en) 1994-01-13 1998-11-03 Calydon Tissue-specific enhancer active in prostate
US5677170A (en) 1994-03-02 1997-10-14 The Johns Hopkins University In vitro transposition of artificial transposons
US5877011A (en) 1996-11-20 1999-03-02 Genzyme Corporation Chimeric adenoviral vectors
CN1242051A (zh) 1996-12-31 2000-01-19 昂尼克斯药物公司 用于肿瘤治疗和预防的致细胞病变病毒
ATE374821T1 (de) 1997-02-20 2007-10-15 Univ Johns Hopkins Med Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren
US20030044384A1 (en) 1997-10-09 2003-03-06 Pro-Virus, Inc. Treatment of neoplasms with viruses
US6291214B1 (en) 1998-05-11 2001-09-18 Glaxo Wellcome Inc. System for generating recombinant viruses
US20020019051A1 (en) 1998-05-27 2002-02-14 Monika Lusky Chimeric adenoviral vectors
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
CN1110553C (zh) 1998-07-15 2003-06-04 杭州赛狮生物技术开发有限公司 基因工程腺病毒及其用途
ATE361988T1 (de) 1998-12-09 2007-06-15 Us Gov Health & Human Serv Recombinanter vector, welcher mehrere kostimulatorische moleküle exprimiert und dessen verwenden
NZ515582A (en) 1999-05-17 2003-11-28 Crucell Holland B Adenovirus derived gene delivery vehicles comprising at least one element of adenovirus type 35
ATE291633T1 (de) 1999-06-01 2005-04-15 Univ Washington Rekombinante adenovirale vektoren, die chimäre fiberproteine exprimieren, für die zellspezifische infektion und genomische integration
US7396679B2 (en) 1999-11-15 2008-07-08 Onyx Pharmaceuticals, Inc. Oncolytic adenovirus
US7456009B2 (en) 2000-03-07 2008-11-25 Merck & Co., Inc. Adenovirus formulations
JP2003534806A (ja) 2000-05-31 2003-11-25 ジェンベク、インコーポレイティッド アデノウイルスベクターのターゲティングの方法および組成物
EP1348030B1 (en) 2001-01-04 2009-11-25 Wadell, Göran Viral vector for gene therapy
US20050175589A1 (en) 2001-07-13 2005-08-11 Btg International Limited Anti-neoplastic viral agents
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
EP1327688A1 (en) 2002-01-14 2003-07-16 Vereniging Voor Christelijk Wetenschappelijk Onderwijs Adenoviruses with enhanced lytic potency
US20030219410A1 (en) 2002-02-01 2003-11-27 Transgene S.A. Adenoviral vectors for modulating the cellular activities associated to PODs
US20060147420A1 (en) 2004-03-10 2006-07-06 Juan Fueyo Oncolytic adenovirus armed with therapeutic genes
WO2003092594A2 (en) 2002-04-30 2003-11-13 Duke University Adeno-associated viral vectors and methods for their production from hybrid adenovirus and for their use
CN1705740B (zh) * 2002-10-15 2013-07-24 佩尔·松内·霍尔姆 具有反向基因表达的腺病毒及其应用
US20040167088A1 (en) 2003-02-25 2004-08-26 Genvec, Inc. Method of using adenoviral vectors with increased persistence in vivo
WO2004087930A1 (en) 2003-03-28 2004-10-14 Saint Louis University Adenovirus replication-competent vectors expressing trail
US20050136035A1 (en) * 2003-06-03 2005-06-23 Derek Ko Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site
EP1646717A4 (en) 2003-07-18 2006-12-20 Onyx Pharma Inc ADENOVIRAL VECTORS OF SUB-GROUP B FOR THE TREATMENT OF DISEASES
US20050186178A1 (en) * 2003-08-28 2005-08-25 Ennist David L. Oncolytic adenoviral vectors encoding GM-CSF
US20080292592A1 (en) 2004-04-30 2008-11-27 Sunil Chada Oncolytic Adenovirus Armed with Therapeutic Genes
CN100361710C (zh) 2004-06-07 2008-01-16 成都康弘生物科技有限公司 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用
US20060292682A1 (en) * 2004-07-22 2006-12-28 Hawkins Lynda K Addition of transgenes into adenoviral vectors
CN101068933A (zh) * 2004-08-25 2007-11-07 细胞基因系统有限公司 用于肿瘤细胞增强转导的纤维修饰的腺病毒载体
JP2008511336A (ja) * 2004-09-01 2008-04-17 アメリカ合衆国 免疫原性が増加したアデノウイルスベクターをインビボで用いる方法
EP1819823A2 (en) 2004-12-01 2007-08-22 Bayer Schering Pharma Aktiengesellschaft Generation of replication competent viruses for therapeutic use
US8765146B2 (en) 2005-08-31 2014-07-01 Genvec, Inc. Adenoviral vector-based malaria vaccines
DE102005055128B4 (de) 2005-11-15 2015-04-02 Universität Rostock Viraler Vektor, dessen Verwendung zur Therapie von Leberzellkarzinomen und pharmazeutische Mittel umfassend den Vektor
ES2304281B1 (es) 2006-02-01 2009-08-12 Dnatrix Inc. Adenovirus oncoliticos para el tratamiento del cancer.
EP2094284A2 (en) 2006-12-22 2009-09-02 Bayer Schering Pharma AG Generation of oncolytic adenoviruses and uses thereof
US20110086005A1 (en) 2008-05-27 2011-04-14 Oncolytics Biotech Inc. Modulating interstitial pressure and oncolytic viral delivery and distribution
CN101381742A (zh) * 2008-10-23 2009-03-11 浙江理工大学 晚期启动子靶向性调控溶瘤腺病毒pCN305载体及其构建方法与应用
ES2385251B1 (es) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
WO2011043719A1 (en) * 2009-10-05 2011-04-14 Ya-Fang Mei Replicating viral vectors for gene therapy
KR101721725B1 (ko) 2010-08-16 2017-03-31 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 아데노바이러스 조립 방법
BR112013006669A2 (pt) * 2010-09-24 2019-09-24 Oncos Therapeutics Oy vetores adenovirais oncolíticos e métodos e usos relacionados aos mesmos
CA2812093A1 (en) 2010-09-24 2012-03-29 Oncos Therapeutics Oy Oncolytic adenoviral vectors coding for monoclonal anti - ctla - 4 antibodies
US20140316369A1 (en) 2011-11-14 2014-10-23 Regenerative Sciences, Llc Suspended particle delivery systems and methods
CN102586327B (zh) 2012-01-18 2013-09-11 陕西师范大学 一步法构建携带外源基因的d24纤维蛋白修饰的条件复制型腺病毒载体及其应用
US20160000842A1 (en) 2013-03-05 2016-01-07 Baylor College Of Medicine Oncolytic virus
GB201322851D0 (en) 2013-12-23 2014-02-12 Psioxus Therapeutics Ltd Method
JP2016540505A (ja) 2013-11-22 2016-12-28 ディーエヌエートリックス インコーポレイテッド アデノウイルス発現免疫細胞刺激受容体アゴニスト
GB201406608D0 (en) * 2014-04-12 2014-05-28 Psioxus Therapeutics Ltd Virus
GB201510197D0 (en) * 2014-06-12 2015-07-29 Psioxus Therapeutics Ltd Method of treating ovarian cancer
GB201503500D0 (en) 2015-03-02 2015-04-15 Ucl Business Plc Cell
US11485791B2 (en) 2015-03-17 2022-11-01 Tilt Biotherapeutics Oy Oncolytic adenoviruses coding for bi-specific antibodies
KR102854512B1 (ko) 2015-04-30 2025-09-04 아카미스 바이오 리미티드 B7 단백질을 암호화하는 종양세포붕괴 아데노바이러스
KR20180108590A (ko) 2015-12-17 2018-10-04 싸이오서스 테라퓨틱스 엘티디. 항-tcr-복합체 항체 또는 단편을 암호화하는 바이러스
WO2017161360A2 (en) 2016-03-18 2017-09-21 Nant Holdings Ip, Llc Multimodal vector for dendritic cell infection
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
CN110214025B (zh) 2016-08-29 2024-08-02 阿卡米斯生物公司 携带双特异性t细胞衔接器的腺病毒
AU2017345764A1 (en) 2016-10-20 2019-05-02 Alpine Immune Sciences, Inc. Secretable variant immunomodulatory proteins and engineered cell therapy
WO2018083259A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018083258A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding at least three transgenes
WO2018083257A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
JP7394628B2 (ja) * 2017-06-01 2023-12-08 アカミス バイオ リミテッド 腫瘍溶解性ウイルスおよび方法
GB201801614D0 (en) 2018-01-31 2018-03-14 Psioxus Therapeutics Ltd Formulation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000015823A1 (en) * 1998-09-11 2000-03-23 Genvec, Inc. Alternatively targeted adenovirus
WO2001053506A2 (en) * 2000-01-21 2001-07-26 Biovex Limited Virus strains for the oncolytic treatment of cancer
WO2005118825A2 (en) * 2004-05-26 2005-12-15 Schering Aktiengesellschaft Chimeric adenoviruses for use in cancer treatment
WO2015059303A1 (en) * 2013-10-25 2015-04-30 Psioxus Therapeutics Limited Oncolytic adenoviruses armed with heterologous genes

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHOI K-J ET AL: "Concurrent delivery of GM-CSF and B7-1 using an oncolytic adenovirus elicits potent antitumor effect.", GENE THERAPY, NATURE PUBLISHING GROUP, LONDON, GB, vol. 13, no. 13, 1 July 2006 (2006-07-01), GB, pages 1010 - 1020, XP002571567, ISSN: 0969-7128, DOI: 10.1038/sj.gt.3302759 *
HERMISTON TERRY W ET AL: "Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes.", CANCER GENE THERAPY, APPLETON & LANGE, NEW YORK, vol. 9, no. 12, 1 December 2002 (2002-12-01), New York, pages 1022 - 1035, XP002380640, ISSN: 0929-1903, DOI: 10.1038/sj.cgt.7700542 *
JIANG, W. CAI, R. YANG, G. CHEN, K. CHEN, Y. LIU, X. QIAN, C.: "The Controlled Transgene Expression in Oncolytic Adenoviral Vectors with Major Late Promoter for Therapy of Cancer", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 13, 1 January 2006 (2006-01-01), US, pages S251, XP005675760, ISSN: 1525-0016 *
P�TZER B M,ET AL: "Improved treatment of pancreatic cancer by IL-12 and B7.1 costimulation: antitumor efficacy and immunoregulation in a nonimmunogenic tumor model.", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 5, no. 4, 1 April 2002 (2002-04-01), US, pages 405 - 412, XP002421571, ISSN: 1525-0016, DOI: 10.1006/mthe.2002.0570 *
Z-B HU, C-T WU, H WANG, Q-W ZHANG, L WANG, R-L WANG, Z-Z LU, L-S WANG: "A simplified system for generating oncolytic adenovirus vector carrying one or two transgenes", CANCER GENE THERAPY, APPLETON & LANGE, vol. 15, no. 3, 1 March 2008 (2008-03-01), pages 173 - 182, XP055017566, ISSN: 09291903, DOI: 10.1038/sj.cgt.7701105 *

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