EA036586B1 - Способ количественного определения чистоты образцов с неразличимыми невооруженным глазом частицами - Google Patents
Способ количественного определения чистоты образцов с неразличимыми невооруженным глазом частицами Download PDFInfo
- Publication number
- EA036586B1 EA036586B1 EA201890740A EA201890740A EA036586B1 EA 036586 B1 EA036586 B1 EA 036586B1 EA 201890740 A EA201890740 A EA 201890740A EA 201890740 A EA201890740 A EA 201890740A EA 036586 B1 EA036586 B1 EA 036586B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- objects
- primary particles
- image
- particles
- sample
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 44
- 238000011002 quantification Methods 0.000 title abstract description 4
- 239000012906 subvisible particle Substances 0.000 title abstract 2
- 239000011164 primary particle Substances 0.000 claims abstract description 97
- 239000002245 particle Substances 0.000 claims description 41
- 230000003612 virological effect Effects 0.000 claims description 14
- 230000002708 enhancing effect Effects 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 5
- 230000007717 exclusion Effects 0.000 claims description 2
- 238000005728 strengthening Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims 1
- 238000000635 electron micrograph Methods 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 19
- 239000000356 contaminant Substances 0.000 description 9
- 239000003344 environmental pollutant Substances 0.000 description 6
- 231100000719 pollutant Toxicity 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 239000002872 contrast media Substances 0.000 description 5
- 230000003321 amplification Effects 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 238000009499 grossing Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000001493 electron microscopy Methods 0.000 description 2
- 239000010954 inorganic particle Substances 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000004627 transmission electron microscopy Methods 0.000 description 2
- 239000013603 viral vector Substances 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012067 mathematical method Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000011146 organic particle Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000012905 visible particle Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B21/00—Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant
- G01B21/28—Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant for measuring areas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B15/00—Measuring arrangements characterised by the use of electromagnetic waves or particle radiation, e.g. by the use of microwaves, X-rays, gamma rays or electrons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
- G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V10/00—Arrangements for image or video recognition or understanding
- G06V10/40—Extraction of image or video features
- G06V10/44—Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/698—Matching; Classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/601—Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0038—Investigating nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/103—Particle shape
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2223/00—Investigating materials by wave or particle radiation
- G01N2223/40—Imaging
- G01N2223/401—Imaging image processing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2223/00—Investigating materials by wave or particle radiation
- G01N2223/40—Imaging
- G01N2223/405—Imaging mapping of a material property
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Theoretical Computer Science (AREA)
- Multimedia (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Signal Processing (AREA)
- Electromagnetism (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Image Analysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402003P | 2016-09-30 | 2016-09-30 | |
| PCT/US2017/050962 WO2018063785A1 (en) | 2016-09-30 | 2017-09-11 | Method for quantification of purity of sub-visible particle samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201890740A1 EA201890740A1 (ru) | 2019-08-30 |
| EA036586B1 true EA036586B1 (ru) | 2020-11-26 |
Family
ID=61762953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201890740A EA036586B1 (ru) | 2016-09-30 | 2017-09-11 | Способ количественного определения чистоты образцов с неразличимыми невооруженным глазом частицами |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US10451566B2 (ko) |
| EP (1) | EP3349872B1 (ko) |
| JP (1) | JP6790091B2 (ko) |
| KR (1) | KR102176815B1 (ko) |
| CN (1) | CN109715259B (ko) |
| AU (1) | AU2017335569B2 (ko) |
| BR (1) | BR112018012570A2 (ko) |
| CA (1) | CA2997325C (ko) |
| CL (1) | CL2018002522A1 (ko) |
| DK (1) | DK3349872T3 (ko) |
| EA (1) | EA036586B1 (ko) |
| ES (1) | ES2774533T3 (ko) |
| HU (1) | HUE048000T2 (ko) |
| IL (1) | IL259279B (ko) |
| MA (1) | MA42888B1 (ko) |
| MX (1) | MX2018012349A (ko) |
| MY (1) | MY193420A (ko) |
| NZ (1) | NZ741498A (ko) |
| PL (1) | PL3349872T3 (ko) |
| PT (1) | PT3349872T (ko) |
| SA (1) | SA519401436B1 (ko) |
| SG (1) | SG11201805521XA (ko) |
| UA (1) | UA125437C2 (ko) |
| WO (1) | WO2018063785A1 (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3349872T (pt) * | 2016-09-30 | 2020-03-13 | Intelligent Virus Imaging Inc | Método para quantificação da pureza das amostras de partículas subvisíveis |
| KR102192033B1 (ko) * | 2019-03-05 | 2020-12-16 | 서울대학교산학협력단 | 전자현미경 이미지 분석 방법 |
| CN112697658A (zh) * | 2019-10-23 | 2021-04-23 | 中国石油化工股份有限公司 | 存储器、电子显微镜颗粒几何性质测定方法、设备和装置 |
| CN116563249A (zh) * | 2023-05-11 | 2023-08-08 | 中国食品药品检定研究院 | 一种眼内注射剂的亚可见颗粒质控方法、系统及设备 |
| CN116817804B (zh) * | 2023-08-24 | 2023-11-03 | 江苏集创原子团簇科技研究院有限公司 | 一种多层石墨烯中离子注入深度精确标定方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5917927A (en) * | 1997-03-21 | 1999-06-29 | Satake Corporation | Grain inspection and analysis apparatus and method |
| US20030072484A1 (en) * | 2001-09-17 | 2003-04-17 | Kokko Eric Gerard | Method and apparatus for identifying and quantifying characteristics of seeds and other small objects |
| US20120244524A1 (en) * | 2007-05-30 | 2012-09-27 | Mohammed Homman | Method for counting and segmenting viral particles in an image |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8805039B2 (en) * | 2005-10-12 | 2014-08-12 | Intelligent Virus Imaging Inc | Identification and classification of virus particles in textured electron micrographs |
| MX2009012265A (es) * | 2007-05-30 | 2009-12-01 | Intelligent Virus Imaging Inc | Un metodo para contar y segmentar particulas virales en una imagen. |
| SE532499C2 (sv) * | 2008-01-18 | 2010-02-09 | Hemocue Ab | Metod och apparat för analys av partiklar i ett vätskeformigt prov |
| JP2011095182A (ja) * | 2009-10-30 | 2011-05-12 | Sysmex Corp | 細胞分析装置及び細胞分析方法 |
| EP2335825A1 (en) * | 2009-12-21 | 2011-06-22 | F. Hoffmann-La Roche AG | Unit and device for the preparation of cells and/or particles in a liquid and method for microscopic analysis |
| US8339586B2 (en) * | 2011-04-15 | 2012-12-25 | Constitution Medical, Inc. | Measuring volume and constituents of cells |
| PT3349872T (pt) * | 2016-09-30 | 2020-03-13 | Intelligent Virus Imaging Inc | Método para quantificação da pureza das amostras de partículas subvisíveis |
-
2017
- 2017-09-11 PT PT178571816T patent/PT3349872T/pt unknown
- 2017-09-11 CN CN201780002461.4A patent/CN109715259B/zh active Active
- 2017-09-11 WO PCT/US2017/050962 patent/WO2018063785A1/en active Application Filing
- 2017-09-11 PL PL17857181T patent/PL3349872T3/pl unknown
- 2017-09-11 DK DK17857181.6T patent/DK3349872T3/da active
- 2017-09-11 JP JP2018521263A patent/JP6790091B2/ja active Active
- 2017-09-11 KR KR1020187017767A patent/KR102176815B1/ko active IP Right Grant
- 2017-09-11 BR BR112018012570-9A patent/BR112018012570A2/pt active Search and Examination
- 2017-09-11 AU AU2017335569A patent/AU2017335569B2/en active Active
- 2017-09-11 ES ES17857181T patent/ES2774533T3/es active Active
- 2017-09-11 US US16/068,232 patent/US10451566B2/en active Active
- 2017-09-11 MX MX2018012349A patent/MX2018012349A/es unknown
- 2017-09-11 MA MA42888A patent/MA42888B1/fr unknown
- 2017-09-11 EA EA201890740A patent/EA036586B1/ru not_active IP Right Cessation
- 2017-09-11 NZ NZ741498A patent/NZ741498A/en not_active IP Right Cessation
- 2017-09-11 HU HUE17857181A patent/HUE048000T2/hu unknown
- 2017-09-11 MY MYPI2018702479A patent/MY193420A/en unknown
- 2017-09-11 EP EP17857181.6A patent/EP3349872B1/en active Active
- 2017-09-11 UA UAA201901540A patent/UA125437C2/uk unknown
- 2017-09-11 CA CA2997325A patent/CA2997325C/en active Active
- 2017-09-11 SG SG11201805521XA patent/SG11201805521XA/en unknown
-
2018
- 2018-05-10 IL IL259279A patent/IL259279B/en unknown
- 2018-09-04 CL CL2018002522A patent/CL2018002522A1/es unknown
-
2019
- 2019-03-27 SA SA519401436A patent/SA519401436B1/ar unknown
- 2019-08-23 US US16/549,603 patent/US11002689B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5917927A (en) * | 1997-03-21 | 1999-06-29 | Satake Corporation | Grain inspection and analysis apparatus and method |
| US20030072484A1 (en) * | 2001-09-17 | 2003-04-17 | Kokko Eric Gerard | Method and apparatus for identifying and quantifying characteristics of seeds and other small objects |
| US20120244524A1 (en) * | 2007-05-30 | 2012-09-27 | Mohammed Homman | Method for counting and segmenting viral particles in an image |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA036586B1 (ru) | Способ количественного определения чистоты образцов с неразличимыми невооруженным глазом частицами | |
| TWI805857B (zh) | 用於特性化一樣品之系統及方法 | |
| US8831306B2 (en) | Flow type particle image analysis method and device | |
| JP2013526717A (ja) | マイクロプレートのウェル壁境界を識別するための方法及びシステム | |
| JP2012511906A (ja) | 多核細胞分類および微小核点数化 | |
| Wakaf et al. | Defect detection based on extreme edge of defective region histogram | |
| Boby et al. | Identification of defects on highly reflective ring components and analysis using machine vision | |
| Nguyen et al. | Cell splitting with high degree of overlapping in peripheral blood smear | |
| JP5525774B2 (ja) | 細胞画像解析装置 | |
| Nellros et al. | Automated image analysis of iron-ore pellet structure using optical microscopy | |
| JP6970112B2 (ja) | 概観画像をセグメント化することにより分散オブジェクトを検査するための方法 | |
| Schumacher et al. | THUNDER imagers: how do they really work | |
| Fan et al. | An automatic machine vision method for the flaw detection on car's body | |
| JP2006349431A (ja) | 画像処理方法および画像処理装置 | |
| CN115082379A (zh) | 一种活性污泥相差显微图像絮体和丝状菌分割方法 | |
| JP5434734B2 (ja) | 微粒子の明度識別方法 | |
| US8712140B2 (en) | Method of analyzing cell structures and their components | |
| DK201570249A1 (en) | Method and system for detection of fluid inclusion | |
| WO2023058456A1 (ja) | 検査装置 | |
| JP7265248B2 (ja) | 自動サンプル検出機能を有する顕微分光装置 | |
| Lee et al. | Counting Platelets: a Novel Image Analysis Algorithm for Detecting and Counting Platelet Adhesion on an Assay Pattern | |
| Gorman et al. | Rockwell Indentation Test for Evaluation of Adhesion of Coatings-aka Daimler-Benz adhesion test | |
| Belini et al. | Reducing costs of Giardia spp. cyst enumeration using machine learning-based systems | |
| von der Esch et al. | DECLARATION OF SCIENTIFIC CONTRIBUTION AND SUMMARY OF TUM-PARTICLETYPER: A DETECTION AND QUANTIFICATION TOOL FOR AUTOMATED ANALYSIS OF (MICROPLASTIC) PARTICLES AND FIBERS | |
| CN114998226A (zh) | 一种金属紧固件点蚀区域的缺陷评价方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |