MA42888B1 - Procédé de quantification de la pureté d'échantillons de particules sous-visibles - Google Patents
Procédé de quantification de la pureté d'échantillons de particules sous-visiblesInfo
- Publication number
- MA42888B1 MA42888B1 MA42888A MA42888A MA42888B1 MA 42888 B1 MA42888 B1 MA 42888B1 MA 42888 A MA42888 A MA 42888A MA 42888 A MA42888 A MA 42888A MA 42888 B1 MA42888 B1 MA 42888B1
- Authority
- MA
- Morocco
- Prior art keywords
- purity
- samples
- sub
- visible particles
- quantifying
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000012906 subvisible particle Substances 0.000 title abstract 2
- 239000011164 primary particle Substances 0.000 abstract 2
- 238000001493 electron microscopy Methods 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B21/00—Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant
- G01B21/28—Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant for measuring areas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B15/00—Measuring arrangements characterised by the use of electromagnetic waves or particle radiation, e.g. by the use of microwaves, X-rays, gamma rays or electrons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
- G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V10/00—Arrangements for image or video recognition or understanding
- G06V10/40—Extraction of image or video features
- G06V10/44—Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/698—Matching; Classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/601—Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0038—Investigating nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/103—Particle shape
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2223/00—Investigating materials by wave or particle radiation
- G01N2223/40—Imaging
- G01N2223/401—Imaging image processing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2223/00—Investigating materials by wave or particle radiation
- G01N2223/40—Imaging
- G01N2223/405—Imaging mapping of a material property
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Theoretical Computer Science (AREA)
- Multimedia (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Signal Processing (AREA)
- Electromagnetism (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Image Analysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Le procédé est destiné à la quantification de la pureté d'échantillons de particules sous-visibles. Un échantillon à analyser est placé dans un microscope électronique pour obtenir une image de microscopie électronique (100) de l'échantillon. L'échantillon contient des objets (114). Les objets (114) qui ont des tailles différentes d'une plage de tailles de particules primaires (120) et de tailles se situant dans la plage de tailles de particules primaires (120) sont améliorés. Les objets (114) sont détect
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662402003P | 2016-09-30 | 2016-09-30 | |
PCT/US2017/050962 WO2018063785A1 (fr) | 2016-09-30 | 2017-09-11 | Procédé de quantification de la pureté d'échantillons de particules sous-visibles |
Publications (2)
Publication Number | Publication Date |
---|---|
MA42888A1 MA42888A1 (fr) | 2018-11-30 |
MA42888B1 true MA42888B1 (fr) | 2020-03-31 |
Family
ID=61762953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA42888A MA42888B1 (fr) | 2016-09-30 | 2017-09-11 | Procédé de quantification de la pureté d'échantillons de particules sous-visibles |
Country Status (24)
Country | Link |
---|---|
US (2) | US10451566B2 (fr) |
EP (1) | EP3349872B1 (fr) |
JP (1) | JP6790091B2 (fr) |
KR (1) | KR102176815B1 (fr) |
CN (1) | CN109715259B (fr) |
AU (1) | AU2017335569B2 (fr) |
BR (1) | BR112018012570A2 (fr) |
CA (1) | CA2997325C (fr) |
CL (1) | CL2018002522A1 (fr) |
DK (1) | DK3349872T3 (fr) |
EA (1) | EA036586B1 (fr) |
ES (1) | ES2774533T3 (fr) |
HU (1) | HUE048000T2 (fr) |
IL (1) | IL259279B (fr) |
MA (1) | MA42888B1 (fr) |
MX (1) | MX2018012349A (fr) |
MY (1) | MY193420A (fr) |
NZ (1) | NZ741498A (fr) |
PL (1) | PL3349872T3 (fr) |
PT (1) | PT3349872T (fr) |
SA (1) | SA519401436B1 (fr) |
SG (1) | SG11201805521XA (fr) |
UA (1) | UA125437C2 (fr) |
WO (1) | WO2018063785A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201805521XA (en) * | 2016-09-30 | 2018-07-30 | Intelligent Virus Imaging Inc | Method for quantification of purity of sub-visible particle samples |
KR102192033B1 (ko) * | 2019-03-05 | 2020-12-16 | 서울대학교산학협력단 | 전자현미경 이미지 분석 방법 |
CN112697658B (zh) * | 2019-10-23 | 2024-09-10 | 中国石油化工股份有限公司 | 存储器、电子显微镜颗粒几何性质测定方法、设备和装置 |
CN116563249A (zh) * | 2023-05-11 | 2023-08-08 | 中国食品药品检定研究院 | 一种眼内注射剂的亚可见颗粒质控方法、系统及设备 |
CN116817804B (zh) * | 2023-08-24 | 2023-11-03 | 江苏集创原子团簇科技研究院有限公司 | 一种多层石墨烯中离子注入深度精确标定方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5917927A (en) * | 1997-03-21 | 1999-06-29 | Satake Corporation | Grain inspection and analysis apparatus and method |
GB2397423B (en) * | 2001-09-17 | 2005-06-01 | Ca Minister Agriculture & Food | A method and apparatus for identifying and quantifying characteristics of seeds and other small objects |
US8805039B2 (en) * | 2005-10-12 | 2014-08-12 | Intelligent Virus Imaging Inc | Identification and classification of virus particles in textured electron micrographs |
DK2149105T3 (da) * | 2007-05-30 | 2021-02-01 | Intelligent Virus Imaging Inc | Fremgangsmåde til optælling og segmentering af viruspartikler i et billede |
US8712141B2 (en) * | 2007-05-30 | 2014-04-29 | Intelligent Virus Imagaing Inc. | Method for counting and segmenting viral particles in an image |
SE532499C2 (sv) * | 2008-01-18 | 2010-02-09 | Hemocue Ab | Metod och apparat för analys av partiklar i ett vätskeformigt prov |
JP2011095182A (ja) * | 2009-10-30 | 2011-05-12 | Sysmex Corp | 細胞分析装置及び細胞分析方法 |
EP2335825A1 (fr) * | 2009-12-21 | 2011-06-22 | F. Hoffmann-La Roche AG | Unité et dispositif pour la préparation de cellules et/ou de particules dans un liquide et procédé d'analyse microscopique |
CN107402178B (zh) * | 2011-04-15 | 2020-05-05 | 罗氏血液诊断股份有限公司 | 测量细胞体积和成份 |
SG11201805521XA (en) * | 2016-09-30 | 2018-07-30 | Intelligent Virus Imaging Inc | Method for quantification of purity of sub-visible particle samples |
-
2017
- 2017-09-11 SG SG11201805521XA patent/SG11201805521XA/en unknown
- 2017-09-11 CN CN201780002461.4A patent/CN109715259B/zh active Active
- 2017-09-11 DK DK17857181.6T patent/DK3349872T3/da active
- 2017-09-11 MX MX2018012349A patent/MX2018012349A/es unknown
- 2017-09-11 MA MA42888A patent/MA42888B1/fr unknown
- 2017-09-11 KR KR1020187017767A patent/KR102176815B1/ko active IP Right Grant
- 2017-09-11 CA CA2997325A patent/CA2997325C/fr active Active
- 2017-09-11 MY MYPI2018702479A patent/MY193420A/en unknown
- 2017-09-11 EP EP17857181.6A patent/EP3349872B1/fr active Active
- 2017-09-11 AU AU2017335569A patent/AU2017335569B2/en active Active
- 2017-09-11 US US16/068,232 patent/US10451566B2/en active Active
- 2017-09-11 UA UAA201901540A patent/UA125437C2/uk unknown
- 2017-09-11 JP JP2018521263A patent/JP6790091B2/ja active Active
- 2017-09-11 EA EA201890740A patent/EA036586B1/ru not_active IP Right Cessation
- 2017-09-11 ES ES17857181T patent/ES2774533T3/es active Active
- 2017-09-11 PT PT178571816T patent/PT3349872T/pt unknown
- 2017-09-11 WO PCT/US2017/050962 patent/WO2018063785A1/fr active Application Filing
- 2017-09-11 PL PL17857181T patent/PL3349872T3/pl unknown
- 2017-09-11 NZ NZ741498A patent/NZ741498A/en not_active IP Right Cessation
- 2017-09-11 HU HUE17857181A patent/HUE048000T2/hu unknown
- 2017-09-11 BR BR112018012570-9A patent/BR112018012570A2/pt active Search and Examination
-
2018
- 2018-05-10 IL IL259279A patent/IL259279B/en unknown
- 2018-09-04 CL CL2018002522A patent/CL2018002522A1/es unknown
-
2019
- 2019-03-27 SA SA519401436A patent/SA519401436B1/ar unknown
- 2019-08-23 US US16/549,603 patent/US11002689B2/en active Active
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