MA42888B1 - Procédé de quantification de la pureté d'échantillons de particules sous-visibles - Google Patents

Procédé de quantification de la pureté d'échantillons de particules sous-visibles

Info

Publication number
MA42888B1
MA42888B1 MA42888A MA42888A MA42888B1 MA 42888 B1 MA42888 B1 MA 42888B1 MA 42888 A MA42888 A MA 42888A MA 42888 A MA42888 A MA 42888A MA 42888 B1 MA42888 B1 MA 42888B1
Authority
MA
Morocco
Prior art keywords
purity
samples
sub
visible particles
quantifying
Prior art date
Application number
MA42888A
Other languages
English (en)
Other versions
MA42888A1 (fr
Inventor
Ida-Maria Sintorn
Gustaf Kylberg
Martin Ryner
Josefina Nilsson
Original Assignee
Intelligent Virus Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intelligent Virus Imaging Inc filed Critical Intelligent Virus Imaging Inc
Publication of MA42888A1 publication Critical patent/MA42888A1/fr
Publication of MA42888B1 publication Critical patent/MA42888B1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B21/00—Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant
    • G01B21/28—Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant for measuring areas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B15/00—Measuring arrangements characterised by the use of electromagnetic waves or particle radiation, e.g. by the use of microwaves, X-rays, gamma rays or electrons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
    • G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features
    • G06V10/44—Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/601—Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/103—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/40—Imaging
    • G01N2223/401—Imaging image processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/40—Imaging
    • G01N2223/405—Imaging mapping of a material property

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Multimedia (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Signal Processing (AREA)
  • Electromagnetism (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Image Analysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Le procédé est destiné à la quantification de la pureté d'échantillons de particules sous-visibles. Un échantillon à analyser est placé dans un microscope électronique pour obtenir une image de microscopie électronique (100) de l'échantillon. L'échantillon contient des objets (114). Les objets (114) qui ont des tailles différentes d'une plage de tailles de particules primaires (120) et de tailles se situant dans la plage de tailles de particules primaires (120) sont améliorés. Les objets (114) sont détect
MA42888A 2016-09-30 2017-09-11 Procédé de quantification de la pureté d'échantillons de particules sous-visibles MA42888B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662402003P 2016-09-30 2016-09-30
PCT/US2017/050962 WO2018063785A1 (fr) 2016-09-30 2017-09-11 Procédé de quantification de la pureté d'échantillons de particules sous-visibles

Publications (2)

Publication Number Publication Date
MA42888A1 MA42888A1 (fr) 2018-11-30
MA42888B1 true MA42888B1 (fr) 2020-03-31

Family

ID=61762953

Family Applications (1)

Application Number Title Priority Date Filing Date
MA42888A MA42888B1 (fr) 2016-09-30 2017-09-11 Procédé de quantification de la pureté d'échantillons de particules sous-visibles

Country Status (24)

Country Link
US (2) US10451566B2 (fr)
EP (1) EP3349872B1 (fr)
JP (1) JP6790091B2 (fr)
KR (1) KR102176815B1 (fr)
CN (1) CN109715259B (fr)
AU (1) AU2017335569B2 (fr)
BR (1) BR112018012570A2 (fr)
CA (1) CA2997325C (fr)
CL (1) CL2018002522A1 (fr)
DK (1) DK3349872T3 (fr)
EA (1) EA036586B1 (fr)
ES (1) ES2774533T3 (fr)
HU (1) HUE048000T2 (fr)
IL (1) IL259279B (fr)
MA (1) MA42888B1 (fr)
MX (1) MX2018012349A (fr)
MY (1) MY193420A (fr)
NZ (1) NZ741498A (fr)
PL (1) PL3349872T3 (fr)
PT (1) PT3349872T (fr)
SA (1) SA519401436B1 (fr)
SG (1) SG11201805521XA (fr)
UA (1) UA125437C2 (fr)
WO (1) WO2018063785A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201805521XA (en) * 2016-09-30 2018-07-30 Intelligent Virus Imaging Inc Method for quantification of purity of sub-visible particle samples
KR102192033B1 (ko) * 2019-03-05 2020-12-16 서울대학교산학협력단 전자현미경 이미지 분석 방법
CN112697658B (zh) * 2019-10-23 2024-09-10 中国石油化工股份有限公司 存储器、电子显微镜颗粒几何性质测定方法、设备和装置
CN116563249A (zh) * 2023-05-11 2023-08-08 中国食品药品检定研究院 一种眼内注射剂的亚可见颗粒质控方法、系统及设备
CN116817804B (zh) * 2023-08-24 2023-11-03 江苏集创原子团簇科技研究院有限公司 一种多层石墨烯中离子注入深度精确标定方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5917927A (en) * 1997-03-21 1999-06-29 Satake Corporation Grain inspection and analysis apparatus and method
GB2397423B (en) * 2001-09-17 2005-06-01 Ca Minister Agriculture & Food A method and apparatus for identifying and quantifying characteristics of seeds and other small objects
US8805039B2 (en) * 2005-10-12 2014-08-12 Intelligent Virus Imaging Inc Identification and classification of virus particles in textured electron micrographs
DK2149105T3 (da) * 2007-05-30 2021-02-01 Intelligent Virus Imaging Inc Fremgangsmåde til optælling og segmentering af viruspartikler i et billede
US8712141B2 (en) * 2007-05-30 2014-04-29 Intelligent Virus Imagaing Inc. Method for counting and segmenting viral particles in an image
SE532499C2 (sv) * 2008-01-18 2010-02-09 Hemocue Ab Metod och apparat för analys av partiklar i ett vätskeformigt prov
JP2011095182A (ja) * 2009-10-30 2011-05-12 Sysmex Corp 細胞分析装置及び細胞分析方法
EP2335825A1 (fr) * 2009-12-21 2011-06-22 F. Hoffmann-La Roche AG Unité et dispositif pour la préparation de cellules et/ou de particules dans un liquide et procédé d'analyse microscopique
CN107402178B (zh) * 2011-04-15 2020-05-05 罗氏血液诊断股份有限公司 测量细胞体积和成份
SG11201805521XA (en) * 2016-09-30 2018-07-30 Intelligent Virus Imaging Inc Method for quantification of purity of sub-visible particle samples

Also Published As

Publication number Publication date
MX2018012349A (es) 2018-12-17
SG11201805521XA (en) 2018-07-30
SA519401436B1 (ar) 2022-01-10
PT3349872T (pt) 2020-03-13
PL3349872T3 (pl) 2020-06-15
US10451566B2 (en) 2019-10-22
EP3349872A1 (fr) 2018-07-25
US20190376910A1 (en) 2019-12-12
US11002689B2 (en) 2021-05-11
UA125437C2 (uk) 2022-03-09
EP3349872B1 (fr) 2019-12-11
JP2019532253A (ja) 2019-11-07
ES2774533T3 (es) 2020-07-21
KR20190039464A (ko) 2019-04-12
EA036586B1 (ru) 2020-11-26
EP3349872A4 (fr) 2019-06-26
KR102176815B1 (ko) 2020-11-10
CN109715259A (zh) 2019-05-03
NZ741498A (en) 2020-03-27
MY193420A (en) 2022-10-12
MA42888A1 (fr) 2018-11-30
DK3349872T3 (da) 2020-03-16
CA2997325A1 (fr) 2018-03-30
AU2017335569A1 (en) 2018-05-10
IL259279A (en) 2018-07-31
EA201890740A1 (ru) 2019-08-30
IL259279B (en) 2021-10-31
CN109715259B (zh) 2021-02-26
WO2018063785A1 (fr) 2018-04-05
CA2997325C (fr) 2023-03-28
US20190011378A1 (en) 2019-01-10
BR112018012570A2 (pt) 2018-12-04
HUE048000T2 (hu) 2020-05-28
CL2018002522A1 (es) 2018-11-30
JP6790091B2 (ja) 2020-11-25
AU2017335569B2 (en) 2019-11-21

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