SA519401436B1 - طريقة للتحديد الكمي لنقاء عينات من جسيمات دون المرئية - Google Patents
طريقة للتحديد الكمي لنقاء عينات من جسيمات دون المرئيةInfo
- Publication number
- SA519401436B1 SA519401436B1 SA519401436A SA519401436A SA519401436B1 SA 519401436 B1 SA519401436 B1 SA 519401436B1 SA 519401436 A SA519401436 A SA 519401436A SA 519401436 A SA519401436 A SA 519401436A SA 519401436 B1 SA519401436 B1 SA 519401436B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- primary particles
- objects
- detected
- quantification
- purity
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000011002 quantification Methods 0.000 title abstract 2
- 239000012906 subvisible particle Substances 0.000 title abstract 2
- 239000011164 primary particle Substances 0.000 abstract 6
- 238000000635 electron micrograph Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B21/00—Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant
- G01B21/28—Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant for measuring areas
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B15/00—Measuring arrangements characterised by the use of electromagnetic waves or particle radiation, e.g. by the use of microwaves, X-rays, gamma rays or electrons
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
- G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V10/00—Arrangements for image or video recognition or understanding
- G06V10/40—Extraction of image or video features
- G06V10/44—Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/698—Matching; Classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/601—Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0038—Investigating nanoparticles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/103—Particle shape
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2223/00—Investigating materials by wave or particle radiation
- G01N2223/40—Imaging
- G01N2223/401—Imaging image processing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2223/00—Investigating materials by wave or particle radiation
- G01N2223/40—Imaging
- G01N2223/405—Imaging mapping of a material property
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Theoretical Computer Science (AREA)
- Multimedia (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Signal Processing (AREA)
- Electromagnetism (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Image Analysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
يتعلق الاختراع الحالي بطريقة للتحديد الكمي لنقاء عينات من جسيم غير مرئي. يتم وضع العينة المطلوب تحليلها في ميكروسكوب إلكتروني للحصول على صورة الفحص المجهري الإلكتروني (100) للعينة. تحتوي العينة على أجسام (114). بحيث يتم تحسين الأجسام (114) التي لها أحجام مختلفة عن مدى حجم الجسيمات الأولية (120) وأحجام تكون في مدى حجم الجسيمات الأولية (120). يتم كشف الأجسام (114) بوصفها جسيمات أولية (120) أو بقايا (106). يتم استبعاد الجسيمات الأولية المكتشفة (120) من الأجسام (114) بحيث تحتوي الأجسام (114) على بقايا (106) ولكن ليس جسيمات أولية (120). يتم قياس مساحة كلية أولى (T1) من البقايا المكتشفة (106). ويتم قياس مساحة كلية ثانية (T2) للجسيمات الأولية المكتشفة (120). شكل 7.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662402003P | 2016-09-30 | 2016-09-30 | |
PCT/US2017/050962 WO2018063785A1 (en) | 2016-09-30 | 2017-09-11 | Method for quantification of purity of sub-visible particle samples |
Publications (1)
Publication Number | Publication Date |
---|---|
SA519401436B1 true SA519401436B1 (ar) | 2022-01-10 |
Family
ID=61762953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA519401436A SA519401436B1 (ar) | 2016-09-30 | 2019-03-27 | طريقة للتحديد الكمي لنقاء عينات من جسيمات دون المرئية |
Country Status (24)
Country | Link |
---|---|
US (2) | US10451566B2 (ar) |
EP (1) | EP3349872B1 (ar) |
JP (1) | JP6790091B2 (ar) |
KR (1) | KR102176815B1 (ar) |
CN (1) | CN109715259B (ar) |
AU (1) | AU2017335569B2 (ar) |
BR (1) | BR112018012570A2 (ar) |
CA (1) | CA2997325C (ar) |
CL (1) | CL2018002522A1 (ar) |
DK (1) | DK3349872T3 (ar) |
EA (1) | EA036586B1 (ar) |
ES (1) | ES2774533T3 (ar) |
HU (1) | HUE048000T2 (ar) |
IL (1) | IL259279B (ar) |
MA (1) | MA42888B1 (ar) |
MX (1) | MX2018012349A (ar) |
MY (1) | MY193420A (ar) |
NZ (1) | NZ741498A (ar) |
PL (1) | PL3349872T3 (ar) |
PT (1) | PT3349872T (ar) |
SA (1) | SA519401436B1 (ar) |
SG (1) | SG11201805521XA (ar) |
UA (1) | UA125437C2 (ar) |
WO (1) | WO2018063785A1 (ar) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3349872T (pt) * | 2016-09-30 | 2020-03-13 | Intelligent Virus Imaging Inc | Método para quantificação da pureza das amostras de partículas subvisíveis |
KR102192033B1 (ko) * | 2019-03-05 | 2020-12-16 | 서울대학교산학협력단 | 전자현미경 이미지 분석 방법 |
CN112697658A (zh) * | 2019-10-23 | 2021-04-23 | 中国石油化工股份有限公司 | 存储器、电子显微镜颗粒几何性质测定方法、设备和装置 |
CN116563249A (zh) * | 2023-05-11 | 2023-08-08 | 中国食品药品检定研究院 | 一种眼内注射剂的亚可见颗粒质控方法、系统及设备 |
CN116817804B (zh) * | 2023-08-24 | 2023-11-03 | 江苏集创原子团簇科技研究院有限公司 | 一种多层石墨烯中离子注入深度精确标定方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5917927A (en) * | 1997-03-21 | 1999-06-29 | Satake Corporation | Grain inspection and analysis apparatus and method |
WO2003025858A2 (en) * | 2001-09-17 | 2003-03-27 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food | Method for identifying and quantifying characteristics of seeds and other small objects |
US8805039B2 (en) * | 2005-10-12 | 2014-08-12 | Intelligent Virus Imaging Inc | Identification and classification of virus particles in textured electron micrographs |
US8712141B2 (en) * | 2007-05-30 | 2014-04-29 | Intelligent Virus Imagaing Inc. | Method for counting and segmenting viral particles in an image |
MX2009012265A (es) * | 2007-05-30 | 2009-12-01 | Intelligent Virus Imaging Inc | Un metodo para contar y segmentar particulas virales en una imagen. |
SE532499C2 (sv) * | 2008-01-18 | 2010-02-09 | Hemocue Ab | Metod och apparat för analys av partiklar i ett vätskeformigt prov |
JP2011095182A (ja) * | 2009-10-30 | 2011-05-12 | Sysmex Corp | 細胞分析装置及び細胞分析方法 |
EP2335825A1 (en) * | 2009-12-21 | 2011-06-22 | F. Hoffmann-La Roche AG | Unit and device for the preparation of cells and/or particles in a liquid and method for microscopic analysis |
US8339586B2 (en) * | 2011-04-15 | 2012-12-25 | Constitution Medical, Inc. | Measuring volume and constituents of cells |
PT3349872T (pt) * | 2016-09-30 | 2020-03-13 | Intelligent Virus Imaging Inc | Método para quantificação da pureza das amostras de partículas subvisíveis |
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2017
- 2017-09-11 PT PT178571816T patent/PT3349872T/pt unknown
- 2017-09-11 CN CN201780002461.4A patent/CN109715259B/zh active Active
- 2017-09-11 WO PCT/US2017/050962 patent/WO2018063785A1/en active Application Filing
- 2017-09-11 PL PL17857181T patent/PL3349872T3/pl unknown
- 2017-09-11 DK DK17857181.6T patent/DK3349872T3/da active
- 2017-09-11 JP JP2018521263A patent/JP6790091B2/ja active Active
- 2017-09-11 KR KR1020187017767A patent/KR102176815B1/ko active IP Right Grant
- 2017-09-11 BR BR112018012570-9A patent/BR112018012570A2/pt active Search and Examination
- 2017-09-11 AU AU2017335569A patent/AU2017335569B2/en active Active
- 2017-09-11 ES ES17857181T patent/ES2774533T3/es active Active
- 2017-09-11 US US16/068,232 patent/US10451566B2/en active Active
- 2017-09-11 MX MX2018012349A patent/MX2018012349A/es unknown
- 2017-09-11 MA MA42888A patent/MA42888B1/fr unknown
- 2017-09-11 EA EA201890740A patent/EA036586B1/ru not_active IP Right Cessation
- 2017-09-11 NZ NZ741498A patent/NZ741498A/en not_active IP Right Cessation
- 2017-09-11 HU HUE17857181A patent/HUE048000T2/hu unknown
- 2017-09-11 MY MYPI2018702479A patent/MY193420A/en unknown
- 2017-09-11 EP EP17857181.6A patent/EP3349872B1/en active Active
- 2017-09-11 UA UAA201901540A patent/UA125437C2/uk unknown
- 2017-09-11 CA CA2997325A patent/CA2997325C/en active Active
- 2017-09-11 SG SG11201805521XA patent/SG11201805521XA/en unknown
-
2018
- 2018-05-10 IL IL259279A patent/IL259279B/en unknown
- 2018-09-04 CL CL2018002522A patent/CL2018002522A1/es unknown
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2019
- 2019-03-27 SA SA519401436A patent/SA519401436B1/ar unknown
- 2019-08-23 US US16/549,603 patent/US11002689B2/en active Active
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