EA035625B1 - Новые соединения и конъюгаты криптофицина, их получение и их терапевтическое применение - Google Patents

Новые соединения и конъюгаты криптофицина, их получение и их терапевтическое применение Download PDF

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Publication number
EA035625B1
EA035625B1 EA201890898A EA201890898A EA035625B1 EA 035625 B1 EA035625 B1 EA 035625B1 EA 201890898 A EA201890898 A EA 201890898A EA 201890898 A EA201890898 A EA 201890898A EA 035625 B1 EA035625 B1 EA 035625B1
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EA
Eurasian Patent Office
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group
formula
reaction
alk
stage
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EA201890898A
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English (en)
Russian (ru)
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EA201890898A1 (ru
Inventor
Антони Биго
Эрве Бушар
Мари-Присцилл Брэн
Франсуа Клер
Цзидун Чжан
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Санофи
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Publication of EA201890898A1 publication Critical patent/EA201890898A1/ru
Publication of EA035625B1 publication Critical patent/EA035625B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Bedding Items (AREA)
EA201890898A 2015-11-05 2016-11-03 Новые соединения и конъюгаты криптофицина, их получение и их терапевтическое применение EA035625B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15306751 2015-11-05
PCT/EP2016/076603 WO2017076998A1 (en) 2015-11-05 2016-11-03 Novel cryptophycin compounds and conjugates, their preparation and their therapeutic use

Publications (2)

Publication Number Publication Date
EA201890898A1 EA201890898A1 (ru) 2018-10-31
EA035625B1 true EA035625B1 (ru) 2020-07-17

Family

ID=54476881

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890898A EA035625B1 (ru) 2015-11-05 2016-11-03 Новые соединения и конъюгаты криптофицина, их получение и их терапевтическое применение

Country Status (35)

Country Link
US (2) US10941139B2 (enExample)
EP (1) EP3371179B1 (enExample)
JP (1) JP6929292B2 (enExample)
KR (1) KR102822076B1 (enExample)
CN (1) CN108349960B (enExample)
AR (1) AR106604A1 (enExample)
AU (1) AU2016347724B2 (enExample)
CA (1) CA3003085A1 (enExample)
CL (1) CL2018001210A1 (enExample)
CO (1) CO2018004581A2 (enExample)
CR (1) CR20180256A (enExample)
CY (1) CY1122441T1 (enExample)
DK (1) DK3371179T3 (enExample)
EA (1) EA035625B1 (enExample)
EC (1) ECSP18034035A (enExample)
ES (1) ES2755101T3 (enExample)
HK (1) HK1256754B (enExample)
HR (1) HRP20191729T1 (enExample)
HU (1) HUE046033T2 (enExample)
IL (1) IL259067B (enExample)
LT (1) LT3371179T (enExample)
MA (1) MA43160B1 (enExample)
MX (1) MX374535B (enExample)
MY (1) MY189448A (enExample)
PH (1) PH12018500852B1 (enExample)
PL (1) PL3371179T3 (enExample)
PT (1) PT3371179T (enExample)
RS (1) RS59498B1 (enExample)
SG (1) SG11201803181SA (enExample)
SI (1) SI3371179T1 (enExample)
TN (1) TN2018000131A1 (enExample)
TW (1) TWI714661B (enExample)
UY (1) UY36979A (enExample)
WO (1) WO2017076998A1 (enExample)
ZA (1) ZA201802322B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI714661B (zh) 2015-11-05 2021-01-01 法商賽諾菲公司 新穎念珠藻素化合物及接合物、其製備與其治療用途
CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
TN2019000303A1 (en) 2017-05-10 2021-05-07 Sanofi Sa Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation
CN108107103B (zh) * 2017-12-14 2020-10-16 华中师范大学 谷氨酸受体的质谱探针及其在脑组织中的空间分布规律检测方法
ES2988904T3 (es) 2019-03-07 2024-11-22 Nobo Medicine Inc Inhibidores de caspasa y métodos de utilización de los mismos
JP2022549971A (ja) 2019-09-30 2022-11-29 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン クリプトフィシン抗がん剤の生体触媒合成
EP4046996A1 (en) 2021-02-19 2022-08-24 Universität Bielefeld Cryptophycin compounds and conjugates thereof
CN118742328A (zh) 2022-02-22 2024-10-01 阿拉里斯生物技术股份公司 包含两个或更多个有效载荷的肽接头
EP4495105A1 (en) 2023-07-17 2025-01-22 Basf Se 3-(4-hydroxybut-2-ynoxy)propanoic acid ester, amide and nitrile derivatives as corrosion protection agents
EP4495108A1 (en) 2023-07-17 2025-01-22 Basf Se 3-[2-(2-oxo-1,3-dioxolan-4-ylidene)ethoxy]propanoic acid derivatives as precursors of monomers in polymerisations
WO2025082990A1 (en) 2023-10-15 2025-04-24 Araris Biotech Ag Antibody-drug conjugates using two different types of topoisomerase i inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020128185A1 (en) * 1998-02-25 2002-09-12 Chuan Shih Pharmaceutical compounds
WO2011001052A1 (fr) * 2009-06-29 2011-01-06 Sanofi-Aventis Nouveaux conjugues, leur preparation et leur application en therapeutique

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0735819B1 (en) * 1993-12-21 2001-07-11 University Of Hawaii Cryptophycins
US7230101B1 (en) 2002-08-28 2007-06-12 Gpc Biotech, Inc. Synthesis of methotrexate-containing heterodimeric molecules
US20050175619A1 (en) 2004-02-05 2005-08-11 Robert Duffy Methods of producing antibody conjugates
EP2010475A2 (en) 2006-04-27 2009-01-07 Intezyne Technologies Incorporated Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof
CN101622276B (zh) 2006-07-18 2015-04-22 赛诺菲-安万特 用于治疗癌症的抗epha2的拮抗抗体
TW201116297A (en) 2009-10-02 2011-05-16 Sanofi Aventis Antibodies that specifically bind to the EphA2 receptor
TWI714661B (zh) * 2015-11-05 2021-01-01 法商賽諾菲公司 新穎念珠藻素化合物及接合物、其製備與其治療用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020128185A1 (en) * 1998-02-25 2002-09-12 Chuan Shih Pharmaceutical compounds
WO2011001052A1 (fr) * 2009-06-29 2011-01-06 Sanofi-Aventis Nouveaux conjugues, leur preparation et leur application en therapeutique

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KOTOKU, N. ; KATO, T. ; NARUMI, F. ; OHTANI, E. ; KAMADA, S. ; AOKI, S. ; OKADA, N. ; NAKAGAWA, S. ; KOBAYASHI, M.: "Synthesis of 15,20-triamide analogue with polar substituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, NL, vol. 14, no. 22, 15 November 2006 (2006-11-15), NL, pages 7446 - 7457, XP027992176, ISSN: 0968-0896 *
MCCOMBS JESSICA R.; OWEN SHAWN C.: "Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry", THE AAPS JOURNAL, SPRINGER US, BOSTON, vol. 17, no. 2, 22 January 2015 (2015-01-22), Boston, pages 339 - 351, XP035473697, DOI: 10.1208/s12248-014-9710-8 *
VISHAL A. VERMA, THOMAS H. PILLOW, LAURA DEPALATIS, GUANGMIN LI, GAIL LEWIS PHILLIPS, ANDREW G. POLSON, HELGA E. RAAB, SUSAN SPENC: "The cryptophycins as potent payloads for antibody drug conjugates", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, vol. 25, no. 4, 1 February 2015 (2015-02-01), pages 864 - 868, XP055212909, ISSN: 0960894X, DOI: 10.1016/j.bmcl.2014.12.070 *

Also Published As

Publication number Publication date
US10941139B2 (en) 2021-03-09
US20210163458A1 (en) 2021-06-03
DK3371179T3 (da) 2019-11-11
IL259067A (en) 2018-06-28
SG11201803181SA (en) 2018-05-30
KR20180073678A (ko) 2018-07-02
CN108349960B (zh) 2022-05-27
CL2018001210A1 (es) 2018-08-17
EP3371179A1 (en) 2018-09-12
UY36979A (es) 2017-06-30
TN2018000131A1 (en) 2019-10-04
CO2018004581A2 (es) 2018-07-19
TW201730164A (zh) 2017-09-01
IL259067B (en) 2021-07-29
ZA201802322B (en) 2019-01-30
MX2018005379A (es) 2018-09-05
PH12018500852A1 (en) 2018-10-29
JP2018535255A (ja) 2018-11-29
PH12018500852B1 (en) 2021-08-11
TWI714661B (zh) 2021-01-01
LT3371179T (lt) 2019-11-11
BR112018008490A2 (pt) 2019-02-12
SI3371179T1 (sl) 2019-11-29
EA201890898A1 (ru) 2018-10-31
ECSP18034035A (es) 2018-05-31
AR106604A1 (es) 2018-01-31
MX374535B (es) 2025-03-06
AU2016347724A1 (en) 2018-05-10
HK1256754B (en) 2020-06-05
EP3371179B1 (en) 2019-08-07
CY1122441T1 (el) 2021-01-27
MA43160B1 (fr) 2019-12-31
NZ741734A (en) 2023-10-27
PL3371179T3 (pl) 2020-02-28
CA3003085A1 (en) 2017-05-11
HUE046033T2 (hu) 2020-01-28
KR102822076B1 (ko) 2025-06-18
HRP20191729T1 (hr) 2019-12-13
US20190382391A1 (en) 2019-12-19
CN108349960A (zh) 2018-07-31
JP6929292B2 (ja) 2021-09-01
WO2017076998A1 (en) 2017-05-11
AU2016347724B2 (en) 2021-04-01
RS59498B1 (sr) 2019-12-31
CR20180256A (es) 2018-08-13
PT3371179T (pt) 2019-11-18
MY189448A (en) 2022-02-14
ES2755101T3 (es) 2020-04-21

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