LT3371179T - Nauji kriptoficino junginiai ir konjugatai, jų gavimas ir terapinis panaudojimas - Google Patents
Nauji kriptoficino junginiai ir konjugatai, jų gavimas ir terapinis panaudojimasInfo
- Publication number
- LT3371179T LT3371179T LT16791017T LT16791017T LT3371179T LT 3371179 T LT3371179 T LT 3371179T LT 16791017 T LT16791017 T LT 16791017T LT 16791017 T LT16791017 T LT 16791017T LT 3371179 T LT3371179 T LT 3371179T
- Authority
- LT
- Lithuania
- Prior art keywords
- conjugates
- preparation
- therapeutic use
- cryptophycin compounds
- novel cryptophycin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15306751 | 2015-11-05 | ||
PCT/EP2016/076603 WO2017076998A1 (en) | 2015-11-05 | 2016-11-03 | Novel cryptophycin compounds and conjugates, their preparation and their therapeutic use |
Publications (1)
Publication Number | Publication Date |
---|---|
LT3371179T true LT3371179T (lt) | 2019-11-11 |
Family
ID=54476881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT16791017T LT3371179T (lt) | 2015-11-05 | 2016-11-03 | Nauji kriptoficino junginiai ir konjugatai, jų gavimas ir terapinis panaudojimas |
Country Status (35)
Country | Link |
---|---|
US (2) | US10941139B2 (lt) |
EP (1) | EP3371179B1 (lt) |
JP (1) | JP6929292B2 (lt) |
KR (1) | KR20180073678A (lt) |
CN (1) | CN108349960B (lt) |
AR (1) | AR106604A1 (lt) |
AU (1) | AU2016347724B2 (lt) |
CA (1) | CA3003085A1 (lt) |
CL (1) | CL2018001210A1 (lt) |
CO (1) | CO2018004581A2 (lt) |
CR (1) | CR20180256A (lt) |
CY (1) | CY1122441T1 (lt) |
DK (1) | DK3371179T3 (lt) |
EA (1) | EA035625B1 (lt) |
EC (1) | ECSP18034035A (lt) |
ES (1) | ES2755101T3 (lt) |
HK (1) | HK1256754B (lt) |
HR (1) | HRP20191729T1 (lt) |
HU (1) | HUE046033T2 (lt) |
IL (1) | IL259067B (lt) |
LT (1) | LT3371179T (lt) |
MA (1) | MA43160B1 (lt) |
MX (1) | MX2018005379A (lt) |
MY (1) | MY189448A (lt) |
PH (1) | PH12018500852A1 (lt) |
PL (1) | PL3371179T3 (lt) |
PT (1) | PT3371179T (lt) |
RS (1) | RS59498B1 (lt) |
SG (1) | SG11201803181SA (lt) |
SI (1) | SI3371179T1 (lt) |
TN (1) | TN2018000131A1 (lt) |
TW (1) | TWI714661B (lt) |
UY (1) | UY36979A (lt) |
WO (1) | WO2017076998A1 (lt) |
ZA (1) | ZA201802322B (lt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI714661B (zh) * | 2015-11-05 | 2021-01-01 | 法商賽諾菲公司 | 新穎念珠藻素化合物及接合物、其製備與其治療用途 |
CN107043380A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
MX2019013421A (es) * | 2017-05-10 | 2020-02-05 | Sanofi Sa | Enlazadores peptidicos y conjugados de criptoficina, utiles en la terapia, y su preparacion. |
CN108107103B (zh) * | 2017-12-14 | 2020-10-16 | 华中师范大学 | 谷氨酸受体的质谱探针及其在脑组织中的空间分布规律检测方法 |
TW202100506A (zh) | 2019-03-07 | 2021-01-01 | 美商柯納特斯製藥公司 | 半胱天冬酶(caspase)抑制劑及其使用方法 |
EP4038085A1 (en) | 2019-09-30 | 2022-08-10 | The Regents of The University of Michigan | Biocatalytic synthesis of cryptophycin anticancer agents |
EP4046996A1 (en) | 2021-02-19 | 2022-08-24 | Universität Bielefeld | Cryptophycin compounds and conjugates thereof |
WO2023161291A1 (en) | 2022-02-22 | 2023-08-31 | Araris Biotech Ag | Peptide linkers comprising two or more payloads |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE203016T1 (de) * | 1993-12-21 | 2001-07-15 | Univ Hawaii | Cryptophycine |
US20020128185A1 (en) * | 1998-02-25 | 2002-09-12 | Chuan Shih | Pharmaceutical compounds |
US7230101B1 (en) | 2002-08-28 | 2007-06-12 | Gpc Biotech, Inc. | Synthesis of methotrexate-containing heterodimeric molecules |
US20050175619A1 (en) | 2004-02-05 | 2005-08-11 | Robert Duffy | Methods of producing antibody conjugates |
EP2010475A2 (en) | 2006-04-27 | 2009-01-07 | Intezyne Technologies Incorporated | Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof |
KR101528939B1 (ko) | 2006-07-18 | 2015-06-15 | 사노피 | 암 치료를 위한 epha2에 대한 길항제 항체 |
FR2947269B1 (fr) * | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
AR078470A1 (es) | 2009-10-02 | 2011-11-09 | Sanofi Aventis | Anticuerpos que se unen especificamente al receptor epha2 |
TWI714661B (zh) | 2015-11-05 | 2021-01-01 | 法商賽諾菲公司 | 新穎念珠藻素化合物及接合物、其製備與其治療用途 |
-
2016
- 2016-11-02 TW TW105135522A patent/TWI714661B/zh active
- 2016-11-03 LT LT16791017T patent/LT3371179T/lt unknown
- 2016-11-03 CR CR20180256A patent/CR20180256A/es unknown
- 2016-11-03 SG SG11201803181SA patent/SG11201803181SA/en unknown
- 2016-11-03 MA MA43160A patent/MA43160B1/fr unknown
- 2016-11-03 PT PT167910173T patent/PT3371179T/pt unknown
- 2016-11-03 EP EP16791017.3A patent/EP3371179B1/en active Active
- 2016-11-03 SI SI201630418T patent/SI3371179T1/sl unknown
- 2016-11-03 AU AU2016347724A patent/AU2016347724B2/en active Active
- 2016-11-03 WO PCT/EP2016/076603 patent/WO2017076998A1/en active Application Filing
- 2016-11-03 TN TNP/2018/000131A patent/TN2018000131A1/en unknown
- 2016-11-03 KR KR1020187015447A patent/KR20180073678A/ko not_active Application Discontinuation
- 2016-11-03 US US15/768,792 patent/US10941139B2/en active Active
- 2016-11-03 EA EA201890898A patent/EA035625B1/ru not_active IP Right Cessation
- 2016-11-03 ES ES16791017T patent/ES2755101T3/es active Active
- 2016-11-03 MX MX2018005379A patent/MX2018005379A/es active IP Right Grant
- 2016-11-03 CA CA3003085A patent/CA3003085A1/en active Pending
- 2016-11-03 PL PL16791017T patent/PL3371179T3/pl unknown
- 2016-11-03 DK DK16791017T patent/DK3371179T3/da active
- 2016-11-03 RS RS20191429A patent/RS59498B1/sr unknown
- 2016-11-03 CN CN201680064372.8A patent/CN108349960B/zh active Active
- 2016-11-03 JP JP2018541548A patent/JP6929292B2/ja active Active
- 2016-11-03 MY MYPI2018701424A patent/MY189448A/en unknown
- 2016-11-03 HU HUE16791017A patent/HUE046033T2/hu unknown
- 2016-11-04 UY UY0001036979A patent/UY36979A/es not_active Application Discontinuation
- 2016-11-04 AR ARP160103379A patent/AR106604A1/es unknown
-
2018
- 2018-04-10 ZA ZA2018/02322A patent/ZA201802322B/en unknown
- 2018-04-20 PH PH12018500852A patent/PH12018500852A1/en unknown
- 2018-04-27 CO CONC2018/0004581A patent/CO2018004581A2/es unknown
- 2018-05-01 IL IL259067A patent/IL259067B/en unknown
- 2018-05-03 EC ECIEPI201834035A patent/ECSP18034035A/es unknown
- 2018-05-04 CL CL2018001210A patent/CL2018001210A1/es unknown
- 2018-12-11 HK HK18115834.8A patent/HK1256754B/zh unknown
-
2019
- 2019-09-24 HR HRP20191729 patent/HRP20191729T1/hr unknown
- 2019-11-06 CY CY20191101166T patent/CY1122441T1/el unknown
-
2020
- 2020-12-10 US US17/118,204 patent/US20210163458A1/en active Pending
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