PL3341481T3 - Kompozycja antysensowna mikrorna-328 i zastosowanie terapeutyczne - Google Patents

Kompozycja antysensowna mikrorna-328 i zastosowanie terapeutyczne

Info

Publication number
PL3341481T3
PL3341481T3 PL16838461T PL16838461T PL3341481T3 PL 3341481 T3 PL3341481 T3 PL 3341481T3 PL 16838461 T PL16838461 T PL 16838461T PL 16838461 T PL16838461 T PL 16838461T PL 3341481 T3 PL3341481 T3 PL 3341481T3
Authority
PL
Poland
Prior art keywords
microrna
therapeutic use
sense composition
sense
composition
Prior art date
Application number
PL16838461T
Other languages
English (en)
Inventor
Suh-Hang H. Juo
Edward Hsi
Chung-Ling Liang
Original Assignee
Kaohsiung Medical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaohsiung Medical University filed Critical Kaohsiung Medical University
Publication of PL3341481T3 publication Critical patent/PL3341481T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL16838461T 2015-08-26 2016-07-28 Kompozycja antysensowna mikrorna-328 i zastosowanie terapeutyczne PL3341481T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562210340P 2015-08-26 2015-08-26
EP16838461.8A EP3341481B1 (en) 2015-08-26 2016-07-28 Microrna-328 anti-sense composition and therapeutic use
PCT/CN2016/092060 WO2017032201A1 (en) 2015-08-26 2016-07-28 Microrna-328 anti-sense composition and therapeutic use

Publications (1)

Publication Number Publication Date
PL3341481T3 true PL3341481T3 (pl) 2021-12-13

Family

ID=58099881

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16838461T PL3341481T3 (pl) 2015-08-26 2016-07-28 Kompozycja antysensowna mikrorna-328 i zastosowanie terapeutyczne

Country Status (9)

Country Link
US (1) US10179913B2 (pl)
EP (1) EP3341481B1 (pl)
JP (1) JP6516196B2 (pl)
KR (1) KR102048165B1 (pl)
CN (1) CN107922948B (pl)
ES (1) ES2877411T3 (pl)
PL (1) PL3341481T3 (pl)
TW (1) TWI585205B (pl)
WO (1) WO2017032201A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110623975B (zh) * 2019-10-09 2022-07-05 新乡医学院 调节TERT基因表达的microRNA328及其应用
WO2022148016A1 (en) * 2021-01-07 2022-07-14 Dreamhawk Vision Biotech, Inc. Method for treating ocular surface diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201100813A1 (ru) * 2006-04-03 2012-06-29 Сантарис Фарма А/С Фармацевтическая композиция
US20090105174A1 (en) 2007-04-20 2009-04-23 Amgen Inc. Nucleic acids hybridizable to micro rna and precursors thereof
WO2009126650A2 (en) * 2008-04-07 2009-10-15 Cornell Research Foundation, Inc. Inhibition of angiognesis
CN101643791A (zh) * 2009-09-04 2010-02-10 哈尔滨医科大学 microRNA-328及其反义核苷酸在诊断、防治心脏疾病中的用途
CN101985628B (zh) 2010-08-13 2012-07-25 哈尔滨医科大学 一种心脏特异microRNA敲减小鼠模型建立的方法
CN102533755A (zh) * 2010-12-30 2012-07-04 苏州吉玛基因股份有限公司 人miR-328反义核酸及其应用
TWI508731B (zh) * 2012-09-20 2015-11-21 Univ Kaohsiung Medical 干擾性ｒｎａ用於製備治療及／或預防近視之藥物的用途
CN103243086A (zh) * 2012-10-23 2013-08-14 北京大学 一种寡聚核苷酸的修饰方法，由该方法得到的修饰寡聚核苷酸及其应用
WO2014085866A1 (en) * 2012-12-06 2014-06-12 Newcastle Innovation Limited USE OF miRNA ANTAGONISTS FOR IMMUNE SYSTEM MODULATION, TREATMENT OF BACTERIAL INFECTIONS AND TREATMENT OF AIRWAYS DISEASES

Also Published As

Publication number Publication date
US10179913B2 (en) 2019-01-15
EP3341481A4 (en) 2019-05-08
KR102048165B1 (ko) 2019-11-22
TW201716573A (zh) 2017-05-16
US20180216109A1 (en) 2018-08-02
KR20180015268A (ko) 2018-02-12
EP3341481A1 (en) 2018-07-04
EP3341481B1 (en) 2021-04-28
TWI585205B (zh) 2017-06-01
CN107922948B (zh) 2021-07-06
JP2018524982A (ja) 2018-09-06
ES2877411T3 (es) 2021-11-16
CN107922948A (zh) 2018-04-17
WO2017032201A1 (en) 2017-03-02
JP6516196B2 (ja) 2019-05-22

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