BR112018008490A2 - compostos e conjugados de criptoficina, sua preparação e seu uso terapêutico - Google Patents

compostos e conjugados de criptoficina, sua preparação e seu uso terapêutico

Info

Publication number
BR112018008490A2
BR112018008490A2 BR112018008490-5A BR112018008490A BR112018008490A2 BR 112018008490 A2 BR112018008490 A2 BR 112018008490A2 BR 112018008490 A BR112018008490 A BR 112018008490A BR 112018008490 A2 BR112018008490 A2 BR 112018008490A2
Authority
BR
Brazil
Prior art keywords
conjugates
therapeutic use
preparation
cryptophycin
cryptophycin compounds
Prior art date
Application number
BR112018008490-5A
Other languages
English (en)
Other versions
BR112018008490B1 (pt
Inventor
Bigot Antony
Bouchard Hervé
Brun Marie-Priscille
Clerc François
Zhang Jidong
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of BR112018008490A2 publication Critical patent/BR112018008490A2/pt
Publication of BR112018008490B1 publication Critical patent/BR112018008490B1/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

a presente invenção refere-se aos compostos de criptoficina de fórmula (i): (i) a invenção também refere-se às cargas úteis de criptoficina, aos conjugados de criptoficina, às composições contendo-os e ao seu uso terapêutico, especialmente como agentes anticâncer. a invenção também se refere ao processo para a preparação desses conjugados.
BR112018008490-5A 2015-11-05 2016-11-03 Compostos e conjugados de criptoficina, processos para a preparação dos mesmos, medicamento e composição farmacêutica BR112018008490B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15306751.7 2015-11-05
EP15306751 2015-11-05
PCT/EP2016/076603 WO2017076998A1 (en) 2015-11-05 2016-11-03 Novel cryptophycin compounds and conjugates, their preparation and their therapeutic use

Publications (2)

Publication Number Publication Date
BR112018008490A2 true BR112018008490A2 (pt) 2019-02-12
BR112018008490B1 BR112018008490B1 (pt) 2023-07-18

Family

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Also Published As

Publication number Publication date
AU2016347724B2 (en) 2021-04-01
IL259067B (en) 2021-07-29
CO2018004581A2 (es) 2018-07-19
PT3371179T (pt) 2019-11-18
TW201730164A (zh) 2017-09-01
HUE046033T2 (hu) 2020-01-28
SI3371179T1 (sl) 2019-11-29
MX2018005379A (es) 2018-09-05
NZ741734A (en) 2023-10-27
RS59498B1 (sr) 2019-12-31
TN2018000131A1 (en) 2019-10-04
MY189448A (en) 2022-02-14
EA035625B1 (ru) 2020-07-17
CL2018001210A1 (es) 2018-08-17
JP2018535255A (ja) 2018-11-29
PL3371179T3 (pl) 2020-02-28
CN108349960A (zh) 2018-07-31
US20190382391A1 (en) 2019-12-19
CY1122441T1 (el) 2021-01-27
HK1256754B (zh) 2020-06-05
CN108349960B (zh) 2022-05-27
CA3003085A1 (en) 2017-05-11
WO2017076998A1 (en) 2017-05-11
SG11201803181SA (en) 2018-05-30
EP3371179A1 (en) 2018-09-12
US10941139B2 (en) 2021-03-09
ZA201802322B (en) 2019-01-30
TWI714661B (zh) 2021-01-01
UY36979A (es) 2017-06-30
HRP20191729T1 (hr) 2019-12-13
LT3371179T (lt) 2019-11-11
US20210163458A1 (en) 2021-06-03
AR106604A1 (es) 2018-01-31
JP6929292B2 (ja) 2021-09-01
DK3371179T3 (da) 2019-11-11
PH12018500852A1 (en) 2018-10-29
EA201890898A1 (ru) 2018-10-31
CR20180256A (es) 2018-08-13
EP3371179B1 (en) 2019-08-07
MA43160B1 (fr) 2019-12-31
PH12018500852B1 (en) 2018-10-29
KR20180073678A (ko) 2018-07-02
ECSP18034035A (es) 2018-05-31
ES2755101T3 (es) 2020-04-21
AU2016347724A1 (en) 2018-05-10
IL259067A (en) 2018-06-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/11/2016, OBSERVADAS AS CONDICOES LEGAIS