EA032003B1 - Анти-tdp-43 антитело - Google Patents

Анти-tdp-43 антитело Download PDF

Info

Publication number
EA032003B1
EA032003B1 EA201490825A EA201490825A EA032003B1 EA 032003 B1 EA032003 B1 EA 032003B1 EA 201490825 A EA201490825 A EA 201490825A EA 201490825 A EA201490825 A EA 201490825A EA 032003 B1 EA032003 B1 EA 032003B1
Authority
EA
Eurasian Patent Office
Prior art keywords
seq
tdp
antibody
antibodies
amino acid
Prior art date
Application number
EA201490825A
Other languages
English (en)
Russian (ru)
Other versions
EA201490825A8 (ru
EA201490825A1 (ru
Inventor
Нитш Рожер
Кристоф Хок
Мария Грация Баренко Монтрасио
Фабио Монтрасио
Ян Гримм
Жан-Люк Берисвиль
Пол Вейнреб
Янаки Кумарасвами
Омар Куинтеро-Монзон
Original Assignee
Байоджен Айдек Интернэшнл Нейросайенз Гмбх
Юниверсити Оф Цюрих
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байоджен Айдек Интернэшнл Нейросайенз Гмбх, Юниверсити Оф Цюрих filed Critical Байоджен Айдек Интернэшнл Нейросайенз Гмбх
Publication of EA201490825A1 publication Critical patent/EA201490825A1/ru
Publication of EA201490825A8 publication Critical patent/EA201490825A8/ru
Publication of EA032003B1 publication Critical patent/EA032003B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Food Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Psychology (AREA)
EA201490825A 2011-10-28 2012-10-26 Анти-tdp-43 антитело EA032003B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161553113P 2011-10-28 2011-10-28
PCT/IB2012/002905 WO2013061163A2 (en) 2011-10-28 2012-10-26 Tdp-43 specific binding molecules

Publications (3)

Publication Number Publication Date
EA201490825A1 EA201490825A1 (ru) 2015-01-30
EA201490825A8 EA201490825A8 (ru) 2016-09-30
EA032003B1 true EA032003B1 (ru) 2019-03-29

Family

ID=47720540

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490825A EA032003B1 (ru) 2011-10-28 2012-10-26 Анти-tdp-43 антитело

Country Status (18)

Country Link
US (3) US9587014B2 (OSRAM)
EP (2) EP2771359B1 (OSRAM)
JP (3) JP6240611B2 (OSRAM)
KR (2) KR102032080B1 (OSRAM)
CN (1) CN104159918B (OSRAM)
AU (1) AU2012327211C9 (OSRAM)
BR (1) BR112014010161B1 (OSRAM)
CA (2) CA3112082A1 (OSRAM)
CL (1) CL2014001074A1 (OSRAM)
EA (1) EA032003B1 (OSRAM)
ES (1) ES2883212T3 (OSRAM)
IL (2) IL232219B (OSRAM)
MX (2) MX357678B (OSRAM)
MY (1) MY167795A (OSRAM)
PH (1) PH12014500940A1 (OSRAM)
SG (1) SG11201401735WA (OSRAM)
WO (1) WO2013061163A2 (OSRAM)
ZA (1) ZA201403680B (OSRAM)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20140049T1 (hr) 2007-01-05 2014-02-28 University Of Zürich Anti beta-amiloid antitijela i njihova upotreba
SG11201401735WA (en) 2011-10-28 2014-05-29 Biogen Idec Internat Neuroscience Gmbh Tdp-43 specific binding molecules
WO2014198528A2 (en) * 2013-06-11 2014-12-18 Paul Scherrer Institut Method for determining mutateable ligand-gpcr binding at single amino acid resolution and pairs of mutated ligand and gpcr
US10191068B2 (en) 2014-01-31 2019-01-29 Arizona Board Of Regents On Behalf Of Arizona State University Antibody based reagents that specifically recognize neurodegenerative disease related forms of the protein TDP-43
EP3174898A2 (en) 2014-07-29 2017-06-07 Neurimmune Holding AG Human-derived anti-huntingtin (htt) antibodies and uses thereof
CN104497121A (zh) * 2014-08-29 2015-04-08 苏州顺升桥生物科技有限公司 淀粉样蛋白tdp-43及其用途
WO2016053610A1 (en) * 2014-10-03 2016-04-07 Academia Sinica Antibodies against pathological forms of tdp-43 and uses thereof
TWI592423B (zh) * 2014-10-03 2017-07-21 中央研究院 可辨識致病性ｔｄｐ－４３之抗體及其用途
US9796778B1 (en) 2014-10-03 2017-10-24 Academia Sinica Antibodies against pathological forms of TDP-43 and uses thereof
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
WO2016196324A1 (en) 2015-05-29 2016-12-08 University Of Floridia Research Foundation, Inc. Methods for diagnosing huntington's disease
WO2017111166A1 (ja) * 2015-12-25 2017-06-29 国立大学法人東京農工大学 Ｔｄｐ－４３細胞内存在量関連疾患治療剤
PL3430397T3 (pl) 2016-03-14 2022-04-04 Biogen International Neuroscience Gmbh Oznaczenie fagocytozy zależnej od przeciwciał do wiarygodnych pomiarów wychwytu zagregowanych białek
EP3440100A4 (en) 2016-04-04 2020-01-22 University of Florida Research Foundation, Incorporated HANDLING EIF3 TO MODULATE A NON-ATG TRANSLATION ASSOCIATED WITH A REPETITION (RAN)
WO2018022479A1 (en) 2016-07-25 2018-02-01 Biogen Ma Inc. Anti-hspa5 (grp78) antibodies and uses thereof
WO2018112362A1 (en) 2016-12-16 2018-06-21 Biogen Ma Inc. Stabilized proteolytically activated growth differentiation factor 11
PE20191708A1 (es) 2017-03-14 2019-11-28 Five Prime Therapeutics Inc ANTICUERPOS DE UNION A VISTA A pH ACIDO
US11345911B2 (en) 2017-04-17 2022-05-31 University Of Florida Research Foundation, Incorporated Regulation of RAN translation by PKR and eIF2A-P pathways
WO2018218352A1 (en) * 2017-05-30 2018-12-06 The University Of British Columbia Epitopes in the rna recognition motif 1 (rrm1) of tdp-43 and misfolding-selective antibodies thereto
KR20250053967A (ko) 2017-08-22 2025-04-22 바이오젠 엠에이 인코포레이티드 항-베타 아밀로이드 항체를 함유하는 약제학적 조성물
WO2019118527A1 (en) * 2017-12-14 2019-06-20 The Johns Hopkins University Novel anti-fungal inhibitors
EP3724232B1 (en) 2017-12-14 2024-12-04 The University of Ottawa Exosome packaging and targeted autophagy
CN111886247A (zh) * 2018-01-05 2020-11-03 Ac免疫有限公司 错折叠tdp-43结合分子
US12215142B2 (en) 2018-03-16 2025-02-04 National University Corporation Shiga University Of Medical Science Antibody fragment degrading and removing abnormal TDP-43
KR20250154550A (ko) 2018-03-21 2025-10-28 파이브 프라임 테라퓨틱스, 인크. 산성 pH에서 VISTA에 결합하는 항체
TW202019398A (zh) * 2018-06-28 2020-06-01 張翔毓 用於治療或預防構形疾病之方法及藥物篩選方法
JP7700036B2 (ja) 2018-07-11 2025-06-30 ファイヴ プライム セラピューティクス インク 酸性ｐＨでＶＩＳＴＡと結合する抗体
AU2019371814A1 (en) 2018-10-29 2021-06-17 Biogen Ma Inc. Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport
CA3123116A1 (en) * 2018-12-14 2020-06-18 The University Of British Columbia Antibodies to misfolded tdp-43 and methods of use
PH12021552938A1 (en) 2019-05-23 2022-07-25 Ac Immune Sa Anti-tdp-43 binding molecules and uses thereof
WO2021026601A1 (en) * 2019-08-12 2021-02-18 Macquarie University Compositions and methods for treatment
US12436154B2 (en) 2019-09-20 2025-10-07 University Of Florida Research Foundation, Incorporated Detection of antibodies against RAN proteins from serum and tissue lysates
GB202004863D0 (en) * 2020-04-02 2020-05-20 Univ Oxford Innovation Ltd Method
WO2021222168A2 (en) 2020-04-28 2021-11-04 Sola Biosciences Llc Compositions and methods for the treatment of tdp-43 proteinopathies
US20230174630A1 (en) * 2020-04-29 2023-06-08 The University Of British Columbia Single chain antibodies and intrabodies to misfolded tdp-43 and methods of use
EP4175716A4 (en) * 2020-07-06 2024-08-21 The Board Of Regents Of The University Of Texas System TDP-43 BIOSENSOR CELL LINES
WO2022034228A1 (en) 2020-08-14 2022-02-17 Ac Immune Sa Humanized anti-tdp-43 binding molecules and uses thereof
CA3203308A1 (en) 2020-11-30 2022-06-02 Enigma Biointelligence, Inc. Non-invasive assessment of alzheimer's disease
MX2023008744A (es) 2021-01-29 2023-10-02 Illimis Therapeutics Inc Molecula de fusion que tiene actividad no inflamatoria inductora de la fagocitosis.
CN112920264B (zh) * 2021-02-08 2022-07-05 武汉大学 Tdp-43蛋白的o-糖基化突变体及其应用
JP6961278B1 (ja) * 2021-03-10 2021-11-05 国立研究開発法人量子科学技術研究開発機構 生体試料中のｔｄｐ−４３を測定する方法及び装置
US20240226230A1 (en) * 2021-05-27 2024-07-11 Mayo Foundation For Medical Education And Research Methods and materials for treating proteinopathies
EP4408470A4 (en) * 2021-10-01 2025-09-03 Univ Utah Res Found PATHOLOGICAL TDP-43 USED AS A BIOMARKER FOR THE DIAGNOSIS OF TDP-43 PROTEINOPATHY
WO2023099788A1 (en) 2021-12-03 2023-06-08 Neurimmune Ag Novel potency assay for antibody-based drugs and useful means therefor
IL315043A (en) 2022-02-16 2024-10-01 Ac Immune Sa Humanized anti-tdp-43 binding molecules and uses thereof
CN119156401A (zh) * 2022-04-08 2024-12-17 Ac免疫有限公司 抗tdp-43结合分子
WO2023205579A1 (en) * 2022-04-18 2023-10-26 The Regents Of The University Of California Compositions and methods for disrupting pathological aggregates
EP4497826A1 (en) 2022-04-22 2025-01-29 Niigata University Tdp-43 aggregation suppressing agent and pharmaceutical composition
WO2024184494A1 (en) 2023-03-08 2024-09-12 Ac Immune Sa Anti-tdp-43 binding molecules and uses thereof
WO2024263701A1 (en) * 2023-06-20 2024-12-26 The Trustees Of Dartmouth College Chimeric antigen receptors (cars) targeting tdp43, tregs expressing said cars, and use thereof for the treatment of als, ftd and ad
KR102859015B1 (ko) * 2023-07-20 2025-09-12 충북대학교 산학협력단 ｃ­Ａｂｌ에 의한 ＴＤＰ­４３의 특이적 인산화 분석을 통한 신경퇴행성 질환을 진단하는 방법 및 이를 이용한 신경퇴행성 질환의 치료제 스크리닝 방법
CN116875738A (zh) * 2023-07-24 2023-10-13 山东省农业科学院畜牧兽医研究所 一种鉴定牛tdp-43基因启动子活性区域的方法
AR133828A1 (es) * 2023-09-15 2025-11-05 Prothena Biosciences Ltd Anticuerpos anti-tdp-43 y sus usos
WO2025186332A1 (en) 2024-03-05 2025-09-12 Ac Immune Sa Vectorized anti-tdp-43 antibodies
CN119331085B (zh) * 2024-10-16 2025-03-14 中国科学院合肥物质科学研究院 沙贝冠状病毒广谱中和抗体及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688511A (en) * 1991-11-05 1997-11-18 Board Of Regents, The University Of Texas System Cellular protein TDP-43 and regulation of HIV-1 gene expression
WO2008081008A1 (en) * 2007-01-05 2008-07-10 University Of Zurich Method of providing disease-specific binding molecules and targets
WO2009099941A2 (en) * 2008-02-01 2009-08-13 Washington University In St. Louis Sequences associated with tdp-43 proteinopathies and methods of using the same
CN101634656A (zh) * 2009-08-21 2010-01-27 武汉三鹰生物技术有限公司 人tdp-43的单抗包被酶标板的制法及elisa检测试剂盒

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934953A2 (en) * 1997-12-03 1999-08-11 Boehringer Mannheim Corporation Complex specific antibodies, method of preparation and uses thereof
US8354236B2 (en) * 2006-09-29 2013-01-15 The Trustees Of The University Of Pennsylvania Detection of neurodegenerative disease
WO2008151055A1 (en) 2007-06-01 2008-12-11 Mayo Foundation For Medical Education And Research Diagnosing neurodegenerative diseases
US8940872B2 (en) * 2007-07-06 2015-01-27 Tokyo Metropolitan Institute Of Medical Science Antibody binding specifically to TDP-43 aggregate
CA2746778C (en) 2008-12-19 2019-04-23 University Of Zurich Human anti-alpha-synuclein autoantibodies
SG11201401735WA (en) 2011-10-28 2014-05-29 Biogen Idec Internat Neuroscience Gmbh Tdp-43 specific binding molecules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688511A (en) * 1991-11-05 1997-11-18 Board Of Regents, The University Of Texas System Cellular protein TDP-43 and regulation of HIV-1 gene expression
WO2008081008A1 (en) * 2007-01-05 2008-07-10 University Of Zurich Method of providing disease-specific binding molecules and targets
WO2009099941A2 (en) * 2008-02-01 2009-08-13 Washington University In St. Louis Sequences associated with tdp-43 proteinopathies and methods of using the same
CN101634656A (zh) * 2009-08-21 2010-01-27 武汉三鹰生物技术有限公司 人tdp-43的单抗包被酶标板的制法及elisa检测试剂盒

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Biogen Idec and Neurimmune Announce Agreement on Three Neurodegenerative Disease Programs", 20 December 2010 (2010-12-20), XP055064808, Retrieved from the Internet: URL:http://www.businesswire.com/news/home/20101220006526/en/Biogen-Idec-Neurimmune-Announce-Agreement-Neurodegenerative-Disease [retrieved on 2013-05-31], the whole document *
"TARDBP (41-7.1): sc-100871", 26 March 2009 (2009-03-26), XP055064934, Retrieved from the Internet: URL:http://datasheets.scbt.com/sc-100871.pdf [retrieved on 2013-06-03], the whole document *
JOHNSON B.S. ET AL.,: "a yeast TDP-43 proteinopathy model: exploring the molecular determinants of TDP-43 aggregation and cellular toxicity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATIONAL ACADEMY OF SCIENCES, US, vol. 105, no. 17, 29 April 2008 (2008-04-29), US, pages 6439 - 6444, XP002534604, ISSN: 0027-8424, DOI: 10.1073/PNAS.0802082105 *
YUKI SHIINA ; KUNIMASA ARIMA ; HIROKO TABUNOKI ; JUN-ICHI SATOH: "TDP-43 Dimerizes in Human Cells in Culture", CELLULAR AND MOLECULAR NEUROBIOLOGY, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 30, no. 4, 31 December 2009 (2009-12-31), Ne, pages 641 - 652, XP019815449, ISSN: 1573-6830 *

Also Published As

Publication number Publication date
IL232219B (en) 2019-11-28
KR20140100480A (ko) 2014-08-14
JP6417451B2 (ja) 2018-11-07
AU2012327211A1 (en) 2013-05-23
PH12014500940A1 (en) 2019-06-26
MX2018008680A (es) 2023-04-18
EA201490825A8 (ru) 2016-09-30
SG11201401735WA (en) 2014-05-29
JP2017205118A (ja) 2017-11-24
US10259866B2 (en) 2019-04-16
BR112014010161B1 (pt) 2022-02-08
CA2853412A1 (en) 2013-05-02
KR20180132977A (ko) 2018-12-12
IL232219A0 (en) 2014-06-30
BR112014010161A2 (pt) 2018-09-25
AU2012327211B2 (en) 2016-03-10
CL2014001074A1 (es) 2015-01-09
WO2013061163A2 (en) 2013-05-02
IL270223B (en) 2021-05-31
EP2771359A2 (en) 2014-09-03
US20200017577A1 (en) 2020-01-16
HK1201846A1 (en) 2015-09-11
JP2019022500A (ja) 2019-02-14
KR101961508B1 (ko) 2019-03-25
WO2013061163A3 (en) 2014-03-06
AU2012327211C9 (en) 2016-11-17
CN104159918A (zh) 2014-11-19
EP2771359B1 (en) 2021-05-19
US20170152308A1 (en) 2017-06-01
MY167795A (en) 2018-09-26
CA3112082A1 (en) 2013-05-02
CA2853412C (en) 2021-05-04
ZA201403680B (en) 2020-05-27
MX2014005048A (es) 2014-11-10
KR102032080B1 (ko) 2019-10-15
MX357678B (es) 2018-07-19
US20140255304A1 (en) 2014-09-11
JP6652609B2 (ja) 2020-02-26
AU2012327211C1 (en) 2016-09-15
JP6240611B2 (ja) 2017-11-29
EA201490825A1 (ru) 2015-01-30
ES2883212T3 (es) 2021-12-07
JP2015505665A (ja) 2015-02-26
NZ624871A (en) 2016-06-24
US11091540B2 (en) 2021-08-17
CN104159918B (zh) 2019-09-13
EP3964524A1 (en) 2022-03-09
US9587014B2 (en) 2017-03-07

Similar Documents

Publication Publication Date Title
KR102032080B1 (ko) Tdp-43 특이적 결합 분자
US12234281B2 (en) Antibody-based therapy of transthyretin (TTR) amyloidosis and human-derived antibodies therefor
US11352441B2 (en) Human anti-SOD1 antibodies
AU2013361107B2 (en) Human anti-tau antibodies
AU2012327211B9 (en) TDP-43 specific binding molecules
KR102594327B1 (ko) 인간-유래의 항-디펩티드 반복체(dpr) 항체
EA031698B1 (ru) Человеческие анти-тау антитела
KR102802736B1 (ko) Ilt7 결합 분자 및 이의 사용 방법
HK40069392A (en) Tdp-43 specific binding molecules
HK1201846B (en) Tdp-43 specific binding molecules