EA031758B1 - Ниацинамид для стимуляции продуцирования антимикробных пептидов - Google Patents

Ниацинамид для стимуляции продуцирования антимикробных пептидов Download PDF

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Publication number
EA031758B1
EA031758B1 EA201692284A EA201692284A EA031758B1 EA 031758 B1 EA031758 B1 EA 031758B1 EA 201692284 A EA201692284 A EA 201692284A EA 201692284 A EA201692284 A EA 201692284A EA 031758 B1 EA031758 B1 EA 031758B1
Authority
EA
Eurasian Patent Office
Prior art keywords
niacinamide
skin
antimicrobial peptides
coli
psoriasin
Prior art date
Application number
EA201692284A
Other languages
English (en)
Russian (ru)
Other versions
EA201692284A1 (ru
Inventor
Амитабха Маджумдар
Мрутхунджая Свами Матхапати
Бхарат Паланисами
Рамиа Сампатха Кумар
Джоти Кумар Тивари
Original Assignee
Юнилевер Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юнилевер Н.В. filed Critical Юнилевер Н.В.
Publication of EA201692284A1 publication Critical patent/EA201692284A1/ru
Publication of EA031758B1 publication Critical patent/EA031758B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Birds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EA201692284A 2014-05-12 2014-05-12 Ниацинамид для стимуляции продуцирования антимикробных пептидов EA031758B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2014/059590 WO2015172801A1 (en) 2014-05-12 2014-05-12 Niacinamide for inducing generation of antimicrobial peptides

Publications (2)

Publication Number Publication Date
EA201692284A1 EA201692284A1 (ru) 2017-03-31
EA031758B1 true EA031758B1 (ru) 2019-02-28

Family

ID=50771476

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692284A EA031758B1 (ru) 2014-05-12 2014-05-12 Ниацинамид для стимуляции продуцирования антимикробных пептидов

Country Status (8)

Country Link
JP (1) JP6446065B2 (es)
CN (2) CN106413680A (es)
BR (1) BR112016024400A2 (es)
EA (1) EA031758B1 (es)
MX (1) MX2016014760A (es)
PH (1) PH12016502047A1 (es)
WO (1) WO2015172801A1 (es)
ZA (1) ZA201607105B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180030721A (ko) 2015-08-10 2018-03-23 마리 케이 인코포레이티드 국소 조성물들
CN108135824B (zh) 2015-10-05 2021-09-17 联合利华知识产权控股有限公司 包含烟酰胺和吡啶2-甲酰胺的组合物
EP3454834B1 (en) * 2016-05-10 2020-09-30 Unilever N.V. A topical antimicrobial composition
EA201892688A1 (ru) 2016-05-26 2019-04-30 Юнилевер Н.В. Противомикробные композиции для местного применения
EP3426276B1 (en) 2017-05-24 2024-01-24 Follea International Synephrine compositions
CN111295190A (zh) * 2017-10-30 2020-06-16 荷兰联合利华有限公司 烟酰胺用于微生物组平衡的用途
CN111683649A (zh) * 2017-12-18 2020-09-18 荷兰联合利华有限公司 基于烟酰胺衍生物的局部组合物
CN111491612B (zh) * 2017-12-18 2023-10-20 联合利华知识产权控股有限公司 局部组合物
WO2019174867A1 (en) 2018-03-13 2019-09-19 Unilever N.V. A sanitizer composition
WO2024041911A1 (en) * 2022-08-25 2024-02-29 Unilever Ip Holdings B.V. A nasal drop composition and device thereof
WO2024042554A1 (en) * 2022-08-25 2024-02-29 Istituto Fondazione Di Oncologia Molecolare Ets A pharmaceutical composition for treatment of viral infections

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026308B1 (en) * 1999-06-25 2006-04-11 The Procter & Gamble Company Topical anti-microbial compositions
WO2006040048A1 (en) * 2004-10-15 2006-04-20 Bayer Consumer Care Ag Acidic and buffered skin-care compositions comprising nicotinamid and an absorbing agent
WO2011133692A1 (en) * 2010-04-20 2011-10-27 Cedars-Sinai Medical Center Boosting immune defense by upregulating ccaat/enhancer binding protein epsilon
WO2012049677A2 (en) * 2010-10-10 2012-04-19 Dermipsor Ltd. Compositions for treating psoriasis of the scalp
WO2012137169A1 (fr) * 2011-04-05 2012-10-11 L'oreal Nouvel actif pour prevenir ou traiter le cuir chevelu
DE102012002592A1 (de) * 2012-02-13 2013-08-14 Dr. Kurt Wolff Gmbh & Co. Kg Verwendung eines Mittels zur Stimulation der Gen-Expression antimikrobieller Peptide (AMP)
EP2742942A1 (en) * 2012-12-14 2014-06-18 Unilever N.V. Niacinamide for inducing generation of antimicrobial peptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN892496A0 (en) * 1996-03-25 1996-04-18 Technical Consultancy Services Pty Limited Acne treatment
CN101019865A (zh) * 2007-01-23 2007-08-22 中国医学科学院皮肤病医院 抗炎、保湿、祛斑的复方烟酰胺药用组合物
US8293790B2 (en) * 2011-10-19 2012-10-23 Dignity Sciences Limited Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof
WO2013186355A1 (en) * 2012-06-15 2013-12-19 Conaris Research Institute Ag A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026308B1 (en) * 1999-06-25 2006-04-11 The Procter & Gamble Company Topical anti-microbial compositions
WO2006040048A1 (en) * 2004-10-15 2006-04-20 Bayer Consumer Care Ag Acidic and buffered skin-care compositions comprising nicotinamid and an absorbing agent
WO2011133692A1 (en) * 2010-04-20 2011-10-27 Cedars-Sinai Medical Center Boosting immune defense by upregulating ccaat/enhancer binding protein epsilon
WO2012049677A2 (en) * 2010-10-10 2012-04-19 Dermipsor Ltd. Compositions for treating psoriasis of the scalp
WO2012137169A1 (fr) * 2011-04-05 2012-10-11 L'oreal Nouvel actif pour prevenir ou traiter le cuir chevelu
DE102012002592A1 (de) * 2012-02-13 2013-08-14 Dr. Kurt Wolff Gmbh & Co. Kg Verwendung eines Mittels zur Stimulation der Gen-Expression antimikrobieller Peptide (AMP)
EP2742942A1 (en) * 2012-12-14 2014-06-18 Unilever N.V. Niacinamide for inducing generation of antimicrobial peptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PIERRE KYME, NILS H. THOENNISSEN, CHING WEN TSENG, GABRIELA B. THOENNISSEN, ANDREA J. WOLF, KENICHI SHIMADA, UTZ O. KRUG, KUNIK LE: "C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice", JOURNAL OF CLINICAL INVESTIGATION, vol. 122, no. 9, 4 September 2012 (2012-09-04), pages 3316 - 3329, XP055128464, ISSN: 00219738, DOI: 10.1172/JCI62070 *
TATSUO HASHIMOTO, THOMAS PERLOT, ATEEQUR REHMAN, JEAN TRICHEREAU, HIROAKI ISHIGURO, MAGDALENA PAOLINO, VERENA SIGL, TOSHIKATSU HAN: "ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation", NATURE, �MACMILLAN JOURNALS LTD., ETC.|, vol. 487, no. 7408, 1 January 2012 (2012-01-01), pages 477 - 481, XP055059617, ISSN: 00280836, DOI: 10.1038/nature11228 *

Also Published As

Publication number Publication date
JP2017515829A (ja) 2017-06-15
MX2016014760A (es) 2017-03-06
WO2015172801A1 (en) 2015-11-19
JP6446065B2 (ja) 2018-12-26
BR112016024400A2 (pt) 2017-08-15
CN106413680A (zh) 2017-02-15
EA201692284A1 (ru) 2017-03-31
PH12016502047A1 (en) 2017-01-09
ZA201607105B (en) 2018-05-30
CN113908074A (zh) 2022-01-11

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