EA031183B1 - Способы улучшения функции диафрагмы - Google Patents
Способы улучшения функции диафрагмы Download PDFInfo
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- EA031183B1 EA031183B1 EA201491605A EA201491605A EA031183B1 EA 031183 B1 EA031183 B1 EA 031183B1 EA 201491605 A EA201491605 A EA 201491605A EA 201491605 A EA201491605 A EA 201491605A EA 031183 B1 EA031183 B1 EA 031183B1
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- Eurasian Patent Office
- Prior art keywords
- diaphragm
- compound
- patient
- skeletal muscle
- muscle
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- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
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- Hematology (AREA)
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- Psychiatry (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201261619261P | 2012-04-02 | 2012-04-02 | |
| PCT/US2013/034824 WO2013151938A1 (en) | 2012-04-02 | 2013-04-01 | Methods for improving diaphragm function |
Publications (2)
| Publication Number | Publication Date |
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| EA201491605A1 EA201491605A1 (ru) | 2015-03-31 |
| EA031183B1 true EA031183B1 (ru) | 2018-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| EA201491605A EA031183B1 (ru) | 2012-04-02 | 2013-04-01 | Способы улучшения функции диафрагмы |
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| US (2) | US20150065525A1 (enExample) |
| EP (1) | EP2834269A4 (enExample) |
| JP (3) | JP6345645B2 (enExample) |
| KR (1) | KR20160046693A (enExample) |
| CN (2) | CN108553467A (enExample) |
| AU (2) | AU2013243671B2 (enExample) |
| BR (1) | BR112014024552A2 (enExample) |
| CA (1) | CA2868507A1 (enExample) |
| EA (1) | EA031183B1 (enExample) |
| HK (1) | HK1206364A1 (enExample) |
| IL (2) | IL234885A0 (enExample) |
| MX (1) | MX354965B (enExample) |
| PH (1) | PH12014502217A1 (enExample) |
| SG (2) | SG10201701101YA (enExample) |
| WO (1) | WO2013151938A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| EP2560488B1 (en) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| AR081331A1 (es) * | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| WO2012178125A1 (en) | 2011-06-22 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CN109316480A (zh) | 2011-07-13 | 2019-02-12 | 赛特凯恩蒂克公司 | 组合als疗法 |
| BR112014025251B1 (pt) * | 2012-04-11 | 2021-03-02 | Fady Malik | uso de um ativador de troponina de músculo esquelético e composição compreendendo o mesmo |
| LT3418281T (lt) | 2012-12-07 | 2021-01-11 | Vertex Pharmaceuticals Inc. | Pirazolo[1,5-a]pirimidinai, naudotini kaip atr kinazės inhibitoriai, skirti vėžinių ligų gydymui |
| CA2903979A1 (en) | 2013-03-14 | 2014-09-18 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| EP2970288A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2970289A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| WO2014143240A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
| HUE046727T2 (hu) | 2013-12-06 | 2020-03-30 | Vertex Pharma | Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai |
| LT3137622T (lt) | 2014-04-29 | 2022-04-25 | Cytokinetics, Inc. | Gyvybinio pajėgumo nykimo mažinimo būdai |
| ES2777608T3 (es) | 2014-06-05 | 2020-08-05 | Vertex Pharma | Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útiles como inhibidores de ATR cinasa, la preparación de dicho compuesto y diferentes formas sólidas del mismo |
| US11179394B2 (en) | 2014-06-17 | 2021-11-23 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of Chk1 and ATR inhibitors |
| US9987279B2 (en) * | 2014-09-09 | 2018-06-05 | Astellas Pharma Inc. | Pharmaceutical composition for prevention and/or treatment of urinary incontinence |
| WO2016193844A1 (en) | 2015-05-29 | 2016-12-08 | Pfizer Inc. | Novel heterocyclic compounds as inhibitors of vanin-1 enzyme |
| US11464774B2 (en) | 2015-09-30 | 2022-10-11 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
| SG11201806416XA (en) | 2016-02-12 | 2018-08-30 | Astellas Pharma Inc | Tetrahydroisoquinoline derivatives |
| US10906888B2 (en) | 2016-07-14 | 2021-02-02 | Pfizer Inc. | Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme |
| JP7687968B2 (ja) | 2019-06-19 | 2025-06-03 | エフ． ホフマン－ラ ロシュ アーゲー | デジタルバイオマーカー |
| CN114051390A (zh) * | 2019-06-19 | 2022-02-15 | 豪夫迈·罗氏有限公司 | 数字生物标志物 |
| JP7728184B2 (ja) | 2019-06-19 | 2025-08-22 | エフ． ホフマン－ラ ロシュ アーゲー | デジタルバイオマーカー |
| TW202116754A (zh) | 2019-07-11 | 2021-05-01 | 美商Ｅ 斯蓋普生物股份有限公司 | 作為ｌｒｒｋ２抑制劑之吲唑及氮雜吲唑 |
| JP7825618B2 (ja) | 2020-11-06 | 2026-03-06 | サイトキネティックス， インコーポレイテッド | 二環式１，４－ジアゼパノン及びその治療的使用 |
| TW202329937A (zh) | 2021-12-03 | 2023-08-01 | 美商英塞特公司 | 雙環胺ｃｋ１２抑制劑 |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
| US20240382564A1 (en) * | 2023-04-17 | 2024-11-21 | Allysta Pharmaceuticals, Inc. | Methods and Compositions for Treating Muscular Dystrophy and Memory Impairment |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070173465A9 (en) * | 1995-10-11 | 2007-07-26 | Monahan Sean D | Expression of zeta negative and zeta positive nucleic acids using a dystrophin gene |
| US20090029345A1 (en) * | 2006-08-01 | 2009-01-29 | Alan Russell | Modulating skeletal muscle |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6814901A (en) * | 2000-06-01 | 2001-12-11 | Univ North Carolina | Methods and compounds for controlled release of recombinant parvovirus vectors |
| CN1283793C (zh) * | 2002-06-03 | 2006-11-08 | 北京大学 | 具有骨骼肌刺激活性和免疫调节作用的趋化素样因子超家族 |
| JP2007501805A (ja) * | 2003-08-08 | 2007-02-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピリジルピペラジニルウレア |
| BRPI0714725B1 (pt) * | 2006-08-02 | 2021-05-25 | Cytokinetics, Inc | Entidade química, composição farmaceuticamente aceitável, e, uso de uma entidade química |
| US8299248B2 (en) * | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| CN101821279A (zh) * | 2007-08-15 | 2010-09-01 | 赛特凯恩蒂克公司 | 某些化学个体、组合物和方法 |
| NL2001694C2 (en) * | 2008-06-18 | 2009-12-22 | Nasophlex B V | Ear stimulator for producing a stimulation signal to an ear. |
| AR081331A1 (es) * | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| AR081626A1 (es) * | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
-
2013
- 2013-04-01 WO PCT/US2013/034824 patent/WO2013151938A1/en not_active Ceased
- 2013-04-01 US US14/389,805 patent/US20150065525A1/en not_active Abandoned
- 2013-04-01 SG SG10201701101YA patent/SG10201701101YA/en unknown
- 2013-04-01 KR KR1020147027435A patent/KR20160046693A/ko not_active Abandoned
- 2013-04-01 CN CN201810509450.1A patent/CN108553467A/zh active Pending
- 2013-04-01 BR BR112014024552A patent/BR112014024552A2/pt not_active Application Discontinuation
- 2013-04-01 EA EA201491605A patent/EA031183B1/ru not_active IP Right Cessation
- 2013-04-01 SG SG11201406270YA patent/SG11201406270YA/en unknown
- 2013-04-01 CA CA2868507A patent/CA2868507A1/en not_active Abandoned
- 2013-04-01 JP JP2015503681A patent/JP6345645B2/ja not_active Expired - Fee Related
- 2013-04-01 CN CN201380018757.7A patent/CN104379597A/zh active Pending
- 2013-04-01 AU AU2013243671A patent/AU2013243671B2/en not_active Ceased
- 2013-04-01 MX MX2014011881A patent/MX354965B/es active IP Right Grant
- 2013-04-01 HK HK15106936.7A patent/HK1206364A1/xx unknown
- 2013-04-01 EP EP13773086.7A patent/EP2834269A4/en not_active Withdrawn
-
2014
- 2014-09-29 IL IL234885A patent/IL234885A0/en unknown
- 2014-10-01 PH PH12014502217A patent/PH12014502217A1/en unknown
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2017
- 2017-02-27 US US15/444,063 patent/US20170266192A1/en not_active Abandoned
- 2017-12-07 AU AU2017272286A patent/AU2017272286B2/en not_active Ceased
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2018
- 2018-05-23 JP JP2018098858A patent/JP2018131460A/ja not_active Ceased
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2019
- 2019-07-05 IL IL267876A patent/IL267876B/en active IP Right Grant
-
2020
- 2020-06-17 JP JP2020104620A patent/JP2020147607A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070173465A9 (en) * | 1995-10-11 | 2007-07-26 | Monahan Sean D | Expression of zeta negative and zeta positive nucleic acids using a dystrophin gene |
| US20090029345A1 (en) * | 2006-08-01 | 2009-01-29 | Alan Russell | Modulating skeletal muscle |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013151938A1 (en) | 2013-10-10 |
| BR112014024552A2 (pt) | 2017-09-19 |
| CN104379597A (zh) | 2015-02-25 |
| CA2868507A1 (en) | 2013-10-10 |
| CN108553467A (zh) | 2018-09-21 |
| MX354965B (es) | 2018-03-27 |
| PH12014502217A1 (en) | 2015-01-12 |
| EP2834269A1 (en) | 2015-02-11 |
| JP2018131460A (ja) | 2018-08-23 |
| IL267876A (en) | 2019-09-26 |
| EA201491605A1 (ru) | 2015-03-31 |
| EP2834269A4 (en) | 2015-12-30 |
| JP2020147607A (ja) | 2020-09-17 |
| US20150065525A1 (en) | 2015-03-05 |
| IL234885A0 (en) | 2014-12-31 |
| AU2017272286A1 (en) | 2018-01-04 |
| IL267876B (en) | 2021-03-25 |
| AU2017272286B2 (en) | 2019-05-09 |
| KR20160046693A (ko) | 2016-04-29 |
| MX2014011881A (es) | 2016-07-20 |
| SG10201701101YA (en) | 2017-04-27 |
| SG11201406270YA (en) | 2014-10-30 |
| JP6345645B2 (ja) | 2018-06-20 |
| HK1206364A1 (en) | 2016-01-08 |
| JP2015516957A (ja) | 2015-06-18 |
| AU2013243671B2 (en) | 2017-09-21 |
| AU2013243671A1 (en) | 2014-10-16 |
| US20170266192A1 (en) | 2017-09-21 |
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