CA2868507A1 - Methods for improving diaphragm function - Google Patents
Methods for improving diaphragm function Download PDFInfo
- Publication number
- CA2868507A1 CA2868507A1 CA2868507A CA2868507A CA2868507A1 CA 2868507 A1 CA2868507 A1 CA 2868507A1 CA 2868507 A CA2868507 A CA 2868507A CA 2868507 A CA2868507 A CA 2868507A CA 2868507 A1 CA2868507 A1 CA 2868507A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- pyrazin
- imidazo
- optionally substituted
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Landscapes
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Applications Claiming Priority (3)
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| US61/619,261 | 2012-04-02 | ||
| PCT/US2013/034824 WO2013151938A1 (en) | 2012-04-02 | 2013-04-01 | Methods for improving diaphragm function |
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| CA2868507A1 true CA2868507A1 (en) | 2013-10-10 |
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| JP (3) | JP6345645B2 (enExample) |
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| CA (1) | CA2868507A1 (enExample) |
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| HK (1) | HK1206364A1 (enExample) |
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| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081331A1 (es) * | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| EP2723746A1 (en) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| WO2013010015A2 (en) | 2011-07-13 | 2013-01-17 | Cytokinetics, Inc. | Combination als therapy |
| SG11201406359TA (en) * | 2012-04-11 | 2014-11-27 | Cytokinetics Inc | Improving resistance to skeletal muscle fatigue |
| BR112015012454B1 (pt) | 2012-12-07 | 2022-07-05 | Vertex Pharmaceuticals Incorporated | Compostos inibidores de atr quinase, seu uso e composição farmacêutica compreendendo os mesmos |
| PE20151939A1 (es) | 2013-03-14 | 2016-01-08 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante |
| WO2014143242A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2014143240A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
| WO2014143241A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| ES2768678T3 (es) | 2013-12-06 | 2020-06-23 | Vertex Pharma | Compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inhibidor de la ATR quinasa, su preparación, diferentes formas sólidas y derivados radiomarcados de las mismas |
| US20170042890A1 (en) | 2014-04-29 | 2017-02-16 | Cytokinetics, Inc. | Methods of reducing decline in vital capacity |
| ES2777608T3 (es) | 2014-06-05 | 2020-08-05 | Vertex Pharma | Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útiles como inhibidores de ATR cinasa, la preparación de dicho compuesto y diferentes formas sólidas del mismo |
| KR20170016498A (ko) | 2014-06-17 | 2017-02-13 | 버텍스 파마슈티칼스 인코포레이티드 | Chk1 및 atr 저해제의 병용물을 사용하는 암의 치료 방법 |
| KR102460731B1 (ko) * | 2014-09-09 | 2022-10-28 | 아스테라스 세이야쿠 가부시키가이샤 | 요실금 예방용 및/또는 치료용의 신규한 의약 조성물 |
| JP2018516254A (ja) | 2015-05-29 | 2018-06-21 | ファイザー・インク | バニン１酵素の阻害薬としての新規なヘテロ環化合物 |
| KR102678021B1 (ko) | 2015-09-30 | 2024-06-26 | 버텍스 파마슈티칼스 인코포레이티드 | Dna 손상제와 병용되는, atr 저해제를 포함하는 암 치료용 약제학적 조성물 |
| RU2743424C2 (ru) | 2016-02-12 | 2021-02-18 | Астеллас Фарма Инк. | Производные тетрагидроизохинолина |
| CN109476645A (zh) | 2016-07-14 | 2019-03-15 | 辉瑞大药厂 | 作为vanin-1酶抑制剂的新的嘧啶甲酰胺 |
| WO2020254346A1 (en) | 2019-06-19 | 2020-12-24 | F. Hoffmann-La Roche Ag | Digital biomarker |
| JP7770928B2 (ja) * | 2019-06-19 | 2025-11-17 | エフ． ホフマン－ラ ロシュ アーゲー | デジタルバイオマーカー |
| US11427558B1 (en) | 2019-07-11 | 2022-08-30 | ESCAPE Bio, Inc. | Indazoles and azaindazoles as LRRK2 inhibitors |
| MX2023004745A (es) | 2020-11-06 | 2023-05-10 | Cytokinetics Inc | 1,4-diazepanonas biciclicas y sus usos terapeuticos. |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
| US20240382564A1 (en) * | 2023-04-17 | 2024-11-21 | Allysta Pharmaceuticals, Inc. | Methods and Compositions for Treating Muscular Dystrophy and Memory Impairment |
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| AU2001268149B2 (en) * | 2000-06-01 | 2005-08-18 | University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| CN1283793C (zh) * | 2002-06-03 | 2006-11-08 | 北京大学 | 具有骨骼肌刺激活性和免疫调节作用的趋化素样因子超家族 |
| EP1651638A1 (en) * | 2003-08-08 | 2006-05-03 | Janssen Pharmaceutica N.V. | Pyridyl piperazinyl ureas |
| US8227603B2 (en) * | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| DK2583970T3 (en) * | 2006-08-02 | 2015-11-16 | Cytokinetics Inc | Certain chemical entities, compositions, and methods comprising imidazopyrimidines |
| US8299248B2 (en) * | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| WO2009023193A1 (en) * | 2007-08-15 | 2009-02-19 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
| NL2001694C2 (en) * | 2008-06-18 | 2009-12-22 | Nasophlex B V | Ear stimulator for producing a stimulation signal to an ear. |
| AR081331A1 (es) * | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| AR081626A1 (es) * | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
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- 2013-04-01 AU AU2013243671A patent/AU2013243671B2/en not_active Ceased
- 2013-04-01 CA CA2868507A patent/CA2868507A1/en not_active Abandoned
- 2013-04-01 EA EA201491605A patent/EA031183B1/ru not_active IP Right Cessation
- 2013-04-01 SG SG10201701101YA patent/SG10201701101YA/en unknown
- 2013-04-01 BR BR112014024552A patent/BR112014024552A2/pt not_active Application Discontinuation
- 2013-04-01 EP EP13773086.7A patent/EP2834269A4/en not_active Withdrawn
- 2013-04-01 KR KR1020147027435A patent/KR20160046693A/ko not_active Abandoned
- 2013-04-01 HK HK15106936.7A patent/HK1206364A1/xx unknown
-
2014
- 2014-09-29 IL IL234885A patent/IL234885A0/en unknown
- 2014-10-01 PH PH12014502217A patent/PH12014502217A1/en unknown
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2017
- 2017-02-27 US US15/444,063 patent/US20170266192A1/en not_active Abandoned
- 2017-12-07 AU AU2017272286A patent/AU2017272286B2/en not_active Ceased
-
2018
- 2018-05-23 JP JP2018098858A patent/JP2018131460A/ja not_active Ceased
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2019
- 2019-07-05 IL IL267876A patent/IL267876B/en active IP Right Grant
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2020
- 2020-06-17 JP JP2020104620A patent/JP2020147607A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HK1206364A1 (en) | 2016-01-08 |
| EA201491605A1 (ru) | 2015-03-31 |
| AU2017272286B2 (en) | 2019-05-09 |
| KR20160046693A (ko) | 2016-04-29 |
| CN104379597A (zh) | 2015-02-25 |
| EA031183B1 (ru) | 2018-11-30 |
| JP2018131460A (ja) | 2018-08-23 |
| AU2017272286A1 (en) | 2018-01-04 |
| BR112014024552A2 (pt) | 2017-09-19 |
| IL267876B (en) | 2021-03-25 |
| JP2020147607A (ja) | 2020-09-17 |
| IL267876A (en) | 2019-09-26 |
| MX354965B (es) | 2018-03-27 |
| AU2013243671A1 (en) | 2014-10-16 |
| EP2834269A1 (en) | 2015-02-11 |
| SG10201701101YA (en) | 2017-04-27 |
| MX2014011881A (es) | 2016-07-20 |
| PH12014502217A1 (en) | 2015-01-12 |
| JP6345645B2 (ja) | 2018-06-20 |
| IL234885A0 (en) | 2014-12-31 |
| CN108553467A (zh) | 2018-09-21 |
| WO2013151938A1 (en) | 2013-10-10 |
| SG11201406270YA (en) | 2014-10-30 |
| JP2015516957A (ja) | 2015-06-18 |
| AU2013243671B2 (en) | 2017-09-21 |
| US20170266192A1 (en) | 2017-09-21 |
| US20150065525A1 (en) | 2015-03-05 |
| EP2834269A4 (en) | 2015-12-30 |
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| EEER | Examination request |
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| FZDE | Discontinued |
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