EA030437B1 - Антитела к cd48 и их применение - Google Patents
Антитела к cd48 и их применение Download PDFInfo
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- EA030437B1 EA030437B1 EA201370081A EA201370081A EA030437B1 EA 030437 B1 EA030437 B1 EA 030437B1 EA 201370081 A EA201370081 A EA 201370081A EA 201370081 A EA201370081 A EA 201370081A EA 030437 B1 EA030437 B1 EA 030437B1
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- antibody
- antigen
- human
- antibodies
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
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| US38674610P | 2010-09-27 | 2010-09-27 | |
| US201161475280P | 2011-04-14 | 2011-04-14 | |
| US201161515490P | 2011-08-05 | 2011-08-05 | |
| PCT/US2011/053193 WO2012047567A1 (en) | 2010-09-27 | 2011-09-26 | Anti-cd48 antibodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
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| EA201370081A1 EA201370081A1 (ru) | 2013-12-30 |
| EA030437B1 true EA030437B1 (ru) | 2018-08-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| EA201370081A EA030437B1 (ru) | 2010-09-27 | 2011-09-26 | Антитела к cd48 и их применение |
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| EP (1) | EP2621952A1 (OSRAM) |
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| AU (1) | AU2011312623B2 (OSRAM) |
| BR (1) | BR112013007314A2 (OSRAM) |
| CA (1) | CA2812748A1 (OSRAM) |
| CL (1) | CL2013000843A1 (OSRAM) |
| EA (1) | EA030437B1 (OSRAM) |
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| MX (1) | MX348417B (OSRAM) |
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| PH (1) | PH12013500564A1 (OSRAM) |
| SG (1) | SG189089A1 (OSRAM) |
| TW (1) | TWI507416B (OSRAM) |
| WO (1) | WO2012047567A1 (OSRAM) |
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| US9533039B2 (en) * | 2010-09-27 | 2017-01-03 | Regeneron Pharmaceuticals, Inc. | Methods of treating systemic lupus erythematosus (SLE) using anti-CD48 antibodies |
| PT3578201T (pt) | 2012-06-28 | 2023-05-10 | Univ Of Central Florida Research Foundation Incorporated | Métodos e composições para células assassinas naturais |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| WO2016036252A2 (en) * | 2014-09-05 | 2016-03-10 | Aimm Therapeutics B.V. | Hepatitis c virus specific antibody |
| DK3270965T3 (da) * | 2015-03-18 | 2020-06-08 | Seattle Genetics Inc | Cd48-antistoffer og konjugater deraf |
| TWI870789B (zh) | 2015-08-04 | 2025-01-21 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| JP6805884B2 (ja) | 2017-02-28 | 2020-12-23 | 住友ゴム工業株式会社 | 二輪自動用空気入りタイヤ |
| SG11201912548XA (en) | 2017-07-06 | 2020-01-30 | Regeneron Pharma | Cell culture process for making a glycoprotein |
| BR112020010615A2 (pt) | 2017-12-22 | 2020-10-27 | Regeneron Pharmaceuticals, Inc. | produto farmacêutico proteico, método e sistema para caracterizar impurezas de produto farmacêutico proteico e de fármaco de baixo peso molecular, método para produzir um anticorpo, anticorpo, e, usos do método e do sistema |
| SG11202005235WA (en) | 2018-01-31 | 2020-07-29 | Regeneron Pharma | System and method for characterizing size and charge variant drug product impurities |
| TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
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| KR20220066393A (ko) | 2019-09-24 | 2022-05-24 | 리제너론 파아마슈티컬스, 인크. | 크로마토그래피의 사용 및 재생을 위한 시스템 및 방법 |
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2011
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- 2011-09-26 US US13/244,960 patent/US9228014B2/en active Active
- 2011-09-26 KR KR1020137008885A patent/KR20140014067A/ko not_active Abandoned
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- 2011-09-26 BR BR112013007314A patent/BR112013007314A2/pt active Search and Examination
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070212353A1 (en) * | 2006-02-14 | 2007-09-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Novel therapeutic target and diagnostic marker for asthma and related conditions |
Non-Patent Citations (2)
| Title |
|---|
| ABADIA-MOLINA, A.C. JI, H. FAUBION, W.A. JULIEN, A. LATCHMAN, Y. YAGITA, H. SHARPE, A. BHAN, A.K. TERHORST, C.: "CD48 Controls T-Cell and Antigen-Presenting Cell Functions in Experimental Colitis", GASTROENTEROLOGY, W.B. SAUNDERS CO., US, vol. 130, no. 2, 1 February 2006 (2006-02-01), US, pages 424 - 434, XP005284545, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2005.12.009 * |
| QIN LIHUI , CHAVIN KENNETH D, LIN JIXUN, YAGITA HIDEO, BROMBERG JONATHAN S: "Anti-CO2 ligand receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 179, no. 1, 1 January 1994 (1994-01-01), US, pages 341 - 346, XP002665957, ISSN: 0022-1007, DOI: 10.1084/jem.179.1.341 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US9228014B2 (en) | 2016-01-05 |
| PH12013500564A1 (en) | 2021-06-02 |
| MY165273A (en) | 2018-03-20 |
| JP2017036324A (ja) | 2017-02-16 |
| IL225484A (en) | 2017-07-31 |
| TWI507416B (zh) | 2015-11-11 |
| CA2812748A1 (en) | 2012-04-12 |
| KR20140014067A (ko) | 2014-02-05 |
| TW201305206A (zh) | 2013-02-01 |
| IL225484A0 (en) | 2013-06-27 |
| CL2013000843A1 (es) | 2014-03-07 |
| CN103261226A (zh) | 2013-08-21 |
| JP2013542194A (ja) | 2013-11-21 |
| MX348417B (es) | 2017-06-12 |
| JP6096117B2 (ja) | 2017-03-15 |
| EA201370081A1 (ru) | 2013-12-30 |
| AU2011312623B2 (en) | 2016-12-15 |
| MX2013003468A (es) | 2013-05-31 |
| CN103261226B (zh) | 2016-06-15 |
| BR112013007314A2 (pt) | 2017-03-21 |
| US20120076790A1 (en) | 2012-03-29 |
| WO2012047567A1 (en) | 2012-04-12 |
| NZ608660A (en) | 2015-03-27 |
| SG189089A1 (en) | 2013-05-31 |
| AU2011312623A1 (en) | 2013-05-02 |
| EP2621952A1 (en) | 2013-08-07 |
| AR083044A1 (es) | 2013-01-30 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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