EA029939B8 - Человеческие связывающие молекулы, обладающие способностью нейтрализовывать вирус гриппа h3n2, и их применение - Google Patents
Человеческие связывающие молекулы, обладающие способностью нейтрализовывать вирус гриппа h3n2, и их применениеInfo
- Publication number
- EA029939B8 EA029939B8 EA201171383A EA201171383A EA029939B8 EA 029939 B8 EA029939 B8 EA 029939B8 EA 201171383 A EA201171383 A EA 201171383A EA 201171383 A EA201171383 A EA 201171383A EA 029939 B8 EA029939 B8 EA 029939B8
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- influenza virus
- binding molecules
- subtype
- molecules capable
- Prior art date
Links
- 241000712461 unidentified influenza virus Species 0.000 title abstract 4
- 230000003472 neutralizing effect Effects 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 241000252870 H3N2 subtype Species 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
Abstract
Изобретение относится к связывающим молекулам, таким как человеческие моноклональные антитела, которые связываются с вирусом гриппа, содержащим HA подтипа H3, таким как H3N2, и обладают нейтрализующей активностью широкого ряда, направленной против таких вирусов гриппа. Изобретение также относится к молекулам нуклеиновой кислоты, кодирующим антитела, к их последовательностям, к композициям, содержащим указанные антитела, и к способам идентификации или получения таких антител. Указанные антитела могут быть использованы для диагностики, профилактики и/или лечения инфекции, вызываемой вирусом гриппа подтипа H3N2. В предпочтительном варианте изобретения указанные антитела обеспечивают перекрестную защиту против инфекций, вызываемых вирусами различных подтипов, в результате чего могут быть осуществлены профилактика и/или лечение инфекций, вызываемых вирусами гриппа подтипов H3, H7 и/или H10.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21589009P | 2009-05-11 | 2009-05-11 | |
EP09159947 | 2009-05-11 | ||
EP10151155 | 2010-01-20 | ||
PCT/EP2010/056217 WO2010130636A1 (en) | 2009-05-11 | 2010-05-06 | Human binding molecules capable of neutralizing influenza virus h3n2 and uses thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201171383A1 EA201171383A1 (ru) | 2012-05-30 |
EA029939B1 EA029939B1 (ru) | 2018-06-29 |
EA029939B8 true EA029939B8 (ru) | 2021-04-21 |
Family
ID=42271865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201171383A EA029939B8 (ru) | 2009-05-11 | 2010-05-06 | Человеческие связывающие молекулы, обладающие способностью нейтрализовывать вирус гриппа h3n2, и их применение |
Country Status (19)
Country | Link |
---|---|
US (2) | US8470327B2 (ru) |
EP (1) | EP2430046B1 (ru) |
JP (2) | JP5813629B2 (ru) |
KR (1) | KR101790354B1 (ru) |
CN (2) | CN102448986B (ru) |
AR (1) | AR076570A1 (ru) |
AU (1) | AU2010247530B2 (ru) |
BR (1) | BRPI1012749B1 (ru) |
CA (1) | CA2761648C (ru) |
CU (1) | CU23938B1 (ru) |
EA (1) | EA029939B8 (ru) |
ES (1) | ES2934102T3 (ru) |
IL (1) | IL216222A (ru) |
MX (1) | MX2011011331A (ru) |
MY (1) | MY183517A (ru) |
NZ (1) | NZ596032A (ru) |
SG (1) | SG176003A1 (ru) |
TW (1) | TWI589300B (ru) |
WO (1) | WO2010130636A1 (ru) |
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WO2009035420A1 (en) * | 2007-09-13 | 2009-03-19 | Temasek Life Sciences Laboratory Limited | Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus h5-subtype or n1-subtype and uses thereof |
FR2921928B1 (fr) * | 2007-10-08 | 2011-03-04 | Sanofi Pasteur | Anticorps monoclonaux specifiques de l'hemagglutinine du virus grippal |
NZ586611A (en) * | 2007-12-06 | 2012-09-28 | Dana Farber Cancer Inst Inc | Antibodies against influenza virus and methods of use thereof |
ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
US8470327B2 (en) | 2009-05-11 | 2013-06-25 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus H3N2 and uses thereof |
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