EA029002B9 - Съедобная композиция - Google Patents
Съедобная композицияInfo
- Publication number
- EA029002B9 EA029002B9 EA201391803A EA201391803A EA029002B9 EA 029002 B9 EA029002 B9 EA 029002B9 EA 201391803 A EA201391803 A EA 201391803A EA 201391803 A EA201391803 A EA 201391803A EA 029002 B9 EA029002 B9 EA 029002B9
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- glucose
- flavonoid
- glucoside
- post
- prandial
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 5
- 229930003935 flavonoid Natural products 0.000 abstract 5
- 235000017173 flavonoids Nutrition 0.000 abstract 5
- 239000008103 glucose Substances 0.000 abstract 5
- 230000000291 postprandial effect Effects 0.000 abstract 4
- 108091006299 SLC2A2 Proteins 0.000 abstract 3
- -1 flavonoid glucoside Chemical class 0.000 abstract 3
- 229930182478 glucoside Natural products 0.000 abstract 3
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 2
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 150000002215 flavonoids Chemical class 0.000 abstract 2
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102100026189 Beta-galactosidase Human genes 0.000 abstract 1
- 102000058058 Glucose Transporter Type 2 Human genes 0.000 abstract 1
- 108090000604 Hydrolases Proteins 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 108010059881 Lactase Proteins 0.000 abstract 1
- IOUVKUPGCMBWBT-DARKYYSBSA-N Phloridzin Natural products O[C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-DARKYYSBSA-N 0.000 abstract 1
- 102000000070 Sodium-Glucose Transport Proteins Human genes 0.000 abstract 1
- 108010080361 Sodium-Glucose Transport Proteins Proteins 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 102000003673 Symporters Human genes 0.000 abstract 1
- 108090000088 Symporters Proteins 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 108010005774 beta-Galactosidase Proteins 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 230000004190 glucose uptake Effects 0.000 abstract 1
- 230000002641 glycemic effect Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 229940116108 lactase Drugs 0.000 abstract 1
- 235000012054 meals Nutrition 0.000 abstract 1
- IOUVKUPGCMBWBT-UHFFFAOYSA-N phloridzosid Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-UHFFFAOYSA-N 0.000 abstract 1
- 235000019139 phlorizin Nutrition 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Продукты или пища с высоким содержанием доступных углеводов, таких как сахароза или крахмал, повышают постпрандиальные концентрации глюкозы в крови. Повторяющиеся высокие постпрандиальные "всплески" глюкозы в плазме ассоциируют с повышенным риском развития диабета второго типа. Неконтролируемые колебания уровня глюкозы являются нежелательными и любое снижение или "притупление" постпрандиальной концентрации глюкозы в крови потенциально является благоприятным. Данное изобретение относится к съедобной композиции для замедления поглощения глюкозы в кишечнике через синергетическое ингибирование как активного натрий-глюкозного котранспортера 1 (SGLT1), так и пассивного транспортера глюкозы 2 (GLUT2), приводя к выравниванию или притуплению постпрандиального глюкозного пика. Таким образом, в первом аспекте изобретения предоставлена съедобная композиция, при этом композиция содержит по меньшей мере 5%, в расчете на сухую массу, по меньшей мере одного флавоноидного агликона и по меньшей мере 5%, в расчете на сухую массу, по меньшей мере одного флавоноидного глюкозида, где флавоноидный глюкозид по меньшей мере на 20%, предпочтительно по меньшей мере на 40%, наиболее предпочтительно по меньшей мере на 60% более устойчив к гидролизу с помощью лактазы-флоридзингидролазы, чем кверцетин-4-глюкозид, и где флавоноидный агликон является ингибитором GLUT2 и флавоноидный глюкозид является ингибитором SGLT1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11168797 | 2011-06-06 | ||
| PCT/EP2012/059956 WO2012168108A1 (en) | 2011-06-06 | 2012-05-29 | An edible composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EA201391803A1 EA201391803A1 (ru) | 2014-03-31 |
| EA029002B1 EA029002B1 (ru) | 2018-01-31 |
| EA029002B9 true EA029002B9 (ru) | 2019-02-28 |
Family
ID=44588275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201391803A EA029002B9 (ru) | 2011-06-06 | 2012-05-29 | Съедобная композиция |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9387219B2 (ru) |
| EP (1) | EP2717721B1 (ru) |
| CN (1) | CN103813723B (ru) |
| AU (1) | AU2012266581B2 (ru) |
| BR (1) | BR112013030171B1 (ru) |
| CA (1) | CA2835753C (ru) |
| EA (1) | EA029002B9 (ru) |
| WO (1) | WO2012168108A1 (ru) |
| ZA (1) | ZA201308549B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2944311A1 (de) * | 2014-05-16 | 2015-11-18 | BioActive Food GmbH | Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen |
| PL3344070T3 (pl) | 2015-09-03 | 2020-06-15 | Unilever Nv | Jadalna kompozycja |
| CN108882742A (zh) * | 2016-02-10 | 2018-11-23 | Pm国际股份公司 | 用以减少和/或阻止肠道葡萄糖吸收的含有番石榴苷的组合物、膳食补充剂、组合物的用途和膳食补充剂的制备方法 |
| WO2019002499A1 (en) * | 2017-06-30 | 2019-01-03 | Unilever Plc | EDIBLE COMPOSITION |
| CN111973580B (zh) * | 2020-09-15 | 2023-01-24 | 河南大学 | 咖啡酸在制备促进葡萄糖吸收药物方面的应用 |
| CN115645431B (zh) * | 2022-12-12 | 2023-03-21 | 汤臣倍健股份有限公司 | 一种组合物及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3806210A1 (de) | 1988-02-26 | 1989-09-07 | Robugen Gmbh | Kamille |
| JP4584453B2 (ja) * | 1998-10-29 | 2010-11-24 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | バイオフラボノールの混合物を含む組成物 |
| JP4719372B2 (ja) * | 2000-06-21 | 2011-07-06 | 花王株式会社 | Ｐｐａｒ依存的遺伝子転写活性化剤 |
| DE10053496A1 (de) | 2000-10-27 | 2002-05-08 | Peter Fuerst | Zusammensetzungen enthaltend Flavonoide und Phloridzin oder Phloretin |
| DK1379146T3 (da) | 2001-03-23 | 2009-08-17 | Nutricia Nv | Præparat til forebyggelse og/eller behandling af ændret knoglemetabolisme |
| FR2836336B1 (fr) | 2002-02-26 | 2004-08-27 | Diana Ingredients | Utilisation dans un traitement cosmetique d'une fraction phenolique riche en dihydrochalcones |
| US20040131749A1 (en) * | 2002-08-29 | 2004-07-08 | Archer-Daniels-Midland Company | Phytochemicals from edible bean process streams |
| JP4012814B2 (ja) * | 2002-12-05 | 2007-11-21 | 剛 李 | 苦蕎麦を原料とするアルドース還元酵素阻害剤及びソルビトール降下剤 |
| US7560131B2 (en) * | 2002-12-24 | 2009-07-14 | Fuji Oil Company, Limited | High solubility composition with high isoflavone concentration and process of producing same |
| JP4344913B2 (ja) * | 2003-01-31 | 2009-10-14 | 株式会社フラバミン | ケルセチン組成物、食品保存剤及びその製造方法 |
| DE102004004034A1 (de) * | 2004-01-27 | 2005-08-18 | Lichtwer Pharma Ag | Zwiebelextrakte |
| US7772195B2 (en) * | 2004-07-29 | 2010-08-10 | Board Of Trustees Of Michigan State University | Methods and compositions for the treatment of obesity, insulin related diseases and hypercholesterolemia |
| WO2006074278A2 (en) | 2005-01-05 | 2006-07-13 | Mitsunori Ono | Compositions for treating diabetes or obesity |
| CN1942097A (zh) | 2005-01-21 | 2007-04-04 | 西斯汀财产有限公司 | 富含根皮苷的植物提取物及使用该提取物调整血糖含量和抗衰老的方法 |
| US20060172012A1 (en) | 2005-01-28 | 2006-08-03 | Finley John W | Anti-inflammatory supplement compositions and regimens to reduce cardiovascular disease risks |
| FR2882933B1 (fr) * | 2005-03-14 | 2007-04-20 | Scalime France Sa | Utilisation d'un extrait d'oignon pour la fabrication d'une composition pour controler la prise de poids |
| WO2006119038A1 (en) | 2005-04-29 | 2006-11-09 | Naturegen, Inc. | Compositions and methods for controlling glucose uptake |
| US20070036874A1 (en) | 2005-08-05 | 2007-02-15 | Litao Zhong | Compositions and methods for controlling glucose and lipid uptake from foods |
| FR2889955B1 (fr) | 2005-08-31 | 2008-12-19 | Cooperative Agricole Elle Et V | Procede d'obtention d'un extrait vegetal de fruits a pepins, extrait vegetal ainsi obtenu et ses utilisations |
| WO2007124102A2 (en) | 2006-04-21 | 2007-11-01 | Western Holdings, Llc | Preparation and use of phlorizin compositions |
| JP5254227B2 (ja) | 2006-07-17 | 2013-08-07 | クリスチャン ラインズ，トーマス | ケルセチン含有組成物 |
| MX2009009996A (es) | 2007-03-19 | 2010-01-20 | Atm Metabolics Lllp | Composicion y metodo para tratar diabetes y trastornos metabolicos. |
| WO2008124105A1 (en) | 2007-04-04 | 2008-10-16 | Naturegen, Inc. | Compositions and methods for obesity, diabetes and metabolic syndrome control and management |
| US20100166851A1 (en) | 2007-05-04 | 2010-07-01 | Nutraceutic Et Business Consulting | Composition having lipolytic activity, production method thereof and use of the composition |
| WO2009066303A2 (en) | 2007-11-22 | 2009-05-28 | Ganga Raju Gokaraju | New synergistic phytochemical composition for the treatment of obesity |
| KR20090125918A (ko) * | 2008-06-03 | 2009-12-08 | (주)에스에스사이언스 | 항당뇨성 조성물 및 그 제조방법 |
| FR2935096B1 (fr) * | 2008-08-21 | 2010-12-10 | Cooperative Agricole D Elle Et Vire | Compositions riches en acide chlorogenique, leur procede d'obtention et leur utilisation |
| IT1392101B1 (it) | 2008-12-12 | 2012-02-09 | Zuccari Societa A Responsabilita Limitata In Breve Zuccari S R L | Composizione comprendente isoflavoni |
| CN101991593A (zh) * | 2009-08-14 | 2011-03-30 | 张景元 | 槲皮苷在制药中的应用 |
| JP5594719B2 (ja) * | 2010-01-06 | 2014-09-24 | 国立大学法人神戸大学 | 筋肉の糖取り込み促進剤 |
-
2012
- 2012-05-29 BR BR112013030171-6A patent/BR112013030171B1/pt active IP Right Grant
- 2012-05-29 CA CA2835753A patent/CA2835753C/en active Active
- 2012-05-29 CN CN201280027352.5A patent/CN103813723B/zh active Active
- 2012-05-29 EP EP12725369.8A patent/EP2717721B1/en active Active
- 2012-05-29 WO PCT/EP2012/059956 patent/WO2012168108A1/en active Application Filing
- 2012-05-29 AU AU2012266581A patent/AU2012266581B2/en active Active
- 2012-05-29 US US14/122,355 patent/US9387219B2/en active Active
- 2012-05-29 EA EA201391803A patent/EA029002B9/ru not_active IP Right Cessation
-
2013
- 2013-11-13 ZA ZA2013/08549A patent/ZA201308549B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2717721A1 (en) | 2014-04-16 |
| EP2717721B1 (en) | 2017-07-12 |
| WO2012168108A1 (en) | 2012-12-13 |
| CN103813723A (zh) | 2014-05-21 |
| US9387219B2 (en) | 2016-07-12 |
| BR112013030171A2 (pt) | 2016-08-09 |
| AU2012266581B2 (en) | 2014-10-30 |
| AU2012266581A1 (en) | 2013-11-21 |
| US20140107052A1 (en) | 2014-04-17 |
| EA201391803A1 (ru) | 2014-03-31 |
| CA2835753A1 (en) | 2012-12-13 |
| ZA201308549B (en) | 2015-02-25 |
| BR112013030171B1 (pt) | 2021-10-05 |
| CA2835753C (en) | 2020-03-10 |
| CN103813723B (zh) | 2017-03-15 |
| EA029002B1 (ru) | 2018-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |
|
| TH4A | Publication of the corrected specification to eurasian patent |