EA201590816A1 - Съедобная композиция, содержащая ресвератрол и моноглюкозид флавоноида - Google Patents
Съедобная композиция, содержащая ресвератрол и моноглюкозид флавоноидаInfo
- Publication number
- EA201590816A1 EA201590816A1 EA201590816A EA201590816A EA201590816A1 EA 201590816 A1 EA201590816 A1 EA 201590816A1 EA 201590816 A EA201590816 A EA 201590816A EA 201590816 A EA201590816 A EA 201590816A EA 201590816 A1 EA201590816 A1 EA 201590816A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- glucose
- edible composition
- postprandial
- flavonoid
- blunting
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229930003935 flavonoid Natural products 0.000 title abstract 2
- 150000002215 flavonoids Chemical class 0.000 title abstract 2
- 235000017173 flavonoids Nutrition 0.000 title abstract 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 title 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 title 1
- 229940016667 resveratrol Drugs 0.000 title 1
- 235000021283 resveratrol Nutrition 0.000 title 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 6
- 239000008103 glucose Substances 0.000 abstract 6
- 230000000291 postprandial effect Effects 0.000 abstract 4
- 108091006299 SLC2A2 Proteins 0.000 abstract 2
- 108091006277 SLC5A1 Proteins 0.000 abstract 2
- 102000058090 Sodium-Glucose Transporter 1 Human genes 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 235000013305 food Nutrition 0.000 abstract 2
- 229920002472 Starch Polymers 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical compound C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 abstract 1
- PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 abstract 1
- 238000009499 grossing Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 230000008092 positive effect Effects 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- -1 sucrose or starch Chemical class 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- YCVPRTHEGLPYPB-VOTSOKGWSA-N trans-pinosylvin Chemical compound OC1=CC(O)=CC(\C=C\C=2C=CC=CC=2)=C1 YCVPRTHEGLPYPB-VOTSOKGWSA-N 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Пищевые продукты или блюда с высоким содержанием доступных углеводов, таких как сахароза или крахмал, повышают постпрандиальную концентрацию глюкозы в крови. Повторяющиеся высокие постпрандиальные "всплески" глюкозы в плазме связаны с повышенным риском развития диабета II типа. Неконтролируемые колебания уровня глюкозы являются нежелательными, и любое снижение или "притупление" постпрандиальной концентрации глюкозы в крови потенциально обеспечивает положительный эффект. Настоящее изобретение относится к съедобной композиции для замедления поглощения глюкозы в кишечнике посредством синергетического ингибирования активного натрий-глюкозного котранспортёра 1 (SGLT1) и пассивного транспортёра глюкозы 2 (GLUT2), что приводит к сглаживанию или притуплению постпрандиального глюкозного пика. В первом аспекте настоящего изобретения предложена съедобная композиция в виде отдельной порции одной или более единичных доз, причём указанная съедобная композиция содержит 20-2000, предпочтительно 30-1000, наиболее предпочтительно 40-500 мг 3,5-дигидрокси-транс-стильбена и 10-2000, предпочтительно 20-1000, наиболее предпочтительно 40-500 мг моноглюкозида флавоноида или моноглюкозида дигидрохалкона.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12195842 | 2012-12-06 | ||
| PCT/EP2013/074833 WO2014086632A1 (en) | 2012-12-06 | 2013-11-27 | An edible composition comprising resveratrol and flavonoid monoglucoside |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201590816A1 true EA201590816A1 (ru) | 2015-11-30 |
| EA032918B1 EA032918B1 (ru) | 2019-08-30 |
Family
ID=47323974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201590816A EA032918B1 (ru) | 2012-12-06 | 2013-11-27 | Съедобная композиция ресвератрола и моноглюкозида флавоноида для снижения постпрандиальной пиковой амплитуды уровня глюкозы в крови или гликемической реакции |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9943535B2 (ru) |
| EP (1) | EP2928323B1 (ru) |
| CN (1) | CN105142426B (ru) |
| BR (1) | BR112015013046A2 (ru) |
| EA (1) | EA032918B1 (ru) |
| WO (1) | WO2014086632A1 (ru) |
| ZA (1) | ZA201504071B (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2928323B1 (en) | 2012-12-06 | 2018-01-03 | Unilever Plc. | An edible composition comprising resveratrol and flavonoid monoglucoside. |
| EP3177287B1 (en) * | 2014-08-08 | 2022-02-23 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| CN105816473B (zh) * | 2015-07-06 | 2018-04-10 | 武汉华纳联合药业有限公司 | 一种黄酮苷类组合物及其制剂和制法 |
| WO2017036926A1 (en) | 2015-09-03 | 2017-03-09 | Unilever Plc | Edible composition |
| WO2017080958A1 (en) * | 2015-11-13 | 2017-05-18 | Unilever Plc | Composition for hair follicle growth |
| CN108882742A (zh) * | 2016-02-10 | 2018-11-23 | Pm国际股份公司 | 用以减少和/或阻止肠道葡萄糖吸收的含有番石榴苷的组合物、膳食补充剂、组合物的用途和膳食补充剂的制备方法 |
| CN108822168B (zh) * | 2018-05-31 | 2020-08-11 | 浙江大学 | 一种锦葵素-3-o-半乳糖苷的分离纯化方法及其应用 |
| CN110669782B (zh) * | 2019-10-10 | 2022-11-01 | 南京农业大学 | 大豆糖转运体基因GmSWEET39的应用 |
| CN111096972B (zh) * | 2020-02-25 | 2023-07-14 | 成都医学院 | 一种预防和/或治疗阿尔茨海默症的药物组合物 |
| MX2022013046A (es) * | 2020-04-17 | 2023-01-30 | Conagen Inc | Bloqueadores de sabor amargo y métodos de uso relacionados. |
| WO2023150624A1 (en) * | 2022-02-02 | 2023-08-10 | RedLeaf Biologics, Inc. | Compositions for food coloring and antioxidant supplementation derived from sorghum |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006074278A2 (en) * | 2005-01-05 | 2006-07-13 | Mitsunori Ono | Compositions for treating diabetes or obesity |
| CN102015030A (zh) * | 2006-03-31 | 2011-04-13 | 帝斯曼知识产权资产管理有限公司 | 化合物和化合物的组合用于改善身体外观的新型用途 |
| DE202007019713U1 (de) | 2006-12-20 | 2016-07-15 | Unilever N.V. | Mundpflegezusammensetzungen |
| JP2010531816A (ja) | 2007-07-04 | 2010-09-30 | ベイジン ギンコ グループ | コケモモ抽出物含有の美容組成物及びその応用 |
| CN100560579C (zh) * | 2007-07-04 | 2009-11-18 | 北京绿色金可生物技术股份有限公司 | 红豆越橘提取物及其制备方法和应用 |
| WO2011107494A1 (de) * | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2928323B1 (en) | 2012-12-06 | 2018-01-03 | Unilever Plc. | An edible composition comprising resveratrol and flavonoid monoglucoside. |
-
2013
- 2013-11-27 EP EP13802293.4A patent/EP2928323B1/en not_active Not-in-force
- 2013-11-27 BR BR112015013046A patent/BR112015013046A2/pt not_active Application Discontinuation
- 2013-11-27 EA EA201590816A patent/EA032918B1/ru not_active IP Right Cessation
- 2013-11-27 WO PCT/EP2013/074833 patent/WO2014086632A1/en active Application Filing
- 2013-11-27 CN CN201380063646.8A patent/CN105142426B/zh not_active Expired - Fee Related
- 2013-11-27 US US14/647,751 patent/US9943535B2/en not_active Expired - Fee Related
-
2015
- 2015-06-05 ZA ZA2015/04071A patent/ZA201504071B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN105142426A (zh) | 2015-12-09 |
| ZA201504071B (en) | 2017-07-26 |
| BR112015013046A2 (pt) | 2017-07-11 |
| EP2928323B1 (en) | 2018-01-03 |
| WO2014086632A1 (en) | 2014-06-12 |
| US20150313927A1 (en) | 2015-11-05 |
| CN105142426B (zh) | 2019-04-16 |
| EP2928323A1 (en) | 2015-10-14 |
| US9943535B2 (en) | 2018-04-17 |
| EA032918B1 (ru) | 2019-08-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201590816A1 (ru) | Съедобная композиция, содержащая ресвератрол и моноглюкозид флавоноида | |
| EA201501032A1 (ru) | Фармацевтическая композиция, способы лечения и ее применения | |
| CL2013001433A1 (es) | Composicion que comprende al menos una n-acetil lactosamina, al menos un oligosacarido sialilado al menos un oligosacarido fucosilado; y su uso en la prevencion de infecciones respiratorias agudas y/o para aliviar los sintomas de dichas infecciones. | |
| BR112018016001A2 (pt) | composição farmacêutica, métodos de tratamento e usos da mesma | |
| CY1120690T1 (el) | Κρυσταλλικη μορφη βενζυλοβενζολικου αναστολεα τουsglt2 | |
| EA201590715A1 (ru) | Производные эксендина-4 как двойные агонисты glp1/глюкагона | |
| BR112016024850A2 (pt) | composições e métodos para modulação da expressão 3 semelhante a antiopoietina | |
| EA201591174A1 (ru) | Функционализированные производные эксендина-4 | |
| EA201290975A8 (ru) | Применение фитоканнабиноида каннабидиварина (cbdv) для лечения эпилепсии | |
| EA201500996A1 (ru) | Терапевтические применения эмпаглифлозина | |
| MX2020010004A (es) | Composicion farmaceutica que comprende empagliflozina, metodos para tratamiento y sus usos. | |
| BR112013027479A2 (pt) | "usos de um composto ou de um oligonucleotídeo modificado dirigidos a apociii, e medicamento compreendendo o referido composto" | |
| MY175997A (en) | Antl-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig protein scaffold for reducing the risk of mortality in a patient having a chronic or acute disease or acute condition | |
| AR087729A1 (es) | Composicion farmaceutica, metodos para tratamiento y usos de los mismos | |
| MX336145B (es) | Metodo para el tratamiento de insuficiencia cardiaca cronica. | |
| EA201791145A1 (ru) | Композиция пищевых волокон | |
| BR112018003842A2 (pt) | método para inibir a absorção de lipídios e/ou promover a excreção de lipídios utilizando d-psicose | |
| BR112016006623A2 (pt) | biscoito para o café da manhã com glicose de liberação lenta | |
| BR112014029301A2 (pt) | métodos de tratamento de síndrome metabólica através de modulação da proteína choque térmico (hsp) 90-beta | |
| BR112015017525A2 (pt) | peptídeo modificado, sal de um peptídeo modificado, medicamento, e, métodos para tratar ou aliviar uma doença cardiovascular e para produzir um peptídeo modificado | |
| WO2018169282A3 (ko) | Atpif1을 함유하는 당뇨 치료용 약학조성물 | |
| EA201391803A1 (ru) | Съедобная композиция | |
| EA201200786A1 (ru) | Комбинированная композиция, содержащая в качестве активного ингредиента l-карнитин или пропионил-l-карнитин, для предотвращения или лечения хронической венозной недостаточности | |
| AR110344A1 (es) | Métodos y regímenes de alimentación que comprenden la administración de composiciones nutricionales que contienen butirato dietario | |
| CO2017001899A2 (es) | Tratamiento del cáncer con el inhibidor de la alfa-amilasa en los animales de compañía |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM RU |