EA025595B1 - Фармацевтические композиции, содержащие 40-о-(2-гидрокси)этилрапамицин - Google Patents

Фармацевтические композиции, содержащие 40-о-(2-гидрокси)этилрапамицин Download PDF

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Publication number
EA025595B1
EA025595B1 EA201490743A EA201490743A EA025595B1 EA 025595 B1 EA025595 B1 EA 025595B1 EA 201490743 A EA201490743 A EA 201490743A EA 201490743 A EA201490743 A EA 201490743A EA 025595 B1 EA025595 B1 EA 025595B1
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EA
Eurasian Patent Office
Prior art keywords
sustained release
pharmaceutical composition
coating
release
hydroxy
Prior art date
Application number
EA201490743A
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English (en)
Russian (ru)
Other versions
EA201490743A1 (ru
Inventor
Анке Дидерих
Курт Лихти
Петер Кюль
Винг Чеунг
Original Assignee
Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201490743A1 publication Critical patent/EA201490743A1/ru
Publication of EA025595B1 publication Critical patent/EA025595B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EA201490743A 2011-10-06 2012-10-03 Фармацевтические композиции, содержащие 40-о-(2-гидрокси)этилрапамицин EA025595B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161544026P 2011-10-06 2011-10-06
PCT/EP2012/069541 WO2013050419A1 (en) 2011-10-06 2012-10-03 Pharmaceutical compositions comprising 40 - o - ( 2 - hydroxy) ethyl - rapamycin

Publications (2)

Publication Number Publication Date
EA201490743A1 EA201490743A1 (ru) 2014-07-30
EA025595B1 true EA025595B1 (ru) 2017-01-30

Family

ID=46968222

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490743A EA025595B1 (ru) 2011-10-06 2012-10-03 Фармацевтические композиции, содержащие 40-о-(2-гидрокси)этилрапамицин

Country Status (24)

Country Link
US (3) US20140242162A1 (OSRAM)
EP (1) EP2763663B1 (OSRAM)
JP (1) JP6368242B2 (OSRAM)
KR (1) KR101643219B1 (OSRAM)
CN (1) CN103874484B (OSRAM)
AR (1) AR088232A1 (OSRAM)
AU (1) AU2012320563B2 (OSRAM)
BR (1) BR112014007902A2 (OSRAM)
CA (1) CA2850995A1 (OSRAM)
CL (1) CL2014000844A1 (OSRAM)
CO (1) CO6930364A2 (OSRAM)
EA (1) EA025595B1 (OSRAM)
ES (1) ES2663744T3 (OSRAM)
GT (1) GT201400062A (OSRAM)
IL (1) IL231648A0 (OSRAM)
MA (1) MA35513B1 (OSRAM)
MX (1) MX2014004166A (OSRAM)
PE (1) PE20141649A1 (OSRAM)
PH (1) PH12014500746A1 (OSRAM)
SG (1) SG11201400730VA (OSRAM)
TN (1) TN2014000114A1 (OSRAM)
TW (1) TWI475993B (OSRAM)
WO (1) WO2013050419A1 (OSRAM)
ZA (1) ZA201401961B (OSRAM)

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TW201503912A (zh) * 2013-03-19 2015-02-01 Novartis Ag 包含癌莫事（ｅｖｅｒｏｌｉｍｕｓ）之醫藥組合物
US10709700B2 (en) 2014-09-15 2020-07-14 Orphazyme A/S Arimoclomol formulation
US20160250270A1 (en) 2015-02-27 2016-09-01 Ebbu, LLC Compositions comprising combinations of purified cannabinoids, with at least one flavonoid, terpene, or mineral
EP3297629A1 (en) 2015-05-20 2018-03-28 Novartis AG Pharmaceutical combination of everolimus with dactolisib
EP3329916A4 (en) 2015-07-28 2019-03-20 Nippon Kayaku Kabushiki Kaisha PHARMACEUTICAL COMPOSITION COMPRISING RAPAMYCIN OR A DERIVATIVE THEREOF, AND PROCESS FOR PRODUCING THE SAME
JP6762158B2 (ja) * 2015-07-28 2020-09-30 日本化薬株式会社 ラパマイシン又はその誘導体を含有する医薬組成物
WO2017038925A1 (ja) * 2015-09-03 2017-03-09 日本化薬株式会社 ラパマイシン又はその誘導体を含有する医薬組成物
JP6854639B2 (ja) * 2016-01-06 2021-04-07 日本化薬株式会社 ラパマイシン誘導体を含有する医薬組成物及びその製造方法
CA3034004C (en) 2016-08-29 2021-08-03 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
US12485129B2 (en) 2016-08-29 2025-12-02 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
BR112019010470A2 (pt) 2016-11-23 2019-09-10 Novartis Ag métodos de realce de resposta imune com everolimo, dactolisib ou ambos
EP3576735A4 (en) * 2017-02-06 2020-07-22 Intas Pharmaceuticals Limited PHARMACEUTICAL COMPOSITION OF EVEROLIMUS
KR102051806B1 (ko) * 2018-01-12 2019-12-04 주식회사 종근당 에베로리무스를 포함하는 안정화된 약제학적 제제
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
JP2023520021A (ja) * 2020-03-30 2023-05-15 アイジーアイエー ファーマシューティカルズ インコーポレイテッド チロシンキナーゼ阻害剤の小児用製剤
WO2022219652A1 (en) * 2021-04-17 2022-10-20 Bdr Pharmaceuticals International Private Limited Novel sublingual pharmaceutical formulations for everolimus
KR102336007B1 (ko) * 2021-06-23 2021-12-07 주식회사 진성이앤지 콘크리트용 우레탄계 방수·방식 도막재 및 이를 이용한 방수·방식 도장 공법
WO2023044024A1 (en) * 2021-09-17 2023-03-23 Novelstar Pharmaceuticals Inc. Novel ph dependent coating drug delivery system
GB202415232D0 (en) 2024-10-16 2024-11-27 Nacamed As Composition

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WO2005034916A1 (en) * 2003-10-03 2005-04-21 Novartis Ag Pharmaceutical multiparticulate composition comprising mycophenolic acid or mycophenolate sodium and combination with rapamycin
WO2010056754A2 (en) * 2008-11-11 2010-05-20 The Board Regents Of The University Of Texas System Inhibition of mammalian target of rapamycin

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